Medicines, Vol. 7, Pages 64: Quantification of the Ability of Natural Products to Prevent Herpes Virus Infection: Medicines, Vol. 7, Pages 64: Quantification of the Ability of Natural Products to Prevent Herpes Virus InfectionMedicines doi: 10.3390/medicines7100064Authors: Kunihiko Fukuchi Hiroshi Sakagami Yoshiaki Sugita Koichi Takao Daisuke Asai Shigemi Terakubo Hiromu Takemura Hirokazu Ohno Misaki Horiuchi Madoka Suguro Tomohiro Fujisawa Kazuki Toeda Hiroshi Oizumi ...
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CancerA first-in-human phase 1 and pharmacological study of TAS-119, a novel selective Aurora A kinase inhibitor in patients with advanced solid tumoursBritish Journal of Cancer, Published online: 06 October 2020; doi:10.1038/s41416-020-01100-3A first-in-human phase 1 and pharmacological study of TAS-119, a novel selective Aurora A kinase inhibitor in patients with advanced solid tumoursCancer03:00Searching for causal relationships of glioma: a phenome-wide Mendelian randomisation studyBritish...
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Clinical Oral Implants ResearchInfluence of ridge preservation on marginal bone loss in single unit implant restorationsClinical Oral Implants ResearchMon Oct 05, 2020 11:17Vertical ridge augmentation (VRA) with Ti‐reinforced d‐PTFE membranes or Ti‐meshes and collagen membranes. 1‐year results of a randomized clinical trialABSTRACT Objectives The aim of this study was to evaluate hard and soft tissues around implants placed in posterior mandible 1 year after vertical ridge augmentation (VRA). Materials...
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Clinical Oral Implants ResearchThe prevalence of peri‐implant disease for subcrestally inserted implants: A cross sectional studyClinical Oral Implants ResearchMon Oct 05, 2020 11:17PES in relation to buccal plate thickness and jumping distance: A 8 year cohort retrospective studyClinical Oral Implants ResearchMon Oct 05, 2020 11:17Prosthetic complications with zirconia single‐piece implants using different cementation methodsClinical Oral Implants ResearchMon Oct 05, 2020 11:17Multi‐center study...
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Clinical Oral Implants ResearchThe effect of antimicrobial photodynamic therapy in the osseointegration of immediately implants placed in a more compromised healing situation such as ligature‐induced periodontitis in dogsClinical Oral Implants ResearchMon Oct 05, 2020 11:17Infrared thermographic evaluation of temperature modifications induced during osteotomies performed with Er:YAG laser, piezosurgery and surgical drill – an animal studyClinical Oral Implants ResearchMon Oct 05, 2020 11:17Evaluation...
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G3: Genes, Genomes, Genetics current issueReference Genome for the Highly Transformable Setaria viridis ME034VSetaria viridis (green foxtail) is an important model system for improving cereal crops due to its diploid genome, ease of cultivation, and use of C4 photosynthesis. The S. viridis accession ME034V is exceptionally transformable, but the lack of a sequenced genome for this accession has limited its utility. We present a 397 Mb highly contiguous de novo assembly of ME034V using ultra-long...
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The Journal of Immunology current issueCanonical Wnts Mediate CD8+ T Cell Noncytolytic Anti-HIV-1 Activity and Correlate with HIV-1 Clinical Status [CLINICAL AND HUMAN IMMUNOLOGY]Key Points CD8+ T cells release Wnts that suppress HIV transcription. Antagonizing Wnts abrogates CD8+ T cell noncytotoxic anti-HIV activity. Wnts correlate with HIV controller status.The Journal of Immunology current issueMon Oct 05, 2020 23:00Correction: A critical role of costimulation during intrathymic development...
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The LaryngoscopeNear‐Infrared Fluorescence Imaging in the Identification of Parathyroid Glands in ThyroidectomyObjectives/Hypothesis To assess the ability of near‐infrared fluorescence imaging (NIFI) to identify parathyroid glands (PGs) among histologically proven PG/non‐PG specimens compared with a surgeon's visual acumen, and to determine NIFI sensitivity in detecting incidentally resected PGs from thyroidectomy specimens, compared to the surgeon's visual inspection. Study Design Prospective...
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Predictive Nomogram for the Necessity of Tracheotomy During Oral and Oropharyngeal Cancer Surgery: Objectives/HypothesisThe individualized risk of airway obstruction after head and neck cancer surgery is unclear, especially oral and oropharyngeal cancer. The study aimed to establish an individualized predictive model for the necessity of temporary tracheotomy in these patients.MethodsPatients who underwent oral and oropharyngeal cancer surgery from 1999 to 2019 were retrospectively reviewed. A nomogram...
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Efficacy and safety of solriamfetol for excessive daytime sleepiness in narcolepsy and obstructive sleep apnea: a systematic review and meta-analysis of clinical trials: Publication date: November 2020Source: Sleep Medicine, Volume 75Author(s): Roshan Subedi, Rajshree Singh, Rahul Kumar Thakur, Bibek K C, Divyanshu Jha, Barun Kumar RayHighlights•Excessive daytime sleepiness is a symptom of narcolepsy and obstructive sleep apnea.•Solriamfetol was effective for the treatment of excessive daytime sleepiness.•Solriamfetol...
