| Related Articles |
Fractures of the hyoid bone; presentation of two cases, with a review of the literature.
Arch Otolaryngol. 1949 Mar;49(3):266-74
Authors: OLMSTEAD EG
PMID: 18124768 [PubMed - indexed for MEDLINE]
| Related Articles |
Intralaryngeal approach for arytenoidectomy in bilateral abductor paralysis of the vocal cords; a preliminary report.
Arch Otolaryngol. 1948 Apr;47(4):505-8
Authors: THORNELL WC
PMID: 18879951 [PubMed - indexed for MEDLINE]
| Related Articles |
[Hemiplegic stroke with unilateral paralysis of the abductors].
Otorinolaringol Ital. 1948;16(3-4):260-2
Authors: PIGNATTI G
PMID: 18868899 [PubMed - indexed for MEDLINE]
| Related Articles |
[Not Available].
Otorinolaringol Ital. 1948;16(3-4):242-5
Authors: PETTERINO PATRIARCA A
PMID: 18868894 [PubMed - indexed for MEDLINE]
| Related Articles |
[Not Available].
Otorinolaringol Ital. 1948;16(3-4):223-8
Authors: CAVAZZANI F
PMID: 18868890 [PubMed - indexed for MEDLINE]
| Related Articles |
Beta hemolytic streptococcus parasitism in infections of the upper respiratory tract.
Arch Otolaryngol. 1947 Dec;46(6):762-72
Authors: FOX N
PMID: 18918224 [PubMed - indexed for MEDLINE]
| Related Articles |
[Not Available].
Helv Paediatr Acta. 1947 Nov;2(5):397-404
Authors: DOLIVO G
PMID: 20273234 [PubMed - indexed for MEDLINE]
| Related Articles |
[Not Available].
Med Monatsschr. 1947 Nov;1(11):496-9
Authors: LORENZ O
PMID: 18857242 [PubMed - indexed for MEDLINE]
| Related Articles |
The upper respiratory tract and the dentist.
Oral Hyg. 1947 Oct;37(10):1730-3
Authors: STUTEVILLE OH
PMID: 20264625 [PubMed - indexed for MEDLINE]
| Related Articles |
The physiology of speech; its laryngeal aspect.
Arch Otolaryngol. 1947 Sep;46(3):416
Authors: WESTLAKE H
PMID: 20340523 [PubMed - indexed for MEDLINE]
| Related Articles |
[Not Available].
Wien Klin Wochenschr. 1947 Aug 22;59(33):543-6
Authors: HOHLBRUGGER H, KELLNER H
PMID: 18921207 [PubMed - indexed for MEDLINE]
| Related Articles |
[Not Available].
Lyon Med. 1947 May 25;177(21):345-8
Authors: REBATTU J, MARTIN H
PMID: 20268749 [PubMed - indexed for MEDLINE]
| Related Articles |
The vallecular sign; its diagnosis and clinical significance.
Am J Roentgenol Radium Ther. 1947 Apr;57(4):435-45
Authors: ARENDT J, WOLF A
PMID: 20295662 [PubMed - indexed for MEDLINE]
| Related Articles |
Use of iodolake in the treatment of upper respiratory tract.
Med World (New York). 1947 Jan;65(1):26-8
Authors: FRANKEL DE
PMID: 20288363 [PubMed - indexed for MEDLINE]
| Related Articles |
Hemophilus influenza epiglottitis.
Clin Proc Child Hosp Dist Columbia. 1946 Jul;2(8):185-8
Authors: STIEGLER C
PMID: 20275892 [PubMed - indexed for MEDLINE]
| Related Articles |
Leeches as temporary endo-parasites in the upper respiratory tract of man.
J Laryngol Otol. 1945 Sep;60:369-72
Authors: REEVES B
PMID: 20982886 [PubMed - indexed for MEDLINE]
2065 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results:
upper respiratory tract infection
These pubmed results were generated on 2018/12/04
PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
| Related Articles |
[Not Available].
Otorinolaringol Ital. 1948;16(5):277-300
Authors: GIUFFRIDA E
PMID: 18876524 [PubMed - indexed for MEDLINE]
| Related Articles |
A rare case of carcinoma in the dog.
Vet Med. 1948 Jan;43(1):33
Authors: FREY WA
PMID: 18934685 [PubMed - indexed for MEDLINE]
| Related Articles |
Hemangioendothelioma; a rare malignant tumor.
Radiology. 1947 Aug;49(2):231-7
Authors: DRUCKER V
PMID: 20256681 [PubMed - indexed for MEDLINE]
| Related Articles |
Primary systemic amyloidosis; jaundice as a rare accompaniment.
Am J Med Sci. 1946 Sep;212(3):275-9
Authors: ORLOFF J, FELDER L
PMID: 20996971 [PubMed - indexed for MEDLINE]
| Related Articles |
Cor biatrium triloculare with transposition of the arterial trunks; a rare congenital cardiac malformation.
J Pathol Bacteriol. 1945 Oct;57:481-5
Authors: BRODIE J
PMID: 21012479 [PubMed - indexed for MEDLINE]
| Related Articles |
Graves' disease; treatment with radioiodine (I131).
Miss Valley Med J. 1949 Jul;71(4):131-4
Authors: SOLEY MH, MILLER ER, FOREMAN N
PMID: 18132663 [PubMed - indexed for MEDLINE]
| Related Articles |
Microsynthesis of C14-labeled ethyl-magnesium iodide.
Nature. 1948 Jan 08;162(4132):61
Authors: GLASCOCK R, ARROL WJ
PMID: 18106152 [PubMed - indexed for MEDLINE]
| Related Articles |
Bleeding polyp of the septum nasi.
Eye Ear Nose Throat Mon. 1949 Jan;28(1):19-22
Authors: WALDAPFEL R
PMID: 18105463 [PubMed - indexed for MEDLINE]
| Related Articles |
Columella reconstruction; a case of nasal deformity resulting from syphilis.
Br J Plast Surg. 1948 Jul;1(2):111-6
Authors: SHAW MH, FELL SR
PMID: 18874762 [PubMed - indexed for MEDLINE]
| Related Articles |
[Not Available].
Arch Mal Prof. 1948;9(4):323
Authors: L'EPEE, BANNEL
PMID: 18933477 [PubMed - indexed for MEDLINE]
| Related Articles |
Fatality under topical and local anesthesia for submucous resection; death before operation.
Newsl Am Soc Anesthesiol. 1948 Jan;12(1):25
Authors: BISHOP HF
PMID: 18915471 [PubMed - indexed for MEDLINE]
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The neglected septal cartilage graft, with experimental observations on the growth of human cartilage grafts.
Arch Otolaryngol. 1945 Nov-Dec;42:384-96
Authors: PEER LA
PMID: 21012410 [PubMed - indexed for MEDLINE]
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Are systematic drain tip or drainage fluid cultures predictive of surgical site infections?
J Hosp Infect. 2018 Nov 27;:
Authors: Macaigne H, Ruggieri VG, L Vallet-Tadeusz, Vernet-Garnier V, Aho-Glélé LS, Bajolet O, Lefebvre A
Abstract
BACKGROUND: Systematic cultures of drain tips or drainage fluids for the early detection of surgical site infections (SSI) are controversial.
AIM: To examine the association between the results of systematic drain tip or drainage fluid cultures and the occurrence of SSI in clean or clean-contaminated surgery.
METHODS: We searched in the Pubmed, and Cat.inist databases for observational studies published before March 31st 2017. We included studies reporting results of drain tip or drainage fluid systematic cultures and SSI after clean or clean-contaminated surgeries, and we performed meta-analyses.
