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Αλέξανδρος Γ. Σφακιανάκης

Sunday, December 27, 2020

Cancers, Vol. 13, Pages 52: Comparative Efficacy and Safety of Anti-PD-1/PD-L1 Immune Checkpoint Inhibitors for Refractory or Relapsed Advanced Non-Small-Cell Lung Cancer—A Systematic Review and Network Meta-Analysis

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Cancers, Vol. 13, Pages 52: Comparative Efficacy and Safety of Anti-PD-1/PD-L1 Immune Checkpoint Inhibitors for Refractory or Relapsed Advanced Non-Small-Cell Lung Cancer—A Systematic Review and Network Meta-Analysis

Cancers doi: 10.3390/cancers13010052

Authors: Koichi Ando Ryo Manabe Yasunari Kishino Sojiro Kusumoto Toshimitsu Yamaoka Akihiko Tanaka Tohru Ohmori Tsukasa Ohnishi Hironori Sagara

The efficacy and safety of immune checkpoint inhibitors (ICIs) in refractory or relapsed advanced non-small-cell lung cancer (NSCLC) have not yet been compared with those of ramucirumab (Ram) plus docetaxel (Doc). Furthermore, comprehensive comparisons between ICIs have not been conducted to date. In the current study, a Bayesian network meta-analysis of related phase III clinical trials was performed to compare the efficacy and safety of Ram+Doc, Niv, Atz, and Doc treatments in patient groups lacking the PD-L1 constraint. Surface under the cumulative ranking area (SUCRA) revealed that the overall survival (OS) of patients treated with Niv was the highest, followed by Atz, Ram+Doc, and Doc. Regarding grades 3–5 treatment-related adverse events (G3–5AEs), the use of Niv was ranked the safest, followed by Atz, Doc, and Ram+Doc. Significant differences in OS were observed between Niv and Ram+Doc, while significant differences in G3–5AEs were observed be tween Ram+Doc and Niv or Atz. In the PD-L1 positive (≥1%) patient subgroup, Pem (10 mg/kg) ranked the highest in efficacy for OS, followed by Niv, Pem (2 mg/kg), Atz, and Doc. These findings may expectedly provide oncologists with useful insights into therapeutic selection for refractory or relapsed advanced NSCLC.

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3D and 4D printing in dentistry and maxillofacial surgery: Printing techniques, materials, and applications

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Publication date: Available online 26 December 2020

Source: Acta Biomaterialia

Author(s): Danial Khorsandi, Amir Fahimipour, Payam Abasian, Sepehr Sadeghpour Saber, Mahla Seyedi, Sonya Ghanavati, Amir Ahmad, Andrea Amoretti De Stephanis, Fatemeh Taghavinezhaddilami, Anna Leonova, Reza Mohammadinejad, Majid Shabani, Barbara Mazzolai, Virgilio Mattoli, Franklin R. Tay, Pooyan Makvandi

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Postpancreatectomy hemorrhage with negative angiographic findings: outcomes of empiric embolization compared to conservative management

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Publication date: Available online 26 December 2020

Source: Clinical Imaging

Author(s): Guan Yang, Zhang Jin-Long, Li Xiao-Hui, Wang Mao-Qiang

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Effects of Iron oxide particles on MRI and mammography in breast Cancer patients after a sentinel lymph node biopsy with paramagnetic tracers

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Publication date: Available online 26 December 2020

Source: Clinical Imaging

Author(s): Erkin ARIBAL, Levent ÇELIK, Cem YILMAZ, Cem DEMIRKIRAN, Davut Can GUNER

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Quarternary α-cyanobenzylsulfonamides: A new subclass of CAA fungicides with excellent anti-Oomycetes activity

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Publication date: 15 January 2021

Source: Bioorganic & Medicinal Chemistry, Volume 30

Author(s): Daniel Stierli, Martin Eberle, Clemens Lamberth, Olivier Jacob, Dirk Balmer, Tanja Gulder

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Stereotactic Radiosurgery for Vestibular Schwannomas: Tumor Control Probability Analyses and Recommended Reporting Standards

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Publication date: Available online 26 December 2020

Source: International Journal of Radiation Oncology*Biology*Physics

Author(s): Scott G. Soltys, Michael T. Milano, Jinyu Xue, Wolfgang A. Tomé, Ellen Yorke, Jason Sheehan, George X. Ding, John P. Kirkpatrick, Lijun Ma, Arjun Sahgal, Timothy Solberg, John Adler, Jimm Grimm, Issam El Naqa