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Hysteroscopic versus cervical injection for sentinel node detection in endometrial cancer: A multicenter prospective randomised controlled trial from the Multicenter Italian Trials in Ovarian cancer (MITO) study group: Publication date: November 2020Source: European Journal of Cancer, Volume 140Author(s): Antonino Ditto, Ivan Casarin, Anna M. Perrone, Paolo Scollo, Fabio Martinelli, Giorgio Bogani, Umberto L.R. Maggiore, Mauro Signorelli, Valentina Chiappa, Giorgio Giorda, Giuseppe Scibilia, Pierandrea...
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Burkholderia cepacia Sepsis in a Previously Healthy Full-Term Infant: Burkholderia cepacia causes sepsis in neonates who are immunocompromised or exposed via nosocomial transmission. We report a case of B. cepacia sepsis in a previously healthy 5-week-old male originally treated for bacterial pneumonia per chest X-ray findings and 3 days of fevers. Regardless of appropriate antibiotics and an initial negative blood culture, he developed severe hypoglycemia, circulatory collapse with disseminated...
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Severe neck pain and odynophagia secondary to acute calcific longus colli tendinitis: a case reportAcute calcific longus colli tendinitis is a rare, noninfectious inflammatory condition caused by the deposition of calcium crystals. The condition is self-limiting, yet commonly misdiagnosed. Here we report a ...Journal of Medical Case Reports - Latest ArticlesSun Sep 06, 2020 03:00Umbilical endometriosis: a case seriesEndometriosis is the presence of endometrial tissue outside the uterine cavity....
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Statistical and entropy-based features can efficiently detect the short-term effect of caffeinated coffee on the cardiac physiology: Publication date: December 2020Source: Medical Hypotheses, Volume 145Author(s): Bikash K. Pradhan, Kunal PalAbstractAn electrocardiograph (ECG) is the most effective way to find the changes in cardiac physiology. It is the representation of the electrical activities of the heart and can be understood using different waves, peaks, and intervals. Several factors affect...
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Damage to the human lumbar cartilage endplate and its clinical implications: AbstractThe cartilaginous endplate (CEP) is a thin layer of hyaline cartilage, and plays an important role in the diffusion of nutrients into the intervertebral discs. Its damage may seriously affect the disc degeneration, and result in low back pain (LBP). However, the structural features of damaged CEPs have not been well characterized, and this hinders our understanding of the etiology of disc degeneration and pain. To...
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MicroRNAs regulate distal region of mandibular development through Hh signaling: microRNAs regulate the distal part of mandibular formation at an early stage of development by involving Hh signaling activity through controlling its inhibitor expression level.microRNAs regulate the distal part of mandibular formation at an early stage of development by involving Hh signaling activity through controlling its inhibitor expression level.AbstractMandibular anomalies are often seen in various congenital...
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The forearm and hand musculature of semi‐terrestrial rhesus macaques (Macaca mulatta) and arboreal gibbons (fam. Hylobatidae). Part II. Quantitative analysis: This study indicates that the overall configuration of the arm and hand musculature of these primates is very similar but there are some apparent differences in relative size which can be linked to differences in forelimb function and which might be related to their specific locomotor behavior.AbstractNonhuman primates have a highly diverse...
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Do females and males exhibit a similar sarcopenic response as a consequence of normoxic and hypoxic bed rest?: New FindingsWhat is the central question of this study?Do females and males exhibit a similar sarcopenic response as a consequence of normoxic and hypoxic bed rest?What is the main finding and its importance?During 10‐day bed rest, exposure to a simulated (normobaric hypoxia) altitude of ∼4000 m does not exert additional significant structural or functional effect on the weight‐bearing...
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Rare case of mesenteric fibromatosis (desmoid tumour) associated with an acute abdomen and sepsis:
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Frequent detection of enterovirus D68 and rhinovirus type C in children with acute respiratory infections.: Frequent detection of enterovirus D68 and rhinovirus type C in children with acute respiratory infections.Eur J Clin Microbiol Infect Dis. 2020 Oct 03;:Authors: Mozhgani SH, Keshavarz M, Mousavi N, Namdari H, Salimi V, Mokhtari-Azad T, Zarei-Ghobadi M, Nadji SA, Ghavami N, Rezaei FAbstract This study aimed to evaluate the prevalence of human rhinoviruses (HRVs) and the emergence of...
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TRPS1: a highly sensitive and specific marker for breast carcinoma, especially for triple-negative breast cancer.: TRPS1: a highly sensitive and specific marker for breast carcinoma, especially for triple-negative breast cancer.Mod Pathol. 2020 Oct 03;:Authors: Ai D, Yao J, Yang F, Huo L, Chen H, Lu W, Soto LMS, Jiang M, Raso MG, Wang S, Bell D, Liu J, Wang H, Tan D, Torres-Cabala C, Gan Q, Wu Y, Albarracin C, Hung MC, Meric-Bernstam F, Wistuba II, Prieto VG, Sahin AA, Ding QAbstract Currently...
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Phase I/II Trial Investigating the Safety, Tolerability, Pharmacokinetics, Immune and Clinical Activity of SX-682 in Combination With TriAdeno Vaccine Regimen and M7824 (TGF-b "Trap/PDLi; Bintrafusp Alpha) in Advanced Solid Tumors (STAT): Conditions: Metastatic Cancer; Solid TumorsInterventions: Drug: SX-682; Drug: M7824; Biological: MVA-BN-CV301; Biological: FPV-CV301Sponsor: National Cancer Institute (NCI)Not yet recruiting
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Lidocaine And Neuromonitoring in Thyroid Surgery: Conditions: Thyroid Neoplasm; Parathyroid Neoplasms; AnesthesiaInterventions: Drug: Intravenous lidocaine; Drug: Intravenous placebo; Procedure: Intra-cuff lidocaine; Procedure: Intra-cuff placeboSponsor: Saint Petersburg State University, RussiaDetailed Description:The use of neuromonitoring in thyroid surgery imposes a number of special demands for anaesthetic management. Such demands include avoiding muscle relaxation and local...
