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Αλέξανδρος Γ. Σφακιανάκης

Friday, December 7, 2018

The rhinologist's role in the management of rathke's cleft cysts.

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The rhinologist's role in the management of rathke's cleft cysts.

Curr Opin Otolaryngol Head Neck Surg. 2018 Nov 16;:

Authors: Kuan EC, Palmer JN, Adappa ND

Abstract
PURPOSE OF REVIEW: To review the recent literature regarding the growing role of rhinologists and otolaryngologists with neurosurgeons in the joint multidisciplinary team approach for managing patients with Rathke's cleft cysts (RCC).
RECENT FINDINGS: The transnasal endoscopic approach to the skull base has become relatively mainstream for surgical treatment of RCCs. Suprasellar lesions, especially those that are purely suprasellar, are associated with higher recurrence rates, though an extended approach may improve dissection and access and therefore aid in lesion removal. Endoscopic cyst drainage is a well tolerated and effective way to treat RCC, and often avoids the postoperative endocrinopathies associated with complete cyst wall removal. Novel techniques have been described for maintaining tract patency, including the use of stents and flaps, in order to prevent cyst stenosis and reaccumulation. A frontier in skull base surgery is in applications for pediatric patients, and managing RCCs in this population surgically appears to be associated with positive outcomes overall.
SUMMARY: Team-based endoscopic skull base surgery has spurred advances in our understanding of skull base disease, including RCCs. Optimal outcomes are most apparent when the experience and technique of both the endoscopist and neurosurgeon have developed jointly over time.

PMID: 30507691 [PubMed - as supplied by publisher]



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Open-neck organ preservation surgery for hypopharyngeal cancer: indications, techniques, limits, and outcomes.

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Open-neck organ preservation surgery for hypopharyngeal cancer: indications, techniques, limits, and outcomes.

Curr Opin Otolaryngol Head Neck Surg. 2018 Nov 16;:

Authors: Bradley PJ, Liu L

Abstract
PURPOSE OF REVIEW: To appraise the practice and role of open-neck organ preserving surgery for hypopharyngeal squamous cell carcinoma and to update the current indications, techniques, limits, and outcomes.
RECENT FINDINGS: The role of primary surgery for hypopharyngeal carcinoma has shifted over the past two decades to primary nonsurgical management with the use of induction or concurrent chemoradiotherapy. The preferred and most suitable tumours for open-neck surgery are the small-volume T stage diseases, with small to medium-volume neck metastases, however such patients are exceedingly rare. Nonetheless, more advanced tumours with cartilage invasion, vocal cord paralysis, or located at piriform apex and postcricoid area, previously unsuitable for open-neck organ preserving surgery, can now be excised and repaired, minimizing morbidity and improving quality of patients' life. Much of this surgical progress has been developed by innovative surgeons using free tissue transfer, accurate placement surgery, reconstruction of a neoglottis, and perfecting the pharyngoesophageal anastomosis. Current practice of open-neck organ preserving surgery for hypopharyngeal carcinoma has been mainly reported in Asia: Korea, Taiwan, Japan, and China.
SUMMARY: There are some patients who are deemed unsuitable and/or unwilling for current treatment by nonsurgical approaches, and open-neck organ preserving laryngopharyngeal surgery may be a more suitable alternative than selecting a 'lesser or modified' chemo or bioradiotherapy regimen, resulting in a prolonged quantity and quality of life.

PMID: 30507694 [PubMed - as supplied by publisher]



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Salivaomics in oral cancer.

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Salivaomics in oral cancer.

Curr Opin Otolaryngol Head Neck Surg. 2018 Nov 30;:

Authors: Aro K, Kaczor-Urbanowicz K, Carreras-Presas CM

Abstract
PURPOSE OF REVIEW: The goal of cancer screening is to detect tumor at an early stage, and early cancer detection is the hallmark of successful treatment. In addition to traditional tissue biopsy-based diagnostics, more reliable, inexpensive, and noninvasive methods are required for early diagnosis of cancer. In this review, we highlight some of the recent advancements in the field of salivary diagnostics in oral cancer.
RECENT FINDINGS: 'Salivaomics' is a broad collection of technologies used to explore different types of molecules contained in saliva. Although many protein and mRNA salivary biomarkers have been identified that can detect oral squamous cell carcinoma (OSCC), none have so far been validated for current clinical use. As the heterogeneity in carcinogenesis and multifactorial cause for OSCC, the most reliable results are gathered with the use of multiple biomarker candidates to improve accuracy and sensitivity of the test used. This further requires sensitive technology to detect salivary biomarkers in low quantities.
SUMMARY: Large scale studies that incorporate proteomic, transcriptomic, and additional 'omics,' need to be initiated to bring technology to clinical point-of-care applications.

PMID: 30507690 [PubMed - as supplied by publisher]



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Endotypes of chronic rhinosinusitis.

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Endotypes of chronic rhinosinusitis.

Curr Opin Otolaryngol Head Neck Surg. 2018 Nov 30;:

Authors: Yip J, Monteiro E, Chan Y

Abstract
PURPOSE OF REVIEW: In contrast to the phenotypic classification of chronic rhinosinusitis (CRS), endotyping categorizes disease variants based on their underlying pathophysiologic mechanisms. Defining CRS endotypes may provide information on the risk for disease progression, recurrence and comorbid conditions, as well as identify suitable therapeutic targets. With the emergence of biologics, endotyping may enable personalized pharmacotherapy for recalcitrant CRS. The purpose of this review is to briefly summarize the pathophysiology and endotypes of CRS, and highlight the biologics that target mediators of CRS.
RECENT FINDINGS: CRS is due to dysregulated immunologic responses to external stimuli, which induces inflammatory mediators. The linkage between innate lymphoid cells, adaptive CD4 T helper and CD8 + cytotoxic T cells has led to proposed endotypes that are based around immune response deviation into type 1, type 2 and type 3 responses. Cluster analysis has attempted to define endotypes, accounting for clinical characteristics, molecular and cellular biomarkers, and treatment response. Biologics targeting epithelial-derived cytokines and immunoglobulin E, as well as mediators of type 1, type 2 and type 3 inflammation, are being investigated in CRS.
SUMMARY: Although there have been significant advances made in the understanding of the pathomechanisms of CRS, there currently remains a lack of full characterization of CRS endotypes.

PMID: 30507689 [PubMed - as supplied by publisher]



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Histopathologic analysis in the diagnosis and management of chronic rhinosinusitis.

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Histopathologic analysis in the diagnosis and management of chronic rhinosinusitis.

Curr Opin Otolaryngol Head Neck Surg. 2018 Nov 30;:

Authors: Shay AD, Tajudeen BA

Abstract
PURPOSE OF REVIEW: New research in the pathogenesis of chronic rhinosinusitis has shed light on an emerging classification system based on endotypes, which help to explain the individualized mechanism of disease in patients suffering from chronic rhinosinusitis with and without nasal polyps. The purpose of this review is to advocate the use of structured histopathologic analysis in the diagnosis and management of patients affected by chronic rhinosinusitis with and without polyps.
RECENT FINDINGS: Numerous studies have demonstrated the role of inflammation in chronic rhinosinusitis and the ensuing histopatholgic changes. Few studies have implemented structured histopathologic analysis to guide diagnosis and treatment. Individualized therapy including biotherapeutics and comprehensive surgery has shown to improve outcomes in patients with refractory disease.
SUMMARY: Structured histopathologic analysis can provide helpful information on the endotype of chronic rhinosinusitis. Routine use in clinical practice should be standardized especially in cases of chronic rhinosinusitis refractory to medical therapy and/or surgery.

PMID: 30507686 [PubMed - as supplied by publisher]



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Management of sphenoid lateral recess encephalocoeles.

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Management of sphenoid lateral recess encephalocoeles.

Curr Opin Otolaryngol Head Neck Surg. 2018 Nov 16;:

Authors: Govindaraju R, Tang IP, Prepageran N

Abstract
PURPOSE OF REVIEW: Sphenoid sinus lateral recess encephalocoeles (SSLRE) are rare occurrences and pose unique challenges due to limited surgical access for endoscopic endonasal repair and also the lack of consensus on optimal perioperative managements specifically in the spontaneous cases, which are also believed to be a variant of idiopathic intracranial hypertension (IIH). Endoscopic endonasal approaches have largely replaced the transcranial route and the techniques are continuously being refined to reduce the neurovascular morbidity and improve outcome.
RECENT FINDINGS: Transpetrygoid is the most utilized approach with modifications suggested to limit bone removal, exposure and preservation of the neurovascular structures as dictated by the extent of the lateral recess. As more experience is gained, extended transphenoidal techniques were also successfully used for access. Lateral transorbital is a new approach to the lateral recess investigated in cadavers. IIH treatment is still controversial in the setting of SSLRE, but it appears rationale to evaluate, monitor and treat if necessary.
SUMMARY: SSLRE management should be tailored to the specific anatomical variances and cause. Modifications of techniques have been described giving different options to access the lateral recess. Successful repair for spontaneous SSLRE may require treatment of IIH if present, but the long-term outcome is still unclear.

PMID: 30507693 [PubMed - as supplied by publisher]



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Contemporary management of juvenile angiofibroma.

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Contemporary management of juvenile angiofibroma.

