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Αλέξανδρος Γ. Σφακιανάκης

Wednesday, February 17, 2021

Laryngeal adenoid cystic carcinoma: Radical or conservative surgery?

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Publication date: Available online 16 February 2021

Source: American Journal of Otolaryngology

Author(s): Marco Lionello, Fabio Canal, Francesca Presotto, Raffaella Palumbo, Giuseppe Rizzotto, Andy Bertolin

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Controlled hypotension may be a potential risk to patients with rhinoplasty

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Publication date: Available online 16 February 2021

Source: American Journal of Otolaryngology

Author(s): Zhijun Lu

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Changes of taste perception after stapes surgery: a prospective cohort study.

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Changes of taste perception after stapes surgery: a prospective cohort study.

Eur Arch Otorhinolaryngol. 2021 Feb 15;:

Authors: Skoloudik L, Krtickova J, Haviger J, Mejzlik J, Chrobok V

Abstract
PURPOSE: Taste perception is often affected after stapes surgery despite effort to preserve chorda tympani nerve. The aim was to examine changes of particular taste qualities and their recovery after operation of otosclerosis.
MATERIALS AND METHODS: Taste function was prospectively investigated with a questionnaire and a taste strip test (TST) preoperatively, 3-5 days and 1 year after stapes surgery with the preservation of CTN.
RESULTS: In the early postoperative examination, 34/42 patients had a lower TST score, 7/42 decrease of taste in the questionnaire. One year after surgery, 11/42 patients had a lower TST score, 1/42 patients decrease of taste in the questionnaire. The most pronounced decrease in the TST score was in sweet (- 1.76 points, p < 0.001), followed by bitter (- 1.71 points, p < 0.001), salty (- 1.64 points, p < 0.001) and sour taste (- 1.33 points, p < 0.001). The sour taste had a significant lower alteration compared to others. Men had significantly pronounced alteration in salty taste compared to women. The complete recovery was proved in bitter taste. Better recovery in bitter taste was observed in patients younger than 45 years of age.
CONCLUSIONS: Gustatory changes after stapes surgery are mostly transient with different impairment and recovery rate for particular taste qualities. A sour taste seems to be relatively resistant to damage. The best recovery rate is in a bitter taste, especially in younger patients.

PMID: 33590337 [PubMed - as supplied by publisher]

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Post-operative healing and long-term stability after mastoid cavity reconstruction using the middle temporal artery and inferior musculoperiosteal flaps.

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Post-operative healing and long-term stability after mastoid cavity reconstruction using the middle temporal artery and inferior musculoperiosteal flaps.

Eur Arch Otorhinolaryngol. 2021 Feb 15;:

Authors: Tan AD, Ng JH, Low DY, Yuen HW

Abstract
PURPOSE: This study aims to evaluate the surgical outcomes with the use of a combination of the middle temporal artery (MTA) flap and the inferior musculoperiosteal (IMP) flap for mastoid obliteration after canal wall down mastoidectomy.
METHODS: Seventy-five patients who have undergone canal wall down mastoidectomy and mastoid obliteration with the MTA and the IMP flaps at a single tertiary hospital were included. Surgical outcomes measured included the creation of a dry mastoid cavity as measured by a previously developed semi-quantitative scale, mastoid cavity epithelization time, rate of revision surgery needed, and rate of recurrent cholesteatoma.
RESULTS: Patients were followed up for a median of 29 months. The median time to epithelization of the mastoid cavity was 2 months. At 1 and 3 months, 36.0% and 76.0% of patients had grade 0 and grade 1 cavities, respectively, with either a dry cavity or one or less episodes of mild otorrhea or sensation of wetness. Hundred percent of the patients achieved a grade 2 (more than one episode of otorrhea or the presence of granulation tissue that promptly resolved with simple treatment) or better cavity at 3 months. One patient re-presented with a grade 3 cavity with uncontrolled infection and daily otorrhea secondary to an attic perforation that manifested at 6 months, requiring revision surgery. There were no recurrent cholesteatomas during the follow-up period.
CONCLUSIONS: The use of the MTA and the IMP flaps for mastoid obliteration may be considered as an adjunct to achieving a safe, dry ear after canal wall down mastoidectomy.