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LncRNA NORAD as a Novel Predictor of Lymph Node Metastasis and Prognosis in Solid Tumors: A Systematic Review and Meta-Analysis: Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Background:Non-coding RNA-activated by DNA damage (NORAD), a novel identified lncRNA, was found to be aberrantly expressed in various types of cancer. This meta-analysis was performed to evaluate the value of lncRNA NORAD as a prognostic biomarker in human cancers.Methods:We searched...
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Automated Intensity Modulated Radiation Therapy Treatment Planning for Cervical Cancer Based on Convolution Neural Network: Technology in Cancer Research &Treatment, Volume 19, Issue , January-December 2020. Purpose:To develop and evaluate an automatic intensity-modulated radiation therapy (IMRT) program for cervical cancer, including a Convolution Neural Network (CNN)-based prediction model and an automated optimization strategy.Methods:A CNN deep learning model was trained to predict a patient-specify...
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Gastrointestinal anastomosis (GIA) stapler as a safe and efficacious damage control tool for high-grade liver injury in hemodynamically unstable patient- A case report.: Gastrointestinal anastomosis (GIA) stapler as a safe and efficacious damage control tool for high-grade liver injury in hemodynamically unstable patient- A case report.Int J Surg Case Rep. 2020 Sep 28;76:77-80Authors: Saqib SU, Iftekhar W, Zafar HAbstract INTRODUCTION: Liver injury occurs in approximately 5% of all trauma...
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Unusual cause of large intrathoracic mass in a young male of Bangladesh: A case report of giant intrathoracic lipoma & literature review.: Unusual cause of large intrathoracic mass in a young male of Bangladesh: A case report of giant intrathoracic lipoma & literature review.Int J Surg Case Rep. 2020 Sep 28;76:73-76Authors: Rahman SMT, Rahim A, Kibria AAAbstract INTRODUCTION: Lipoma in the thoracic cavity is very rare, unlike any subcutaneous lipoma, and can often grow very large...
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Management of a primary retroperitoneal hydatid cyst ruptured in the abdominal wall: A case report.: Management of a primary retroperitoneal hydatid cyst ruptured in the abdominal wall: A case report.Int J Surg Case Rep. 2020 Sep 28;76:69-72Authors: Maghrebi H, Ben Mahmoud A, Haddad A, Cheikhrouhou S, Sebei A, Chaker Y, Boukriba S, Jeribi B, Rebai W, Kacem MJAbstract INTRODUCTION: Hydatid disease is a global zoonosis. Any organ of the human body can be involved. Single or multiple locations...
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Laparoscopic management of celiac artery compression syndrome: A case report.: What are the symptoms of celiac artery stenosis?Patients with celiac artery compression syndrome may complain of abdominal pain in the epigastric area, anorexia, and/or diarrhea. Typically, the onset of the pain is after food intake (post-prandial pain). The pain may be associated with nausea and emesis.Aug 13, 2020Celiac Artery Compression Syndrome - StatPearls - NCBI BookshelfLaparoscopic management of celiac artery...
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Renal cell carcinoma presenting as a tumor on the scalp: A case report.: Renal cell carcinoma presenting as a tumor on the scalp: A case report.Int J Surg Case Rep. 2020 Sep 24;76:56-59Authors: Krogerus C, Svenning M, Pilt AP, Trøstrup HAbstract INTRODUCTION: Renal cell carcinoma (RCC) is often diagnosed as an incidental finding on imaging studies and about a fourth of patients have metastases by the time of diagnosis. RCC is known to metastasize widely but cutaneous metastases are considered...
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Symptomatic lump during lockdown - A case of de Garengeot's hernia.: De Garengeot's hernia is rare and describes a femoral hernia containing the vermiform appendixSymptomatic lump during lockdown - A case of de Garengeot's hernia.Int J Surg Case Rep. 2020 Sep 21;76:107-110Authors: Jackman J, Aswad MG, Chowdhury AAbstract INTRODUCTION: De Garengeot's hernia is rare and describes a femoral hernia containing the vermiform appendix. Pre-operative diagnosis is at times difficult and operative...
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Morel Lavallée Lesion - A case report and review of literature.: What is a Morel Lavallee lesion?Morel-Lavallée lesion is a closed degloving soft tissue injury, as a result of abrupt separation of skin and subcutaneous tissue from the underlying fascia.Morel-Lavallée lesion: A closed degloving injury that requires real ...Morel Lavallée Lesion - A case report and review of literature.Int J Surg Case Rep. 2020 Sep 25;76:103-106Authors: Pikkel YY, Hasan MJ, Ben-Yehuda Raz D, Ben-Naftaly Y, Duek OS,...
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Automated Pupillometry as a Triage and Assessment Tool in Patients with Traumatic Brain Injury.: Automated Pupillometry as a Triage and Assessment Tool in Patients with Traumatic Brain Injury.World Neurosurg. 2020 Oct 01;:Authors: El Ahmadieh TY, Bedros NM, Stutzman SE, Nyancho D, Venkatachalam AM, MacAllister M, Ban VS, Dahdaleh NS, Aiyagari V, Figueroa S, White JA, Batjer H, Bagley CA, Olson HDM, Aoun SGAbstract OBJECTIVE: Traumatic brain injury (TBI) is a leading cause of morbidity and...