Curr Opin Otolaryngol Head Neck Surg. 2018 Nov 30;:

Authors: Bertazzoni G, Schreiber A, Ferrari M, Nicolai P

Abstract
PURPOSE OF REVIEW: To illustrate the latest developments and trends in the management of juvenile angiofibroma.
RECENT FINDINGS: Endoscopic surgery is currently the primary management strategy for juvenile angiofibroma. Recent reports on the use of multiportal approaches have contributed to further extend its indications. Studies from different countries suggest that the lesion can display variable growth rates not only in relation to patient age. The same concept applies to residual lesions. For this reason, retreatment of persistent juvenile angiofibromas is indicated when serial imaging clearly shows that the lesion is growing. When redo surgery is potentially associated with high morbidity for the critical relationships of the lesion with adjacent structures, stereotactic or intensity-modulated radiation therapy can be an alternative. Early use of MRI in the postoperative course is a highly effective way to detect residual lesions.
SUMMARY: Contemporary management of juvenile angiofibroma should primarily rely on endoscopic surgery to obtain radical tumor resection. Recent evidence on the behavior of residual postoperative juvenile angiofibroma and the development of conformal RT techniques have helped to clarify the role of watchful waiting and radiotherapy (RT) as alternatives to aggressive procedures in cases with critical extension of the lesion. Although radical excision is the primary therapeutic objective, the benign nature of juvenile angiofibroma and the reported tendency of small residual lesions to remain stable or involute, especially in postpubertal patients, should always be kept in mind to avoid unnecessary morbidity.
VIDEO ABSTRACT: In the video, two of the authors describe the content of the review and present the main topics discussed in the article. https://ift.tt/2zCohVk.

PMID: 30507688 [PubMed - as supplied by publisher]



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Indications and endonasal treatment of petrous apex cholesterol granulomas.

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Indications and endonasal treatment of petrous apex cholesterol granulomas.

Curr Opin Otolaryngol Head Neck Surg. 2018 Nov 30;:

Authors: Kohanski MA, Palmer JN, Adappa ND

Abstract
PURPOSE OF REVIEW: Lesions of the petrous apex of the temporal bone can be challenging to access and approaches laterally through the mastoid as well as medially through an endonasal approach are utilized to access this region while preserving function of adjacent structures. Cholesterol granulomas of the petrous apex requiring surgery are marsupialized to prevent expansion of the inflamed cyst and relieve associated clinical symptoms. The endonasal approach to the petrous apex has in the past been limited to lesions medial to the internal carotid artery.
RECENT FINDINGS: Endoscopic approaches have been developed to expand the range of petrous apex lesions that are accessible endonasally. These endonasal corridors include a nasopharyngeal/transclival corridor, lateralization of the internal carotid artery to create an expanded medial window, a pterygopalatine infrapetrosal approach, and a contralateral maxillary approach, which allow improved access to the inferior and lateral petrous apex. Nasoseptal flaps may reduce the risk of postoperative stenosis of the drainage tract.
SUMMARY: Endoscopic endonasal approaches can be used safely to address both medial and lateral/inferior petrous apex lesions. Morbidity of these procedures is low and use of a nasoseptal flap may limit restenosis of the drainage pathway.

PMID: 30507687 [PubMed - as supplied by publisher]



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Current indications for balloon sinuplasty.

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Current indications for balloon sinuplasty.

Curr Opin Otolaryngol Head Neck Surg. 2018 Nov 30;:

Authors: Cingi C, Bayar Muluk N, Lee JT

Abstract
PURPOSE OF REVIEW: The purpose of the review is to evaluate the current indications and contraindications for balloon sinuplasty and review the clinical trials performed in this area.
RECENT FINDINGS: The indications for balloon sinus dilatation are somewhat similar to those for endoscopic sinus surgery. Balloon sinus ostial dilation (BSD) has been found to be most effective in the treatment of recurrent acute sinusitis (RARS) and chronic rhinosinusitis without nasal polyposis (CRSsNP) that has been refractory to medical therapy. Multiple randomized clinical trials have demonstrated the efficacy of BSD in improving quality-of-life outcomes in patients with limited CRSsNP in both the clinic and operating room settings. However, because BSD merely dilates blocked sinusal ostia without removing tissue, it is typically restricted to addressing disorder involving the frontal, sphenoid, and maxillary sinuses. Individuals who have significant disease of the ethmoid sinus may have BSD adjunctively with endoscopic sinus surgery. BSD is unsuitable as a primary treatment modality in pansinus polyposis, widespread fungal sinusitis, connective tissue disorders at an advanced stage, or potential malignancy. A recent expert clinical consensus statement also concluded that BSD is not appropriate for treatment of patients with headache that do not meet the diagnostic criteria for CRS or RARS or patients who do not have both positive findings of sinus disease on computed tomography and sinonasal symptoms.
SUMMARY: Balloon sinuplasty is an option in the treatment of sinusitis that has failed appropriate medical therapy. Evidence is best for limited disease in patients with CRSsNP affecting the frontal, sphenoid, and maxillary sinuses. Because BSD can be performed in the office setting, it can be a viable therapeutic alternative in patients with comorbidities who are unable to tolerate general anesthesia.

PMID: 30507684 [PubMed - as supplied by publisher]



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Review and update on extracorporeal septoplasty.

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Review and update on extracorporeal septoplasty.

Curr Opin Otolaryngol Head Neck Surg. 2018 Nov 30;:

Authors: McGrath M, Bell E, Locketz GD, Becker DG

Abstract
PURPOSE OF REVIEW: To examine the recent literature on extracorporeal septoplasty.
RECENT FINDINGS: The literature suggests that extracorporeal septoplasty is an effective approach for both functional and cosmetic treatment of moderate to severe deformities of the caudal and dorsal septum. The procedure can be performed via an endonasal or external approach based on the nature of the deformity and the experience of the surgeon, although recent literature highlights various advantages of an external approach. The use of polydioxanone foil as a scaffold for septal reconstruction is widely accepted, and can enhance the technical performance of this technique. Although reported complication rates are low, tip deprojection and rotation have been observed in cases where extracorporeal septoplasty is performed without simultaneous rhinoplasty.
SUMMARY: Extracorporeal septoplasty is a useful technique in the armamentarium of surgeons addressing deviations of the dorsal and caudal septum.

PMID: 30507685 [PubMed - as supplied by publisher]



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Thailand Dyspepsia Guidelines: 2018.

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Thailand Dyspepsia Guidelines: 2018.

J Neurogastroenterol Motil. 2018 Nov 23;:

Authors: Pittayanon R, Leelakusolvong S, Vilaichone RK, Rojborwonwitaya J, Treeprasertsuk S, Mairiang P, Chirnaksorn S, Chitapanarux T, Kaosombatwattana U, Sottisuporn J, Sansak I, Phisalprapa P, Bunchorntavakul C, Chuenrattanakul S, Chakkaphak S, Boonsirichan R, Wiwattanachang O, Maneerattanaporn M, Piyanirun W, Mahachai V

Abstract
The management of dyspepsia in limited-resource areas has not been established. In 2017, key opinion leaders throughout Thailand gathered to review and evaluate the current clinical evidence regarding dyspepsia and to develop consensus statements, rationales, levels of evidence, and grades of recommendation for dyspepsia management in daily clinical practice based on the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach. This guideline is mainly focused on the following four topics: (1) evaluation of patients with dyspepsia, (2) management, (3) special issues (overlapping gastroesophageal reflux disease/irritable bowel syndrome and non-steroidal anti-inflammatory drug/aspirin use), and (4) long-term follow-up and management to provide guidance for physicians in Thailand and other limited-resource areas managing such patients.

PMID: 30504528 [PubMed - as supplied by publisher]



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Role of Acid Suppression in Acid-related Diseases: Proton Pump Inhibitor and Potassium-competitive Acid Blocker.

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Role of Acid Suppression in Acid-related Diseases: Proton Pump Inhibitor and Potassium-competitive Acid Blocker.

J Neurogastroenterol Motil. 2018 Nov 20;:

Authors: Mori H, Suzuki H

Abstract
Proton pump inhibitors are commonly utilized for the treatment of gastric acid-related conditions, such as gastroesophageal reflux disease, peptic ulcer disease, and Helicobacter pylori infection, and for the prevention of low-dose aspirin or nonsteroidal anti-inflammatory drug associated peptic ulcers. Vonoprazan is a first-in-class potassium-competitive acid blocker, which has distinct advantages compared to other conventional proton pump inhibitors in terms of the rate and effectiveness at which gastric acid suppression occurs. Due to its strong gastric acid suppression capabilities, vonoprazan serves as an effective drug for the treatment of gastroesophageal reflux disease and H. pylori infection.

PMID: 30504527 [PubMed - as supplied by publisher]



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Colonic Electromechanical Abnormalities Underlying Post-operative Ileus: A Systematic and Critical Review.

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Colonic Electromechanical Abnormalities Underlying Post-operative Ileus: A Systematic and Critical Review.

J Neurogastroenterol Motil. 2018 Nov 19;:

Authors: Wells CI, O'Grady G, Bissett IP

Abstract
Post-operative ileus (POI) is an inevitable consequence of major abdominal surgery, and may be prolonged in up to 30% of patients. Ileus is commonly presumed to result from paralysis of the GI tract, though there is little direct evidence to support this view. The aim of this review is to systematically search and critically review the literature investigating post-operative colonic electrical and mechanical activity. MEDLINE and Embase databases were systematically searched for articles investigating post-operative colonic motor or electrical activity in human patients. Nineteen original articles investigating post-operative colonic motor or electrical activity were identified. Most studies have used low-resolution techniques, with intermittent recordings of colonic motility. Numerous studies have shown that colonic electrical and motor activity does not cease routinely following surgery, but is of abnormal character for 3-6 days following laparotomy. One recent high-resolution manometry study identified hyperactive cyclic motor patterns occurring in the distal colon on the first post-operative day. Low-resolution studies have shown colonic slow waves are not inhibited by surgery, and are present even in the immediate post-operative period. Recovery of normal motility appears to occur in a proximal to distal direction and is temporally correlated with the clinical return of bowel function. No studies have investigated motility specifically in prolonged POI. Future studies should use high-resolution techniques to accurately characterise abnormalities in electrical and mechanical function underlying POI, and correlate these changes with clinical recovery of bowel function.

