Annual trends in Google searches provides insights related to rhinosinusitis exacerbations

xlomafota13 shared this article with you from Inoreader Annual trends in Google searches provides insights related to rhinosinusitis exacerbations Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2021 Apr 20. doi: 10.1007/s00405-021-06806-5. Online ahead of print. ABSTRACT PURPOSE: Temporal trends of disease-specific internet searches may provide novel insights into seasonal dynamics of disease burden and, by extension, disease pathophysiology. The aim of this study was to define the temporal trends in rhinosinusitis-specific internet searches. METHODS: This was a cross sectional analysis of search volume for predefined search terms. Google trends was used to explore the volume of searches for five specific search terms related to rhinosinusitis: nose, mucus, sinus, sinusitis, chronic sinusitis, which were entered into Google web search between 2004 and 2019. Results were analyzed within search "context" which included temporally associated related searches. Relative search volume (RSV) was analyzed for English and non-English speaking countries from the Northern and Southern hemispheres. Analys is of seasonality was performed using the cosinor model. RESULTS: The five specific search terms were most related to rhinosinusitis-related search contexts, indicating that they were appropriately reflective of internet queries by patients for rhinosinusitis. The RSV for rhinosinusitis-related terms and more general search terms increased with each passing year indicating constant interest in rhinosinusitis. Cosinor time series analysis revealed inquiry peaks in winter months for all five specific rhinosinusitis-related search terms independent from the hemisphere. CONCLUSION: Over a 15-year period, Google searches with rhinosinusitis-specific search terms consistently peaked during the winter around the world. These findings indirectly support the model of viral infection or exposure as the predominant cause of acute rhinosinusitis and acute exacerbations of chronic rhinosinusitis. PMID:33877434 | DOI:10.1007/s00405-021-06806-5 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Oral tongue squamous cell carcinomas in young patients according to their smoking status: a GETTEC study

xlomafota13 shared this article with you from Inoreader Oral tongue squamous cell carcinomas in young patients according to their smoking status: a GETTEC study Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2021 Apr 20. doi: 10.1007/s00405-021-06793-7. Online ahead of print. ABSTRACT BACKGROUND: Incidence of oral tongue squamous cell carcinoma (OTSCC) is increasing, especially in young adults, despite decreasing tobacco and alcohol consumption. METHODS: This multicentric retrospective study of 185 young adults with OTSCC (median follow-up 43 months), investigated risk factors, tumour characteristics and oncological outcomes according to the smoking status. RESULTS: Overall, 38% of patients were smokers (S). Non-smokers (NS) were significantly younger than S. Sex ratios were 1.1 for N and 1.8 for S. NS patients were less frequently cannabis or alcohol users than S, but were more likely to have a history of leukoplakia. Second primaries were observed in NS (4.4%) and in S (12.7%). Despite more frequent local relapse in NS (p = 0.018), there was no difference in diagnostic stage and overall survival bet ween groups. CONCLUSION: OTSCC affects differently young S and NS patients suggesting the existence of a specific clinical entity of OTSCC in non-smoking young adults. PMID:33877432 | DOI:10.1007/s00405-021-06793-7 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Influence of travel burden on tumor classification and survival of head and neck cancer patients