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Vertebral Artery Stump Syndrome Due To Chronic Complicated Aortic Dissection: A Case Report.: Vertebral Artery Stump Syndrome Due To Chronic Complicated Aortic Dissection: A Case Report.World Neurosurg. 2020 Oct 01;:Authors: Gupta M, Sagi V, Yekula A, Golts E, Lane JS, Pannell JSAbstract BACKGROUND: Vertebral artery stump syndrome (VASS) arises when thrombi of an occluded proximal vertebral artery propagate to the brain and cause posterior circulation strokes. This phenomenon has been described...
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Carotid endarterectomy for intractable repetitive stenosis following carotid artery stenting.: Carotid endarterectomy for intractable repetitive stenosis following carotid artery stenting.World Neurosurg. 2020 Oct 01;:Authors: Sato D, Ogawa S, Fujimoto S, Suzuki T, Ueda M, Ota TAbstract Restenosis after carotid artery stenting (CAS) has raised concerns regarding the long-term durability of carotid stenting. Recurrent restenosis after multiple endovascular interventions may pose a challenge...
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Obstructive sleep apnoea and adherence to continuous positive airway therapy among Australian women.: Obstructive sleep apnoea and adherence to continuous positive airway therapy among Australian women.Intern Med J. 2020 Oct 04;:Authors: Heraganahally SS, Zaw KK, Tip S, Jing X, Mingi JJ, Howarth T, Roy A, Falhammar H, Sajkov DAbstract BACKGROUND: Clinical characteristics of women with different obstructive sleep apnoea (OSA) severity and adherence to Continuous Positive Airway Pressure (CPAP)...
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Low arousal threshold is associated with unfavorable shift of PAP compliance over time in patients with OSA.: Low arousal threshold is associated with unfavorable shift of PAP compliance over time in patients with OSA.Sleep Breath. 2020 Oct 04;:Authors: Wu H, Fang F, Wu C, Zhan X, Wei YAbstract PURPOSE: To determine the predictive factors of initial and long-term adherence to positive airway pressure (PAP) therapy and factors leading to an unfavorable shift of PAP compliance. METHODS:...
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SLEEP ABNORMALITIES AND POLYSOMNOGRAPHIC PROFILE IN CHILDREN WITH DRUG-RESISTANT EPILEPSY.: SLEEP ABNORMALITIES AND POLYSOMNOGRAPHIC PROFILE IN CHILDREN WITH DRUG-RESISTANT EPILEPSY.Seizure. 2020 Sep 25;82:59-64Authors: Manokaran RK, Tripathi M, Chakrabarty B, Pandey RM, Gulati SAbstract PURPOSE: This study aims to assess the prevalence of sleep abnormalities in children with drug-resistant epilepsy (DRE) and characterize their polysomnographic profile and to further compare it with well-controlled...
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MicroRNAs: New contributors to mechano-electric coupling and atrial fibrillation.: MicroRNAs: New contributors to mechano-electric coupling and atrial fibrillation.Prog Biophys Mol Biol. 2020 Oct 01;:Authors: Ravelli F, Masè MAbstract Atrial fibrillation (AF) is a multifactorial disease, which often occurs in the presence of underlying cardiac abnormalities and is supported by electrophysiological and structural alterations, generally referred to as atrial remodeling. Abnormal substrates...
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OSAS and upper pharynx surgery: Does basilingual collapsus always rhyme with failure?: OSAS and upper pharynx surgery: Does basilingual collapsus always rhyme with failure?Eur Ann Otorhinolaryngol Head Neck Dis. 2020 Sep 30;:Authors: Baudouin R, Alali A, Hans S, Blumen M, Chabolle FAbstract OBJECTIVE: Drug-induced-sedation endoscopy (DISE) has proved superior to awake clinical examination for diagnosis of upper-airway obstruction sites and surgical planning. Our question is: does multilevel...
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Voxel-based superimposition of Cone Beam CT scans for orthodontic and craniofacial follow-up: Overview and clinical implementation.: Voxel-based superimposition of Cone Beam CT scans for orthodontic and craniofacial follow-up: Overview and clinical implementation.Int Orthod. 2020 Sep 30;:Authors: Dot G, Rafflenbeul F, Salmon BAbstract INTRODUCTION: The increasing use of three-dimensional (3D) imaging in orthodontics has led to the development of 3D superimposition techniques. These techniques...
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Laryngeal dysfunction in severe asthma: A cross sectional observational study.: Laryngeal dysfunction in severe asthma: A cross sectional observational study.J Allergy Clin Immunol Pract. 2020 Oct 01;:Authors: Vertigan AE, Kapela SL, Gibson PGAbstract BACKGROUND: Laryngeal disorders can contribute to disease burden in severe asthma yet the nature of laryngeal disorders in severe asthma is poorly understood. OBJECTIVE: The aim of this study was to examine laryngeal function in patients...
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In Mixed Lymphocyte Reaction, the Hypoxia-Inducible Factor Prolyl-Hydroxylase Inhibitor Roxadustat Suppresses Cellular and Humoral Alloimmunity.: In Mixed Lymphocyte Reaction, the Hypoxia-Inducible Factor Prolyl-Hydroxylase Inhibitor Roxadustat Suppresses Cellular and Humoral Alloimmunity.Arch Immunol Ther Exp (Warsz). 2020 Oct 04;68(6):31Authors: Eleftheriadis T, Pissas G, Mavropoulos A, Nikolaou E, Filippidis G, Liakopoulos V, Stefanidis IAbstract Hypoxia-inducible factor (HIF) prolyl-hydroxylase...
