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Αλέξανδρος Γ. Σφακιανάκης

Tuesday, September 22, 2020

Medicine by Alexandros G. Sfakianakis

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  Plastic and Reconstructive Surgery - Published Ahead-of-PrintSystematic Surgical Approach to Alar Base Surgery in RhinoplastyIn an era with smartphone photography and social media (specifically "selfies"), basal view aesthetics is becoming increasingly important. Achieving balance between the nasal base and the remainder of the nose and face while preserving or restoring external valve function are essential to a successful rhinoplasty. Without a systematic approach to the nasal base, it is more...
Medicine by Sfakianakis G. Alexandros
09:59
subthalamic nucleus (STN) stimulation in patients with Parkinson's disease
Subthalamic nucleus deep brain stimulation modulates two distinct neurocircuits.: Related ArticlesSubthalamic nucleus deep brain stimulation modulates two distinct neurocircuits.Ann Neurol. 2020 Sep 20;:Authors: Shen L, Jiang C, Hubbard CS, Ren J, He C, Wang D, Dahmani L, Guo Y, Liu Y, Xu S, Meng F, Zhang J, Liu H, Li LAbstract OBJECTIVE: Current understanding of the neuromodulatory effects of deep brain stimulation (DBS) on large-scale brain networks remains elusive, largely due to the...
Medicine by Sfakianakis G. Alexandros
09:59
The role of melatonin and its analogues in epilepsy.
The role of melatonin and its analogues in epilepsy.: Related ArticlesThe role of melatonin and its analogues in epilepsy.Rev Neurosci. 2020 Sep 21;:Authors: Khan S, Khurana M, Vyas P, Vohora DAbstract Extensive research has gone into proposing a promising link between melatonin administration and attenuation of epileptic activity, the majority of which suggest its propensity as an antiseizure with antioxidant and neuroprotective properties. In the past few years, a number of studies highlighting...
Medicine by Sfakianakis G. Alexandros
09:59
Physical exercise and 5-hydroxytryptophan, a precursor for serotonin synthesis, reduce penicillin-induced epileptiform activity.
Physical exercise and 5-hydroxytryptophan, a precursor for serotonin synthesis, reduce penicillin-induced epileptiform activity.: Physical exercise and 5-hydroxytryptophan, a precursor for serotonin synthesis, reduce penicillin-induced epileptiform activity.Epilepsy Behav. 2020 Sep 17;112:107403Authors: Kayacan Y, Ghojebeigloo BE, Çerit G, Kocacan SE, Ayyıldız MAbstract AIM: Previous studies have shown that 5- hydroxytryptophan (5-HTP) and exercise play an important role in the synthesis...
Medicine by Sfakianakis G. Alexandros
09:59
Preoperative Magnetic Resonance Image Quality in Motion Disorder Patients Scheduled for Deep Brain Stimulation Surgery
Preoperative Magnetic Resonance Image Quality in Motion Disorder Patients Scheduled for Deep Brain Stimulation Surgery: Background: To obtain magnetic resonance (MR) images of good quality for accurate target localization in deep brain stimulation (DBS) surgery, sedation or anesthesia may be used, although their usefulness has not been proven. Objective: To assess whether sedation or general anesthesia (GA) improve the quality of MR imaging (MRI). Methods: The records of DBS procedures for Parkinson's...
Medicine by Sfakianakis G. Alexandros
09:59
Trastuzumab plus lapatinib was significantly more toxic among older patients and had worse treatment completion. Trastuzumab was generally well tolerated.
Tolerability and toxicity of trastuzumab or trastuzumab + lapatinib in older patients: a sub-analysis of the ALTTO trial (BIG 2-06; NCCTG (Alliance) N063D).: Related ArticlesTolerability and toxicity of trastuzumab or trastuzumab + lapatinib in older patients: a sub-analysis of the ALTTO trial (BIG 2-06; NCCTG (Alliance) N063D).Breast Cancer Res Treat. 2020 Sep 19;:Authors: Pondé N, Agbor-Tarh D, Dal Lago L, Korde LA, Hilbers F, Jackisch C, Werner O, Gelber RD, Jatoi A, Dueck AC, Moreno-Aspitia...