PMID: 30504526 [PubMed - as supplied by publisher]



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"Leave It All Behind": The Role of Mental Demands and Mental Detachment in Relation to Dance Students' Health and Well-Being.

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"Leave It All Behind": The Role of Mental Demands and Mental Detachment in Relation to Dance Students' Health and Well-Being.

Med Probl Perform Art. 2018 Dec;33(4):258-264

Authors: Balk YA, de Jonge J, van Rijn R, Stubbe J

Abstract
AIMS: Adequate physical and mental (i.e., cognitive and emotional) recovery is essential for dancers' health and well-being. However, studies investigating the role of mental demands and recovery in dance are scarce. A potentially effective mental recovery strategy is detachment from dance, which refers to the absence of performance-related thoughts, emotions, and feelings during time away from dance. The first aim of this study was to investigate the relation between 1) cognitive and emotional demands in dance and 2) health and well-being of dance students. The second aim was to examine whether the recovery strategy of mental detachment moderated the relation between cognitive and emotional demands and dancers' health and well-being.
METHODS: A cross-sectional survey study was conducted among 80 full-time dance students enrolled in a bachelor's degree in either dance (n=45) or dance teacher (n=35). Dependent variables were health problems, concentration difficulties, and positive affect.
RESULTS: Hierarchical regression analyses showed that cognitive demands and cognitive detachment were not associated with dance students' health and well-being. In contrast, emotional demands were negatively related to positive affect and positively related to concentration difficulties. Emotional detachment was positively related to positive affect and negatively related to health problems. Moreover, emotional detachment moderated (i.e., buffered) the negative relation between emotional demands and positive affect.
CONCLUSIONS: These findings highlight the importance of considering emotional aspects of effort and recovery in dance. It is recommended that dance students consider ways to emotionally distance themselves from negative dance-related emotions and feelings during their free time.

PMID: 30508828 [PubMed - in process]



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Recognizing and Managing Snapping Hip Syndrome in Dancers.

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Recognizing and Managing Snapping Hip Syndrome in Dancers.

Med Probl Perform Art. 2018 Dec;33(4):286-291

Authors: Nolton EC, Ambegaonkar JP

Abstract
BACKGROUND: Snapping hip syndrome (SHS) is a common hip pathology in dancers. SHS can be either internal or external, resulting from muscle tendon tightness from repetitive hip flexion and extension, accompanied with hip abduction and/or external rotation. Muscular tightness may cause the tendon to become taut and snap over a bony prominence during hip movement, leading to muscular weakness and reduced range of motion from pain. Because SHS is poorly identified and can present similarly to other hip pathologies, many SHS incidences are underreported or misdiagnosed. Though SHS can begin as a harmless popping sensation, pain can become severe enough to limit dancers' activities and potentially result in the development of concomitant issues.
EVALUATION: Physical examination for snapping hip includes moving the hip from flexion, abduction, and external rotation (FABER) into extension, adduction, and rotated to a neutral position. Dynamic ultrasound can also be used to study SHS, as using this method allows clinicians to observe the snapping tendon in real-time. Radiographs and magnetic resonance imaging may serve to rule out other differential diagnoses.
MANAGEMENT: Conservative management through rehabilitative therapy is the standard for initial management. In severe cases, arthroscopic intervention may be useful in releasing tension in the pathological tendon. Active rest with training modifications should be attempted to mitigate further injury.
CONCLUSION: Early and comprehensive examination and management can help to reduce SHS risk and potentially decrease the ability of this debilitating condition to derail a dancer's career.

PMID: 30508831 [PubMed - in process]



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Removing Boundaries to Enhance Communication Between People.

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Removing Boundaries to Enhance Communication Between People.

Med Probl Perform Art. 2018 Dec;33(4):292-293

Authors: Bronner S

Abstract
Regardless of your view of national or global politics, we are living through an era of toxic partisan rhetoric. From belligerent tweets on Twitter to "fake news" on Facebook and Instagram, where is this taking us? It is so easy to misunderstand a text and even an email. I've been thinking about the artists we work with and what we do in our professional lives. Performance is a form of communication between the artist and audience. The artist on stage can feel the unspoken response by the audience (even before there is or isn't applause or boos). There is an energy, a connection.

PMID: 30508822 [PubMed - in process]



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Balance in Theatrical Dance Performance: A Systematic Review.

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Balance in Theatrical Dance Performance: A Systematic Review.

Med Probl Perform Art. 2018 Dec;33(4):275-285

Authors: Clarke F, Koutedakis Y, Wilson M, Wyon M

Abstract
AIM: Due to movement complexity and the use of interdisciplinary styles, all theatrical dance genres require dancers to have excellent balance skills to meet choreographic demands. The aim of this systematic review was to evaluate the experimental evidence for the relationship between balance and dance performance, including balance testing, balance training, and balance performance. The key focus was on balance and theatrical styles of dance, involving adult participants who were either in full-time dance training or professional dancers.
METHODS: The databases MEDLINE, PubMed, Cumulative Index to Nursing & Allied Health (CINAHL), SPORTDiscus, Cochrane, ScienceDirect, and Google Scholar were searched using MeSH terms "postural balance," "balance, postural," "musculoskeletal equilibrium," and "postural equilibrium," and used in combination with "dance," between 1980 and 2016. PRISMA recommendations were applied in modifications to the search terms.
RESULTS: The initial search revealed 1,140 published articles. After applying inclusion and exclusion criteria, 47 articles were judged to be relevant for further assessment using the GRADE system. Results revealed only 1 randomized controlled trial (RCT); the remaining articles were experimental without randomisation or pre-experimental, thus achieving low scores. A total of 39 articles focused on balance ability, including postural sway and control; 5 were related to multi-joint coordination; and 3 investigated laterality and balance. Female ballet dancers were the most studied population, while a wide range of measurement tools and balance tasks were employed.
CONCLUSION: The available material on balance and dance performance is of rather low quality. There is a need for more RCTs and intervention balance studies.

PMID: 30508830 [PubMed - in process]



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Musculoskeletal Demands in Violin and Viola Playing: A Literature Review.

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Musculoskeletal Demands in Violin and Viola Playing: A Literature Review.

Med Probl Perform Art. 2018 Dec;33(4):265-274

Authors: Rensing N, Schemmann H, Zalpour C

Abstract
BACKGROUND/AIMS: Research in music medicine has reported incidence rates of musculoskeletal disorders of approx. 70% in instrumental musicians. String players have the highest risk, with rates of performance-related musculoskeletal disorders (PRMDs) of 65% to 88%. Playing the violin or viola requires complex neuromusculoskeletal skills, and the high frequency of repetitive movements, dynamic and static muscle load, awkward postures, poor technique, and practice time are factors causing musculoskeletal strain. In ergonomic terms, these disorders can be categorized based on extrinsic and intrinsic loads. Identification of intrinsic loads, such as muscle utilization and joint motion, is necessary to understand factors influencing musculoskeletal disorders associated with violin playing. The aim of this study was to review the literature on musculoskeletal demands in violin and viola playing.
METHODS: A literature search was conducted in the PubMed, COCHRANE, and CINAHL electronic databases from 1999 to 2015 using the search terms violin, viola, high strings, movement, posture, and synonyms. A manual search of Medical Problems of Performing Artists was also conducted. Additional references were identified by searching the citations and reference lists of all identified relevant studies.
RESULTS: The results suggest that an asymmetric playing posture, the associated muscle activity, and joint mobility may contribute to musculoskeletal problems in violin and viola players. Evidence suggests an increased load of intrinsic factors in violin/viola performance.
CONCLUSION: The identification of intrinsic loads in violin and viola playing may facilitate the development of prevention strategies and interventions.

PMID: 30508829 [PubMed - in process]



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Influence of Different Instrument Carrying Systems on the Kinematics of the Spine of Saxophonists.

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Influence of Different Instrument Carrying Systems on the Kinematics of the Spine of Saxophonists.

Med Probl Perform Art. 2018 Dec;33(4):251-257

Authors: Piatek S, Hartmann J, Günther P, Adolf D, Seidel EJ

Abstract
AIMS: Back strain is a common musculoskeletal complaint affecting musicians, which may be related to unsuitable playing positions causing fatigue and muscle tension. In this study, three saxophone-carrying systems (neck-strap, shoulder-strap, and Saxholder) were examined for their effects on spinal column kinematics.
METHODS: The influence of saxophone-carrying systems was investigated in 14 physically healthy alto saxophonists using ultrasound topometry. Additional tests were performed on 1 subject to examine the influence of the different weights of alto, tenor, and baritone saxophones with the three different carrying systems.
RESULTS: The clearest difference between two systems (shoulder-strap vs Saxholder) was found in the angle at which the player's head bows forward while playing (3.35°; 95% CI 0.44, 6.26; p=0.0272). The use of the Saxholder resulted in a physiologically favorable axial position of the head. The head posture to ankle distance showed that the shoulder-strap and Saxholder, compared to the neck-strap, allowed a sagittal straightening and therefore advantageous axially balanced body position, although the differences were not statistically significant. The Saxholder also enabled a stabilization in the frontal section of the shoulders. In additional tests on 1 subject, the coefficient of variation showed that the instruments' weights had a larger influence on the physiologically favorable balanced body position than the different carrying systems.
CONCLUSION: This pilot study was able to show that the technique of sonometric examination (Zebris) is an effective way to investigate the influence of instrument-carrying systems on the kinematics of the spine. The Saxholder may be physiologically advantageous, but further research with a larger sample is needed to verify the findings.