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Pulmonary Artery Intimal Sarcoma: A Diagnostic Challenge Using a Multimodal Approach: Pulmonary artery intimal sarcoma (PAIS) is a rare tumor without clear syndromic presentation other than nonspecific symptoms of cough, dyspnea, and weight loss. This diagnosis is difficult due to challenging radiographic interpretations of multiple imaging modalities. We present a case of a 60-year-old male, who presented to his pulmonologist and underwent a CT chest with IV contrast that initially suggested primary...
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Ecological opportunity as a driving force for radiation events and time-dependent evolutionary rates in papillomaviruses [NEW RESULTS]: Papillomaviruses (PVs) have a wide host range, infecting mammals, birds, turtles, and snakes. The recent discovery of PVs in different fish species allows for a more complete reconstruction of the evolutionary history of the viral family. In this study we perform phylogenetic dating to analyse evolutionary events that occurred during PV evolution, as well as to estimate...
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Influence of Cortisol Awakening Response on Telomere length: Trends for males and females: AbstractAlthough telomere attrition is associated with the process of normal ageing, shorter telomere length (TL) has been associated with acute and chronic stressors. A neurobiological factor hypothesised to be responsible for this accelerated attrition is the dysregulation of the cortisol stress response, which can induce DNA damage affecting DNA telomeric caps. Marked sex differences are reported in both...
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Peripheral nerve regeneration following injury is altered in mice lacking P2X7 receptor: AbstractPeripheral nerve injuries are debilitating, and current clinical management is limited to surgical intervention, which often lead to poor functional outcomes. Development of pharmacological interventions aimed a enhancing regeneration may improve this. One potential pharmacological target is the P2X purinergic receptor 7 (P2X7R) expressed in Schwann cells, which is known to play a role during the development...
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Time Efficiency in Stereotactic Robot-Assisted Surgery: An Appraisal of the Surgical Procedure and Surgeon's Learning Curve: Background: Frame-based stereotactic procedures are still the gold standard in neurosurgery. However, there is an increasing interest in robot-assisted technologies. Introducing these increasingly complex tools in the clinical setting raises the question about the time efficiency of the system and the essential learning curve of the surgeon. Methods: This retrospective study...
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The comprehensive complication index is associated with a significant increase in complication severity between 30 and 90 days after radical cystectomy for bladder cancerPublication date: Available online 5 October 2020Source: European Journal of Surgical OncologyAuthor(s): Maximilian Haas, Toni Huber, Christoph Pickl, Bas W.G. van Rhijn, Miodrag Gužvić, Michael Gierth, Johannes Breyer, Maximilian Burger, Roman MayrEuropean Journal of Surgical Oncology (EJSO)Mon Oct 05, 2020 13:59Older frail prehabilitated...
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Phenotypic and molecular spectrum of pyridoxamine-5'-phosphate oxidase (PNPO) deficiency: a scoping review of 87 cases of PNPO deficiency.Related Articles Phenotypic and molecular spectrum of pyridoxamine-5'-phosphate oxidase (PNPO) deficiency: a scoping review of 87 cases of PNPO deficiency. Clin Genet. 2020 Sep 04;: Authors: Alghamdi M, Bashiri FA, Abdelhakim M, Adly N, Jamjoom DZ, Sumaily KM, Alghanem B, Arold ST Abstract Pyridoxamine-5'-phosphate oxidase (PNPO) deficiency is an autosomal recessive...
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NREM sleep arousal-related disorders reflect cognitive impairment in Parkinson's disease.: NREM sleep arousal-related disorders reflect cognitive impairment in Parkinson's disease.Sleep Med. 2020 Sep 05;75:491-496Authors: Terzaghi M, Minafra B, Zangaglia R, Picascia M, Pozzi N, Cremascoli R, Arnaldi D, Versino M, Sinforiani E, Rustioni V, Pacchetti C, Manni RAbstract BACKGROUND: Sleep disorders and cognitive impairment are frequently reported in Parkinson's disease (PD) as non-motor disabling...
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Clinical phenotypes of patients hospitalized for an asthma exacerbation: prognostic implications.: Clinical phenotypes of patients hospitalized for an asthma exacerbation: prognostic implications.J Allergy Clin Immunol Pract. 2020 Oct 01;:Authors: Zhang X, Zhang L, Wang G, Feng M, Liang R, McDonald V, Zhang HP, Yu H, Liang ZA, Wang L, Marks GB, Li WM, Wang G, Gibson PGAbstract BACKGROUND: Hospitalization due to acute asthma exacerbation (AE) is a highly detrimental situation requiring critical...
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Genome-wide association study of cardiovascular disease in testicular cancer patients treated with platinum-based chemotherapy.: Genome-wide association study of cardiovascular disease in testicular cancer patients treated with platinum-based chemotherapy.Pharmacogenomics J. 2020 Oct 03;:Authors: Steggink LC, Boer H, Meijer C, Lefrandt JD, Terstappen LWMM, Fehrmann RSN, Gietema JAAbstract Genetic variation may mediate the increased risk of cardiovascular disease (CVD) in chemotherapy-treated...
