Upper Airway Stimulation for Children With Down Syndrome and Obstructive Sleep Apnea

alexandrossfakianakis shared this article with you from Inoreader Upper Airway Stimulation for Children With Down Syndrome and Obstructive Sleep Apnea via JAMA Otolaryngology–Head & Neck Surgery Current Issue The treatment of persistent obstructive sleep apnea (OSA) after an adenotonsillectomy is a challenge, especially for children with Down syndrome. As otolaryngologists with sleep subcertification, we are keenly aware of the current limitations for both medical and secondary surgical treatment options for this cohort. We applaud the insight of Yu and colleagues for their landmark investigation in this issue of JAMA Otolaryngology–Head & Neck Surgery on upper airway stimulation (UAS) for adolescents with Down syndrome and OSA, which expan ds the role of UAS from adults to children. View on Web

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Hyperbaric Oxygen Therapy for Sudden Sensorineural Hearing Loss Meta-analysis

alexandrossfakianakis shared this article with you from Inoreader Hyperbaric Oxygen Therapy for Sudden Sensorineural Hearing Loss Meta-analysis via JAMA Otolaryngology–Head & Neck Surgery Current Issue To the Editor We read with great interest the recent meta-analysis from Joshua et al, titled "Hyperbaric Oxygen Therapy [HBOT] for Patients with Sudden Sensorineural Hearing Loss [SSNHL]" and the commentary by Moody-Antonio et al. View on Web

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A Middle-aged Woman With Parotid Swelling

alexandrossfakianakis shared this article with you from Inoreader A Middle-aged Woman With Parotid Swelling via JAMA Otolaryngology–Head & Neck Surgery Current Issue A 53-year-old woman with a history of coronary artery dise ase and prior myocardial infarction that was treated with warfarin presents to the emergency department after awakening with right preauricular and right upper neck swelling. What is your diagnosis? View on Web

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Tumor Grade and Immunotherapy Response in Head and Neck Squamous Cell Carcinoma

alexandrossfakianakis shared this article with you from Inoreader Tumor Grade and Immunotherapy Response in Head and Neck Squamous Cell Carcinoma via JAMA Otolaryngology–Head & Neck Surgery Current Issue This cohort study investigates the association between tu mor grade and immunotherapy response in patients with recurrent or metastatic head and neck squamous cell carcinoma. View on Web

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Silent Sinus Syndrome Involving the Frontal Sinus

alexandrossfakianakis shared this article with you from Inoreader Silent Sinus Syndrome Involving the Frontal Sinus via JAMA Otolaryngology–Head & Neck Surgery Current Issue This case report describes a man in his 50s who presented with a 1-year history of a painless, progressive sunken appearance of his right eye and was subsequently diagnosed with right frontal silent sinus syndrome. View on Web

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A phase 2 pharmacodynamic dose‐finding, safety, and efficacy study of dalteparin for pediatric venous thromboembolism treatment in children with and without cancer

alexandrossfakianakis shared this article with you from Inoreader A phase 2 pharmacodynamic dose‐finding, safety, and efficacy study of dalteparin for pediatric venous thromboembolism treatment in children with and without cancer via Pediatric Blood & Cancer Abstract Data from registrational trials of pediatric venous thromboembolism (VTE) treatment are sparse, especially among cancer patients. We conducted a prospective, multicenter, open-label trial (NCT00952380) on dose-finding, safety, and efficacy (measured by 90-day risks of clinically relevant bleeding [CRB] and symptomatic recurrent VTE [srVTE]) of twice-daily subcutaneous dalteparin for acute VTE treatment in patients ≤18 years old. Among 38 patients (cancer, n = 26; noncancer, n = 12), median dalteparin dose requirements per kilogram varied with age but not cancer status. Risks of CRB and srVTE were <4% in cancer and noncancer subgroups. Dalteparin is an important FDA-approved treatment for pediatric VTE, particularly with cancer. View on Web

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Molecular characterization of metachronous atypical teratoid rhabdoid tumors occurring in a young man 15 years apart

alexandrossfakianakis shared this article with you from Inoreader Molecular characterization of metachronous atypical teratoid rhabdoid tumors occurring in a young man 15 years apart via Pediatric Blood & Cancer View on Web

