Papillary mucinous metaplasia: a distinct precursor of mucinous adenocarcinoma of the endometrium

xlomafota13 shared this article with you from Inoreader Papillary mucinous metaplasia: a distinct precursor of mucinous adenocarcinoma of the endometrium Via International Journal of Clinical and Experimental Pathology Int J Clin Exp Pathol. 2022 Feb 15;15(2):83-87. eCollection 2022. ABSTRACT Mucinous adenocarcinoma of the endometrium is heterogeneous, consisting of endometrioid adenocarcinoma composed of >50% mucinous cells, low-grade mucinous adenocarcinoma, microglandular adenocarcinoma, and gastric (gastrointestinal)-type adenocarcinoma. Previous studies have reported that papillary mucinous metaplasia is a possible precancerous lesion of mucinous adenocarcinoma with frequent KRAS mutations. Recently, we encountered a case of pure mucinous adenocarcinoma of the endometrium with concurrent papillary mucinous metaplasia in a 35-year-old woman. She underwent 6-month hormonal therapy for atypical endometrial hyperplasia. A follow-up biopsy led to a diagnosis of mucinous adenocarcinoma; therefore, total hysterectomy was performed. The tumor showed abundant intracytoplasmic mucin and mild-to-moderate cytologic atypia with papillary architectu re. KRAS mutation analysis revealed a point mutation from GGT to GTT in codon 12. Although papillary mucinous metaplasia showed an overexpression of p16INK4, especially in the intragrandular papillary tufts, and a low MKi67 labeling index, overt mucinous adenocarcinoma with a loss of P16INK4a expression showed a high proliferating index of MKI67. The mass presented with stage ІA disease. During follow-up, the patient was stable and showed no recurrence. Considering the histologic similarity and incidence of KRAS mutations between papillary mucinous metaplasia and mucinous adenocarcinoma, papillary mucinous metaplasia may be a precancerous lesion for a subset of mucinous adenocarcinoma of the endometrium. PMID:35265257 | PMC:PMC8902477 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Hearing preservation in cochlear implant recipients: A cross‐sectional cohort study

xlomafota13 shared this article with you from Inoreader Hearing preservation in cochlear implant recipients: A cross‐sectional cohort study Via Clinical Otolaryngology Abstract Objectives A surge of new developments and research regarding cochlear implants and hearing preservation resulted in several treatment options in the last 5 years. By reviewing our CI population of this period, we aimed to investigate hearing preservation rates and the effect of different treatment options on hearing preservation. Design Retrospectively, all adult cochlear implant recipients with preoperative residual hearing at lower frequencies (threshold <80 dB hearing level) in a single tertiary referral centre between 2015 and 2020 were analysed. Patients were classified into four groups based on their hearing preservation outcome. Subsequently, differences between the four groups regarding several patient dependent and independent factors were investigated. Results In this study, 140 patients were included, which is 46% of all adult CI recipients. Complete hearing preservation was achieved in 14 patients (10%), and complete loss of residual hearing in 48 patients (34%). The lateral wall array and local application of corticosteroids were associated with better hearing preservation. Intravenous corticosteroids, local hyaluronic acid and surgical experience had no effect on hearing preservation rates. Speech perception was not better in patients with residual hearing. Conclusion Approximately half of all adult cochlear implant recipients had residual hearing at lower frequencies before surgery. In current medical practice, only electrode choice seems to have a clear effect on hearing preservation rates. The majority of CI recipients lose their residual hearing after cochlear implantation. Much improvement in treating CI recipients is needed to preserve their residual hearing in the future. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Bilateral vertebral arteries arising distal to the left subclavian artery: embryological and anatomical description

xlomafota13 shared this article with you from Inoreader Bilateral vertebral arteries arising distal to the left subclavian artery: embryological and anatomical description Via radiol anat Surg Radiol Anat. 2022 Mar 9. doi: 10.1007/s00276-022-02903-0. Online ahead of print. ABSTRACT Abnormalities in the origin of vertebral arteries are relatively uncommon, but extremely rare when this abnormality happens on both sides. We present an anatomic variation in which both vertebral arteries came from the proximal descending thoracic aorta beyond the left subclavian artery with no other supra-aortic vessels accompanying the abnormality. The right vertebral artery took a retro-oesophageal course (lusoria artery), while the right and the left vertebral arteries enter the transverse foramina at the 7th cervical vertebra. From an embryological point of view, and overall controversial, this anomaly can be explained by the bilateral persistence of the 8th intersegmental artery as the origin of vertebral artery, instead of the dorsal segment of the 7th intersegmental artery being the origin, which is normally the case. The adequate identification of vertebral artery anomalies in complementary explorations is very important to avoid misdiagnosed vertebral occlusions or unexpected vertebral artery injuries during supra-aortic trunks, thyroid, and oesophagus open surgeries, among others, or even over the course of endovascular procedures. PMID:35266028 | DOI:10.1007/s00276-022-02903-0 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Quality Indicators for the Diagnosis and Management of Primary Hyperparathyroidism

xlomafota13 shared this article with you from Inoreader Quality Indicators for the Diagnosis and Management of Primary Hyperparathyroidism Via JAMA Otolaryngology–Head & Neck Surgery Current Issue This quality improvement study develops quality indicator s to evaluate the diagnosis and treatment of primary hyperparathyroidism that could measure, improve, and optimize quality of care and outcomes for patients with this disease. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Use of FDG-PET/CT to Predict Immunotherapy Treatment Response in Patients With OCSCC