xlomafota13 shared this article with you from Inoreader Influence of travel burden on tumor classification and survival of head and neck cancer patients Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2021 Apr 20. doi: 10.1007/s00405-021-06816-3. Online ahead of print. ABSTRACT PURPOSE: Cancer patients have to overcome various barriers to obtain diagnostics and treatment at head and neck cancer centers. Travel distance to a specialized hospital may result in psychosocial and financial distress, thus interfering with diagnostics, treatment, and follow-up care. In this study, we have aimed to analyze the association of travel distance with cTNM status, UICC stage at primary diagnosis, and survival outcomes of head and neck cancer (HNC) patients. METHODS: We have analyzed data of 1921 consecutive HNC patients diagnosed between 2014 and 2019 at the head and neck cancer center of the Comprehensive Cancer Center Ulm (CCCU), Germany. Postal code-based travel distance calculation in kilometers, TNM status, and UICC stage were recorded at initial diagnosis. The assembly of travel distance-related groups (shor t, intermediate, long-distance) has been investigated. Moreover, group-related survival and recurrence analysis have been performed. RESULTS: In contrast to observations from overseas, no association of travel distance and higher cTNM status or UICC stage at primary diagnosis has been observed. Furthermore, no significant differences for recurrence-free survival and overall survival by travel distance were detected. CONCLUSION: In southern Germany, travel distance to head and neck cancer centers seems to be tolerable. Travel burden is not synonymous with travel distance alone but also involves sociodemographic, monetary, and disease-specific aspects as well as accessibility to proper infrastructure of transport and health care system. PMID:33877433 | DOI:10.1007/s00405-021-06816-3 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Importance of TORCH Profile in Hearing Impaired Paediatric Population Planned for Cochlear Implant: A Study From an Eastern India Tertiary Care Centre

xlomafota13 shared this article with you from Inoreader Importance of TORCH Profile in Hearing Impaired Paediatric Population Planned for Cochlear Implant: A Study From an Eastern India Tertiary Care Centre Via Otolaryngology Indian Abstract TORCH group of infections are one of the most common causes of bilateral profound hearing loss in a developing country like ours. Seroprevalance is quite high in eastern part of our country. Screening for TORCH infections in children's with profound hearing loss has significant prognostic, planning and policy forming implications. To evaluate the seroprevalance of TORCH infections in prospective cochlear implant children and its significance. Ours is a retrospective study conducted from 2017 to 2018 on 50 children with bilateral profound hearing loss attending the Department of ENT at AIIMS, Patna. Thorough clinical and audiological assessment of the patients was done using objective tests like OAE (otoacoustic emission), ABR (auditory brainstem response) and subjective tests like BOA(behavioural audiometry) and PTA (puretone audiometry) wherever feasible. Blood samples were collected and serotesting was done using ELISA for Toxoplasma, Rubella, Cytomegalovirus (CMV) and Herpes Simplex Virus (HSV) (TORCH). We found that IgM was negative for all patients. Seroprevalance for IgG was 16.3% for toxoplasma, 74.4% for rubella, 69.8% for CMV and 20.9% for HSV. All the children had bilateral severe to profound loss on ABR and bilateral REFER on OAE. As prevalence of TORCH infection is quite common in India and is an established risk factor for sensorineural hearing loss with multisystem involvement screening for the same will help in early identification and in decision making for cochlear implantation thus improving the prognosis and also aid in policy making. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Targeting EML4-ALK gene fusion variant 3 in thyroid cancer

xlomafota13 shared this article with you from Inoreader Targeting EML4-ALK gene fusion variant 3 in thyroid cancer Via radioactive iodine Endocr Relat Cancer. 2021 Apr 1:ERC-20-0436.R1. doi: 10.1530/ERC-20-0436. Online ahead of print. ABSTRACT Finding targetable gene fusions can expand the limited treatment options in radioactive iodine-refractory (RAI-r) thyroid cancer. To that end, we established a novel cell line 'JVE404' derived from an advanced RAI-r papillary thyroid cancer (PTC) patient, harboring an EML4-ALK gene fusion variant 3 (v3). Different EML4-ALK gene fusions can have different clinical repercussions. JVE404 cells were evaluated for cell viability and cell signaling in response to ALK inhibitors crizotinib, ceritinib and lorlatinib, in parallel to the patient's treatment. He received, after first-line lenvatinib, crizotinib (Drug Rediscovery Protocol (DRUP) trial), and lorlatinib (compassionate use). In vitro treatment with crizotinib or ceritinib decreased viability in JVE404, but most potently and significantly only with lorlatinib. Western blot analysis showed a near total decrease of 99% and 89%, respectively, in pALK and pERK expression levels in JVE404 cells with lorlatinib, in contrast to remaining signal intensities of a half and a third of control, respectively, with crizotinib. The patient had a six-month lasting stable disease on crizotinib, but progressive disease occurred, including the finding of cerebral metastases, at 8 months. With lorlatinib, partial response, including clinical cerebral activity, was already achieved at 11 weeks' use and ongoing partial respon se at 7 months. To our best knowledge, this is the first reported case describing a patient-specific targeted treatment with lorlatinib based on an EML-ALK gene fusion v3 in a thyroid cancer patient, and own cancer cell line. Tumor-agnostic targeted therapy may provide valuable treatment options in personalized medicine. PMID:33878728 | DOI:10.1530/ERC-20-0436 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Functional electrostimulation associated with phonation in women without vocal disorders

