Related Articles Novel role of BRCA1 interacting C-terminal helicase 1 (BRIP1) in breast tumour cell invasion. J Cell Mol Med. 2020 Sep 05;: Authors: Rizeq B, Sif S, Nasrallah GK, Ouhtit A Abstract Breast cancer (BC) is the most common malignancy and the leading cause of death in women worldwide. Only 5%-10% of mutations in BRCA genes are associated with familial breast tumours in Eastern countries, suggesting the contribution of other...
Sun Sep 06, 2020 13:41
Related Articles Selective VEGFR-2 inhibitors: Synthesis of pyridine derivatives, cytotoxicity and apoptosis induction profiling. Bioorg Chem. 2020 Aug 26;103:104222 Authors: AbdelHaleem A, Mansour AO, AbdelKader M, Arafa RK Abstract VEGFR-2 is a key regulator in cancer angiogenesis. This research displays the design and synthesis of novel 3-cyano-6-naphthylpyridine scaffold-based derivatives as selective VEGFR-2 inhibitors and cytotoxic...
Sun Sep 06, 2020 13:41
Related Articles Host cell p53 associates with the feline calicivirus major viral capsid protein VP1, the protease-polymerase NS6/7, and the double-stranded RNA playing a role in virus replication. Virology. 2020 Aug 27;550:78-88 Authors: Trujillo-Uscanga A, Gutiérrez-Escolano AL Abstract p53 is implicated in several cellular pathways such as induction of cell-cycle arrest, differentiation, senescence, and apoptosis. p53 is activated by...
Sun Sep 06, 2020 13:41
Related Articles Design, synthesis and biological evaluation of novel (E)-N-phenyl-4-(pyridine-acylhydrazone) benzamide derivatives as potential antitumor agents for the treatment of multiple myeloma (MM). Bioorg Chem. 2020 Aug 26;103:104189 Authors: Li XY, Li S, Lu GQ, Wang DP, Liu KL, Qian XH, Xue WH, Meng FH Abstract A series of novel (E)-N-phenyl-4-(pyridine-acylhydrazone) benzamide derivatives were designed, synthesized, and evaluated...
Sun Sep 06, 2020 13:41
Related Articles ERCC6L promotes the progression of hepatocellular carcinoma through activating PI3K/AKT and NF-κB signaling pathway. BMC Cancer. 2020 Sep 05;20(1):853 Authors: Chen H, Wang H, Yu X, Zhou S, Zhang Y, Wang Z, Huang S, Wang Z Abstract BACKGROUND: Excision Repair Cross-Complementation group 6-like (ERCC6L) has been shown to exhibit carcinogenic effect in several malignant tumors. However, the function and molecular mechanism...
Tue Sep 08, 2020 11:29
Related Articles In vitro screening of plant extracts traditionally used as cancer remedies in Ghana - 15-Hydroxyangustilobine A as the active principle in Alstonia boonei leaves. J Ethnopharmacol. 2020 Sep 03;:113359 Authors: Spiegler V, Greiffer L, Jacobtorweihen J, Asase A, Lanvers-Kaminsky C, Hempel G, Agyare C, Hensel A Abstract ETHNOPHARMACOLOGICAL RELEVANCE: Cancer represents a major health burden and drain on the global healthcare...
Tue Sep 08, 2020 11:29
Related Articles Radio-sensitizing effect of a cocktail of phytochemicals on HepG2 cell proliferation, motility and survival. Biomed Pharmacother. 2020 Sep 03;131:110620 Authors: Abdraboh ME, Essa ZS, Abdelrazzak AB, El-Far YM, Elsherbini Y, El-Zayat MM, Ali DA Abstract Radio-resistance is a major hurdle challenging oncologist worldwide. Despite their anti-cancer characteristics, the implication of phytochemicals in clinical trials is still...
Tue Sep 08, 2020 11:29
Related Articles Effective Delivery of a Microtubule Polymerization Inhibitor Synergizes with Standard Regimens in Models of Pancreatic Ductal Adenocarcinoma. Clin Cancer Res. 2019 09 15;25(18):5548-5560 Authors: Eberle-Singh JA, Sagalovskiy I, Maurer HC, Sastra SA, Palermo CF, Decker AR, Kim MJ, Sheedy J, Mollin A, Cao L, Hu J, Branstrom A, Weetall M, Olive KP Abstract PURPOSE: Pancreatic ductal adenocarcinoma (PDA) is a deadly cancer that...
Tue Sep 08, 2020 14:29
Related Articles CRM197 reverses paclitaxel resistance by inhibiting the NAC-1/Gadd45 pathway in paclitaxel-resistant ovarian cancer cells. Cancer Med. 2019 10;8(14):6426-6436 Authors: Tang XH, Li H, Zheng XS, Lu MS, An Y, Zhang XL Abstract Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a new promising target for the treatment of ovarian cancer. Our previous study showed that cross-reacting material 197 (CRM197), a...
Tue Sep 08, 2020 14:29
Related Articles Liposome as drug delivery system enhance anticancer activity of iridium (III) complex. J Liposome Res. 2020 Sep 07;:1-46 Authors: Gu Y, Bai L, Zhang Y, Zhang H, Xing D, Tian L, Zhou Y, Hao J, Liu Y Abstract Herein an Ir(III) complex [Ir(Hppy)2(HMNPIP)](PF6) (Ir1, Hppy =2-phenylpyridine, HMNPIP =2-(1H-imidazo[4,5-f][1,10]phenanthroline-3-yl)-6-methoxy-4-nitrophenol) was prepared and characterized. Due to the low anticancer...