PMID: 30508827 [PubMed - in process]



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Heeled Shoes Increase Knee Work Demand During Repeated Hopping in Dancers.

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Heeled Shoes Increase Knee Work Demand During Repeated Hopping in Dancers.

Med Probl Perform Art. 2018 Dec;33(4):243-250

Authors: Mikkelsen P, Jarvis DN, Kulig K

Abstract
AIMS: Dancers have high injury rates of the lower extremity. External factors such as footwear likely alter the work demands placed on the lower extremity joints when performing dance-style movements. Research on pedestrians shows an increase in knee work demand when wearing heels, which may occur in dancers as well. The purpose of this study was to assess the effect of heeled shoes on lower extremity joint work demand during a basic dance-specific jump (sauté) in dancers when compared to barefoot.
METHODS: Ten healthy, female dancers (age 25.6±4.7 yrs; height 1.7±0.1 m; weight 64.9±9.2 kg; mean years of dance training 17.6±6.4) performed repetitive vertical bipedal dance jumps (sautés) barefoot as well as wearing heeled dance shoes. Sagittal plane hip, knee, and ankle kinetics were calculated. Percentages of work done by these joints were calculated in comparison to the work done by the leg as a whole and compared between the two conditions.
RESULTS: During a dance-specific jump, the percent contribution of energy absorption was significantly different at the ankle and knee between the two conditions. The ankle contribution decreased from 50.7±6.1% in the bare condition to 34.9±5.3% in the shod condition (p=0.002), and the knee contribution increased from 38.6±3.9% barefoot to 55.1±2.8% shod (p=0.002). The same pattern was seen for energy generation, with the ankle contribution decreasing from 48.1±7.3% to 35.6±6.9% and the knee contribution increasing from 43.3±5.6% to 56.4±6.1% in the bare vs shod condition (both p=0.002). There was no significant difference in the percent contribution from the hip.
CONCLUSION: With heeled shoes, there is a shift in work demand from the ankle to the knee with no change at the hip as compared to barefoot.

PMID: 30508826 [PubMed - in process]



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Pain Perception in Clarinetists with Playing-Related Pain After Implementing a Specific Exercise Program.

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Pain Perception in Clarinetists with Playing-Related Pain After Implementing a Specific Exercise Program.

Med Probl Perform Art. 2018 Dec;33(4):238-242

Authors: Gallego Cerveró C, Martín Ruiz J, Ruiz Sanchis L, Ros Ros C

Abstract
BACKGROUND: Wind musicians suffer injuries resulting from muscle overuse and poor postural habits, often due to the lack of required physical fitness. For this reason, it is important to study and analyze the characteristics of their activity in order to select appropriate preventive exercises.
METHODS: 10 clarinetists, who were experiencing joint pain due to instrumental practice, followed a specific program of physical activity, 3 times a week for 2 months. To assess postural changes after its implementation, the Langlade test and muscle pain scale were used at the beginning and the end of the program.
RESULTS: The results show a significant decrease in perceived pain (p<0.001) and changes in the dorsal spine (p=0.001). Given the relationship between the improvement in the Langlade item, which refers to the correct position of the shoulder blades, and muscle pain, with a correlation level of 0.582, it can be said that a change in the shoulder girdle position leads to a decrease of pain in that area.
CONCLUSIONS: In this pilot study of 10 clarinetists, a regular program of physical activity for 9 weeks led to an observable change in posture and a reduction in pain using self-report measures.

PMID: 30508825 [PubMed - in process]



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Muscle Activation in the Main Muscle Groups of the Lower Limbs in High-Level Dancesport Athletes.

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Muscle Activation in the Main Muscle Groups of the Lower Limbs in High-Level Dancesport Athletes.

Med Probl Perform Art. 2018 Dec;33(4):231-237

Authors: Liébana E, Monleón C, Morales R, Pablos C, Moratal C, Blasco E

Abstract
Dancers are subjected to high-intensity workouts when they practice dancesport, and according to the literature, they are prone to injury, primarily of the lower limbs. The purpose of this study was to determine whether differences exist in relative activation amplitudes for dancers involved in dancesport due to muscle, gender, and type of dance. Measurements were carried out using surface electromyography equipment during the choreography of a performance in the following leg muscles: rectus femoris, biceps femoris, tibialis anterior, and gastrocnemius medialis. Eight couples of active dancesport athletes (aged 20.50±2.75 yrs) were analyzed. Significant gender differences were found in rumba in the tibialis anterior (p≤0.05) and gastrocnemius medialis (p≤0.05). Based on the different activations, it is possible to establish possible mechanisms of injury, as well as tools for preventing injuries and improving sports performance.

PMID: 30508824 [PubMed - in process]



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Body Satisfaction, Performance Perception, and Weight Loss Behavior in Young Female Dancers.

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Body Satisfaction, Performance Perception, and Weight Loss Behavior in Young Female Dancers.

Med Probl Perform Art. 2018 Dec;33(4):225-230

Authors: Gearhart MG, Sugimoto D, Meehan WP, Stracciolini A

Abstract
OBJECTIVE: To understand the impact of body satisfaction and performance perception on intentional weight loss behavior and body mass index (BMI) in young female dancers.
METHODS: Young female dancers who visited an injury prevention center were provided a questionnaire including three questions designed to elicit their body satisfaction, perception of weight toward performance, and any intentional weight loss behavior. Binary responses (yes/no) were compared between the three questions using chi-square analysis. Also, a binary logistic regression was performed to find an indicator for intentional weight loss behaviors. Finally, BMI was compared among subgroups.
RESULTS: Data from 43 young female dancers, aged 12-23 yrs, were analyzed. Dancers who were not happy with their weight were more likely to engage with intentional weight loss activity than dancers who were happy with their weight (p=0.002). Those who did not believe that their athletic activities were influenced by their weight were less likely engage with intentional weight loss and more likely to be happy with their weight than dancers who believed that athletic activities were influenced by their weight (p=0.049 and 0.015, respectively). Binary logistic regression indicated female dancers who were not happy with their body weight had nearly 9 times greater odds of intentional weight loss activity (p=0.029). There were no BMI differences among the three subgroups.
CONCLUSION: Intentional weight loss behavior is heavily influenced by body satisfaction in young female dancers regardless of their current BMI.

PMID: 30508823 [PubMed - in process]



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Prioritising Performance--Where Does Health Fit In?

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Prioritising Performance--Where Does Health Fit In?

Med Probl Perform Art. 2018 Sep;33(3):221-222

Authors: Ackermann BJ

Abstract
Elite performance encompasses a complex balancing act involving a series of professionals attempting to help an individual perform to the limit of their abilities, whilst simultaneously striving to further their capacity. Teachers and performance scientists are under pressure to try to push performers harder to be able to achieve success in competitions, performances and their career. Clinicians must strive to keep the physical and mental health of performers in as good shape as possible while they are balancing these often extreme physical and psychological training demands--'the show must go on.' Efforts to better understand mechanisms that may impact both performance capacity and risk to health are therefore highly important, and feature in research presented in the current issue.

PMID: 30508821 [PubMed - in process]



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Epidemiology and microbiology of skin and soft tissue infections: preliminary results of a National registry.

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Epidemiology and microbiology of skin and soft tissue infections: preliminary results of a National registry.

J Chemother. 2018 Dec 03;:1-6

Authors: Silvano E, Giuseppe S, Angelo P, Paola B, Gianno G, Claudio M, Blerta K, Carlo C, Lorenzo M, Daniela F, Giulia P, Marco L, Roberto B, Guglielmo B, Alberto Enrico M, Pierluigi B, Sandro P, Alessandra C, Giovanni A, Francesca S, Consuelo G, Andrea T, Sara F, Anna C, Teresa S, Giovanni C, Maria Paola C, Elisabetta S, Pierangelo R, Giulia M, Roberto F, Antonio C, Claudia C, Claudia G, Mario T, Angela Raffaella L, Giuseppe F, Tullio P, Calogero B, Iaria C, Carmelo I, Sofia S, Giulio S, Anna I, Mauro S, Italian Society of Infectious and Tropical Diseases

Abstract
Skin and soft tissue infections (SSTIs) represent a wide range of clinical conditions characterized by a considerable variety of clinical presentations and severity. Their aetiology can also vary, with numerous possible causative pathogens. While other authors previously published analyses on several types of SSTI and on restricted types of patients, we conducted a large nationwide surveillance programme on behalf of the Italian Society of Infectious and Tropical Diseases to assess the clinical and microbiological characteristics of the whole SSTI spectrum, from mild to severe life-threatening infections, in both inpatients and outpatients. Twenty-five Infectious Diseases (ID) Centres throughout Italy collected prospectively data concerning both the clinical and microbiological diagnosis of patients affected by SSTIs via an electronic case report form. All the cases included in our database, independently from their severity, have been managed by ID specialists joining the study while SSTIs from other wards/clinics have been excluded from this analysis. Here, we report the preliminary results of our study, referring to a 12-month period (October 2016-September 2017). During this period, the study population included 254 adult patients and a total of 291 SSTI diagnoses were posed, with 36 patients presenting more than one SSTIs. The type of infection diagnosed, the aetiological micro-organisms involved and some notes on their antimicrobial susceptibilities were collected and are reported herein. The enrichment of our registry is ongoing, but these preliminary results suggest that further analysis could soon provide useful information to better understand the national epidemiologic data and the current clinical management of SSTIs in Italy.

PMID: 30508410 [PubMed - as supplied by publisher]



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Transurethral resection of the prostate: Are we following the guidelines? - Outcomes from the Global Prevalence of Infections in Urology (GPIU) study.

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Transurethral resection of the prostate: Are we following the guidelines? - Outcomes from the Global Prevalence of Infections in Urology (GPIU) study.