xlomafota13 shared this article with you from Inoreader Use of FDG-PET/CT to Predict Immunotherapy Treatment Response in Patients With OCSCC Via JAMA Otolaryngology–Head & Neck Surgery Current Issue This study assesses whether there are changes on fluoro-[ 18F]-deoxy-2-D-glucose positron emission tomography/computed tomography scans in patients with oral cavity squamous cell cancer receiving neoadjuvant immunotherapy. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Development and Validation of a Novel At-home Smell Assessment

xlomafota13 shared this article with you from Inoreader Development and Validation of a Novel At-home Smell Assessment Via JAMA Otolaryngology–Head & Neck Surgery Current Issue This diagnostic study develops and validates a simple scr eening assessment for olfactory dysfunction using common household items. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Is a 4-Day Low-Iodine Diet Sufficient for Radioactive Iodine Ablation in Differentiated Thyroid Cancer Treatment?

xlomafota13 shared this article with you from Inoreader Is a 4-Day Low-Iodine Diet Sufficient for Radioactive Iodine Ablation in Differentiated Thyroid Cancer Treatment? Via Clinical Thyroidology Clinical Thyroidology, Volume 34, Issue 3, Page 123-126, March 2022. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

18F–FDG–PET/CT May Reduce Unnecessary Thyroid Surgery in Cytologically Indeterminate Thyroid Nodules

xlomafota13 shared this article with you from Inoreader 18F–FDG–PET/CT May Reduce Unnecessary Thyroid Surgery in Cytologically Indeterminate Thyroid Nodules Via Clinical Thyroidology Clinical Thyroidology, Volume 34, Issue 3, Page 116-118, March 2022. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The Role of a Computer-Aided Diagnosis System in the Interpretation of Thyroid Nodules with Challenging Sonographic Features

xlomafota13 shared this article with you from Inoreader The Role of a Computer-Aided Diagnosis System in the Interpretation of Thyroid Nodules with Challenging Sonographic Features Via Clinical Thyroidology Clinical Thyroidology, Volume 34, Issue 3, Page 112-115, March 2022. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Prevalence of “Higher-Risk” Adverse Histological Features Found at Autopsy in Patients with Occult Differentiated Thyroid Cancer

xlomafota13 shared this article with you from Inoreader Prevalence of "Higher-Risk" Adverse Histological Features Found at Autopsy in Patients with Occult Differentiated Thyroid Cancer Via Clinical Thyroidology Clinical Thyroidology, Volume 34, Issue 3, Page 127-131, March 2022. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Pharyngolaryngeal Morbidity With the Laryngeal Mask Airway SupremeTM at Different Fiberoptic Bronchoscopy Grades: An Observational Study

xlomafota13 shared this article with you from Inoreader Pharyngolaryngeal Morbidity With the Laryngeal Mask Airway SupremeTM at Different Fiberoptic Bronchoscopy Grades: An Observational Study Via Journal of Voice To assess whether the different fiberoptic bronchoscopy (FOB) grades of laryngeal mask airway (LMA) Supreme™ affects pharyngolaryngeal morbidity (PLM, including sore throat, dysphonia, pharyngoxerosis, and dysphagia) after general anesthesia. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Surgical Outcomes Following Vestibular Schwannoma Resection in Patients over the Age of Sixty-five

xlomafota13 shared this article with you from Inoreader Surgical Outcomes Following Vestibular Schwannoma Resection in Patients over the Age of Sixty-five Via Journal of Neurological Surgery Part B: Skull Base J Neurol Surg B Skull Base DOI: 10.1055/a-1771-0504 Objective Vestibular schwannoma (VS) are benign, often slow growing neoplasms. Some institutions opt for radiosurgery in symptomatic patients of advanced age versus surgical resection. The aim of the study is to analyze surgical outcomes of VS in patients over the age of 65 who were either not candidates for or refused radiosurgery. Methods This includes retrospective analysis of VS patients between 1988 and 2020. Demographics, tumor characteristics, surgical records, and clinical outcomes were recorded. Patient preference for surgery over radiosurgery was recorded in the event that patients were offered both. Facial nerve outcomes were quantified using House-Brackmann (HB) scores. Tumor growth was defined by increase in size of >2 mm. Results In total, 64 patients were included of average age 72.4 years (65–84 years). Average maximum tumor diameter was 29 mm (13–55 mm). Forty-five patients were offered surgery or GKRS, and chose surgery commonly due to radiation aversion (48.4%). Gross total resection was achieved in 39.1% (n = 25), near total 32.8% (n = 21), and subtotal 28.1% (n = 18). Average hospitalization was 5 days [2–17] with 75% (n = 48) discharged home. Postoperative HB scores were good (HB1–2) in 43.8%, moderate (HB3–4) in 32.8%, and poor (HB5–6) in 23.4%. HB scores improved to good in 51.6%, moderate in 31.3%, and remained poor in 17.1%, marking a rate of facial nerve improvement of 10.9%. Tumor control was achieved in 95.3% of cases at an average follow-up time of 37.8 months. Conclusion VS resection can be safely performed in patients over the age of 65. Advanced age should not preclude a symptomatic VS patient from being considered for surgical resection. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.