FINDINGS: Seventeen studies, including 4,390 patients for drain tip cultures and 1,288 for drainage fluid cultures, were selected. The pooled negative predictive values were high (99%, 95% CI [98-100] for drain tip cultures and 98%, 95% CI [94-100] for drainage fluid cultures). The positive predictive values were low (11%, 95% CI [2-24] for drain tip cultures and 12%, 95% CI [3-24] for drainage fluid cultures). The sensitivities were low (41%, 95% CI [12-73] for drain tip cultures and 37%, 95% CI [16-60] for drainage fluid cultures). The specificities were high (93%, 95% CI [88-96]) for drain tip cultures and moderate (77%, 95% CI [54-94]) for drainage fluid cultures.
CONCLUSION: Systematic cultures of drain tips or drainage fluids appear not to be relevant, because their positive predictive values were low in the prediction of SSI.
PMID: 30500389 [PubMed - as supplied by publisher]
| Related Articles |
Evaluation of the mechanical cleaning efficacy of dental handpieces.
J Hosp Infect. 2018 Nov 27;:
Authors: Offner D, Brisset L, Musset AM
Abstract
OBJECTIVE: Dental handpieces undergo a decontamination process before reutilization. Thorough cleaning is a prerequisite to effective sterilization, to guarantee safety and prevent cross-infections. The objective of this study was to assess the cleaning efficacy offered by devices dedicated to dental handpieces.
MATERIAL AND METHODS: PIDTests©, which are patented tubes made out of transparent material and designed to replace handpieces in cleaning devices, were artificially stained by Soil Test© (Browne/STERIS). Three cycles were performed with PIDTests© connected to every handpiece adapter in the 4 different machines tested: X-Cid 2© (Micro-Mega) with a total of 9 PIDTests©; iCare+© (NSK) with 9 PIDTests©; DAC Universal© (W&H) with 18 PIDTests©; and BioDA 80© (VR2M) with 24 PIDTests©. A visual evaluation and a biuret reaction test were performed.
RESULTS: In 3 of the tested cleaning devices (X-Cid2©, iCare+© and DAC Universal©), all of the PIDTests© showed Soil Test© residues, on the internal and external surfaces indicating cleaning was ineffective. Only the BioDA 80© showed no residual stains on all the PIDTests© and negative biuret reaction test results, making the cleaning effective.
CONCLUSION: Manufacturers should optimize the cleaning device parameters, based on the Sinner circle (grouping compensatory parameters which influence the effectiveness of a cleaning process, such as pressure, temperature, time, detergent concentration), to improve cleaning efficacy and enable dental surgeons to ensure the safety. Although PIDTest© are the only tool to provide visual indications on the cleaning efficacy of washer-disinfectors dedicated to handpieces, manufacturers should continue with the development of improved and validated tools to assess cleaning efficacy.
PMID: 30500388 [PubMed - as supplied by publisher]
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The overall bioburden by total colony count does not predict presence of pathogens with high clinical relevance in the environment of hospitals and community.
J Hosp Infect. 2018 Nov 27;:
Authors: Widmer FC, Frei R, Romanyuk A, Sutter ST, Widmer AF
Abstract
BACKGROUND: Healthcare associated infections (HAIs) affect millions of patients, increasing morbidity and mortality. Pathogens of HAIs originate from both the patient's own flora and the environment, including multidrug-resistant organisms.
AIM: This study aimed (i) to determine the bioburden on different types of high-touch surfaces and (ii) to identify cultures to the species level and stratify strains in low and high clinical relevance.
DESIGN: Comparing bioburden with presence of pathogens of high clinical relevance (PHCR) in a tertiary care center and urban environment.
METHODS: The overall bioburden measured by total colony count (TCC) was assessed by Tryptic Soy contact plates and two selective agars to improve detection of PHCR. Isolates were routinely identified to the species level by matrix-assisted laser desorption/ionization - time of flight mass spectrometry (MALDI-TOF). Definition of PHCR was based on listings outlined by the Centers for Disease Control & Prevention (CDC).
FINDINGS: 1 431 contact plates were processed from 477 surface areas: 153 from hospitals and 324 from publicly accessible institutions or devices. In 73 samples, ≥1 PHCR was identified from cultures. TCC poorly correlated with presence of PHCR.
CONCLUSION: TCC poorly predicted presence of PHCR, rendering results from environmental sampling with TCC difficult to interpret. MALDI-TOF technique allows identifying large numbers of isolates at low cost from the environment. Further studies on environmental contamination should use MALDI-TOF to identify all grown pathogens for identification.
PMID: 30500387 [PubMed - as supplied by publisher]
| Related Articles |
Multi-centre study on cultural dimensions and perceived attitudes of nurses towards influenza vaccination uptake.
J Hosp Infect. 2018 Nov 27;:
Authors: Kwok KO, Li KK, Lee SS, Chng PHY, Wei VWI, Ismail NH, Mosli N, Koh D, Lai A, Lim JW
Abstract
This study explored how cultural values affected Health Belief Model (HBM) components and the influenza vaccine uptake among nurses across three Asian populations using a survey conducted in 2017 (N = 3971). The vaccination coverages were 33.5% (Brunei), 35.6% (Hong Kong) and 69.5% (Singapore). Three HBM components (perceived susceptibility, perceived benefits and cues to action) were positively associated with vaccination. A direct negative link and an indirect positive link via HBM were observed between collectivism and vaccination, whereas a negative indirect link via HBM between power distance and vaccination was observed. Cultural values, notably collectivism, advanced HBM to study nurses' vaccination.
PMID: 30500386 [PubMed - as supplied by publisher]
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Hepatitis C virus transmission in a Dutch haemodialysis unit: detailed outbreak investigation using NS5A gene sequencing.
J Hosp Infect. 2018 Nov 27;:
Authors: Heikens E, Hetem DJ, Jousma-Rutjes JPW, Nijhuis W, Boland GJ, Hommes NH, Thang OHD, Schuurman R
Abstract
BACKGROUND: Haemodialysis is a risk factor for hepatitis C virus (HCV) transmission. Two patients receiving haemodialysis in a Dutch dialysis unit in The Hague were found to seroconvert to HCV in December 2016 after the yearly routine control for blood-borne viruses. Following the presumed time of infection, three chronically infected HCV patients were identified as possible index cases.
AIM: To confirm inter-patient transmission and to identify the source.
METHODS: Molecular investigation and review of medical records were performed.
FINDINGS: Both of the incident cases and one of the three possible index cases were demonstrated to be infected with HCV genotype 2b based on 5'UTR sequencing. Epidemiological relatedness between these viruses was further investigated by sequencing of the NS5A region. Phylogenetic analysis clearly identified the incident cases and the index case to represent a cluster distinct from unrelated controls with HCV genotype 2b. Detailed review of the medical records identified two possible incidents that might have resulted in the HCV transmission cases: contamination of the venous pressure-sensing port due to high venous pressures or incomplete compliance with infection control precautions of the unit staff during handling of two incidents, that occurred at the same time in a single haemodialysis session with the index patient as well as both incident cases present.
CONCLUSION: This study demonstrates that detailed incident recording in combination with state-of-the-art molecular investigations such as sequencing of the NS5A region resulted in unravelling a set of two HCV transmissions that occurred at an haemodialysis unit.
PMID: 30500385 [PubMed - as supplied by publisher]
| Related Articles |
Antiseptic efficacies of waterless hand rub, chlorhexidine scrub, and povidone-iodine scrub in surgical settings: a meta-analysis of randomized controlled trials.