J Chemother. 2018 Dec 03;:1-5

Authors: Köves B, Tenke P, Tandogdu Z, Cai T, Bogenhard F, Wullt B, Naber K, Bartoletti R, Cek M, Kulchavenya E, Perepanova T, Pilatz A, Bonkat G, Erik Bjerklund Johansen T, Wagenlehner F

Abstract
Transurethral resection of the prostate (TURP) is one of the most common urological procedures. With the increasing rate of multiresistant infections including urosepsis, it is essential for all surgeons to adhere to the relevant international guidelines to prevent infectious complications. The aim of this prospective, multinational, multicentre study was to evaluate compliance with recommended infection control measures regarding TURP procedures. The study was performed as a side questionnaire to the annual Global Prevalence Study of Infections in Urology (GPIU) between 2006 and 2009. Patients that had undergone TURP were eligible. Baseline data about hospitals and patients were collected. The questionnaire contained questions regarding preoperative microbiological investigations, catheter care and performance of perioperative antibiotic prophylaxis. A total of 825 men were included from 138 participating centres from Africa, Asia, Europe and South America. Only 50.1% of the patients received perioperative antibiotic prophylaxis with a median duration of 3 days (interquartile range [IQR] = 1-7 days). Preoperative urine culture was taken in 59.2%. The catheter was replaced in 1 week prior to the surgery only in 38.3% of cases. Compliance with the recommended infection control measures regarding TURP were only moderate, despite high grade recommendations in relevant international Guidelines. Stronger guideline adherence is necessary to improve patient care decrease antibiotic consumption in line with antibiotic stewardship in surgical practices.

PMID: 30508403 [PubMed - as supplied by publisher]



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Are Increased Masticatory Forces Risk for Primary 2nd Molars without Successors? A 3D FEA Study.

Are Increased Masticatory Forces Risk for Primary 2nd Molars without Successors? A 3D FEA Study.

J Clin Pediatr Dent. 2018 Dec 06;:

Authors: Demirel A, Sarı Ş

Abstract
OBJECTIVE: Persistent primary teeth with healthy crown-root structures and acceptable functional and esthetic properties may be preserved over a long-term period if needed. However, they may experience root resorption, ankylosis or infraocclusion especially in the second or third decades of life. Despite a lack of sufficient detailed data, increases in occlusal forces by age are known to cause destructive stresses on root surfaces and periodontal tissue. The aim of this study was to evaluate the effect of increasing occlusal forces on mandibular persistent primary molars by using 3D finite element analysis.
STUDY DESIGN: The impact of increased masticatory forces on compressive and tensile stresses in tooth and surrounding tissue was simulated in two different models (simulating child and adult mouths) by using 3D finite element analysis.
RESULTS: In both models, the stress values increased by age and compressive stresses were seen on internal root surfaces, while the tensile stresses focused on the furcation area and external root surfaces.
CONCLUSION: It was concluded that practices such as reducing occlusal surface width may be used to diminish the occlusal forces for long-term tooth survival in persistent primary molars.

PMID: 30520701 [PubMed - as supplied by publisher]



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A Survey of Pediatric Dentists on the Treatment Timing and Modalities for White Spot Lesions in the United States.

A Survey of Pediatric Dentists on the Treatment Timing and Modalities for White Spot Lesions in the United States.

J Clin Pediatr Dent. 2018 Dec 06;:

Authors: Saito T, Park JH, Bay C

Abstract
PURPOSE: The purpose of this study was to estimate the prevalence of white spot lesions (WSLs) in various practice settings and patient populations, and to gather information about the treatment timing and modalities used by pediatric dentists in the United States.
STUDY DESIGN: A fourteen question, multiple choice, electronic survey was developed and distributed to 6,092 active American Academy of Pediatric Dentistry (AAPD) members.
RESULTS: A total of 625 active members responded, garnering a 9.7% response rate. Before treatment, there were significantly more WSLs reported in Corporate practice than Multi-Doctor Practice (P=0.002), and significantly more WSLs in Academics/Hospital-Based Practices than in Multi-Doctor Practices (P=0.002). For WSLs after treatment, there were significantly more WSLs in Academic/Hospital-Based practices than in single-practitioner settings (P=0.003). Approximately 38% of pediatric dentists preferred to treat WSLs before, during or after orthodontic treatment, while 23% treat only before and 20% treat only after treatment. The three most common treatment modalities for WSLs, were prescription fluoride toothpaste (5000 ppm), fluoride varnish, and fluoride rinse. Approximately 47% of respondents reported they were "very comfortable" treating WSLs and 31.0% felt "comfortable."
CONCLUSIONS: The prevalence of WSLs differed across types of practice. There is no agreement among pediatric dentist as to timing and treatment modalities for WSLs.

PMID: 30520700 [PubMed - as supplied by publisher]



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In Vivo Evaluation of Customized Pulse Oximeter and Sensitivity Pulp Tests for Assessment Of Pulp Vitality.

In Vivo Evaluation of Customized Pulse Oximeter and Sensitivity Pulp Tests for Assessment Of Pulp Vitality.

J Clin Pediatr Dent. 2018 Dec 06;:

Authors: Sharma DS, Mishra S, Banda NR, Vaswani S

Abstract
OBJECTIVE: The purpose of this study was to test a customized pulse oximeter (CPO) for evaluation of pulp vitality in primary and permanent teeth against clinical diagnosis (vital and untreated non-vital) in order to expand its clinical use for pulp preservation.
STUDY DESIGN: CPO was evaluated on intact primary and permanent central or lateral incisor (CI, LI) teeth- vital (group 1, 20n each); untreated non-vital (group 2, 10n each) and; root filled non-vital (group 3, 10n each) of children 4-12 years according to inclusion/exclusion criteria. For each patient CPO was first applied on finger followed by vitality tests in following sequence-electrical, pulse oximetry and thermal tests.
RESULTS: Mean oxygen saturation (%SpO2) in permanent and primary-vital teeth was 88.78% & 87.77% respectively; non-vital teeth was 74.67% & 75.00% respectively; and in all root filled teeth was 0%. Tooth and finger oxygen saturation values showed strong positive relationship in vital primary or permanent teeth and; no correlation in untreated non-vital primary or permanent teeth. The accuracy rate of thermal pulp test and pulse oximetry was 100% and for electrical pulp test it was 90% for permanent and 86.67% for primary teeth.
CONCLUSION: The CPO tested in this study proved to be a valuable adjunct for diagnosing pulp vitality by objective means.

PMID: 30520699 [PubMed - as supplied by publisher]



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Case Report in Clinical Pediatric Dentistry: How to Review, Organize and Prepare a Manuscript.

Case Report in Clinical Pediatric Dentistry: How to Review, Organize and Prepare a Manuscript.

J Clin Pediatr Dent. 2018 Dec 06;:

Authors: Garrocho-Rangel A, Flores-Arriaga JC, Saadia M, Pozos-Guillén A

Abstract
A case report is a useful type of publication to describe information on unusual clinical diseases or syndromes, new management techniques, potential risk factors/oral disease associations, and uncommon side effects or responses to traditional dental treatments. In the practice of Dentistry and Medicine, the publication of case reports has the purpose of sharing new clinical experiences and knowledge with interested colleagues. Case reports in the field of Evidence-Based Pediatric Dentistry convey unique contributions to the clinical practice and help improve the process of clinical decision making in the form of a brief written communication. Additionally, case reports are potential resources of new hypotheses for more complex methodological designs in clinical research studies and are one of the best ways to get started in scholarly writing. The purposes of the present report were to comment on the role, relevance, and main limitations of case reports in Clinical Pediatric Dentistry, to describe the reasons for writing a case report and some recommendations for critically reviewing a published case report, and finally, to provide the fundamentals of preparing a case report manuscript in a structured manner.

PMID: 30520698 [PubMed - as supplied by publisher]



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Current indications for balloon sinuplasty.

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Current indications for balloon sinuplasty.

Curr Opin Otolaryngol Head Neck Surg. 2018 Nov 30;:

Authors: Cingi C, Bayar Muluk N, Lee JT

Abstract
PURPOSE OF REVIEW: The purpose of the review is to evaluate the current indications and contraindications for balloon sinuplasty and review the clinical trials performed in this area.
RECENT FINDINGS: The indications for balloon sinus dilatation are somewhat similar to those for endoscopic sinus surgery. Balloon sinus ostial dilation (BSD) has been found to be most effective in the treatment of recurrent acute sinusitis (RARS) and chronic rhinosinusitis without nasal polyposis (CRSsNP) that has been refractory to medical therapy. Multiple randomized clinical trials have demonstrated the efficacy of BSD in improving quality-of-life outcomes in patients with limited CRSsNP in both the clinic and operating room settings. However, because BSD merely dilates blocked sinusal ostia without removing tissue, it is typically restricted to addressing disorder involving the frontal, sphenoid, and maxillary sinuses. Individuals who have significant disease of the ethmoid sinus may have BSD adjunctively with endoscopic sinus surgery. BSD is unsuitable as a primary treatment modality in pansinus polyposis, widespread fungal sinusitis, connective tissue disorders at an advanced stage, or potential malignancy. A recent expert clinical consensus statement also concluded that BSD is not appropriate for treatment of patients with headache that do not meet the diagnostic criteria for CRS or RARS or patients who do not have both positive findings of sinus disease on computed tomography and sinonasal symptoms.
SUMMARY: Balloon sinuplasty is an option in the treatment of sinusitis that has failed appropriate medical therapy. Evidence is best for limited disease in patients with CRSsNP affecting the frontal, sphenoid, and maxillary sinuses. Because BSD can be performed in the office setting, it can be a viable therapeutic alternative in patients with comorbidities who are unable to tolerate general anesthesia.