xlomafota13 shared this article with you from Inoreader Functional electrostimulation associated with phonation in women without vocal disorders Via CoDAS : Sociedade Brasileira de Fonoaudiologia RESUMO Objetivo Verificar o efeito imediato da corrente elétrica excitomotora, denominada FES, na qualidade vocal e no tempo máximo de fonação (TMF), e possíveis desconfortos, em mulheres sem alteração vocal, com aplicação em intensidade máxima suportada (IMS) e associada à fonação. Método Estudo experimental com 20 mulheres adultas normofônicas. Elas emitiram a vogal /a/ sustentada e depois foi aplicada a FES durante emissão da mesma vogal. Foram cinco séries com três minutos de emissão cada, intercaladas com descanso passivo; o estímulo elétrico foi na IMS pela participante, ajustado por série. Antes e após as emissões as vozes foram gravadas e coletados os TMF e a intensidade dos estímulos. A qualidade vocal foi classificada por juízes. Foram comparados os dados pré e pós emissão/eletroestimulação em cada fase. A análise qualitativa foi realizada a partir de sintomas autorreferidos. Resultados Não houve diferença na qualidade vocal e nos TMF entre os momentos pré e pós nas duas fases. A diferença entre a IMS e a intensidade de percepção do estímulo foi maior na série 1 em relação à série 2. Houve aumento da IMS na série 5 em relação à série 1. Não foram relatados sintomas negativos imediatos ou em até 48 horas após os procedimentos. Conclusão A corrente FES em IMS, associada à fonação, não gerou mudança imediata na qualidade vocal, nos TMF ou desconfortos autorreferidos pelas mulheres sem alteração vocal, mesmo com aumento gradual do estímulo. ABSTRACT Purpose To verify the immediate effect of the Excitomotor Electrical Current, called Functional Electrical Stimulation (FES), on vocal quality, Maximum Phonation Time (MPT) and possible discomfort, in women without vocal alteration, with application at Maximum Supported Intensity (MSI) and associated with phonation. Methods Experimental study with 20 normophonic adult women. They emitted the sustained vowel / a / and then it was appli ed to FES during emission of the same vowel. There were five series with three minutes of emission each, interspersed with passive rest. The electrical stimulus was at the MSI by the participant, adjusted by series. Before and after the emissions the voices were recorded and the MPT and the intensity of the stimuli were collected. The vocal quality was rated by judges. Statistical analysis made it possible to compare pre and post emission / electrostimulation data in each phase. Qualitative analysis was performed based on self-reported symptoms. Results There was no difference in vocal quality and MPT between pre and post moments in both phases. The difference between MSI and stimulus perception intensity was greater in series 1 than in series 2. There was an increase in MSI in series 5 compared to series 1. No significant negative symptoms or within 48h after procedures were reported. Conclusion The FES at MSI, associated with phonation, did not generate an immediate change in vo cal quality, in the MPT or self-reported discomforts by women without vocal alteration, even with a gradual increase in the stimulus, series by series. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Investigation of the neural discrimination of acoustic characteristics of speech sounds in normal-hearing individuals through Frequency-following Response (FFR)