J Hosp Infect. 2018 Nov 27;:
Authors: Ho YH, Wang YC, Loh EW, Tam KW
Abstract
BACKGROUND: Presurgical hand washing is crucial for preventing surgical site infections (SSIs). Chlorhexidine gluconate (CHG) and povidone-iodine (PI) products have been conventionally used as hand scrubs for presurgical hand preparation. However, waterless hand rub (WHR) products have been developed for operating room staff.
AIM: The aim of this study was to conduct a systematic review and meta-analysis to compare the antiseptic efficacies of WHR, CHG, and PI in surgical settings.
METHODS: PubMed, Embase, and Cochrane Library databases as well as the ClinicalTrials.gov registry were searched for studies published before October 2018. Randomized controlled trials (RCTs) comparing the clinical outcomes of the use of WHRs, CHG, or PI for presurgical hand washing were included. A random effects model was used for meta-analysis. Colony-forming unit (cfu) counts, SSI rates, and preference and compliance were determined to measure efficacies.
FINDINGS: Eleven RCTs involving 5135 participants were included. Residual cfu counts were significantly lower in the WHR and CHG groups than in the PI group. The differences in cfu counts between the WHR and CHG groups were non-significant. No significant differences were observed in the SSI rates between the WHR and traditional hand scrub groups. Moreover, WHRs were considered most favourable and were associated with higher compliance rates than the other products.
CONCLUSION: WHRs and CHG exhibited higher antiseptic efficacies than PI. However, additional studies with consistent outcome measurements and accurate grouping are required to obtain comprehensive results. Moreover, preference, compliance, and the cost determine the selection of hand wash products.
PMID: 30500384 [PubMed - as supplied by publisher]
 | Related Articles |
Perioperative Management of Buprenorphine: Solving the Conundrum.
Pain Med. 2018 Nov 30;:
Authors: Quaye AN, Zhang Y
Abstract
Objective: There is no consensus on the optimal perioperative management of patients on buprenorphine (BUP) for opioid use disorder (OUD). This article will review the available literature on BUP and the analgesic efficacy of BUP combined with full mu-opioid agonists and discuss the conflicting management strategies in the context of acute pain and our institution's protocol for the periprocedural management of BUP.
Methods: We searched published data on BUP periprocedural management from inception through March 2018 without language restrictions. Study selection included publications reporting outcomes on perioperative pain management in OUD patients maintained on BUP.
Results: Our search resulted in four case reports supporting periprocedural discontinuation of BUP and two case series, one secondary observational study, one prospective matched cohort study, and four retrospective cohort studies supporting periprocedural continuation of BUP. No clinical trials were identified.
Conclusions: Maintaining BUP perioperatively does not lead to worsened clinical outcomes. Patients can receive adequate pain control from mu-opioid agonists while maintained on BUP. Based upon available evidence, we recommend continuing BUP at a reduced dose when indicated to avoid withdrawal symptoms and to facilitate the analgesic efficacy of mu-opioid agonists administered in combination for acute postoperative pain.
PMID: 30500943 [PubMed - as supplied by publisher]
| Related Articles |
Regenerative Medicine: Ushering in a New Era in Pain Medicine.
Pain Med. 2018 Nov 30;:
Authors: McCormick ZL, Hooten M
PMID: 30500942 [PubMed - as supplied by publisher]
| Related Articles |
On Depression and Cervical Epidural Steroids.
Pain Med. 2018 Nov 29;:
Authors: Bogduk N
PMID: 30500941 [PubMed - as supplied by publisher]
 | Related Articles |
Living with alopecia areata: An online qualitative survey study.
Br J Dermatol. 2018 Nov 30;:
Authors: Davey L, Clarke V, Jenkinson E
Abstract
BACKGROUND: Living with alopecia areata, totalis and universalis (collectively referred to here as AA) involves unpredictable, sometimes rapid hair loss. There is currently no effective treatment and patients describe feelings of shock, loss, trauma and disrupted identity. Cultural meanings attached to hair and hair loss, including associations between hair and femininity, and hair loss and cancer may exacerbate distress. Consequently, wigs and make-up are frequently used as camouflage, but this can produce feelings of inauthenticity, shame and anxiety.
OBJECTIVES: To explore how meanings associated with hair and hair loss influence experiences of living with AA. To identify how this understanding might inform practice by healthcare professionals to best support patients to cope with the condition.
METHODS: Ninety-five participants with AA completed an online qualitative survey about their experiences of living with the condition. Data were subjected to thematic analysis within a critical realist theoretical framework.
RESULTS: Four themes were identified: It's (not) just hair; A restricted life; Abandon hope all ye who lose their hair; and Seeking support in "a highly personal journey".
CONCLUSIONS: Findings suggest that negative cultural meanings of hair and hair loss are pervasive and may drive social avoidance and camouflage behaviours in people with AA. Normalising social interactions with healthcare practitioners, significant others and peers were cited as pivotal to positive adjustment. Support groups and online forums were highly valued particularly as few had been offered specialist psychological support. Future research should develop and evaluate psychological support to address the specific challenges of living with AA. This article is protected by copyright. All rights reserved.
PMID: 30501016 [PubMed - as supplied by publisher]
| Related Articles |
A randomized, double-blind, phase III trial of personalized peptide vaccination for recurrent glioblastoma.
Neuro Oncol. 2018 Nov 30;:
Authors: Narita Y, Arakawa Y, Yamasaki F, Nishikawa R, Aoki T, Kanamori M, Nagane M, Kumabe T, Hirose Y, Ichikawa T, Kobayashi H, Fujimaki T, Goto H, Takeshima H, Ueba T, Abe H, Tamiya T, Sonoda Y, Natsume A, Kakuma T, Sugita Y, Komatsu N, Yamada A, Sasada T, Matsueda S, Shichijo S, Itoh K, Terasaki M
Abstract
Background: We conducted a phase III trial of personalized peptide vaccination (PPV) for human leucocyte antigen (HLA)-A24+ recurrent glioblastoma to develop a new treatment modality.
Methods: We randomly assigned 88 recurrent glioblastoma patients to receive PPV (n=58) or the placebo (n=30) at a 2-to-1 ratio. Four of 12 warehouse peptides selected based on preexisting peptide-specific IgG levels or the corresponding placebos were injected 1/week for 12 weeks.
Results: Our trial met to neither the primary (overall survival, OS) nor secondary endpoints. Unfavorable factors for OS of 58 PPV patients as compared to 30 placebo patients were SART2-93 peptide selection (n=13 vs 8, hazard ratio<HR>;15.9), >=70 years old (4 vs 4, 7.87), >70 kg body weight (10 vs 7, 4.11), and performance status (PS)3 (8 vs 2, 2.82), respectively. Consequently, the median OS for PPV patients without SAR2-93 selection plus one of these 3 favorable factors (<70 years old, =<70kg, or PS0-2) was significantly longer than that for the corresponding placebo patients (HR; 0.49, 0.44, or 0.51), respectively. Preexisting immunity against both all 12 warehouse peptides besides SART2-93 and the other cytotoxic T lymphocyte epitope peptides was significantly depressed in the patients with SART2-93 selection (n=21) as compared to that of the patients without SART2-93 selection (n=67). Biomarkers correlative for favorable OS of the PPV patients were a lower percentage of CD11b+CD14+HLA-DRlow immunosuppressive monocytes and a higher percentage of CD4+CD45RA- activated T cells, the intermediate levels of CCL2, VEGF, IL-7, IL-17, or haptoglobin, respectively.
Conclusion: This phase III trial met to neither the primary nor secondary endpoints.