PMID: 30507684 [PubMed - as supplied by publisher]



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Management of sphenoid lateral recess encephalocoeles.

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Management of sphenoid lateral recess encephalocoeles.

Curr Opin Otolaryngol Head Neck Surg. 2018 Nov 16;:

Authors: Govindaraju R, Tang IP, Prepageran N

Abstract
PURPOSE OF REVIEW: Sphenoid sinus lateral recess encephalocoeles (SSLRE) are rare occurrences and pose unique challenges due to limited surgical access for endoscopic endonasal repair and also the lack of consensus on optimal perioperative managements specifically in the spontaneous cases, which are also believed to be a variant of idiopathic intracranial hypertension (IIH). Endoscopic endonasal approaches have largely replaced the transcranial route and the techniques are continuously being refined to reduce the neurovascular morbidity and improve outcome.
RECENT FINDINGS: Transpetrygoid is the most utilized approach with modifications suggested to limit bone removal, exposure and preservation of the neurovascular structures as dictated by the extent of the lateral recess. As more experience is gained, extended transphenoidal techniques were also successfully used for access. Lateral transorbital is a new approach to the lateral recess investigated in cadavers. IIH treatment is still controversial in the setting of SSLRE, but it appears rationale to evaluate, monitor and treat if necessary.
SUMMARY: SSLRE management should be tailored to the specific anatomical variances and cause. Modifications of techniques have been described giving different options to access the lateral recess. Successful repair for spontaneous SSLRE may require treatment of IIH if present, but the long-term outcome is still unclear.

PMID: 30507693 [PubMed - as supplied by publisher]



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The rhinologist's role in the management of rathke's cleft cysts.

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The rhinologist's role in the management of rathke's cleft cysts.

Curr Opin Otolaryngol Head Neck Surg. 2018 Nov 16;:

Authors: Kuan EC, Palmer JN, Adappa ND

Abstract
PURPOSE OF REVIEW: To review the recent literature regarding the growing role of rhinologists and otolaryngologists with neurosurgeons in the joint multidisciplinary team approach for managing patients with Rathke's cleft cysts (RCC).
RECENT FINDINGS: The transnasal endoscopic approach to the skull base has become relatively mainstream for surgical treatment of RCCs. Suprasellar lesions, especially those that are purely suprasellar, are associated with higher recurrence rates, though an extended approach may improve dissection and access and therefore aid in lesion removal. Endoscopic cyst drainage is a well tolerated and effective way to treat RCC, and often avoids the postoperative endocrinopathies associated with complete cyst wall removal. Novel techniques have been described for maintaining tract patency, including the use of stents and flaps, in order to prevent cyst stenosis and reaccumulation. A frontier in skull base surgery is in applications for pediatric patients, and managing RCCs in this population surgically appears to be associated with positive outcomes overall.
SUMMARY: Team-based endoscopic skull base surgery has spurred advances in our understanding of skull base disease, including RCCs. Optimal outcomes are most apparent when the experience and technique of both the endoscopist and neurosurgeon have developed jointly over time.

PMID: 30507691 [PubMed - as supplied by publisher]



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Open-neck organ preservation surgery for hypopharyngeal cancer: indications, techniques, limits, and outcomes.

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Open-neck organ preservation surgery for hypopharyngeal cancer: indications, techniques, limits, and outcomes.

Curr Opin Otolaryngol Head Neck Surg. 2018 Nov 16;:

Authors: Bradley PJ, Liu L

Abstract
PURPOSE OF REVIEW: To appraise the practice and role of open-neck organ preserving surgery for hypopharyngeal squamous cell carcinoma and to update the current indications, techniques, limits, and outcomes.
RECENT FINDINGS: The role of primary surgery for hypopharyngeal carcinoma has shifted over the past two decades to primary nonsurgical management with the use of induction or concurrent chemoradiotherapy. The preferred and most suitable tumours for open-neck surgery are the small-volume T stage diseases, with small to medium-volume neck metastases, however such patients are exceedingly rare. Nonetheless, more advanced tumours with cartilage invasion, vocal cord paralysis, or located at piriform apex and postcricoid area, previously unsuitable for open-neck organ preserving surgery, can now be excised and repaired, minimizing morbidity and improving quality of patients' life. Much of this surgical progress has been developed by innovative surgeons using free tissue transfer, accurate placement surgery, reconstruction of a neoglottis, and perfecting the pharyngoesophageal anastomosis. Current practice of open-neck organ preserving surgery for hypopharyngeal carcinoma has been mainly reported in Asia: Korea, Taiwan, Japan, and China.
SUMMARY: There are some patients who are deemed unsuitable and/or unwilling for current treatment by nonsurgical approaches, and open-neck organ preserving laryngopharyngeal surgery may be a more suitable alternative than selecting a 'lesser or modified' chemo or bioradiotherapy regimen, resulting in a prolonged quantity and quality of life.

PMID: 30507694 [PubMed - as supplied by publisher]



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Endotypes of chronic rhinosinusitis.

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Endotypes of chronic rhinosinusitis.

Curr Opin Otolaryngol Head Neck Surg. 2018 Nov 30;:

Authors: Yip J, Monteiro E, Chan Y

Abstract
PURPOSE OF REVIEW: In contrast to the phenotypic classification of chronic rhinosinusitis (CRS), endotyping categorizes disease variants based on their underlying pathophysiologic mechanisms. Defining CRS endotypes may provide information on the risk for disease progression, recurrence and comorbid conditions, as well as identify suitable therapeutic targets. With the emergence of biologics, endotyping may enable personalized pharmacotherapy for recalcitrant CRS. The purpose of this review is to briefly summarize the pathophysiology and endotypes of CRS, and highlight the biologics that target mediators of CRS.
RECENT FINDINGS: CRS is due to dysregulated immunologic responses to external stimuli, which induces inflammatory mediators. The linkage between innate lymphoid cells, adaptive CD4 T helper and CD8 + cytotoxic T cells has led to proposed endotypes that are based around immune response deviation into type 1, type 2 and type 3 responses. Cluster analysis has attempted to define endotypes, accounting for clinical characteristics, molecular and cellular biomarkers, and treatment response. Biologics targeting epithelial-derived cytokines and immunoglobulin E, as well as mediators of type 1, type 2 and type 3 inflammation, are being investigated in CRS.
SUMMARY: Although there have been significant advances made in the understanding of the pathomechanisms of CRS, there currently remains a lack of full characterization of CRS endotypes.

PMID: 30507689 [PubMed - as supplied by publisher]



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Salivaomics in oral cancer.

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Salivaomics in oral cancer.

Curr Opin Otolaryngol Head Neck Surg. 2018 Nov 30;:

Authors: Aro K, Kaczor-Urbanowicz K, Carreras-Presas CM

Abstract
PURPOSE OF REVIEW: The goal of cancer screening is to detect tumor at an early stage, and early cancer detection is the hallmark of successful treatment. In addition to traditional tissue biopsy-based diagnostics, more reliable, inexpensive, and noninvasive methods are required for early diagnosis of cancer. In this review, we highlight some of the recent advancements in the field of salivary diagnostics in oral cancer.
RECENT FINDINGS: 'Salivaomics' is a broad collection of technologies used to explore different types of molecules contained in saliva. Although many protein and mRNA salivary biomarkers have been identified that can detect oral squamous cell carcinoma (OSCC), none have so far been validated for current clinical use. As the heterogeneity in carcinogenesis and multifactorial cause for OSCC, the most reliable results are gathered with the use of multiple biomarker candidates to improve accuracy and sensitivity of the test used. This further requires sensitive technology to detect salivary biomarkers in low quantities.
SUMMARY: Large scale studies that incorporate proteomic, transcriptomic, and additional 'omics,' need to be initiated to bring technology to clinical point-of-care applications.

PMID: 30507690 [PubMed - as supplied by publisher]



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Oncologic management of sinonasal undifferentiated carcinoma.

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Oncologic management of sinonasal undifferentiated carcinoma.

Curr Opin Otolaryngol Head Neck Surg. 2018 Nov 16;:

Authors: Tyler MA, Holmes B, Patel ZM

Abstract
PURPOSE OF REVIEW: This article reviews the latest treatment paradigms in sinonasal undifferentiated carcinoma (SNUC).
RECENT FINDINGS: The aggressive biology and associated advanced presentation of SNUC make successful treatment a challenge shared across medical specialties. Still, studies reporting outcomes in SNUC indicate that an aggressive treatment strategy consisting of surgery, radiation and chemotherapy offers the best chance of prolonged survival.
SUMMARY: Successful treatment of SNUC requires highly specialized care at tertiary cancer treatment facilities. A better understanding of the biology of the disease coupled with increasing outcome reporting will lead to optimized treatment regimens.

PMID: 30507692 [PubMed - as supplied by publisher]



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Histopathologic analysis in the diagnosis and management of chronic rhinosinusitis.

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Histopathologic analysis in the diagnosis and management of chronic rhinosinusitis.

Curr Opin Otolaryngol Head Neck Surg. 2018 Nov 30;:

Authors: Shay AD, Tajudeen BA

Abstract
PURPOSE OF REVIEW: New research in the pathogenesis of chronic rhinosinusitis has shed light on an emerging classification system based on endotypes, which help to explain the individualized mechanism of disease in patients suffering from chronic rhinosinusitis with and without nasal polyps. The purpose of this review is to advocate the use of structured histopathologic analysis in the diagnosis and management of patients affected by chronic rhinosinusitis with and without polyps.
RECENT FINDINGS: Numerous studies have demonstrated the role of inflammation in chronic rhinosinusitis and the ensuing histopatholgic changes. Few studies have implemented structured histopathologic analysis to guide diagnosis and treatment. Individualized therapy including biotherapeutics and comprehensive surgery has shown to improve outcomes in patients with refractory disease.
SUMMARY: Structured histopathologic analysis can provide helpful information on the endotype of chronic rhinosinusitis. Routine use in clinical practice should be standardized especially in cases of chronic rhinosinusitis refractory to medical therapy and/or surgery.