Medicine by Sfakianakis G. Alexandros
09:59
Transpedicular Approach for Ventral Epidural Abscess Evacuation in the Cervical Spine - A Technical Note.
Transpedicular Approach for Ventral Epidural Abscess Evacuation in the Cervical Spine - A Technical Note.: Transpedicular Approach for Ventral Epidural Abscess Evacuation in the Cervical Spine - A Technical Note.World Neurosurg. 2020 Sep 17;:Authors: Lara-Reyna J, Yaeger KA, Margetis KAbstract OBJECTIVE: Spinal epidural abscess is a pathology that may require prompt surgical intervention. Ventral cervical abscesses pose a particular challenge regarding the approach for surgical evacuation....
Medicine by Sfakianakis G. Alexandros
09:59
The Relevance of SNPs at 3'UTR Region of CASP7 and miR-371b-5p Associated Diseases
The Relevance of SNPs at 3'UTR Region of CASP7 and miR-371b-5p Associated Diseases: A Computational Analysis.: The Relevance of SNPs at 3'UTR Region of CASP7 and miR-371b-5p Associated Diseases: A Computational Analysis.Cell Biochem Biophys. 2020 Sep 19;:Authors: Safdar M, Zaheer S, Khailany RA, Parvez S, Naveed M, Bhuiyan P, Ozaslan M, Moatasam R, Al-Attar MS, Khan MA, Junejo YAbstract The process of genetically programmed cell death, or apoptosis, plays a crucialrolein cellular homeostasis...
Medicine by Sfakianakis G. Alexandros
09:59
environmental pollutants and ovarian reserve..........................................Elevated levels of nitrous dioxide are associated with lower anti-Mullerian hormone (AMH)
Elevated levels of nitrous dioxide are associated with lower AMH levels: a real-world analysis.: Elevated levels of nitrous dioxide are associated with lower AMH levels: a real-world analysis.Hum Reprod. 2020 Sep 20;:Authors: La Marca A, Spaggiari G, Domenici D, Grassi R, Casonati A, Baraldi E, Trenti T, Simoni M, Santi DAbstract STUDY QUESTION: Are there any associations between environmental pollutants and ovarian reserve, expressed by anti-Mullerian hormone (AMH) serum levels? ...
Medicine by Sfakianakis G. Alexandros
09:59
KRASG12C Inhibition with Sotorasib in Advanced Solid Tumors
KRASG12C Inhibition with Sotorasib in Advanced Solid Tumors: New England Journal of Medicine, Ahead of Print. AbstractBACKGROUNDNo therapies for targeting KRAS mutations in cancer have been approved. The KRAS p.G12C mutation occurs in 13% of non–small-cell lung cancers (NSCLCs) and in 1 to 3% of colorectal cancers and other cancers. Sotorasib is a small molecule that selectively and irreversibly targets KRASG12C.METHODSWe conducted a phase 1 trial of sotorasib in patients with advanced solid tumors...
Medicine by Sfakianakis G. Alexandros
09:59
Tetrandrine enhances antitumor effects of the histone deacetylase inhibitor MS-275 in human cancer in a Bax- and p53-dependent manner.
Tetrandrine enhances antitumor effects of the histone deacetylase inhibitor MS-275 in human cancer in a Bax- and p53-dependent manner.: Tetrandrine enhances antitumor effects of the histone deacetylase inhibitor MS-275 in human cancer in a Bax- and p53-dependent manner.Eur J Pharmacol. 2020 Sep 17;:173575Authors: Li H, Xu X, Zhang Y, Tang X, Li WAbstract MS-275 (Entinostat), is an oral histone deacetylase (HDAC) inhibitor with a high specificity for class 1 HDACs. As single agent, MS-275...
Medicine by Sfakianakis G. Alexandros
09:59
KRAS Is Indeed Druggable
One Step at a Time — Clinical Evidence that KRAS Is Indeed Druggable: New England Journal of Medicine, Ahead of Print. Overall survival among patients with advanced-stage KRASG12C non–small-cell lung cancer (NSCLC) or colorectal cancer is approximately 1 to 2 years; this startling statistic has fueled nearly four decades of research dedicated to the search for a KRAS-targeted drug.1,2 Because RAS has picomolar affinity for guanosine triphosphate (GTP) and intracellular GTP concentrations are exceedingly...