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Brentuximab vedotin plus nivolumab as first-line therapy in older or chemotherapy-ineligible patients with Hodgkin lymphoma (ACCRU): a multicentre, single-arm, phase 2 trial.: Brentuximab vedotin plus nivolumab as first-line therapy in older or chemotherapy-ineligible patients with Hodgkin lymphoma (ACCRU): a multicentre, single-arm, phase 2 trial.Lancet Haematol. 2020 Oct 01;:Authors: Cheson BD, Bartlett NL, LaPlant B, Lee HJ, Advani RJ, Christian B, Diefenbach CS, Feldman TA, Ansell SMAbstract...
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Encapsulating Peritoneal Sclerosis: A Case Report and Literature Review.: Encapsulating Peritoneal Sclerosis: A Case Report and Literature Review.Am J Case Rep. 2020 Oct 04;21:e925341Authors: Al-Lawati AI, Al Shaibi M, Al Mahruqi G, Augustine T, Moinuddin Z, Al Hinai M, Al Moqbali R, Al Qadhi HAbstract BACKGROUND Encapsulating peritoneal sclerosis (EPS) is a rare, life-threatening, and serious complication of long-term peritoneal dialysis (PD). No evidence-based management strategy has been...
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Computed tomography angiography study of the azygos vein course and termination into superior vena cava: gender and age impact.: Computed tomography angiography study of the azygos vein course and termination into superior vena cava: gender and age impact.Surg Radiol Anat. 2020 Oct 03;:Authors: Koutsouflianiotis K, Daniil G, Paraskevas G, Piagkou M, Chrysanthou C, Natsis KAbstract PURPOSE: The study highlights azygos vein (AV) topography, arrangement and confluence morphometry in dyspnoea...
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Brentuximab vedotin plus nivolumab as first-line therapy in older or chemotherapy-ineligible patients with Hodgkin lymphoma (ACCRU): a multicentre, single-arm, phase 2 trial.Brentuximab vedotin plus nivolumab as first-line therapy in older or chemotherapy-ineligible patients with Hodgkin lymphoma (ACCRU): a multicentre, single-arm, phase 2 trial. Lancet Haematol. 2020 Oct 01;: Authors: Cheson BD, Bartlett NL, LaPlant B, Lee HJ, Advani RJ, Christian B, Diefenbach CS, Feldman TA, Ansell SM Abstract...
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Novel role of BRCA1 interacting C-terminal helicase 1 (BRIP1) in breast tumour cell invasion.Related Articles Novel role of BRCA1 interacting C-terminal helicase 1 (BRIP1) in breast tumour cell invasion. J Cell Mol Med. 2020 Sep 05;: Authors: Rizeq B, Sif S, Nasrallah GK, Ouhtit A Abstract Breast cancer (BC) is the most common malignancy and the leading cause of death in women worldwide. Only 5%-10% of mutations in BRCA genes are associated with familial breast tumours in Eastern countries, suggesting...
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Novel N-(aryl/heteroaryl)-2-chlorobenzenesulfonamide derivatives: Synthesis and anticancer activity evaluation.: Novel N-(aryl/heteroaryl)-2-chlorobenzenesulfonamide derivatives: Synthesis and anticancer activity evaluation.Bioorg Chem. 2020 Sep 24;104:104309Authors: Bułakowska A, Sławiński J, Siedlecka-Kroplewska K, Stasiłojć G, Serocki M, Heldt MAbstract A new series of N-(aryl/heteroaryl)-2-chlorobenzenesulfonamide derivatives 4-21 have been synthesized, and evaluated at the National...
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Biomimetic microbioreactor-supramolecular nanovesicles improve enzyme therapy of hepatic cancer.: Biomimetic microbioreactor-supramolecular nanovesicles improve enzyme therapy of hepatic cancer.Nanomedicine. 2020 Oct 01;:102311Authors: He X, Feng J, Yan S, Zhang Y, Zhong C, Liu Y, Shi D, Abagyan R, Xiang T, Zhang JAbstract A novel biomimetic nanovesicle-loaded supramolecular enzyme-based therapeutics has been developed. Here, using a biomimetic lipid-D-α-tocopherol polyethylene glycol succinate...
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Diltiazem potentiates the cytotoxicity of gemcitabine and 5-fluorouracil in PANC-1 human pancreatic cancer cells through inhibition of P-glycoprotein.: Diltiazem potentiates the cytotoxicity of gemcitabine and 5-fluorouracil in PANC-1 human pancreatic cancer cells through inhibition of P-glycoprotein.Life Sci. 2020 Oct 01;:118518Authors: El-Mahdy HA, El-Husseiny AA, Kandil YI, Gamal El-Din AMAbstract AIM: Pancreatic cancer (PC) is one of the most aggressive tumors with dismal survival and...
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Repurposing of niclosamide as a STAT3 inhibitor to enhance the anticancer effect of chemotherapeutic drugs in treating colorectal cancer.: Repurposing of niclosamide as a STAT3 inhibitor to enhance the anticancer effect of chemotherapeutic drugs in treating colorectal cancer.Life Sci. 2020 Oct 01;:118522Authors: Wu MM, Zhang Z, Tong CWS, Yan VW, Cho WCS, To KKWAbstract AIMS: Colorectal cancer (CRC) is the third most common cancer worldwide. Mutation of various cell signaling molecules or...