PMID: 33590338 [PubMed - as supplied by publisher]

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four injections every 2-4 days or three injections at 1-week intervals : Comparison of two different intratympanic corticosteroid injection protocols as salvage treatments for idiopathic sudden sensorineural hearing loss.

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Comparison of two different intratympanic corticosteroid injection protocols as salvage treatments for idiopathic sudden sensorineural hearing loss.

Eur Arch Otorhinolaryngol. 2021 Feb 16;:

Authors: Andrianakis A, Moser U, Kiss P, Holzmeister C, Andrianakis D, Tomazic PV, Wolf A, Graupp M

Abstract
PURPOSE: We aimed to investigate the effect of interval length and total count of intratympanic steroid (ITS) injections in salvage treatment of patients with idiopathic sudden sensorineural hearing loss (ISSNHL).
METHODS: This retrospective case-control study included 64 patients with ISSNHL, who were treated with ITS injections as salvage therapy at a tertiary referral centre. From September 2019 to December 2020, 32 patients received up to four injections every 2-4 days (revised-protocol group). These patients were 1:1 matched to patients, who received up to three injections at 1-week intervals between January 2014 and August 2019 (initial-protocol group). Hearing outcomes of the two groups were compared.
RESULTS: Both ITS salvage treatment protocols resulted in a statistically significant hearing improvement (p < 0.05). The initial-protocol declined hearing thresholds by 12 ± 11.7 dB (p < 0.001, d = 1, P = 99%). Mean hearing function was improved by 13.4 ± 19.1 dB in the revised-protocol group [p < 0.001, d = 0.7, P = 98%]. A clinically significant hearing improvement (> 10 dB) was seen in 18 patients (58.1%) in the initial-protocol group and in 14 patients (41.9%) in the revised-protocol group. A comparison of the hearing outcomes between protocol groups revealed no statistically significant differences (p > 0.05).
CONCLUSION: These results indicate that a shorter injection interval does not lead to better hearing outcomes in ITS salvage treatment for ISSNHL. Moreover, fewer ITS injections may reduce costs, physical/mental stress of the patients and lower the risk of persistent tympanic perforations.

PMID: 33591388 [PubMed - as supplied by publisher]

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Comparison of two different intratympanic corticosteroid injection protocols as salvage treatments for idiopathic sudden sensorineural hearing loss.

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Comparison of two different intratympanic corticosteroid injection protocols as salvage treatments for idiopathic sudden sensorineural hearing loss.

Eur Arch Otorhinolaryngol. 2021 Feb 16;:

Authors: Andrianakis A, Moser U, Kiss P, Holzmeister C, Andrianakis D, Tomazic PV, Wolf A, Graupp M

Abstract
PURPOSE: We aimed to investigate the effect of interval length and total count of intratympanic steroid (ITS) injections in salvage treatment of patients with idiopathic sudden sensorineural hearing loss (ISSNHL).
METHODS: This retrospective case-control study included 64 patients with ISSNHL, who were treated with ITS injections as salvage therapy at a tertiary referral centre. From September 2019 to December 2020, 32 patients received up to four injections every 2-4 days (revised-protocol group). These patients were 1:1 matched to patients, who received up to three injections at 1-week intervals between January 2014 and August 2019 (initial-protocol group). Hearing outcomes of the two groups were compared.
RESULTS: Both ITS salvage treatment protocols resulted in a statistically significant hearing improvement (p < 0.05). The initial-protocol declined hearing thresholds by 12 ± 11.7 dB (p < 0.001, d = 1, P = 99%). Mean hearing function was improved by 13.4 ± 19.1 dB in the revised-protocol group [p < 0.001, d = 0.7, P = 98%]. A clinically significant hearing improvement (> 10 dB) was seen in 18 patients (58.1%) in the initial-protocol group and in 14 patients (41.9%) in the revised-protocol group. A comparison of the hearing outcomes between protocol groups revealed no statistically significant differences (p > 0.05).
CONCLUSION: These results indicate that a shorter injection interval does not lead to better hearing outcomes in ITS salvage treatment for ISSNHL. Moreover, fewer ITS injections may reduce costs, physical/mental stress of the patients and lower the risk of persistent tympanic perforations.