PMID: 30500939 [PubMed - as supplied by publisher]
24 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results:
These pubmed results were generated on 2018/12/04
PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
2094 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results:
upper respiratory tract infection
These pubmed results were generated on 2018/12/04
PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
| Related Articles |
An improved technique for frontal and ethmoid sinuses.
Xray Tech. 1948 Jan;19(4):184
Authors: HUDIS D
PMID: 18907403 [PubMed - indexed for MEDLINE]
| Related Articles |
An acrylic obturator employed in the repair of an obstructed frontonasal duct.
Arch Otolaryngol. 1947 Feb;45(2):209-14
Authors: NEW GB, ERICH JB
PMID: 20290278 [PubMed - indexed for MEDLINE]
| Related Articles |
Fractures of the skull involving the frontal air sinuses due to localised violence; a study of 30 cases.
S Afr Med J. 1946 May 11;20:234-7
Authors: SARTORIUS K
PMID: 20986347 [PubMed - indexed for MEDLINE]
| Related Articles |
Fractures of the skull involving the frontal air sinuses due to localised violence; a study of 30 cases.
S Afr Med J. 1946 Apr 27;20:202 passim
Authors: SARTORIUS K
PMID: 20984087 [PubMed - indexed for MEDLINE]
| Related Articles |
Kartagener's triad; situs inversus, absent frontal sinuses with maxillary ethmoid and sphenoid infection, and bronchiectasis.
J Kans Med Soc. 1946 Mar;47:93-6
Authors: DELP MH
PMID: 21017365 [PubMed - indexed for MEDLINE]
| Related Articles |
Differential responses to spectrally degraded speech within human auditory cortex: An intracranial electrophysiology study.
Hear Res. 2018 Nov 22;371:53-65
Authors: Nourski KV, Steinschneider M, Rhone AE, Kovach CK, Kawasaki H, Howard MA
Abstract
Understanding cortical processing of spectrally degraded speech in normal-hearing subjects may provide insights into how sound information is processed by cochlear implant (CI) users. This study investigated electrocorticographic (ECoG) responses to noise-vocoded speech and related these responses to behavioral performance in a phonemic identification task. Subjects were neurosurgical patients undergoing chronic invasive monitoring for medically refractory epilepsy. Stimuli were utterances /aba/ and /ada/, spectrally degraded using a noise vocoder (1-4 bands). ECoG responses were obtained from Heschl's gyrus (HG) and superior temporal gyrus (STG), and were examined within the high gamma frequency range (70-150 Hz). All subjects performed at chance accuracy with speech degraded to 1 and 2 spectral bands, and at or near ceiling for clear speech. Inter-subject variability was observed in the 3- and 4-band conditions. High gamma responses in posteromedial HG (auditory core cortex) were similar for all vocoded conditions and clear speech. A progressive preference for clear speech emerged in anterolateral segments of HG, regardless of behavioral performance. On the lateral STG, responses to all vocoded stimuli were larger in subjects with better task performance. In contrast, both behavioral and neural responses to clear speech were comparable across subjects regardless of their ability to identify degraded stimuli. Findings highlight differences in representation of spectrally degraded speech across cortical areas and their relationship to perception. The results are in agreement with prior non-invasive results. The data provide insight into the neural mechanisms associated with variability in perception of degraded speech and potentially into sources of such variability in CI users.
PMID: 30500619 [PubMed - as supplied by publisher]
| Related Articles |
[Not Available].
Acta Otorhinolaryngol Belg. 1948;2(3):245-50
Authors: CHAUSSE C
PMID: 18102490 [PubMed - indexed for MEDLINE]
22 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results:
These pubmed results were generated on 2018/12/04
PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
| Related Articles |
Dimethyloxalylglycine preconditioning enhances protective effects of bone marrow-derived mesenchymal stem cells in Aβ- induced Alzheimer disease.
Physiol Behav. 2018 Nov 27;199:265-272
Authors: Esmaeilzade B, Artimani T, Amiri I, Najafi R, Shahidi S, Sabec M, Farzadinia P, Zare M, Zahiri M, Soleimani Asl S
Abstract
Mesenchymal stem cell (MSC) transplantation therapy has been proposed as a promising approach for the treatment of neurodegenerative disease. Chemical and pharmacological preconditioning before transplantation could optimize the therapeutic properties of transplanted MSCs. In this study, we hypothesized that preconditioning treatment with a prolyl hydroxylase inhibitor, dimethyloxalylglycine (DMOG), will increase MSC efficacy and paracrine effects in an amyloid-β (Aβ)-injected Alzheimer rat model. MSCs were incubated in different concentrations of DMOG for 24 h. Cell viability, migration, and antioxidant capacity was assessed in DMOG-treated and non-treated MSCs before transplantation into Aβ-injected rats. In vitro analysis revealed that DMOG treatment increased cell viability, migration, and expression of CXCR4, CCR2, Nrf2, and HIF-1α in the MSCs. Our in vivo results show that DMOG preconditioning enhances a MSC-mediated rescue of learning and memory function in Aβ-injected rats. Furthermore, we found an increased level of BDNF and total antioxidant capacity in the hippocampus of Aβ-injected rats following transplantation of preconditioned relative to untreated MSCs. Our results suggest that preconditioning MSCs with DMOG before transplantation may enhance the efficacy of stem cell based therapy in neurodegenerative disease.
PMID: 30500334 [PubMed - as supplied by publisher]
24 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results:
These pubmed results were generated on 2018/12/04
PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
| Related Articles |
Potentialities and limitations of corrective rhinoplasty.
N Y State J Med. 1948 Oct 01;48(19):2160-4
Authors: SAFIAN LS
PMID: 18886984 [PubMed - indexed for MEDLINE]
| Related Articles |
The effect of rhinoplasty on the refractive error.
Eye Ear Nose Throat Mon. 1948 Oct;27(10):457-60
Authors: ERSNER MS, ALEXANDER MH, GETTES BC
PMID: 18885465 [PubMed - indexed for MEDLINE]
| Related Articles |
Role of the septum in rhinoplasty.
Arch Otolaryngol. 1948 Aug;48(2):189-201
Authors: MALINIAC JW
PMID: 18111361 [PubMed - indexed for MEDLINE]
| Related Articles |
Plastic repair of the obstructing nasal septum.
Arch Otolaryngol. 1948 Jan;47(1):7-20
Authors: FOMON S, GILBERT JG
PMID: 18920515 [PubMed - indexed for MEDLINE]
| Related Articles |
[Not Available].
Pract Otorhinolaryngol (Basel). 1948;10(1-2):282-91
Authors: RAPIN M
PMID: 18908772 [PubMed - indexed for MEDLINE]
| Related Articles |
Mucous membrane grafts from the inferior turbinate in reconstruction of the orbit.
U S Nav Med Bull. 1947 Nov-Dec;47(6):1014-8
Authors: SCHENCK HP
PMID: 20272968 [PubMed - indexed for MEDLINE]
| Related Articles |
The role of the rhinologist in plastic surgery.
Eye Ear Nose Throat Mon. 1947 Nov;26(11):589-94
Authors: KING ED
PMID: 20269969 [PubMed - indexed for MEDLINE]
| Related Articles |
The push-back operation for repair of cleft palate.
Plast Reconstr Surg (1946). 1946 Sep;1:145-69
Authors: DORRANCE GM, BRANSFIELD JW
PMID: 21000873 [PubMed - indexed for MEDLINE]
38 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results:
These pubmed results were generated on 2018/12/04
PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
| Related Articles |
Intravenous Hydroxocobalamin Versus Hextend Versus Control for Class III Hemorrhage Resuscitation in a Prehospital Swine Model.
