Blog Archive

Αλέξανδρος Γ. Σφακιανάκης

Monday, October 5, 2020

 


Influence of ridge preservation on marginal bone loss in single unit implant restorations
Clinical Oral Implants Research
Mon Oct 05, 2020 11:17
Vertical ridge augmentation (VRA) with Ti‐reinforced d‐PTFE membranes or Ti‐meshes and collagen membranes. 1‐year results of a randomized clinical trial
ABSTRACT Objectives The aim of this study was to evaluate hard and soft tissues around implants placed in posterior mandible 1 year after vertical ridge augmentation (VRA). Materials and Methods 40 patients with vertical defects were enrolled and treated according to the study protocol. Patients were randomly divided into two study groups: reinforced‐PTFE membranes (group‐A) and titanium‐meshes plus collagen membranes (group‐B). All patients received simultaneously implants which were evaluated...
Clinical Oral Implants Research
Mon Oct 05, 2020 16:13
Clinical variability of TUBB‐associated disorders: Diagnosis through reanalysis
Abstract A range of clinical findings have been associated with heterozygous mutations in the Beta Tubulin (TUBB) gene, including microcephaly, structural brain abnormalities, intellectual disability, and skin creases. We report a 5‐year‐old male who presented for evaluation of cleft palate, cardiac defects, growth retardation, hemivertebrae causing scoliosis, and preauricular skin tags. Previous clinical exome sequencing of this patient was nondiagnostic, but reanalysis in the research setting...
American Journal of Medical Genetics Part A
Mon Oct 05, 2020 13:24
Puerarin Inhibits the Progression of Bladder Cancer by Regulating circ_0020394/miR-328-3p/NRBP1 Axis
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Cancer Biotherapy & Radiopharmaceuticals - Table of Contents
Mon Oct 05, 2020 10:00
Clinical Observation of Double Percutaneous Nephrostomy Combined with Ureter Occlusion Stent for Treating Cervical Cancer Complicated with Vesicovaginal Fistula
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Cancer Biotherapy & Radiopharmaceuticals - Table of Contents
Mon Oct 05, 2020 10:00
Rapid and easy-to-use ES cell manipulation device with a small groove near culturing wells
Production of genetically modified mice including Knock-out (KO) or Knock-in (KI) mice is necessary for organism-level phenotype analysis. Embryonic stem cell (ESC)-based technologies can produce many genetica...
BMC Research Notes
Mon Oct 05, 2020 03:00
Brain-derived neurotrophic factor Val66Met polymorphism affects cortical thickness of rostral anterior cingulate in patients with major depressive disorder
Objective The neuro-anatomical substrates of major depressive disorder (MDD) remain poorly understood. Brain-derived neurotrophic factor (BDNF) gene polymorphism (Val66Met/rs6265) is associated with neuro-plasticity and development. In the present study, we explore the influence of BDNF gene polymorphism on cortical thickness in nonelderly, first episode, drug-naive patients with MDD. Methods Two hundred and sixteen participants (105 MDD patients and 111 healthy controls) were divided into...
NeuroReport - Current Issue
01:32
Rodent models for intravascular ischemic cerebral infarction: a review of influencing factors and method optimization
Rodent models for cerebral infarction are useful for studying human focal ischemic cerebral infarction, by simulating etiological and pathophysiological mechanisms. However, differences in the selection of anesthetic drugs, surgical methods and other factors may affect the extent to which preclinical models reflect the human condition. This review summarizes these factors. We searched pertinent literature from the MEDLINE and Web of Science databases, and reviewed differences in rodent strain, anesthesia...
NeuroReport - Current Issue
01:32
Brief mindfulness training increased glutamate metabolism in the anterior cingulate cortex
Mindfulness meditation has become a promising intervention for promoting health and well-being. Neuroimaging studies have shown its beneficial effects on brain functional activity, connectivity, and structures following months to years of practice. A series of randomized controlled trials indicated that one form of mindfulness meditation, the integrative body-mind training (IBMT) induces brain functional and structural changes in brain regions related to self-control networks such as the anterior...
NeuroReport - Current Issue
01:32
The small molecule inhibitor PR-619 protects retinal ganglion cells against glutamate excitotoxicity
Glutamate excitotoxicity may contribute to the death of retinal ganglion cell (RGC) in glaucoma and other retinal diseases such as ischemia. Deubiquitinating enzyme (DUB) inhibitors are emerging as attractive targets for pharmacological intervention in neurodegenerative diseases. However, the role of PR-619, the broad spectrum DUB inhibitor, on RGCs under different stressful environment remains largely unknown. This study was designed to investigate the role of PR-619 in regulating mitophagy of RGCs...
NeuroReport - Current Issue
01:32
Peripheral vascular endothelial growth factor changes after transcranial magnetic stimulation in treatment-resistant depression
Objectives To determine if vascular endothelial growth factor (VEGF) changes with transcranial magnetic stimulation (TMS) in treatment-resistant major depressive disorder (MDD). Methods Serum from a naturalistic population of 15 patients with MDD was collected at baseline and after standard TMS treatment. VEGF concentration was determined via ELISA. Inventory of Depressive Symptomatology Self Report and Patient Health Questionnaire were used as a measure of depression symptom severity, clinical...