Medicine by Sfakianakis G. Alexandros
09:59
Survival with Olaparib in Metastatic Castration-Resistant Prostate Cancer
Survival with Olaparib in Metastatic Castration-Resistant Prostate Cancer: New England Journal of Medicine, Ahead of Print. NEJM GroupFollow UsSign InCreate AccountSUBSCRIBEDevice Global HeaderSUBSCRIBEOR RENEWFree full text is available with an account for a limited time. Create a free account now. Already have an account? Sign in .ORIGINAL ARTICLEFREE PREVIEWSurvival with Olaparib in Metastatic Castration-Resistant Prostate CancerList of authors.Maha Hussain, M.D., Joaquin Mateo, M.D., Karim Fizazi,...
Medicine by Sfakianakis G. Alexandros
09:59
Phase 1 dose escalation trial of volasertib in combination with decitabine in patients with acute myeloid leukemia.
Phase 1 dose escalation trial of volasertib in combination with decitabine in patients with acute myeloid leukemia.: Phase 1 dose escalation trial of volasertib in combination with decitabine in patients with acute myeloid leukemia.Int J Hematol. 2020 Sep 20;:Authors: Cortes J, Podoltsev N, Kantarjian H, Borthakur G, Zeidan AM, Stahl M, Taube T, Fagan N, Rajeswari S, Uy GLAbstract Polo-like kinase 1 (PLK1) regulates mitotic checkpoints and cell division. PLK1 overexpression is reported...
Medicine by Sfakianakis G. Alexandros
09:59
Atranones from Stachybotrys chartarum and their antitumor activities in MG-63 human osteosarcoma cells.
Atranones from Stachybotrys chartarum and their antitumor activities in MG-63 human osteosarcoma cells.: Stachybotrys chartarum - Wikipediaen.wikipedia.org › wiki › Stachybotrys_chartarumStachybotrys chartarum also known as black mold or toxic black mold, is a variety of microfungus that produces its conidia in slime heads.Atranones from Stachybotrys chartarum and their antitumor activities in MG-63 human osteosarcoma cells.Fitoterapia. 2020 Sep 17;:104727Authors: Qin YD, Fang FM, Zhou JJ, Wang...
Medicine by Sfakianakis G. Alexandros
09:59
Targeting DNA and mutant p53 by a naphthalimide derivative, NA20, exhibits selective inhibition in gastric tumorigenesis by blocking mutant p53-EGFR signaling pathway.
Targeting DNA and mutant p53 by a naphthalimide derivative, NA20, exhibits selective inhibition in gastric tumorigenesis by blocking mutant p53-EGFR signaling pathway.: Related ArticlesTargeting DNA and mutant p53 by a naphthalimide derivative, NA20, exhibits selective inhibition in gastric tumorigenesis by blocking mutant p53-EGFR signaling pathway.Eur J Pharmacol. 2020 Sep 17;:173584Authors: Zhang G, Li L, Bi J, Wu Y, Li EAbstract Mutations of p53 in cancer cells not only subvert its...
Medicine by Sfakianakis G. Alexandros
09:59
Deoxyelephantopin, a novel naturally occurring phytochemical impairs growth, induces G2/M arrest, ROS-mediated apoptosis and modulates lncRNA expression against uterine leiomyoma
Deoxyelephantopin, a novel naturally occurring phytochemical impairs growth, induces G2/M arrest, ROS-mediated apoptosis and modulates lncRNA expression against uterine leiomyoma: Publication date: November 2020Source: Biomedicine & Pharmacotherapy, Volume 131Author(s): Vivek Pandey, Anima Tripathi, Anjali Rani, Pawan K. Dubey
Medicine by Sfakianakis G. Alexandros
09:59
Elucidation of the aberrant 3′ splice site selection by cancer-associated mutations on the U2AF1
Elucidation of the aberrant 3′ splice site selection by cancer-associated mutations on the U2AF1:
Medicine by Sfakianakis G. Alexandros
09:59
The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution
The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution:
Medicine by Sfakianakis G. Alexandros
09:59
Management of unilateral temporomandibular joint ankylosis & orthomorphic correction in a patient with Marfan syndrome: A rare case report.
