The premise of precision cancer medicine is elegantly simple. The basic concept involves the analysis — molecular and otherwise — of a tumor to identify key attributes that allow for the selection of therapeutic agents with a high likelihood of killing that particular tumor, while minimizing side…
In July 2018, the Journal published the results of TAILORx (Trial Assigning Individualized Options for Treatment). This randomized trial conducted by Sparano et al. showed the noninferiority of endocrine therapy to chemoendocrine therapy with respect to invasive disease–free survival among women…
Clinicopathological features, including tumor size, histologic grade, and the presence of axillary lymph-node metastases, provide prognostic information about disease recurrence in women who have localized breast cancer after surgery, but these features have not been shown to be predictive of…
Almost all cancers arise in organs and tissues containing cells that have the ability, for the lifetime of the organism, to replicate in order to maintain and replace cells that are lost because of aging or damage. For example, the entire lining of the gut is replaced approximately every 7 days,…
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