xlomafota13 shared this article with you from Inoreader Investigation of the neural discrimination of acoustic characteristics of speech sounds in normal-hearing individuals through Frequency-following Response (FFR) Via CoDAS : Sociedade Brasileira de Fonoaudiologia RESUMO Objetivo Avaliar como as vias auditivas codificam e diferenciam as sílabas plosivas [ga],[da] e [ba], por meio do potencial evocado auditivo Frequency Following Response (FFR), nas crianças em desenvolvimento típico. Método Vinte crianças (6-12 anos) foram avaliadas por meio do FFR para estímulos [ga],[da] e [ba]. Os estímulos foram compostos por seis formantes, sendo diferenciados na transição F2 e F3 (porção transiente). Os demais formantes foram idênticos nas três sílabas (porção sustentada). Foram analisadas latências de 16 ondas que compõe a porção transiente do estímulo (<70ms) e latências de 21 ondas da porção sustentada (90-160ms) nas respostas neurais obtidas para cada uma das sílabas. Resultados As respostas eletrofisiológicas registradas por meio do FFR demonstraram que as latências da porção transiente da resposta neural foram diferentes nas três silabas evocadas. Além disso, os valores de latência das ondas da porção t ransiente foram aumentando progressivamente, sendo [ga]<[da]<[ba]. Já na porção sustentada da resposta, não houve diferenças significantes nas latências das ondas que compõe essa porção. Conclusão O FFR mostrou-se uma ferramenta eficiente na investigação da discriminação subcortical de diferenças acústicas dos sons de fala, uma vez que demonstrou diferentes resposta eletrofisiológica para três silabas evocadas. Na porção transiente (consoantes) foram observadas mudanças de latência e na porção sustentada (vogal) não houve diferenças entre as latências para os três estímulos. Esses resultados demonstram a capacidade neural de distinção entre características acústicas dos estímulos [ga],[da],[ba]. ABSTRACT Purpose To evaluate how the auditory pathways encode and discriminate the plosive syllables [ga], [da] and [ba] using the auditory evoked Frequency-following Response (FFR) in children with typical development. Methods Twenty children ag ed 6-12 years were evaluated using the FFR for the [ga], [da] and [ba] stimuli. The stimuli were composed of six formants and were differentiated in the F2 to F3 transition (transient portion). The other formants were identical in the three syllables (sustained portion). The latencies of the 16 waves of the transient portion (<70ms) and of the 21 waves of the sustained portion (90-160ms) of the stimuli were analyzed in the neural responses obtained for each of the syllables. Results The transient portion latencies were different in the three syllables, indicating a distinction in the acoustic characteristics of these syllables through their neural representations. In addition, the transient portion latencies progressively increased in the following order: [ga] <[da] <[ba], whereas no significant differences were observed in the sustained portion. Conclusion The FFR proved to be an efficient tool to investigate the subcortical acoustic differences in speech sounds, since i t demonstrated different electrophysiological responses for the three evoked syllables. Changes in latency were observed in the transient portion (consonants) but not in the sustained portion (vowels) for the three stimuli. These results indicate the neural ability to distinguish between acoustic characteristics of the [ga], [da] and [ba] stimuli. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Recessive LOXHD1 variants cause a prelingual down-sloping hearing loss: genotype-phenotype correlation and three additional children with novel variants

xlomafota13 shared this article with you from Inoreader Recessive <em>LOXHD1</em> variants cause a prelingual down-sloping hearing loss: genotype-phenotype correlation and three additional children with novel variants Via International Journal of Pediatric Otorhinolaryngology Publication date: June 2021 Source: International Journal of Pediatric Otorhinolaryngology, Volume 145 Author(s): Sha Yu, Wen-xia Chen, Yun-Fei Zhang, Chao Chen, Yihua Ni, Bo Duan, Huijun Wang, Zheng-min Xu View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Critical review of clinical practice guidelines for evaluation of neck mass in adults