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Within‐patient evaluation of chewing efficiency and maximum bite force of conventional dentures, fixed prostheses, and milled bar overdentures used for All‐on‐4 implant rehabilitation of atrophied mandibular ridges: A short‐term randomized trial

alexandrossfakianakis shared this article with you from Inoreader Within‐patient evaluation of chewing efficiency and maximum bite force of conventional dentures, fixed prostheses, and milled bar overdentures used for All‐on‐4 implant rehabilitation of atrophied mandibular ridges: A short‐term randomized trial via Clinical Implant Dentistry and Related Research Abstract Purpose This crossover study aimed to evaluate chewing efficiency and maximum bite force (BF) of conventional dentures, fixed prostheses, and milled bar overdentures (MO) used for All-on-4 implant rehabilitation of atrophied mandibular ridges. Methods Sixteen edentulous participants with resorbed mandibular ridges received new conventional dentures (CD, control). Four implants were inserted after 3 months in the mandible using the All-on-4 protocol and loaded immediately with acrylic prosthesis. In a crossover manner, each patient had either fixed restoration (FR, 12 occlusal units) or MO (14 occlusal units) randomly in a crossover study design. Chewing efficiency was evaluated using the mixing ability test. The hue deviation (HD) of two-colored gum was calculated after being chewed for 5, 10, 20, 30, and 50 masticatory cycles. Maximum BF was evaluated using a BF device. HD and BF were measured after using CD, FR, and MO prostheses. Results For all groups, the highest HD (i.e., the lowest chewing efficiency) was noted with 5 strokes, followed by 10, 20, 30 strokes, and the lowest HD (i.e., the highest chewing efficiency) was noted with 50 strokes. For all number of chewing strokes, CD showed the highest HD, then FR, and MO recorded the lowest HD. The highest BF was observed with MO, then FR, and the lowest BF was noted with CD. Conclusion Within the limitations of this short-term investigation, both FR and MO used for All-on-4 implant rehabilitation of patients with resorbed mandibular ridges improve masticatory efficiency and maximum BFs compared to CD. However, MO was associated with significantly higher chewing efficiency and maximum BFs than fixed prosthesis. View on Web

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Evaluation of anterolateral thigh flap dimensions with virtual flap models

alexandrossfakianakis shared this article with you from Inoreader Evaluation of anterolateral thigh flap dimensions with virtual flap models via International Journal of Oral and Maxillofacial Surgery via MedWorm.com Free flaps are commonly used for head and neck reconstruction. However, flap dimensions are still evaluated by visual and tactile assessment. The aim of this study was to enable preoperative planning of flap dimensions for soft tissue reconstruction based on clinical parameters. Computed tomography records from 230 patients dated from 2009 to 2019 were analysed retrospectively. A virtual, three-dimensional anterolateral thigh flap model was standardized, aligned to segmented leg models in two positions, and flap thicknesses and volumes were determined. (Source: International Journal of Oral and Maxillofacial Surgery) View on Web

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Epithelial –myoepithelial carcinoma of the maxillofacial and sinonasal region: a systematic review of presenting characteristics, treatment modalities, and associated outcomes

alexandrossfakianakis shared this article with you from Inoreader Epithelial –myoepithelial carcinoma of the maxillofacial and sinonasal region: a systematic review of presenting characteristics, treatment modalities, and associated outcomes via International Journal of Oral and Maxillofacial Surgery via MedWorm.com Epithelial –myoepithelial carcinoma (EMC) is a rare salivary gland malignancy. Controversy exists in the literature regarding the effectiveness of treatment modalities employed in the management of EMC. This systematic review was undertaken to understand the presenting characteristics of EMC and identify the most common treatment modalities and their associated outcomes, in order to help guide an evidenced-based approach to the algorithm of care. The MEDLINE (PubMed) and Embase databases were searched (up to February 23, 2022), and the review was performed in accordance with the PRISMA statement. (Source: International Journal of Oral and Maxillofacial Surgery) View on Web

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Oncological outcome of contralateral submental artery island flap versus primary closure in tongue squamous cell carcinoma: randomized non-inferiority clinical trial

alexandrossfakianakis shared this article with you from Inoreader Oncological outcome of contralateral submental artery island flap versus primary closure in tongue squamous cell carcinoma: randomized non-inferiority clinical trial via International Journal of Oral and Maxillofacial Surgery via MedWorm.com The aim of this study was to test the non-inferiority of the contralateral submental island flap (CSIF) compared with primary closure (PC) regarding local recurrence after partial glossectomy in patients with oral tongue squamous cell carcinoma (OTSCC). This open-label, non-inferiority randomized controlled trial enrolled patients with cT1 –2 lateralized OTSCC. The primary outcome was local recurrence by 12 months postoperative. Non-inferiority would be declared if the upper limit of the two-sided 95% confidence interval (CI) for the proportion difference in local recurrence between the two groups did not exceed a non-inferiority ma rgin of 15.0%. (Source: International Journal of Oral and Maxillofacial Surgery) View on Web

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