PMID: 30507686 [PubMed - as supplied by publisher]



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Contemporary management of juvenile angiofibroma.

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Contemporary management of juvenile angiofibroma.

Curr Opin Otolaryngol Head Neck Surg. 2018 Nov 30;:

Authors: Bertazzoni G, Schreiber A, Ferrari M, Nicolai P

Abstract
PURPOSE OF REVIEW: To illustrate the latest developments and trends in the management of juvenile angiofibroma.
RECENT FINDINGS: Endoscopic surgery is currently the primary management strategy for juvenile angiofibroma. Recent reports on the use of multiportal approaches have contributed to further extend its indications. Studies from different countries suggest that the lesion can display variable growth rates not only in relation to patient age. The same concept applies to residual lesions. For this reason, retreatment of persistent juvenile angiofibromas is indicated when serial imaging clearly shows that the lesion is growing. When redo surgery is potentially associated with high morbidity for the critical relationships of the lesion with adjacent structures, stereotactic or intensity-modulated radiation therapy can be an alternative. Early use of MRI in the postoperative course is a highly effective way to detect residual lesions.
SUMMARY: Contemporary management of juvenile angiofibroma should primarily rely on endoscopic surgery to obtain radical tumor resection. Recent evidence on the behavior of residual postoperative juvenile angiofibroma and the development of conformal RT techniques have helped to clarify the role of watchful waiting and radiotherapy (RT) as alternatives to aggressive procedures in cases with critical extension of the lesion. Although radical excision is the primary therapeutic objective, the benign nature of juvenile angiofibroma and the reported tendency of small residual lesions to remain stable or involute, especially in postpubertal patients, should always be kept in mind to avoid unnecessary morbidity.
VIDEO ABSTRACT: In the video, two of the authors describe the content of the review and present the main topics discussed in the article. https://ift.tt/2zCohVk.

PMID: 30507688 [PubMed - as supplied by publisher]



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Indications and endonasal treatment of petrous apex cholesterol granulomas.

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Indications and endonasal treatment of petrous apex cholesterol granulomas.

Curr Opin Otolaryngol Head Neck Surg. 2018 Nov 30;:

Authors: Kohanski MA, Palmer JN, Adappa ND

Abstract
PURPOSE OF REVIEW: Lesions of the petrous apex of the temporal bone can be challenging to access and approaches laterally through the mastoid as well as medially through an endonasal approach are utilized to access this region while preserving function of adjacent structures. Cholesterol granulomas of the petrous apex requiring surgery are marsupialized to prevent expansion of the inflamed cyst and relieve associated clinical symptoms. The endonasal approach to the petrous apex has in the past been limited to lesions medial to the internal carotid artery.
RECENT FINDINGS: Endoscopic approaches have been developed to expand the range of petrous apex lesions that are accessible endonasally. These endonasal corridors include a nasopharyngeal/transclival corridor, lateralization of the internal carotid artery to create an expanded medial window, a pterygopalatine infrapetrosal approach, and a contralateral maxillary approach, which allow improved access to the inferior and lateral petrous apex. Nasoseptal flaps may reduce the risk of postoperative stenosis of the drainage tract.
SUMMARY: Endoscopic endonasal approaches can be used safely to address both medial and lateral/inferior petrous apex lesions. Morbidity of these procedures is low and use of a nasoseptal flap may limit restenosis of the drainage pathway.

PMID: 30507687 [PubMed - as supplied by publisher]



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Review and update on extracorporeal septoplasty.

Related Articles

Review and update on extracorporeal septoplasty.

Curr Opin Otolaryngol Head Neck Surg. 2018 Nov 30;:

Authors: McGrath M, Bell E, Locketz GD, Becker DG

Abstract
PURPOSE OF REVIEW: To examine the recent literature on extracorporeal septoplasty.
RECENT FINDINGS: The literature suggests that extracorporeal septoplasty is an effective approach for both functional and cosmetic treatment of moderate to severe deformities of the caudal and dorsal septum. The procedure can be performed via an endonasal or external approach based on the nature of the deformity and the experience of the surgeon, although recent literature highlights various advantages of an external approach. The use of polydioxanone foil as a scaffold for septal reconstruction is widely accepted, and can enhance the technical performance of this technique. Although reported complication rates are low, tip deprojection and rotation have been observed in cases where extracorporeal septoplasty is performed without simultaneous rhinoplasty.
SUMMARY: Extracorporeal septoplasty is a useful technique in the armamentarium of surgeons addressing deviations of the dorsal and caudal septum.

PMID: 30507685 [PubMed - as supplied by publisher]



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Contemporary management of juvenile angiofibroma.

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Contemporary management of juvenile angiofibroma.

Curr Opin Otolaryngol Head Neck Surg. 2018 Nov 30;:

Authors: Bertazzoni G, Schreiber A, Ferrari M, Nicolai P

Abstract
PURPOSE OF REVIEW: To illustrate the latest developments and trends in the management of juvenile angiofibroma.
RECENT FINDINGS: Endoscopic surgery is currently the primary management strategy for juvenile angiofibroma. Recent reports on the use of multiportal approaches have contributed to further extend its indications. Studies from different countries suggest that the lesion can display variable growth rates not only in relation to patient age. The same concept applies to residual lesions. For this reason, retreatment of persistent juvenile angiofibromas is indicated when serial imaging clearly shows that the lesion is growing. When redo surgery is potentially associated with high morbidity for the critical relationships of the lesion with adjacent structures, stereotactic or intensity-modulated radiation therapy can be an alternative. Early use of MRI in the postoperative course is a highly effective way to detect residual lesions.
SUMMARY: Contemporary management of juvenile angiofibroma should primarily rely on endoscopic surgery to obtain radical tumor resection. Recent evidence on the behavior of residual postoperative juvenile angiofibroma and the development of conformal RT techniques have helped to clarify the role of watchful waiting and radiotherapy (RT) as alternatives to aggressive procedures in cases with critical extension of the lesion. Although radical excision is the primary therapeutic objective, the benign nature of juvenile angiofibroma and the reported tendency of small residual lesions to remain stable or involute, especially in postpubertal patients, should always be kept in mind to avoid unnecessary morbidity.
VIDEO ABSTRACT: In the video, two of the authors describe the content of the review and present the main topics discussed in the article. https://ift.tt/2zCohVk.

PMID: 30507688 [PubMed - as supplied by publisher]



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Indications and endonasal treatment of petrous apex cholesterol granulomas.

Related Articles

Indications and endonasal treatment of petrous apex cholesterol granulomas.

Curr Opin Otolaryngol Head Neck Surg. 2018 Nov 30;:

Authors: Kohanski MA, Palmer JN, Adappa ND

Abstract
PURPOSE OF REVIEW: Lesions of the petrous apex of the temporal bone can be challenging to access and approaches laterally through the mastoid as well as medially through an endonasal approach are utilized to access this region while preserving function of adjacent structures. Cholesterol granulomas of the petrous apex requiring surgery are marsupialized to prevent expansion of the inflamed cyst and relieve associated clinical symptoms. The endonasal approach to the petrous apex has in the past been limited to lesions medial to the internal carotid artery.
RECENT FINDINGS: Endoscopic approaches have been developed to expand the range of petrous apex lesions that are accessible endonasally. These endonasal corridors include a nasopharyngeal/transclival corridor, lateralization of the internal carotid artery to create an expanded medial window, a pterygopalatine infrapetrosal approach, and a contralateral maxillary approach, which allow improved access to the inferior and lateral petrous apex. Nasoseptal flaps may reduce the risk of postoperative stenosis of the drainage tract.
SUMMARY: Endoscopic endonasal approaches can be used safely to address both medial and lateral/inferior petrous apex lesions. Morbidity of these procedures is low and use of a nasoseptal flap may limit restenosis of the drainage pathway.

PMID: 30507687 [PubMed - as supplied by publisher]



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Open-neck organ preservation surgery for hypopharyngeal cancer: indications, techniques, limits, and outcomes.

Related Articles

Open-neck organ preservation surgery for hypopharyngeal cancer: indications, techniques, limits, and outcomes.

Curr Opin Otolaryngol Head Neck Surg. 2018 Nov 16;:

Authors: Bradley PJ, Liu L

Abstract
PURPOSE OF REVIEW: To appraise the practice and role of open-neck organ preserving surgery for hypopharyngeal squamous cell carcinoma and to update the current indications, techniques, limits, and outcomes.
RECENT FINDINGS: The role of primary surgery for hypopharyngeal carcinoma has shifted over the past two decades to primary nonsurgical management with the use of induction or concurrent chemoradiotherapy. The preferred and most suitable tumours for open-neck surgery are the small-volume T stage diseases, with small to medium-volume neck metastases, however such patients are exceedingly rare. Nonetheless, more advanced tumours with cartilage invasion, vocal cord paralysis, or located at piriform apex and postcricoid area, previously unsuitable for open-neck organ preserving surgery, can now be excised and repaired, minimizing morbidity and improving quality of patients' life. Much of this surgical progress has been developed by innovative surgeons using free tissue transfer, accurate placement surgery, reconstruction of a neoglottis, and perfecting the pharyngoesophageal anastomosis. Current practice of open-neck organ preserving surgery for hypopharyngeal carcinoma has been mainly reported in Asia: Korea, Taiwan, Japan, and China.
SUMMARY: There are some patients who are deemed unsuitable and/or unwilling for current treatment by nonsurgical approaches, and open-neck organ preserving laryngopharyngeal surgery may be a more suitable alternative than selecting a 'lesser or modified' chemo or bioradiotherapy regimen, resulting in a prolonged quantity and quality of life.