xlomafota13 shared this article with you from Inoreader Critical review of clinical practice guidelines for evaluation of neck mass in adults Via Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial Braz J Otorhinolaryngol. 2021 Apr 10:S1808-8694(21)00064-1. doi: 10.1016/j.bjorl.2021.03.005. Online ahead of print. ABSTRACT OBJECTIVE: Several clinical practice guidelines have been produced and disseminated for the evaluation of a neck mass. However, to date, the quality and methodologic rigor of these clinical practice guidelines have not been appraised. Therefore, this study set out to identify and assess the methodologic quality of national and international guidelines for the evaluation and management of neck masses in adults. METHODS: We conducted a comprehensive search of EMBASE, MEDLINE/PubMed, SCOPUS and grey literature sources until September 2020. The quality of these guidelines was assessed by four reviewers using the Appraisal of Guidelines for Research and Evaluation, 2nd edition (AGREE II). Domain scores were considered acceptable quality if they scored >60%, and Intraclass Correlation Coefficients (ICC) were calculated to assess agreement among the appraisers. RESULTS: Seven guidelines were assessed for evaluation. Among these, only the American Academy of Otolaryngology (AAO), Cancer Care Manitoba (CCMB), and the American Society of Clinical Oncology (ASCO) achieved an overall rating of "high". The remaining four guidelines achieved ratings of either "average" or "low". The "Scope and Purpose" domain achieved the highest mean score (94.4%±5.0%), and lowest was "Applicability" (51.5%±29.2%). ICC analysis showed substantial to very good agreement across all domains (0.75-0.98). CONCLUSION: These findings highlight the variability in methodologic quality of guidelines for the evaluation and management of adult neck mass. The results from this analysis highlight the need to improve guidelines development process for this topic and may guide the selection and use of these guidelines in clinical practice. PMID:33879419 | DOI:10.1016/j.bjorl.2021.03.005 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

'The You-Adson-Brown Forceps': A quantifiable instrument for graft fixation

xlomafota13 shared this article with you from Inoreader "The You-Adson-Brown Forceps": A quantifiable instrument for graft fixation Via Journal of plastic, reconstructive & aesthetic surgery : JPRAS J Plast Reconstr Aesthet Surg. 2021 Mar 30:S1748-6815(21)00131-5. doi: 10.1016/j.bjps.2021.03.041. Online ahead of print. NO ABSTRACT PMID:33879417 | DOI:10.1016/j.bjps.2021.03.041 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Blood supply of the male breast nipple-areola complex evaluated by CTA

xlomafota13 shared this article with you from Inoreader Blood supply of the male breast nipple-areola complex evaluated by CTA Via Journal of plastic, reconstructive & aesthetic surgery : JPRAS J Plast Reconstr Aesthet Surg. 2021 Mar 10:S1748-6815(21)00086-3. doi: 10.1016/j.bjps.2021.02.006. Online ahead of print. ABSTRACT PURPOSE: In addition to women, men also undergo breast surgeries, and early studies on the blood supply of breasts are nearly all conducted in female subjects. The vasculature of the male breast is seldom studied. Understanding the male-specific blood supply of the breast is important for pre-operative planning and reducing complications. The purpose of this retrospective study is to fill the gap in the literature by describing the main blood supply and its orientation in the male breast. METHODS: We retrospectively evaluated thoracic computed tomographic angiography (CTA) data from January 1, 2017 to July 30, 2019. Single or multiple dominant arteries and their origins were traced, and the artery route and orientation related to the nipple-areola complex (NAC) were revealed through data analysis of t he images. RESULTS: Totally, 284 breasts were included. Most breasts were supplied by a single dominant artery (196, 69%), among which the lateral thoracic artery (LTA; 119, 41.9%; type I) and internal thoracic artery (ITA; 63, 22.2%; type II) were the most common arteries. A minority of breasts were supplied by vascular anastomoses formed by dual arteries (17, 6.0%; type III), and in 25.0% of breasts, no specific dominant artery was found (type IV). The predominant artery distribution was evaluated. CONCLUSION: This study cohort of male thoracic CTA provided and analysed the elaborate vascular anatomy of the NAC region. Our results favour inferior periareolar incision in regard to diminished vascular-related complications in male surgeries without pre-operative vascular evaluation. This study also suggests that super-lateral or lower-lateral-based pedicles can reserve more vasculature. PMID:33879411 | DOI:10.1016/j.bjps.2021.02.006 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.