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Small animal IMRT using 3D printed compensators

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Publication date: Available online 26 December 2020

Source: International Journal of Radiation Oncology*Biology*Physics

Author(s): Gage Redler, Erik Pearson, Xinmin Liu, Inna Gertsenshteyn, Boris Epel, Charles Pelizzari, Bulent Aydogan, Ralph Weichselbaum, Howard J. Halpern, Rodney D. Wiersma

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Radiotherapy alone for human papillomavirus-related squamous cell carcinoma of the oropharynx: a single-arm, phase 2 study

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Publication date: Available online 26 December 2020

Source: International Journal of Radiation Oncology*Biology*Physics

Author(s): Norihiko Takemoto, Yuji Seo, Susumu Nakahara, Yasuo Yoshioka, Teruki Teshima, Takashi Fujii, Fumiaki Isohashi, Keisuke Otani, Tadashi Yoshii, Yukinori Takenaka, Motoyuki Suzuki, Takahito Fukusumi, Atsushi Hanamoto, Toshimichi Yasui, Takahiro Michiba, Yoshifumi Yamamoto, Shigetoshi Shimamoto, Hidenori Tanaka, Mitsuaki Tatsumi, Kazuhiko Ogawa

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WbaP is required for swarm motility and intramacrophage multiplication of Salmonella Enteritidis spiC mutant by glucose use ability

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Publication date: Available online 26 December 2020

Source: Microbiological Research

Author(s): Yaonan Wang, Guifeng Liu, Jian Zhang, Dan Gu, Maozhi Hu, Yunzheng Zhang, Zhiming Pan, Shizhong Geng, Xin'an Jiao

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Diffusion tensor imaging of oral carcinoma: Clinical evaluation and comparison with histopathological findings 1

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Publication date: Available online 26 December 2020

Source: Magnetic Resonance Imaging

Author(s): Ichiro Yamada, Norio Yohino, Misaki Yokokawa, Yu Oikawa, Hiroyuki Harada, Keigo Hikishima, Tohru Kurabayashi, Yukihisa Saida, Ukihide Tateishi, Yae Ohata

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Cancers, Vol. 13, Pages 53: Prognostic Clinical and Biologic Features for Overall Survival after Relapse in Childhood Medulloblastoma

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Cancers, Vol. 13, Pages 53: Prognostic Clinical and Biologic Features for Overall Survival after Relapse in Childhood Medulloblastoma

Cancers doi: 10.3390/cancers13010053

Authors: Sophie Huybrechts Gwénaël Le Teuff Arnault Tauziède-Espariat Caroline Rossoni Anaïs Chivet Émilie Indersie Pascale Varlet Stéphanie Puget Rachid Abbas Olivier Ayrault Léa Guerrini-Rousseau Jacques Grill Dominique Valteau-Couanet Christelle Dufour

Given the very poor prognosis for children with recurrent medulloblastoma, we aimed to identify prognostic factors for survival post-relapse in children with childhood medulloblastoma. We retrospectively collected clinico-biological data at diagnosis and main clinical characteristics at relapse of children newly diagnosed with a medulloblastoma between 2007 and 2017 at Gustave Roussy and Necker Hospital. At a median follow-up of 6.6 years (range, 0.4–12.3 years), relapse occurred in 48 out 155 patients (31%). The median time from diagnosis to relapse was 14.3 months (range, 1.2–87.2 months). Relapse was local in 9, metastatic in 22 and combined (local and metastatic) in 17 patients. Second-line treatment consisted of chemotherapy in 31 cases, radiotherapy in 9, SHH-inhibitor in four and no treatment in the remaining four. The 1-year overall survival rate post-relapse was 44.8% (CI 95%, 31.5% to 59.0%). While molecular subgrouping at diagnosis was significantly associated with survival post-relapse, the use of radiotherapy at relapse and time to first relapse (>12 months) might also have a potential impact on post-relapse survival.

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Additive manufacturing of wood flour/polyhydroxyalkanoates (PHA) fully bio-based composites based on micro-screw extrusion system

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Publication date: 1 February 2021

Source: Materials & Design, Volume 199

Author(s): Jing Tian, Run Zhang, Yihui Wu, Ping Xue

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Sirt1 activation negatively regulates overt apoptosis in Mtb-infected macrophage through Bax

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Publication date: February 2021

Source: International Immunopharmacology, Volume 91

Author(s): Hong Yang, Jianxia Chen, Yanghaoyu Chen, Yan Jiang, Baoxue Ge, Ling Hong

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