PMID: 30507694 [PubMed - as supplied by publisher]



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Histopathologic analysis in the diagnosis and management of chronic rhinosinusitis.

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Histopathologic analysis in the diagnosis and management of chronic rhinosinusitis.

Curr Opin Otolaryngol Head Neck Surg. 2018 Nov 30;:

Authors: Shay AD, Tajudeen BA

Abstract
PURPOSE OF REVIEW: New research in the pathogenesis of chronic rhinosinusitis has shed light on an emerging classification system based on endotypes, which help to explain the individualized mechanism of disease in patients suffering from chronic rhinosinusitis with and without nasal polyps. The purpose of this review is to advocate the use of structured histopathologic analysis in the diagnosis and management of patients affected by chronic rhinosinusitis with and without polyps.
RECENT FINDINGS: Numerous studies have demonstrated the role of inflammation in chronic rhinosinusitis and the ensuing histopatholgic changes. Few studies have implemented structured histopathologic analysis to guide diagnosis and treatment. Individualized therapy including biotherapeutics and comprehensive surgery has shown to improve outcomes in patients with refractory disease.
SUMMARY: Structured histopathologic analysis can provide helpful information on the endotype of chronic rhinosinusitis. Routine use in clinical practice should be standardized especially in cases of chronic rhinosinusitis refractory to medical therapy and/or surgery.

PMID: 30507686 [PubMed - as supplied by publisher]



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Oncologic management of sinonasal undifferentiated carcinoma.

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Oncologic management of sinonasal undifferentiated carcinoma.

Curr Opin Otolaryngol Head Neck Surg. 2018 Nov 16;:

Authors: Tyler MA, Holmes B, Patel ZM

Abstract
PURPOSE OF REVIEW: This article reviews the latest treatment paradigms in sinonasal undifferentiated carcinoma (SNUC).
RECENT FINDINGS: The aggressive biology and associated advanced presentation of SNUC make successful treatment a challenge shared across medical specialties. Still, studies reporting outcomes in SNUC indicate that an aggressive treatment strategy consisting of surgery, radiation and chemotherapy offers the best chance of prolonged survival.
SUMMARY: Successful treatment of SNUC requires highly specialized care at tertiary cancer treatment facilities. A better understanding of the biology of the disease coupled with increasing outcome reporting will lead to optimized treatment regimens.

PMID: 30507692 [PubMed - as supplied by publisher]



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Management of sphenoid lateral recess encephalocoeles.

Related Articles

Management of sphenoid lateral recess encephalocoeles.

Curr Opin Otolaryngol Head Neck Surg. 2018 Nov 16;:

Authors: Govindaraju R, Tang IP, Prepageran N

Abstract
PURPOSE OF REVIEW: Sphenoid sinus lateral recess encephalocoeles (SSLRE) are rare occurrences and pose unique challenges due to limited surgical access for endoscopic endonasal repair and also the lack of consensus on optimal perioperative managements specifically in the spontaneous cases, which are also believed to be a variant of idiopathic intracranial hypertension (IIH). Endoscopic endonasal approaches have largely replaced the transcranial route and the techniques are continuously being refined to reduce the neurovascular morbidity and improve outcome.
RECENT FINDINGS: Transpetrygoid is the most utilized approach with modifications suggested to limit bone removal, exposure and preservation of the neurovascular structures as dictated by the extent of the lateral recess. As more experience is gained, extended transphenoidal techniques were also successfully used for access. Lateral transorbital is a new approach to the lateral recess investigated in cadavers. IIH treatment is still controversial in the setting of SSLRE, but it appears rationale to evaluate, monitor and treat if necessary.
SUMMARY: SSLRE management should be tailored to the specific anatomical variances and cause. Modifications of techniques have been described giving different options to access the lateral recess. Successful repair for spontaneous SSLRE may require treatment of IIH if present, but the long-term outcome is still unclear.

PMID: 30507693 [PubMed - as supplied by publisher]



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The rhinologist's role in the management of rathke's cleft cysts.

Related Articles

The rhinologist's role in the management of rathke's cleft cysts.

Curr Opin Otolaryngol Head Neck Surg. 2018 Nov 16;:

Authors: Kuan EC, Palmer JN, Adappa ND

Abstract
PURPOSE OF REVIEW: To review the recent literature regarding the growing role of rhinologists and otolaryngologists with neurosurgeons in the joint multidisciplinary team approach for managing patients with Rathke's cleft cysts (RCC).
RECENT FINDINGS: The transnasal endoscopic approach to the skull base has become relatively mainstream for surgical treatment of RCCs. Suprasellar lesions, especially those that are purely suprasellar, are associated with higher recurrence rates, though an extended approach may improve dissection and access and therefore aid in lesion removal. Endoscopic cyst drainage is a well tolerated and effective way to treat RCC, and often avoids the postoperative endocrinopathies associated with complete cyst wall removal. Novel techniques have been described for maintaining tract patency, including the use of stents and flaps, in order to prevent cyst stenosis and reaccumulation. A frontier in skull base surgery is in applications for pediatric patients, and managing RCCs in this population surgically appears to be associated with positive outcomes overall.
SUMMARY: Team-based endoscopic skull base surgery has spurred advances in our understanding of skull base disease, including RCCs. Optimal outcomes are most apparent when the experience and technique of both the endoscopist and neurosurgeon have developed jointly over time.

PMID: 30507691 [PubMed - as supplied by publisher]



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Salivaomics in oral cancer.

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Salivaomics in oral cancer.

Curr Opin Otolaryngol Head Neck Surg. 2018 Nov 30;:

Authors: Aro K, Kaczor-Urbanowicz K, Carreras-Presas CM

Abstract
PURPOSE OF REVIEW: The goal of cancer screening is to detect tumor at an early stage, and early cancer detection is the hallmark of successful treatment. In addition to traditional tissue biopsy-based diagnostics, more reliable, inexpensive, and noninvasive methods are required for early diagnosis of cancer. In this review, we highlight some of the recent advancements in the field of salivary diagnostics in oral cancer.
RECENT FINDINGS: 'Salivaomics' is a broad collection of technologies used to explore different types of molecules contained in saliva. Although many protein and mRNA salivary biomarkers have been identified that can detect oral squamous cell carcinoma (OSCC), none have so far been validated for current clinical use. As the heterogeneity in carcinogenesis and multifactorial cause for OSCC, the most reliable results are gathered with the use of multiple biomarker candidates to improve accuracy and sensitivity of the test used. This further requires sensitive technology to detect salivary biomarkers in low quantities.
SUMMARY: Large scale studies that incorporate proteomic, transcriptomic, and additional 'omics,' need to be initiated to bring technology to clinical point-of-care applications.

PMID: 30507690 [PubMed - as supplied by publisher]



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Endotypes of chronic rhinosinusitis.

Related Articles

Endotypes of chronic rhinosinusitis.

Curr Opin Otolaryngol Head Neck Surg. 2018 Nov 30;:

Authors: Yip J, Monteiro E, Chan Y

Abstract
PURPOSE OF REVIEW: In contrast to the phenotypic classification of chronic rhinosinusitis (CRS), endotyping categorizes disease variants based on their underlying pathophysiologic mechanisms. Defining CRS endotypes may provide information on the risk for disease progression, recurrence and comorbid conditions, as well as identify suitable therapeutic targets. With the emergence of biologics, endotyping may enable personalized pharmacotherapy for recalcitrant CRS. The purpose of this review is to briefly summarize the pathophysiology and endotypes of CRS, and highlight the biologics that target mediators of CRS.
RECENT FINDINGS: CRS is due to dysregulated immunologic responses to external stimuli, which induces inflammatory mediators. The linkage between innate lymphoid cells, adaptive CD4 T helper and CD8 + cytotoxic T cells has led to proposed endotypes that are based around immune response deviation into type 1, type 2 and type 3 responses. Cluster analysis has attempted to define endotypes, accounting for clinical characteristics, molecular and cellular biomarkers, and treatment response. Biologics targeting epithelial-derived cytokines and immunoglobulin E, as well as mediators of type 1, type 2 and type 3 inflammation, are being investigated in CRS.
SUMMARY: Although there have been significant advances made in the understanding of the pathomechanisms of CRS, there currently remains a lack of full characterization of CRS endotypes.

PMID: 30507689 [PubMed - as supplied by publisher]



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Review and update on extracorporeal septoplasty.

Related Articles

Review and update on extracorporeal septoplasty.

Curr Opin Otolaryngol Head Neck Surg. 2018 Nov 30;:

Authors: McGrath M, Bell E, Locketz GD, Becker DG

Abstract
PURPOSE OF REVIEW: To examine the recent literature on extracorporeal septoplasty.
RECENT FINDINGS: The literature suggests that extracorporeal septoplasty is an effective approach for both functional and cosmetic treatment of moderate to severe deformities of the caudal and dorsal septum. The procedure can be performed via an endonasal or external approach based on the nature of the deformity and the experience of the surgeon, although recent literature highlights various advantages of an external approach. The use of polydioxanone foil as a scaffold for septal reconstruction is widely accepted, and can enhance the technical performance of this technique. Although reported complication rates are low, tip deprojection and rotation have been observed in cases where extracorporeal septoplasty is performed without simultaneous rhinoplasty.
SUMMARY: Extracorporeal septoplasty is a useful technique in the armamentarium of surgeons addressing deviations of the dorsal and caudal septum.

PMID: 30507685 [PubMed - as supplied by publisher]



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