Mil Med. 2018 Nov 05;183(11-12):e721-e729
Authors: Bebarta VS, Garrett N, Boudreau S, Castaneda M
Abstract
Background: Hydroxyethyl starch (Hextend) has been used for hemorrhagic shock resuscitation, however, hydroxyethyl starch may be associated with adverse outcomes.
Objective: To compare systolic blood pressure (sBP) in animals that had 30% of their blood volume removed and treated with intravenous hydroxocobalamin, hydroxyethyl starch, or no fluid.
Methods: Twenty-eight swine (45-55 kg) were anesthetized and instrumented with continuous femoral and pulmonary artery pressure monitoring. Animals were hemorrhaged 20 mL/kg over 20 minutes and then administered 150 mg/kg IV hydroxocobalamin in 180 mL saline, 500 mL hydroxyethyl starch, or no fluid and monitored for 60 minutes. Data were modeled using repeated measures multivariate analysis of variance.
Results: There were no significant differences before treatment. At 20 minutes after hemorrhage, there was no significant difference in mean sBP between treated groups, however, control animals displayed significantly lower mean sBP (p < 0.001). Mean arterial pressure and heart rate improved in the treated groups but not in the control group (p < 0.02). Prothrombin time was longer and platelet counts were lower in the Hextend group (p < 0.05). Moreover, thromboelastography analysis showed longer clotting (K) times (p < 0.05) for the hydroxyethyl starch-treated group.
Conclusion: Hydroxocobalamin restored blood pressure more effectively than no treatment and as effectively as hydroxyethyl starch but did not adversely affect coagulation.
PMID: 30500921 [PubMed - in process]
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Histone deacetylase-1 as a prognostic factor and mediator of gastric cancer progression by enhancing glycolysis.
Hum Pathol. 2018 Nov 27;:
Authors: Jiang Z, Yang H, Zhang X, Wang Z, Rong R, Wang X
Abstract
Histone deacetylase 1 (HDAC1) has been shown to be closely associated with tumor development. We investigated its effects on survival and biological behavior in gastric cancer (GC). HDAC1 expression and glycolysis activity were analyzed in a cohort of 252 samples of primary GC tumors and in vitro study. High HDAC1 (HDAC1High) staining was seen in 60.7% patients with GCs, which was significantly greater than was seen in normal epithelial cells (19.4%; P<.005). HDAC1High expression was associated with larger tumor size (P=.001), advanced T stage (P=.001), lymph node metastases (N stage; P<.001), and lymphovascular invasion (P=.005). Univariate and multivariate survival analyses showed HDAC1 expression to be an independent prognostic factor for both disease-free survival (DFS) and overall survival (OS) (P<.05). In vitro studies showed a notably decreased glycolysis rate in HDAC1-knockdown cells. In patients' samples, HDAC1High expression was always accompanied with high SUVmax value (P<.05). A hypoxia-inducible factor (HIF)-1α response element (HRE)-luciferase reporter system showed HDAC1 to affect HIF1α activity at dose dependent. In conclusion, HDAC1 promotes glycolysis in GC, and affects HIF-1α activity in tumor progression and metastasis. HDAC1High expression was also an independent adverse prognostic factor for OS and DFS.
PMID: 30500418 [PubMed - as supplied by publisher]
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Management of Patients with renal mass lesions based on renal biopsy cytology results.
Hum Pathol. 2018 Nov 27;:
Authors: Huang X, Griffin B, Lin X
Abstract
The benefit of renal biopsy, especially in patients with a history of malignancy (HOM), has not been well-studied. We studied the clinical management of 339 renal masses following fine needle aspirate (FNA) and/or core needle biopsy (CNB) with touch preparation. 41% of patients had HOM, which did not increase the incidence of renal malignancy. The main reasons for renal biopsy were HOM and small renal masses (≤ 3cm). The most common renal masses were clear cell renal cell carcinoma (CCRCC) (32%). 30% of renal masses metastasized. The overall accuracy of renal biopsy for subclassification was 76%. Nephrectomy was selected to manage 41% of renal masses, most for primary renal carcinoma (PRCa). Chemo-radiation was selected to treat 15% of patients, especially those with lymphoma (93%), metastatic malignancy (93%) and urothelial carcinoma (69%). Ablation was used to treat 6% of patients. Active surveillance was selected for 34% of patients, predominantly those with benign condition. Our results showed that renal biopsy was an easy and less aggressive tool for obtaining adequate diagnostic materials to render reliable and accurate diagnoses. Initial renal biopsy prevented unnecessary nephrectomy in patients with diagnoses of metastatic malignancy, lymphoma and majority of benign tumors/lesions (for the majority of, but not all cases). Renal biopsy avoided chemo-radiation against prior HOM in patients with diagnosis of benign tumors/lesions (22% of all patients) and PRCa (38%). Therefore, renal biopsy significantly impacts the management of patients with renal mass, and any questionable renal mass should be biopsied before further management.
PMID: 30500417 [PubMed - as supplied by publisher]
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Overexpression of serum response factor is correlated with poor prognosis in patients with gastric cancer.
Hum Pathol. 2018 Nov 27;:
Authors: Yin J, Lv X, Hu S, Zhao X, Liu Q, Xie H
Abstract
Serum response factor (SRF) is highly expressed in many tumors, including gastric cancer. However, the exact prognostic utility of SRF in patients with gastric cancer remains unclear. Therefore, in this study, we investigated the expression and prognostic value of SRF in patients with gastric cancer. SRF expression was detected by immunohistochemistry in 149 gastric cancer samples. The relationship between SRF expression and clinicopathological characteristics along with the prognostic significance of SRF in disease-free survival and overall survival of patients was analyzed. We found that the expression of SRF was significantly increased in gastric cancer tissues compared with adjacent noncancerous tissues. Overexpression of SRF was significantly correlated with histological differentiation, invasion depth, lymph node metastasis, and TNM stage. Furthermore, disease-free survival rate and overall survival rate were both significantly lower for patients with high SRF expression. Multivariate Cox regression analysis identified high SRF expression as an independent prognostic factor for disease-free survival but not for overall survival. Our findings indicate that overexpression of SRF may play an important role in human gastric cancer recurrence and prognosis. SRF may serve as a predictive marker for prognosis of gastric cancer.
PMID: 30500416 [PubMed - as supplied by publisher]
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Technical Note: Influence of entrance window deformation on reference dosimetry measurement in various beam modalities.
Med Phys. 2018 Nov 30;:
Authors: Kinoshita N, Kohno R, Oguchi H
Abstract
PURPOSE: Phantoms for horizontal-beam geometry can avoid issues in vertical-beam geometry, such as change in chamber depth due to evaporation, and defining the origin at the water surface. However, their thin entrance-windows would deform when these phantoms are filled, which can change the chamber depth, as pointed out by IAEA TRS-398. Currently, few reports [Arib et al., J. Appl. Clin. Med. Phys. 7, 55-64 (2006), and Kinoshita et al., Rep. Pract. Oncol. Radiother. 23, 199-206 (2018)] are available with practical data on window deformation. Therefore, we investigated the influence of entrance-window deformation on chamber depths in water phantoms and the measurements in various beam modalities.
METHODS: To examine widely used phantoms and phantoms with different characteristics, three phantom types were investigated (the number of phantoms investigated appears in parentheses): PTW-type 41023 (2), Qualita-QWP-04 (2), and IBA-WP34 (2). Prior to the investigation, these phantoms were stored for acclimatization in a room for approximately 10 h under the following two conditions: (1) room temperature: 21 ± 2 °C; (2) room temperature: 27 ± 2 °C. Using a dial indicator, the centers of the windows were monitored every 30 min for 12 h immediately after the phantoms were filled, in a treatment room at the room-temperature of 21 ± 2 °C.