Tue Sep 08, 2020 14:29
Related Articles Anti-migratory effects of Piper betle leaf aqueous extract on cancer cells and its microtubule targeting properties. J Zhejiang Univ Sci B. 2020 Sept.;21(9):745-748 Authors: Looi ML, Wong AKH, Gnapragasan SA, Japri AZ, Rajedadram A, Pin KY Abstract Piper betle (PB), also known as "betel" in Malay language, is a tropical Asian vine. PB leaves are commonly chewed by Asians along with betel quid. It contains phenols such as...
Tue Sep 08, 2020 14:29
Related Articles [Effect of Huaier aqueous extract on growth and metastasis of human non-small cell lung cancer NCI-H1299 cells and its underlying mechanisms]. Zhongguo Zhong Yao Za Zhi. 2020 Aug;45(15):3700-3706 Authors: Tian YY, Yang AL, Chen XN, Ren HM, Liu YX, Qiu HL, Tang LM, Huang HM, Tu PF, Hu ZD Abstract This study aims to investigate the effect of Huaier aqueous extract on the growth and metastasis of human non-small cell lung...
Tue Sep 08, 2020 14:29
Related Articles Targeting UDP-glucose dehydrogenase inhibits ovarian cancer growth and metastasis. J Cell Mol Med. 2020 Sep 07;: Authors: Lin LH, Chou HC, Chang SJ, Liao EC, Tsai YT, Wei YS, Chen HY, Lin MW, Wang YS, Chien YA, Yu XR, Chan HL Abstract More than 70% of patients with ovarian cancer are diagnosed in advanced stages. Therefore, it is urgent to identify a promising prognostic marker and understand the mechanism of ovarian cancer...
Tue Sep 08, 2020 14:29
Related Articles Topological Features of Histone H2A Monoubiquitination. Dokl Biochem Biophys. 2020 Jul;493(1):193-197 Authors: Kudriaeva AA, Lipkin VM, Belogurov AA Abstract The cellular response to DNA damage protects the essential information stored in the genome. This mechanism is crucial in terms of the cancer prevention and aging progression. The DNA damage response (DDR) consists of a complex network controlling the cell cycle and...
Tue Sep 08, 2020 14:29
Related Articles MiR-34a affects G2 arrest in prostate cancer PC3 cells via Wnt pathway and inhibits cell growth and migration. Eur Rev Med Pharmacol Sci. 2020 Aug;24(16):8349-8358 Authors: Dong B, Xu GC, Liu ST, Liu T, Geng B Abstract OBJECTIVE: To investigate the effect and mechanism of miRNA-34a overexpression on proliferation and migration of PC3 prostate cancer cells. PATIENTS AND METHODS: Benign prostatic hyperplasia tissue...
Tue Sep 08, 2020 14:29
Related Articles The effects of Arctigenin-Valine ester on chemotherapy-induced myelosuppression in mice. Bioorg Med Chem. 2019 06 15;27(12):2480-2486 Authors: Han M, Jia X, Cai E, Yang L, Dai M, Sun N, Jiang S, Shu H Abstract OBJECTIVE: To explore whether Arctigenin-Valine ester (ARG-V) can treat myelosuppression caused by chemotherapy. METHODS: The number of peripheral blood cells of the mice was measured by an automatic blood analyzer,...
Wed Sep 09, 2020 13:20
Related Articles Synthesis, characterization, and photodynamic therapy activity of 5,10,15,20-Tetrakis(carboxyl)porphyrin. Bioorg Med Chem. 2019 06 15;27(12):2598-2608 Authors: Zhang Z, Yu HJ, Wu S, Huang H, Si LP, Liu HY, Shi L, Zhang HT Abstract Water-soluble porphyrins are considered promising drug candidates for photodynamic therapy (PDT). This study investigated the PDT activity of a new water-soluble, anionic porphyrin (1-Zn), which possesses...
Wed Sep 09, 2020 13:20
Related Articles Linc00261 suppresses growth and metastasis of non-small cell lung cancer via repressing epithelial-mesenchymal transition. Eur Rev Med Pharmacol Sci. 2019 May;23(9):3829-3837 Authors: Liao J, Dong LP Abstract OBJECTIVE: Long non-coding RNAs (lncRNAs) have been identified to participate in the development and progression of various types of cancers, including non-small cell lung cancer (NSCLC). However, the expression and function...
Wed Sep 09, 2020 13:20
Related Articles Pathogen Molecular Pattern Receptor Agonists: Treating Cancer by Mimicking Infection. Clin Cancer Res. 2019 11 01;25(21):6283-6294 Authors: Aleynick M, Svensson-Arvelund J, Flowers CR, Marabelle A, Brody JD Abstract Immunotherapies such as checkpoint blockade have achieved durable benefits for patients with advanced stage cancer and have changed treatment paradigms. However, these therapies rely on a patient's own a priori...
Wed Sep 09, 2020 13:20
Related Articles MicroRNA-33a-5p suppresses colorectal cancer cell growth by inhibiting MTHFD2. Clin Exp Pharmacol Physiol. 2019 10;46(10):928-936 Authors: Yan Y, Zhang D, Lei T, Zhao C, Han J, Cui J, Wang Y Abstract Colorectal cancer (CRC) is one of the most common malignancies with high levels of invasiveness, drug resistance and mortality, but the internal mechanisms of CRC are largely unknown. MicroRNAs (miRs) have been reported to be involved...
Wed Sep 09, 2020 13:20
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