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Inflammatory features and predictors for postsurgical outcomes in patients with nasal polyps stratified by local and systemic eosinophilia.: Inflammatory features and predictors for postsurgical outcomes in patients with nasal polyps stratified by local and systemic eosinophilia.Int Forum Allergy Rhinol. 2020 Oct 04;:Authors: Pan L, Liao B, Guo CL, Liu JX, Wang H, Long XB, Liu ZAbstract BACKGROUND: In this study we aimed to identify inflammatory patterns and predictors associated with clinical...
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Risk of autoimmune diseases in recurrent aphthous ulcer patients: A nationwide population study.: Risk of autoimmune diseases in recurrent aphthous ulcer patients: A nationwide population study.Oral Dis. 2020 Oct 03;:Authors: Lee YC, Jeong SJ, Eun YG, Song R, Oh IHAbstract OBJECTIVE: To estimate the risk of developing autoimmune disease in patients diagnosed having recurrent aphthous stomatitis (RAS) through a nationwide population-based cohort study METHODS: This study included two group...
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Evaluation of the Neurogenic Potential in the Rat Inferior Colliculus from Early Postnatal Days Until Adulthood.: Evaluation of the Neurogenic Potential in the Rat Inferior Colliculus from Early Postnatal Days Until Adulthood.Mol Neurobiol. 2020 Oct 03;:Authors: Engert J, Rak K, Bieniussa L, Scholl M, Hagen R, Voelker JAbstract Neural stem cells (NSCs) have been recently identified in the inferior colliculus (IC). These cells are of particular interest, as no casual therapeutic options for...
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Prognostic performance of TNM8 staging rules in oral cavity squamous cell carcinoma.: Prognostic performance of TNM8 staging rules in oral cavity squamous cell carcinoma.Oral Oncol. 2020 Oct 01;111:105021Authors: Jawad H, Ashaari SS, O'Shea R, Callanan D, Sheahan P, Feeley LAbstract BACKGROUND: Two major changes to the staging of oral cavity squamous cell carcinoma (OCSCC) were adopted in TNM8: (1) depth of invasion is now used for T staging and (2) extranodal extension for N staging. The...
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An oral presentation of dermatofibromasarcoma protuberans with literature review: A case report.: An oral presentation of dermatofibromasarcoma protuberans with literature review: A case report.Int J Surg Case Rep. 2020 Sep 28;76:98-102Authors: Martinez C, McDougal E, Gilstrap J, Friedman HI, Rivera MAbstract INTRODUCTION: Dermatofibrosarcoma protuberans (DFSP) is an uncommon, locally invasive soft tissue tumor with a high rate of recurrence after surgical intervention. DFSP primarily occurs...
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Endoscopic resection of large endonasal hemangioma: Case report.: Endoscopic resection of large endonasal hemangioma: Case report.Int J Surg Case Rep. 2020 Sep 24;76:52-55Authors: Alhomaidi Y, Alokaili R, Albawardi E, Alotaibi NHAbstract INTRODUCTION: Hemangiomas are common vascular benign tumors of the head and neck region. However, it is uncommon for them to arise in the paranasal sinus mucosal tissues. Paranasal sinus hemangiomas have nonspecific characteristics clinically and radiologically,...
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Portrait of a CAF: The story of cancer-associated fibroblasts in head and neck cancer.: Portrait of a CAF: The story of cancer-associated fibroblasts in head and neck cancer.Oral Oncol. 2020 Oct 01;110:104972Authors: Custódio M, Biddle A, Tavassoli MAbstract Complex interactions take place during cancer formation and progression. In this regard, there has been increasing focus on the non-malignant cells that make up the tumour microenvironment (TME), and how they interact with malignant...
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Identifying three otopathologies in humans.: Identifying three otopathologies in humans.Hear Res. 2020 Sep 24;398:108079Authors: Parker MAAbstract OBJECTIVES: Hearing-in-noise (HIN) is a primary complaint of both the hearing impaired and the hearing aid user. Both auditory nerve (AN) function and outer hair cell (OHC) function are thought to contribute to HIN, but their relative contributions are still being elucidated. OHCs play a critical role in HIN by fine tuning the motion of the basilar...
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Systematic Review of Mohs Micrographic Surgery in Children: Identifying Challenges and Practical Considerations for Successful Application.: Systematic Review of Mohs Micrographic Surgery in Children: Identifying Challenges and Practical Considerations for Successful Application.J Am Acad Dermatol. 2020 Oct 01;:Authors: Zargham H, Khachemoune AAbstract BACKGROUND: Few data exist to guide the application of Mohs micrographic surgery (MMS) in the pediatric population. OBJECTIVE: To...
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A new instrument for septorhinoplasty "The modified Heidemann spatula".: A new instrument for septorhinoplasty "The modified Heidemann spatula".J Plast Reconstr Aesthet Surg. 2020 Sep 19;:Authors: Facciuto E, Filomena V, Kallaverja E, Spuntarelli C, Boschetti CEPMID: 33011109 [PubMed - as supplied by publisher]
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Comparing the prevalence of attention deficit hyperactivity disorder in hearing-impaired children with normal-hearing peers.: Comparing the prevalence of attention deficit hyperactivity disorder in hearing-impaired children with normal-hearing peers.Arch Pediatr. 2020 Sep 30;:Authors: Soleimani R, Jalali MM, Faghih HAAbstract OBJECTIVES: The most important aspect of hearing loss is its effect on the communication abilities of individuals. The aim of this study was to compare the prevalence...