Management of unilateral temporomandibular joint ankylosis & orthomorphic correction in a patient with Marfan syndrome: A rare case report.: Management of unilateral temporomandibular joint ankylosis & orthomorphic correction in a patient with Marfan syndrome: A rare case report.Int J Surg Case Rep. 2020 Sep 11;75:157-161Authors: Rudagi BM, Rishabh J, Arif M, Namrata C, Shahbaaz N, Gaurav BAbstract INTRODUCTION: Marfan syndrome (MFS) is a disorder of the connective tissue that is...
Medicine by Sfakianakis G. Alexandros
09:59
Indwelling Interscalene Nerve Catheters for Shoulder Arthroplasty.
Pulmonary Comorbidities Are Associated with Increased Major Complication Rates Following Indwelling Interscalene Nerve Catheters for Shoulder Arthroplasty.: Pulmonary Comorbidities Are Associated with Increased Major Complication Rates Following Indwelling Interscalene Nerve Catheters for Shoulder Arthroplasty.Orthop Clin North Am. 2020 Oct;51(4):527-532Authors: Power I, Throckmorton TW, Smith RA, Azar FM, Brolin TJAbstract Pulmonary comorbidities and ASA physical status class III and IV...
Medicine by Sfakianakis G. Alexandros
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APRIL promotes humoral immunity in humans................A proliferation-inducing ligand (APRIL), also known as tumor necrosis factor ligand superfamily member 13 (TNFSF13), is a protein of the TNF superfamily recognized by the cell surface receptor TACI.
It's that time of year - APRIL promotes humoral immunity in humans: Publication date: Available online 21 September 2020Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Stuart G. TangyeThe protein encoded by this gene is a member of the tumor necrosis factor ligand (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vivo experiments suggest an important...
Medicine by Sfakianakis G. Alexandros
09:59
plasm soluble Tim-3 (sTim-3)...................Elevated plasma sTIM-3 levels in severe Covid-19 patients.................Immune dysfunction is the main characteristic of sepsis. T cell Ig and mucin domain protein 3 (Tim-3) on the monocytes has been reported to promote immune homeostasis during sepsis
Elevated plasma sTIM-3 levels in severe Covid-19 patients: Publication date: Available online 21 September 2020Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Thor Ueland, Lars Heggelund, Andreas Lind, Aleksander R. Holten, Kristian Tonby, Annika E. Michelsen, Synne Jenum, Marthe J. Jørgensen, Andreas Barratt-Due, Linda G. Skeie, Ingvild Nordøy, Mai Sasaki Aanensen Fraz, Else Quist-Paulsen E, Søren E. Pischke, Simreen K. Johal, Liv Hesstvedt, Mette Bogen, Børre Fevang, Bente Halvorsen,...
Medicine by Sfakianakis G. Alexandros
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Metastatic prostate adenocarcinoma to cervical lymph nodes
Metastatic prostate adenocarcinoma to cervical lymph nodes: an unusual diagnosis on fine-needle aspiration biopsy.: Metastatic prostate adenocarcinoma to cervical lymph nodes: an unusual diagnosis on fine-needle aspiration biopsy.J Am Soc Cytopathol. 2020 Aug 25;:Authors: Albadri ST, Salomão DAbstract INTRODUCTION: Metastatic prostatic adenocarcinoma (PAC) has mostly involved the pelvic lymph nodes; metastases to the cervical lymph nodes are exceedingly rare. MATERIALS AND METHODS:...
Medicine by Sfakianakis G. Alexandros
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schizophrenia may be a neurodevelopmental and neurodegenerative disorder.............................Fluoxetine attenuates prepulse inhibition deficit
Fluoxetine attenuates prepulse inhibition deficit induced by neonatal administration of MK-801 in mice: Increasing evidence supports schizophrenia may be a neurodevelopmental and neurodegenerative disorder. Fluoxetine, a selective serotonin reuptake inhibitor, has been reported to have neuroprotective effects and be effective in treating neurodegenerative disorders including schizophrenia. The objective of the present study was to evaluate the effect and underlying neuroprotective mechanism of fluoxetine...
Medicine by Sfakianakis G. Alexandros
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
Telephone consultation 11855 int 1193,