PMID: 33591388 [PubMed - as supplied by publisher]

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Disease-specific quality of life and psychological distress after endoscopic tympanoplasty.

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Disease-specific quality of life and psychological distress after endoscopic tympanoplasty.

Eur Arch Otorhinolaryngol. 2021 Feb 16;:

Authors: Lucidi D, Reale M, Fermi M, Bassano E, Bonali M, Fernandez IJ, Presutti L, Alicandri-Ciufelli M

Abstract
PURPOSE: To assess the postoperative quality of life (QoL) of patients operated on for chronic otitis media (COM) and cholesteatoma by endoscopic approach, with respect to disease-specific complaints and psychological distress, using two validated questionnaires: Chronic Ear Survey (CES) and Depression Anxiety Stress Scale-21 (DASS-21).
METHODS: Eighty-five consecutive patients operated on for cholesteatoma and COM by endoscopic tympanoplasty from March 2018 to February 2020 filled in CES and DASS-21, within one month prior to surgery. A second administration of each questionnaire was performed at the yearly postoperative evaluation. A multivariate analysis using a linear regression model was performed to evaluate the role of the different variables associated with the questionnaires' subscales and overall scores.
RESULTS: A significant improvement was achieved in all CES and DASS-21 subscales after endoscopic tympanoplasty. No patient showed a DASS-21 score compatible with a psychological distress both at the pre- and postoperative assessments. At multivariate analysis, the only significant factors associated with postoperative improvement in CES scores were preoperative DASS-21 "depression" score and months of follow-up.
CONCLUSION: Endoscopic tympanoplasty shows significantly improved QoL as assessed by disease-specific and psycho-emotional questionnaires. A subjective favourable effect of fully endoscopic ear surgery was demonstrated.

PMID: 33591389 [PubMed - as supplied by publisher]

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Auditory and Visual System White Matter Is Differentially Impacted by Normative Aging in Macaques.

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Auditory and Visual System White Matter Is Differentially Impacted by Normative Aging in Macaques.

J Neurosci. 2020 11 11;40(46):8913-8923

Authors: Gray DT, De La Peña NM, Umapathy L, Burke SN, Engle JR, Trouard TP, Barnes CA

Abstract
Deficits in auditory and visual processing are commonly encountered by older individuals. In addition to the relatively well described age-associated pathologies that reduce sensory processing at the level of the cochlea and eye, multiple changes occur along the ascending auditory and visual pathways that further reduce sensory function in each domain. One fundamental question that remains to be directly addressed is whether the structure and function of the central auditory and visual systems follow similar trajectories across the lifespan or sustain the impacts of brain aging independently. The present study used diffusion magnetic resonance imaging and electrophysiological assessments of auditory and visual system function in adult and aged macaques to better understand how age-related changes in white matter connectivity at multiple levels of each sensory system might impact auditory and visual function. In particular, the fractional anisotropy (FA) of auditory and visual system thalamocortical and interhemispheric corticocortical connections was estimated using probabilistic tractography analyses. Sensory processing and sensory system FA were both reduced in older animals compared with younger adults. Corticocortical FA was significantly reduced only in white matter of the auditory system of aged monkeys, while thalamocortical FA was lower only in visual system white matter of the same animals. Importantly, these structural alterations were significantly associated with sensory function within each domain. Together, these results indicate that age-associated deficits in auditory and visual processing emerge in part from microstructural alterations to specific sensory white matter tracts, and not from general differences in white matter condition across the aging brain.SIGNIFICANCE STATEMENT Age-associated deficits in sensory processing arise from structural and functional alterations to both peripheral sensory organs and central brain regions. It r emains unclear whether different sensory systems undergo similar or distinct trajectories in function across the lifespan. To provide novel insights into this question, this study combines electrophysiological assessments of auditory and visual function with diffusion MRI in aged macaques. The results suggest that age-related sensory processing deficits in part result from factors that impact the condition of specific white matter tracts, and not from general decreases in connectivity between sensory brain regions. Such anatomic specificity argues for a framework aimed at understanding vulnerabilities with relatively local influence and brain region specificity.