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Effect of 1.5-T and 3.0-T magnetic resonance imaging on the ceramic adhesion and physical properties of prosthetic substructures.: Effect of 1.5-T and 3.0-T magnetic resonance imaging on the ceramic adhesion and physical properties of prosthetic substructures.J Prosthet Dent. 2020 Sep 30;:Authors: Baysal N, Ayyıldız S, Orujalipoor I, Erol BFAbstract STATEMENT OF PROBLEM: Magnetic resonance imaging (MRI) is a cross-sectional imaging technique that is widely used in the detection of pathologies...
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Primary epithelioid angiosarcoma originating from the mandibular gingiva: a case report of an extremely rare oral lesion.: Primary epithelioid angiosarcoma originating from the mandibular gingiva: a case report of an extremely rare oral lesion.World J Surg Oncol. 2020 Oct 03;18(1):260Authors: Komatsu Y, Miyamoto I, Ohashi Y, Katagiri K, Saito D, Obara M, Takeda Y, Shiga K, Yamada HAbstract BACKGROUND: Angiosarcoma occurs very rarely in the oral cavity, and the epithelioid type is even rarer....
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Positive predictive value for diffusion-weighted magnetic resonance imaging in pediatric cholesteatoma: A retrospective study: Publication date: December 2020Source: International Journal of Pediatric Otorhinolaryngology, Volume 139Author(s): Rémi Hervochon, Monique Elmaleh-Berges, Martine Francois, Alix Marhic, Abdullah Bahakim, Natacha Teissier, Thierry Van Den AbbeeleAbstractObjectivesThe aims of this study were first to calculate the Positive Predictive Value (PPV) of DW-MRI to detect cholesteatoma...
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Radiological Evidence to Changes in the Olfactory Bulb Volume depending on Body Mass Index in the Childhood: Publication date: Available online 5 October 2020Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Murat Karaoglan, Hale Colakoglu ErHighlights•The olfactory control of energy homeostasis is maintained through the interplay between the olfactory bulbs (OB) and adipose tissue.•Bimodal changes in olfactory bulb volume indicate that olfactory control acts to provide energy...
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The Role of Inflammation in the Pathogenesis of Preeclampsia: Preeclampsia (PE) affects 5-8% of pregnant women, and it is the major cause of perinatal morbidity and mortality. It is defined as arterial hypertension in women after 20 weeks of gestation which cooccurs with proteinuria (300 mg/d) or as arterial hypertension which is accompanied by one of the following: renal failure, liver dysfunction, hematological or neurological abnormalities, intrauterine growth restriction, or uteroplacental insufficiency....
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Management of a Unique Sinonasal Undifferentiated Carcinoma Subtype in the Era of SARS-CoV-2: The novel coronavirus (SARS-CoV-2) pandemic has influenced the timeliness of care for patients with both common and rare conditions, particularly those affecting high-risk operative sites such as the upper aerodigestive tract. Sinonasal undifferentiated carcinoma (SNUC) represents a rare malignancy of the sinonasal tract, a unique subset of which has never been previously reported in the otolaryngology literature...
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Reverse radiodorsal artery‐pedicled thumb metacarpal vascularized bone graft for osteochondral fracture of the thumb interphalangeal joint with a bone defect: A case report: AbstractOsteochondral fractures of the fingers are challenging to treat, and it is mandatory to acquire early bone union and joint surface reconstruction to obtain satisfactory outcomes. These injuries sometimes occur as open fractures with poor soft tissue condition and bone defect adjacent to osteochondral fragment. For such...
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Decrease in Chitinase 3-Like Protein 1 Levels Reflects Improvement in Liver Fibrosis after HCV Eradication: Aim. The success of direct-acting antivirals (DAAs) against hepatitis C virus is a major breakthrough in hepatology. Previous studies have shown that chitinase 3-like protein 1 (CHI3L1) was a marker for staging of liver fibrosis caused by HCV. In this investigation, we used CHI3L1 as a surrogate marker to compare dynamic hepatic fibrosis variations following the elimination of HCV among cases...
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Prognostic Role of Serum Amino Acids in Head and Neck Cancer: Introduction. Serum amino acid (AA) profiles represent a valuable tool in the metabolic assessment of cancer patients; still, information on the AA pattern in head and neck cancer (HNC) patients is insufficient. The aim of the study was to assess whether serum AA levels were associated with the stage of neoplastic disease and prognosis in primary HNC patients. Methods. Two hundred and two primary HNC patients were included in the study....
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The Role of Circulating RBP4 in the Type 2 Diabetes Patients with Kidney Diseases: A Systematic Review and Meta-Analysis: Background. Diabetic nephropathy is a common and serious complication of diabetes mellitus (DM) and is one of the leading causes of end-stage renal disease worldwide. Although there have been many investigations on biomarkers for DN, there is no consistent conclusion about reliable biomarkers. The purpose of this study was to perform a systematic review and meta-analysis of the...
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Effects of early nutritional intervention by a nutritional support team for patients with head and neck cancer undergoing chemoradiotherapy or radiotherapy: AbstractBackgroundWe analyzed the effects of early nutritional intervention by a nutritional support team (NST) in patients with head and neck squamous cell carcinoma (HNSCC) undergoing chemoradiotherapy or radiotherapy.MethodsThis study investigated whether early nutritional interventions by a multidisciplinary NST improve body weight loss,...
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WAVE3 phosphorylation regulates the interplay between PI3K, TGF-β, and EGF signaling pathways in breast cancer: Oncogenesis, Published online: 05 October 2020; doi:10.1038/s41389-020-00272-0WAVE3 phosphorylation regulates the interplay between PI3K, TGF-β, and EGF signaling pathways in breast cancer
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