RESULTS: Immediately after the phantoms were filled, the window deformation ranged from -0.07 (inward-deformation) to 0.3 mm (outward-deformation) among the six phantoms, in comparison with empty phantom windows. For 12 h after the phantoms were filled, the change in the deformation was up to 0.23 mm, but typically less than 0.15 mm.
CONCLUSIONS: Reference dosimetry in photon, electron, and proton beams would not be influenced significantly by these window behaviors, whereas the window deformation has a slight impact on those in heavy-ion beams. This article is protected by copyright. All rights reserved.
PMID: 30500984 [PubMed - as supplied by publisher]
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Mixed tumor of nose treated by rhinoplastic procedure.
Ann Otol Rhinol Laryngol. 1949 Jun;58(2):488-93
Authors: LAFF HI
PMID: 18146441 [PubMed - indexed for MEDLINE]
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Repair of the septal perforation; a rhinologic problem; a rhinoplastic approach; author's technique.
Laryngoscope. 1949 Feb;59(2):130-46
Authors: SEELEY RC
PMID: 18113052 [PubMed - indexed for MEDLINE]
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Rhinoplastic surgery; some general considerations.
J Iowa State Med Soc. 1948 Oct;38(10):443-7
Authors: HUFFMAN WC, LIERLE DM
PMID: 18883272 [PubMed - indexed for MEDLINE]
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The do's and don'ts of postoperative rhinoplasties.
Eye Ear Nose Throat Mon. 1948 Aug;27(8):366-8
Authors: SEELEY RC
PMID: 18876512 [PubMed - indexed for MEDLINE]
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Total nasal reconstruction; the standardized and simplified Indian method.
Chin Med J. 1948 May;66(5):243-6
Authors: SUNG RR
PMID: 18886713 [PubMed - indexed for MEDLINE]
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Management of septal deformities in rhinoplastic correction.
Arch Otolaryngol. 1947 Jan;45(1):77-89
Authors: EISENSTODT LW
PMID: 20284479 [PubMed - indexed for MEDLINE]
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Two problems; care of the deafened and rhinoplastic surgery.
Trans Am Acad Ophthalmol Otolaryngol. 1946 Sep-Oct;51:11-7
Authors: COATES GM
PMID: 20275088 [PubMed - indexed for MEDLINE]
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Surgical and pathological outcomes of elective neck dissection during salvage total laryngectomy.
Clin Otolaryngol. 2018 Nov 30;:
Authors: Asimakopoulos P, Thompson CSG, Hogg GE, Evans AS, Adamson RM, Vernham GA, Nixon IJ
Abstract
The rate of occult nodal metastases during primary laryngectomy with no clinical or radiological evidence of neck disease (cN0) has been found to be as high as 20%. Therefore, bilateral elective neck dissection is usually recommended. However, the role of neck dissection in the salvage laryngectomy setting remains unclear. Improvements in the accuracy of cross sectional imaging mean occult disease is less common. This article is protected by copyright. All rights reserved.
PMID: 30501000 [PubMed - as supplied by publisher]
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Predictors of Unplanned Returns to the Operating Room within 30 Days in Neurosurgery: Insights from a National Surgical Registry.
World Neurosurg. 2018 Nov 27;:
Authors: Kerezoudis P, Alvi MA, Spinner RJ, Meyer FB, Habermann EB, Bydon M
Abstract
BACKGROUND: In the modern, increasingly pay-for-performance era, unplanned ROR is gaining attention as a surgical quality metric. However, large-scale data on the appropriateness and utility of this measure in neurosurgery are scarce.
OBJECTIVE: To provide a comprehensive description of all unplanned returns to the operating room (RORs) after neurosurgical procedures in a national surgical registry and identify factors associated with ROR.
METHODS: We queried the American College of Surgeons National Surgical Quality Improvement Program multicenter database for patients undergoing neurosurgical procedures during 2012-2016. Multivariable logistic regression was conducted to identify factors associated with 30-day unplanned ROR following the three most common inpatient cranial and spinal operations: craniotomy for intra-axial neoplasm, convexity/falx meningioma or skull base tumors, anterior cervical discectomy and fusion, posterior lumbar decompression and posterior lumbar fusion.
RESULTS: A total of 193,459 cases were identified, of which 7067 (3.7%) had at least one unplanned ROR within 30 days after the index procedure (inpatient-4.3%, outpatient-1.5%). Overall, the most common reasons were wound complication/surgical site infection (0.7%), hematoma evacuation (0.6%) and repeat surgery (0.5%). On multivariable analysis, the relative amount of variation in reoperation risk was found to be 1-24% for demographics, 1-19% for comorbidities, 1-6% for preoperative lab values and 4-58% for operative characteristics.
CONCLUSIONS: These findings may inform stakeholders on the optimal parameters that need to be taken into account when crafting, endorsing and implementing quality metrics for neurosurgery that aim to assess surgical performance and reward or penalize hospitals and providers.
PMID: 30500576 [PubMed - as supplied by publisher]
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[Surgical treatment of peripheral facial palsy in fractures of the cranial base].
Nord Med. 1949 Feb 25;41(8):368
Authors: BEHRMAN W
PMID: 18149357 [PubMed - indexed for MEDLINE]
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Hyperostosis cranialis interna; the Morgagni and Stewart-Morel syndromes; examination of females suffering from diabetes mellitus and other endocrine disorders as well as female epileptics.
Acta Med Scand. 1947 Jun 02;128(1):71-102
Authors: PEDERSEN J
PMID: 18895758 [PubMed - indexed for MEDLINE]
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Suprasellar meningiomas associated with scotomatous field defects.
Arch Ophthal. 1946 Jun;35:624-42
Authors: SCHLEZINGER NS, ALPERS BJ, WEISS BP
PMID: 20990379 [PubMed - indexed for MEDLINE]
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Detection of glycoproteins B and H genotypes to predict the development of Cytomegalovirus disease in solid organ transplant recipients.
J Clin Virol. 2018 Nov 13;109:50-56
Authors: Barrado L, Prieto C, Hernando S, Folgueira L
Abstract
BACKGROUND: Our study focuses on the role that human Cytomegalovirus (CMV) genotypes play in the development of disease.
OBJECTIVES: (1) To analyze the frequency of various genotype envelope proteins (gB, gH) in a group of solid organ transplant (SOT) recipients; (2) to assess their correlation with CMV disease; (3) to study the association between any of the genotypes and viral loads.
STUDY DESIGN: A retrospective observational study conducted by analyzing CMV gB and gH genotypes detected with real-time polymerase chain reaction (PCR)-specific assays in 162 CMV-positive blood samples from 62 SOT recipients. Demographic, clinical, and microbiological data were recorded.
RESULTS: Mixed gB genotypes were associated with viral syndrome (70%, p = .004), earlier presentation of symptoms (48.27 ± 27.03 versus 74.33 ± 47.25 days, respectively, p = .001), and higher median of the plasma viral load log10 (UI/ml) than infection with a single genotype (p = .004). Furthermore, the gB3 genotype was detected more frequently in patients who presented with asymptomatic viremia (77.27%, p < .0001). The gH1 genotype was more frequent (65%) in patients who presented with asymptomatic viremia (p = .003), and it caused infection later than gH2 or the mixed genotype (84.88 ± 48.10 versus 57.91 ± 39.18 days, respectively, p < .001).
