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Αλέξανδρος Γ. Σφακιανάκης

Saturday, June 29, 2019

A CRISPR Way to Identify Cancer Targets
The premise of precision cancer medicine is elegantly simple. The basic concept involves the analysis — molecular and otherwise — of a tumor to identify key attributes that allow for the selection of therapeutic agents with a high likelihood of killing that particular tumor, while minimizing side…
The New England Journal of Medicine: Search Results in Hematology\Oncology
4h
Clinical and Genomic Risk to Guide the Use of Adjuvant Therapy for Breast Cancer
Clinicopathological features, including tumor size, histologic grade, and the presence of axillary lymph-node metastases, provide prognostic information about disease recurrence in women who have localized breast cancer after surgery, but these features have not been shown to be predictive of…
The New England Journal of Medicine: Search Results in Hematology\Oncology
4h
Nonbacterial Thrombotic Endocarditis
Figure 1.
The New England Journal of Medicine: Search Results in Hematology\Oncology
4h
The Precision of Evidence Needed to Practice "Precision Medicine"
In July 2018, the Journal published the results of TAILORx (Trial Assigning Individualized Options for Treatment). This randomized trial conducted by Sparano et al. showed the noninferiority of endocrine therapy to chemoendocrine therapy with respect to invasive disease–free survival among women…
The New England Journal of Medicine: Search Results in Hematology\Oncology
4h
A Targeted Agent for Sickle Cell Disease — Changing the Protein but Not the Gene
Affecting an estimated 100,000 Americans and millions worldwide, sickle cell disease is among the most common inherited blood disorders in humans and is associated with profound complications and premature death. The pathophysiology of sickle cell disease begins with a single amino acid…
The New England Journal of Medicine: Search Results in Hematology\Oncology
4h
Abatacept for Severe Immune Checkpoint Inhibitor–Associated Myocarditis
To the Editor: Immune checkpoint inhibitors are broadly active treatments for cancer, but they can result in immune-related adverse events. Immune checkpoint inhibitor–induced myocarditis occurs infrequently (in We present a case in which the use of abatacept (a cytotoxic T-lymphocyte–associated…
The New England Journal of Medicine: Search Results in Hematology\Oncology
4h
Case 18-2019: A 24-Year-Old Woman with a Pelvic Mass
Presentation of Case. Dr. Alexander Melamed: A 24-year-old woman was seen in the emergency department of this hospital because of a pelvic mass. The patient had been well until 4 weeks before this presentation, when she began to notice an increased frequency of vaginal bleeding. At that time, an…
The New England Journal of Medicine: Search Results in Hematology\Oncology
4h
Adjuvant Chemotherapy plus Radiation for Locally Advanced Endometrial Cancer
Women with locally advanced (International Federation of Gynecology and Obstetrics [FIGO] stage III or IVA) endometrial carcinoma are a heterogeneous group of patients who are at risk for both local and systemic disease recurrence. Clinical and pathologic factors affecting the risk of recurrence…
The New England Journal of Medicine: Search Results in Hematology\Oncology
4h
Alemtuzumab for Immune-Related Myocarditis Due to PD-1 Therapy
To the Editor: Myocarditis caused by immune checkpoint inhibitors, such as programmed death 1 (PD-1) therapy, although representing less than 1% of immune-related adverse events, is a potentially fatal condition that was associated with a mortality of 42% in a large series. This condition overlaps…
The New England Journal of Medicine: Search Results in Hematology\Oncology
4h
Cytoplasmic Blebs in T-Cell Prolymphocytic Leukemia
Figure 1.
The New England Journal of Medicine: Search Results in Hematology\Oncology
4h
Venetoclax and Obinutuzumab in Patients with CLL and Coexisting Conditions
Most patients with chronic lymphocytic leukemia (CLL) are older than 70 years of age and have clinically relevant coexisting conditions. Such patients require more effective but less toxic regimens. The CLL11 trial established chlorambucil–obinutuzumab as a standard of care in these patients. BCL2…
The New England Journal of Medicine: Search Results in Hematology\Oncology
4h
Clinical and Therapeutic Implications of Cancer Stem Cells
Almost all cancers arise in organs and tissues containing cells that have the ability, for the lifetime of the organism, to replicate in order to maintain and replace cells that are lost because of aging or damage. For example, the entire lining of the gut is replaced approximately every 7 days,…
The New England Journal of Medicine: Search Results in Hematology\Oncology
4h
Overall Survival with Ribociclib plus Endocrine Therapy in Breast Cancer
Although breast cancer is known to be more aggressive and to be associated with a poorer prognosis in younger women than in older women, the recommended treatment for hormone receptor–positive, human epidermal growth factor receptor 2 (HER2)–negative advanced breast cancer in premenopausal and…
The New England Journal of Medicine: Search Results in Hematology\Oncology
4h
Five-Year Outcomes with Dabrafenib plus Trametinib in Metastatic Melanoma
Historically, metastatic melanoma has been associated with a poor prognosis, but the introduction of BRAF- and MEK-targeted therapies and immune checkpoint inhibitors has substantially improved outcomes in these patients. Each of these therapies — including drugs that target programmed cell death 1…
The New England Journal of Medicine: Search Results in Hematology\Oncology
4h
Enzalutamide with Standard First-Line Therapy in Metastatic Prostate Cancer
Several randomized trials have established the benefits of adding docetaxel or abiraterone to testosterone suppression in men with metastatic, hormone-sensitive prostate cancer. The survival benefits associated with docetaxel early in the course of treatment, particularly in men with high-volume…
The New England Journal of Medicine: Search Results in Hematology\Oncology
4h
Maintenance Olaparib for Germline BRCA-Mutated Metastatic Pancreatic Cancer
Metastatic pancreatic cancer is particularly refractory to treatment. Current standard-of-care first-line treatments are associated with a median progression-free survival of approximately 6 months, and fewer than 10% of patients are alive 5 years after the initial diagnosis. Loss-of-function…
The New England Journal of Medicine: Search Results in Hematology\Oncology
4h
Apalutamide for Metastatic, Castration-Sensitive Prostate Cancer
The initial treatment for metastatic prostate cancer is androgen-deprivation therapy (ADT) through medical or surgical castration. In the past few years, results from several large, randomized, phase 3 clinical trials have shown longer survival, particularly among patients with high-risk or…
The New England Journal of Medicine: Search Results in Hematology\Oncology
4h
Gemcitabine and Cisplatin Induction Chemotherapy in Nasopharyngeal Carcinoma
Nasopharyngeal carcinoma is a head and neck cancer with a specific geographic distribution. It affected an estimated 130,000 patients worldwide in 2018, with the highest rates occurring in regions in South China, Southeastern Asia, and North Africa. More than 70% of patients receive a diagnosis of…
The New England Journal of Medicine: Search Results in Hematology\Oncology
4h

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