Radiological Evidence to Changes in the Olfactory Bulb Volume depending on Body Mass Index in the Childhood

Radiological Evidence to Changes in the Olfactory Bulb Volume depending on Body Mass Index in the Childhood:



Publication date: Available online 5 October 2020

Source: International Journal of Pediatric Otorhinolaryngology

Author(s): Murat Karaoglan, Hale Colakoglu Er



Highlights

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The olfactory control of energy homeostasis is maintained through the interplay between the olfactory bulbs (OB) and adipose tissue.



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Bimodal changes in olfactory bulb volume indicate that olfactory control acts to provide energy balance, mediated by positive in the overweight and obese children, negative feedback in the morbidly obese group.





Abstract

Objective

Energy balance is preserved through the exchange between body weight and adipose tissue across the multi-faceted complex network that is composed of the sensorial, metabolic, and neuro-endocrine circuits. The olfactory control of energy homeostasis is maintained through the interplay between the olfactory bulb (OB) and adipose tissue. While extremely studied, most researches still report controversial results and sensorial regulation of obesity is not fully understood. This study aims to investigate the interplay between olfactory bulb volume (OBV) as a radiological clue of sensorial control and obesity in children.



Subjects and Method

Children (n=195) were classified into four groups based on body mass index (BMI) percentiles: normal weight(n=89), overweight(n=31), obese(n=32) and morbidly obese(n=43). OBV were calculated using MRI.



Results

Mean OBV was higher in children with obesity than in those of normal weights. The means of OBV are found higher in the overweight and obese children (43.76±9.50-49.29±8.61mm3) than in those of morbidly obese(38.23±11.52mm3)(p<0.001). In overweight and obese children, a positive correlation were found between the BMI and OBV (roverweigh=0.275-robese=0.377), while in the morbidly obese group, there was a negative correlation(rseverelyobese= -0.445).



Conclusion

This study reveals that OBV is higher in obese children. Also, it shows that there is a positive correlation between OBV and BMI in overweight and obese children and a negative correlation in the morbidly obese group. These radiological bimodal changes in OBV indicate that olfactory control acts to provide energy balance, mediated by positive in the overweight and obese children, negative feedback in the morbidly obese group.



Keywords

olfactory bulb volumebody mass indexobesity