CONCLUSIONS: Patients who presented mixed gB genotypes more frequently developed clinical manifestations and earlier, higher, plasma viral loads. The detection of gB and gH genotypes by real-time PCR can provide relevant information to stratify the risk of SOT recipients to develop symptomatic infection by CMV.
PMID: 30500488 [PubMed - as supplied by publisher]
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Early Post-Intensive Care Syndrome among Older Adult Sepsis Survivors Receiving Home Care.
J Am Geriatr Soc. 2018 Nov 30;:
Authors: Riegel B, Huang L, Mikkelsen ME, Kutney-Lee A, Hanlon AL, Murtaugh CM, Bowles KH
Abstract
BACKGROUND/OBJECTIVES: New or worsened disabilities in functional, cognitive, or mental health following an intensive care unit (ICU) stay are referred to as post-intensive care syndrome (PICS). PICS has not been described in older adults receiving home care. Our aim was to examine the relationship between length of ICU stay and PICS among older adults receiving home care. We expected that patients in the ICU for 3 days or longer would demonstrate significantly more disability in all three domains on follow-up than those not in the ICU. A secondary aim was to identify patient characteristics increasing the odds of disability.
DESIGN: Retrospective cohort study.
SETTING: Hospitalization for sepsis in the United States.
PARTICIPANTS: A total of 21 520 Medicare patients receiving home care and reassessed a median of 1 day (interquartile range 1-2 d) after hospital discharge.
MEASUREMENTS: PICS was defined as a decline or worsening in one or more of 16 indicators tested before and after hospitalization using OASIS (Home Health Outcome and Assessment Information Set) and Medicare claims data.
RESULTS: The sample was predominantly female and white. All had sepsis, and most (81.8%) had severe sepsis. In adjusted models, an ICU stay of 3 days or longer, compared with no ICU stay, increased the odds of physical disability. Overall, the declines were modest and found in specific activities of daily living (16% for feeding and lower body dressing to 26% for oral medicine management). No changes were identified in cognition or mental health. Significant determinants of new or worsened physical disabilities were sepsis severity, older age, depression, frailty, and dementia.
CONCLUSION: Older adults receiving home care who develop sepsis and are in an ICU for 3 days or longer are likely to develop new or worsened physical disabilities. Whether these disabilities remain after the early postdischarge phase requires further study.
PMID: 30500988 [PubMed - as supplied by publisher]
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Response to Letter to the Editor: "Characterization of the CYP11A1 Non-synonymous Variant p.E314K in Children Presenting with Adrenal Insufficiency".
J Clin Endocrinol Metab. 2018 Nov 30;:
Authors: Kolli V, Lao Q, Merke DP
PMID: 30500909 [PubMed - as supplied by publisher]
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Body-weight fluctuation and incident diabetes mellitus, cardiovascular disease, and mortality: a 16-year prospective cohort study.
J Clin Endocrinol Metab. 2018 Nov 29;:
Authors: Oh TJ, Moon JH, Choi SH, Lim S, Park KS, Cho NH, Jang HC
Abstract
Context: Body-weight fluctuation (weight cycling) has been found to be associated with higher mortality and cardiovascular events in patients with coronary artery disease. However, there are very limited data regarding the relationship between body-weight fluctuation and health-related outcomes in the general population.
Methods: We examined whether body-weight fluctuation can associate incident diabetes mellitus and cardiovascular events, and mortality in a Korean population from the Korean Genome and Epidemiology Study. The intra-individual fluctuations of body weight were calculated by average successive variability (ASV), and health-related outcomes were collected every 2 years for 16 years in 3,678 participants.
Results: Participants with a high ASV of body weight were more obese and had higher blood pressure and HbA1c levels at baseline than those with a low ASV of body weight. A one-unit increase in ASV of body weight was associated with increase in mortality (HR 1.46, 95% CI 1.32-1.62, P < 0.001). However, the association between the ASV of body weight and incident diabetes mellitus seemed to be influenced by baseline body mass index (BMI); negative effect in subjects with BMI < 25 kg/m2 (HR 1.36, 95% CI 1.11-1.65, P = 0.003) and protective effect in those with BMI ≥ 25 kg/m2 (HR 0.76, 95% CI 0.60-0.95, P = 0.014). There was no association between the ASV of body weight and cardiovascular event.
Conclusion: Body-weight fluctuation was associated with mortality. In addition, the effect of body-weight fluctuation on incident diabetes mellitus depended on the presence of obesity at baseline.
PMID: 30500906 [PubMed - as supplied by publisher]
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Letter to the Editor: "Characterization of the CYP11A1 Non-synonymous Variant p.E314K in Children Presenting with Adrenal Insufficiency".
J Clin Endocrinol Metab. 2018 Nov 30;:
Authors: Roucher-Boulez F, Goursaud C, Mallet D, Morel Y
PMID: 30500894 [PubMed - as supplied by publisher]
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Bifidobacterium may benefit the prevention of necrotizing enterocolitis in preterm infants: A systematic review and meta-analysis.
Int J Surg. 2018 Nov 27;61:17-25
Authors: Zhu XL, Tang XG, Qu F, Zheng Y, Zhang WH, Diao YQ
Abstract
AIM: A systematic review and meta-analysis was designed to evaluate the efficacy and safety of Bifidobacterium for preventing necrotizing enterocolitis (NEC) in preterm infants.
METHODS: We searched the Cochrane Library, PubMed, EMBASE and Web of Science to December 2017. Risk ratio (RR) with 95% confidence intervals (CIs) were estimated to compare the outcomes of the groups. For the pooled RR estimating the incidence of NEC, we also performed subgroup analysis. Besides, sensitivity analysis was performed to examine the stability of the combined results. Two reviewers assessed trial quality and extracted data independently. The work has been reported in line with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) and AMSTAR (Assessing the methodological quality of systematic reviews) Guidelines. All statistical analyses were performed using standard statistical procedures provided in Review Manager 5.2.
RESULTS: Twenty four randomized, placebo-controlled studies (N = 6155 participants) were included in this analysis, of which twenty two studies were used for assessing the efficacy of Bifidobacterium for preventing NEC and seventeen for assessing the safety (sepsis and death). When comparing Bifidobacterium groups with control groups, the relative risk of developing NEC (RR 0.38, 95% CI 0.25-0.58; P < 0.00001) or death (RR 0.74, 95% CI 0.60-0.92; P = 0.006) was significantly lower in the Bifidobacterium groups. No significant difference in the incidence of sepsis was found (RR 0.87, 95% CI 0.73-1.03; P = 0.11). In addition, significant results for NEC were also found in all subgroups we made.
CONCLUSIONS: Bifidobacterium may have a beneficial effect and be safe in preventing necrotizing enterocolitis in preterm infants.
PMID: 30500473 [PubMed - as supplied by publisher]
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A novel hybrid fixation (percutaneous anterior pelvic bridge with K-wire) for the treatment of traumatic pelvic ring injury: A prospective study.
Int J Surg. 2018 Nov 28;61:11-16
Authors: Huang G, Cai L, Jia X, Ji Y, Zhou Y, Mou X, Zhu Q, He F, Zhang Z
Abstract
BACKGROUND: The aim of the study was to introduce a novel percutaneous technique for the treatment of pelvic ring injuries using a percutaneous anterior pelvic bridge (PAPB) with K-wire.
METHODS: From December 2010 to November 2016, a prospective study of 86 patients with anterior pelvic ring fracture (42 utilizing PAPB with K-wire and 44 utilizing PAPB). Patient data was retrieved from electronic charts. Radiological results were assessed based on the Matta criteria system to evaluate the quality of the reduction and time to union. Functional outcomes were evaluated using the Majeed scoring system. Postoperative complications were also recorded.
