Cancer Science,

Different sensitivities of senescent breast cancer cells to immune cell‐mediated cytotoxicity

Abstract Senescence is a state of growth arrest induced in not only normal cells but also cancer cells by aging or stress, which triggers DNA damage. Despite growth suppression, senescent cancer cells promote tumor formation and recurrence by producing cytokines and growth factors; this state is designated as the senescence‐associated secretory phenotype (SASP). In this study, we examined the susceptibility of senescent human breast cancer cells to immune cell‐mediated cytotoxicity. Doxorubicin...

Cancer Science

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