Systemic sclerosis is a rare and heterogeneous autoimmune disease characterized by immune dysregulation, microvascular damage, and organ fibrosis. Interstitial lung disease (ILD) is a common manifestation of systemic sclerosis that tends to occur early in the course of disease; the condition places…
Presentation of Case. Dr. Taylor A. Lebeis: A 52-year-old woman who had undergone orthotopic heart transplantation because of dilated cardiomyopathy was admitted to this hospital with painful red lesions on the left arm and leg. Eight years before this admission, the patient had ongoing episodes of…
The majority of burn injuries are minor and either do not require treatment or can be treated by any caregiver. More severe burns can result in clinically significant morbidity and, unless treated appropriately, can lead to severe scarring. Major burns lead to a profound systemic response that has…
Historically, metastatic melanoma has been associated with a poor prognosis, but the introduction of BRAF- and MEK-targeted therapies and immune checkpoint inhibitors has substantially improved outcomes in these patients. Each of these therapies — including drugs that target programmed cell death 1…
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