RESULTS: Age, sex, cause of injury, type of fracture, functional recovery, American Society of Anesthesiologists classification, union time, Majeed scoring and complications did not differ significantly between the two groups. The quality of the reduction and pain scoring differed between groups (all p-values < 0.05). Group A got better reduction and less pain scoring.
CONCLUSIONS: The novel percutaneous technique with hybrid fixation using PAPB with K-wire is a successful alternative for the treatment of pelvic ring injuries, which results in better quality of reduction and less pain scoring outcomes comparing to PAPB. May the PAPB + K-wire could provide more stability.
PMID: 30500472 [PubMed - as supplied by publisher]
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Laundry detergents and detergent residue after rinse directly disrupt tight junction barrier integrity in human bronchial epithelial cells.
J Allergy Clin Immunol. 2018 Nov 27;:
Authors: Wang M, Tan G, Eljaszewicz A, Meng Y, Wawrzyniak P, Acharya S, Altunbulakli C, Westermann P, Dreher A, Yan L, Wang C, Akdis M, Zhang L, Nadeau KC, Akdis CA
Abstract
BACKGROUND: Defects in epithelial barrier have recently been associated with asthma and other allergies. The influence of laundry detergents on human bronchial epithelial cells (HBECs) and their barrier function remain unknown.
OBJECTIVE: We investigated the effects of laundry detergents on cytotoxicity, barrier function, transcriptome and epigenome in HBECs.
METHODS: Air-liquid interface cultures of primary HBECs from healthy control subjects, asthma and chronic obstructive pulmonary disease patients were exposed to laundry detergents and detergent residue after rinse. The cytotoxicity and epithelial barrier function were evaluated. RNA sequencing, assay for transposase accessible chromatin with high-throughput sequencing and DNA methylation arrays were used for checking transcriptome and epigenome.
RESULTS: Laundry detergents and rinse residue showed dose dependent toxic effect to HBECs with irregular cell shape and leakage of lactate dehydrogenase after 24h exposure. A disrupted epithelial barrier function was found with decreased transepithelial electric resistance, increased paracellular flux and stratified tight junction immunostaining in HBECs exposed to laundry detergent at 1:25,000 dilutions or rinse residue at further 1:10 dilutions. RNA sequencing analysis showed that lipid metabolism, apoptosis progress and epithelial-derived alarmins related genes were up-regulated, while cell adhesion related genes were down-regulated by laundry detergent at 1:50,000 dilutions after 24h exposure without substantially affecting chromatin accessibility and DNA methylation.
CONCLUSION: Our data demonstrate that laundry detergents even at a very high dilution and rinse residue show significant cell toxic and directly disruptive effects on the tight junction barrier integrity of HBECs without affecting the epigenome and tight junction genes expression.
PMID: 30500342 [PubMed - as supplied by publisher]
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| Related Articles |
Laundry detergents and detergent residue after rinse directly disrupt tight junction barrier integrity in human bronchial epithelial cells.
J Allergy Clin Immunol. 2018 Nov 27;:
Authors: Wang M, Tan G, Eljaszewicz A, Meng Y, Wawrzyniak P, Acharya S, Altunbulakli C, Westermann P, Dreher A, Yan L, Wang C, Akdis M, Zhang L, Nadeau KC, Akdis CA
Abstract
BACKGROUND: Defects in epithelial barrier have recently been associated with asthma and other allergies. The influence of laundry detergents on human bronchial epithelial cells (HBECs) and their barrier function remain unknown.
OBJECTIVE: We investigated the effects of laundry detergents on cytotoxicity, barrier function, transcriptome and epigenome in HBECs.
METHODS: Air-liquid interface cultures of primary HBECs from healthy control subjects, asthma and chronic obstructive pulmonary disease patients were exposed to laundry detergents and detergent residue after rinse. The cytotoxicity and epithelial barrier function were evaluated. RNA sequencing, assay for transposase accessible chromatin with high-throughput sequencing and DNA methylation arrays were used for checking transcriptome and epigenome.
RESULTS: Laundry detergents and rinse residue showed dose dependent toxic effect to HBECs with irregular cell shape and leakage of lactate dehydrogenase after 24h exposure. A disrupted epithelial barrier function was found with decreased transepithelial electric resistance, increased paracellular flux and stratified tight junction immunostaining in HBECs exposed to laundry detergent at 1:25,000 dilutions or rinse residue at further 1:10 dilutions. RNA sequencing analysis showed that lipid metabolism, apoptosis progress and epithelial-derived alarmins related genes were up-regulated, while cell adhesion related genes were down-regulated by laundry detergent at 1:50,000 dilutions after 24h exposure without substantially affecting chromatin accessibility and DNA methylation.
CONCLUSION: Our data demonstrate that laundry detergents even at a very high dilution and rinse residue show significant cell toxic and directly disruptive effects on the tight junction barrier integrity of HBECs without affecting the epigenome and tight junction genes expression.
PMID: 30500342 [PubMed - as supplied by publisher]
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Deep learning for lung cancer prognostication: A retrospective multi-cohort radiomics study.
PLoS Med. 2018 Nov;15(11):e1002711
Authors: Hosny A, Parmar C, Coroller TP, Grossmann P, Zeleznik R, Kumar A, Bussink J, Gillies RJ, Mak RH, Aerts HJWL
Abstract
BACKGROUND: Non-small-cell lung cancer (NSCLC) patients often demonstrate varying clinical courses and outcomes, even within the same tumor stage. This study explores deep learning applications in medical imaging allowing for the automated quantification of radiographic characteristics and potentially improving patient stratification.
METHODS AND FINDINGS: We performed an integrative analysis on 7 independent datasets across 5 institutions totaling 1,194 NSCLC patients (age median = 68.3 years [range 32.5-93.3], survival median = 1.7 years [range 0.0-11.7]). Using external validation in computed tomography (CT) data, we identified prognostic signatures using a 3D convolutional neural network (CNN) for patients treated with radiotherapy (n = 771, age median = 68.0 years [range 32.5-93.3], survival median = 1.3 years [range 0.0-11.7]). We then employed a transfer learning approach to achieve the same for surgery patients (n = 391, age median = 69.1 years [range 37.2-88.0], survival median = 3.1 years [range 0.0-8.8]). We found that the CNN predictions were significantly associated with 2-year overall survival from the start of respective treatment for radiotherapy (area under the receiver operating characteristic curve [AUC] = 0.70 [95% CI 0.63-0.78], p < 0.001) and surgery (AUC = 0.71 [95% CI 0.60-0.82], p < 0.001) patients. The CNN was also able to significantly stratify patients into low and high mortality risk groups in both the radiotherapy (p < 0.001) and surgery (p = 0.03) datasets. Additionally, the CNN was found to significantly outperform random forest models built on clinical parameters-including age, sex, and tumor node metastasis stage-as well as demonstrate high robustness against test-retest (intraclass correlation coefficient = 0.91) and inter-reader (Spearman's rank-order correlation = 0.88) variations. To gain a better understanding of the characteristics captured by the CNN, we identified regions with the most contribution towards predictions and highlighted the importance of tumor-surrounding tissue in patient stratification. We also present preliminary findings on the biological basis of the captured phenotypes as being linked to cell cycle and transcriptional processes. Limitations include the retrospective nature of this study as well as the opaque black box nature of deep learning networks.
CONCLUSIONS: Our results provide evidence that deep learning networks may be used for mortality risk stratification based on standard-of-care CT images from NSCLC patients. This evidence motivates future research into better deciphering the clinical and biological basis of deep learning networks as well as validation in prospective data.
PMID: 30500819 [PubMed - in process]