PMID: 33051354 [PubMed - indexed for MEDLINE]

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Salivary Gland Choristoma of the Middle Ear in a Child

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Salivary Gland Choristoma of the Middle Ear in a Child: A Case Report.

Ear Nose Throat J. 2021 Feb 16;:145561321995024

Authors: Jančíková J, Šikolová S, Machač J, Ježová M, Pavlovská D, Urík M

Abstract
Salivary gland choristoma is an extremely rare middle ear pathology. We present the case of a 10-year-old girl with unilateral conductive hearing loss. Tympanotomy showed a nonspecific middle ear mass, absence of stapes, anomaly of incus, and displaced facial nerve. It was not possible to remove the mass completely. Histology confirmed salivary gland choristoma. The hearing in this case can be improved with a bone-anchored hearing aid.

PMID: 33591818 [PubMed - as supplied by publisher]

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A Standardized Procedure for Upper Mediastinal Lymph Node Dissection Improves the Safety and Efficacy of Robotic McKeown Esophagectomy

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ABSTRACT

Background

Recurrent laryngeal nerve (RLN) palsy is a common complication of upper mediastinal lymph node dissection (UMLND) in the context of esophageal cancer surgery. In an effort to reduce its occurrence, we developed a standardized surgical procedure that allows flexible suspension of the left RLN during robotic McKeown esophagectomy.

Patients and methods

Patients who received robotic McKeown esophagectomy for cancer were divided into two groups (pre‐ versus post‐standardization). Perioperative outcomes were retrospectively compared.

Results

The pre‐ and post‐standardization groups consisted of 44 and 42 patients, respectively. There were no significant intergroup differences in terms of number of dissected lymph nodes. Compared with the pre‐standardization group, patients treated after standardization had a markedly lowered incidence of left RLN palsy (20.5% versus 4.8%, respectively, p=0.029) and a reduced mean thoracic operating time (161.05 versus 131 min, respectively, p<0.001).

Conclusion

Our standardized surgical approach is efficient and may increase the safety of UMLND.

This article is protected by copyright. All rights reserved.

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Frameless stereotactic brain biopsy: a prospective study on robot‐assisted brain biopsies performed on 32 patients by using the RONNA G4 system

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Abstract

Background

We present a novel robotic neuronavigation system, RONNA G4, used for precise preoperative planning and frameless neuronavigation, developed by a research group from the University of Zagreb and neurosurgeons from the University Hospital Dubrava, Zagreb, Croatia. The aim of study is to provide comprehensive error measurement analysis of the system used for brain biopsy.

Methods

Frameless stereotactic robot‐assisted biopsies were performed on thirty‐two consecutive patients. Post‐operative CT and MRI scans were assessed to precisely measure and calculate target point error (TPE) and entry point error (EPE).

Results

The application accuracy of the RONNA system for TPE was 1.95 ± 1.11 mm, while for EPE was 1.42 ± 0.74 mm. The total diagnostic yield was 96.87%. Linear regression showed statistical significance between the TPE and EPE and the angle of the trajectory on the bone.

Conclusion

The RONNA G4 robotic system is a precise and highly accurate autonomous neurosurgical assistant for performing frameless brain biopsies.

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