Pigment Cell & Melanoma Research: 

Loss‐of‐function mutations in the melanocortin‐1‐receptor (Mc1r) cause disruption of dorso‐ventral countershading in teleost fish

Abstract The Melanocortin 1 receptor (MC1R) is the central melanocortin receptor involved in vertebrate pigmentation. Mutations in this gene cause variations in coat coloration in amniotes. Additionally, in mammals MC1R is the main receptor for agouti signaling protein (ASIP), making it the critical receptor for the establishment of dorsal‐ventral countershading. In fish, Mc1r is also involved in pigmentation but it has been almost exclusively studied in relation to melanosome dispersion activity...

Wiley: Pigment Cell & Melanoma Research: Table of Contents

21m

C57BL/6 congenic mouse NRASQ61K melanoma cell lines are highly sensitive to the combination of MEK and AKT inhibitors in vitro and in vivo

Abstract RAS is frequently mutated in various tumors and known to be difficult to target. NRASQ61K/R are the second most frequent mutations found in human skin melanoma after BRAFV600E. Aside from surgery, various approaches, including targeted therapies, immunotherapies, and combination therapies, are used to treat patients carrying NRAS mutations, but they are inefficient. Here, we established mouse NRASQ61K melanoma cell lines and genetically derived isografts (GDIs) from Tyr::NRASQ61K mouse...

Wiley: Pigment Cell & Melanoma Research: Table of Contents

21m