NeuroReport - Current Issue
01:32
Fluoxetine attenuates prepulse inhibition deficit induced by neonatal administration of MK-801 in mice
Increasing evidence supports schizophrenia may be a neurodevelopmental and neurodegenerative disorder. Fluoxetine, a selective serotonin reuptake inhibitor, has been reported to have neuroprotective effects and be effective in treating neurodegenerative disorders including schizophrenia. The objective of the present study was to evaluate the effect and underlying neuroprotective mechanism of fluoxetine on the sensorimotor gating deficit, a schizophrenia-like behavior in a neurodevelopmental schizophrenic...
NeuroReport - Current Issue
01:32
Acute damage to the blood–brain barrier and perineuronal net integrity in a clinically-relevant of rat model traumatic brain
Closed-head, frontal impacts in which the brain undergoes both lateral and rotational acceleration comprise the majority of human traumatic brain injury (TBI). Here, we utilize a clinically relevant model to examine the effects of a single concussion on aspects of brain integrity: the blood–brain barrier, the perineuronal nets (PNNs), and diffuse axonal injury. Adult, male Sprague–Dawley rats received either a frontal, closed-head concussive TBI, or no injury and were evaluated at 1- or 7-day post-injury....
NeuroReport - Current Issue
01:32
The influence of the cross-modal emotional pre-preparation effect on audiovisual integration
Previous studies have shown that the cross-modal pre-preparation effect is an important factor for audiovisual integration. However, the facilitating influence of the pre-preparation effect on the integration of emotional cues remains unclear. Therefore, this study examined the emotional pre-preparation effect during the multistage process of audiovisual integration. Event-related potentials (ERPs) were recorded while participants performed a synchronous or asynchronous integration task with fearful...
NeuroReport - Current Issue
01:32
Voting is Open for the 2020 Oticon Focus on People Awards
Voting is now open for the 2020 Oticon Focus on People Awards at www.Oticon.com/FOP. People are invited to cast their votes for the 12 finalists who represent the "best of the best" from this year's nominations in each of four categories: Student, Adult, Advocacy and Practitioner. The total number of votes received by each finalist will help to determine who will be the first, second and third place winners in each category.This is the 22nd  year that the Oticon Focus on People Awards has honored...
Audiology
Mon Oct 05, 2020 13:51
Impact of Improper Approach to Identify Lid Wiper Epitheliopathy (LWE)
Clinical Ophthalmology
01:29
Quality of Life After Combined Cataract and Minimally Invasive Glaucoma Surgery in Glaucoma Patients
Clinical Ophthalmology
01:30
The Older Adults With Rectal Cancer—Does Age Matter?: A Single-center Experience
Objectives: Oncological treatments of older patients have many unresolved questions mainly because of the fact that these patients were not eligible to be included in most clinical trials. The aim of this study was to evaluate the treatment approach to localized rectal cancer in the older population, including complication rates and overall survival in patients treated with curative intent. Materials and Methods: A retrospective review of patients older than 80 years old (group A) who...
American Journal of Clinical Oncology - Published Ahead-of-Print
Fri Oct 02, 2020 03:00
Type 2 Diabetes Mellitus Induced Paracrine Effects on Breast Cancer Metastasis Through Extracellular Vesicles Derived from Human Mesenchymal Stem Cells
Stem Cells and Development, Ahead of Print.
Stem Cells and Development
Mon Oct 05, 2020 10:00
A Randomized Trial Comparing Antibiotics with Appendectomy for Appendicitis
Appendectomy has long been the standard treatment for appendicitis, even though successful use of antibiotic therapy as an alternative was reported more than 60 years ago. Although there have been several randomized trials of antibiotics for appendicitis in adults, exclusion of important subgroups…
The New England Journal of Medicine: Search Results in Primary Care\Hospitalist\Clinical Practice
Mon Oct 05, 2020 03:00
Antibiotics for Appendicitis — Proceed with Caution
More than 30 years ago, while I was in training, the best diagnostician I have ever met said — much to my surprise — that some patients who had uncomplicated appendicitis could be successfully treated nonoperatively. He had drawn that conclusion from his practical experiences in the medical corps,…
The New England Journal of Medicine: Search Results in Primary Care\Hospitalist\Clinical Practice
Mon Oct 05, 2020 03:00
S2k guidelines for the therapy of pathological scars (hypertrophic scars and keloids) – Update 2020
Wiley: JDDG: Journal der Deutschen Dermatologischen Gesellschaft: Table of Contents
Sun Oct 04, 2020 21:00
Manifestations, clinical course and prognostic markers in cutaneous polyarteritis nodosa
Summary Background and objectives Cutaneous polyarteritis nodosa (CPAN) is a comparatively rare form of vasculitis that affects small arteries and arterioles in the panniculus and dermo‐subcutaneous junction. Limited information is available regarding its course in the European population. The aim of this study is to characterize the manifestations and prognostic markers of recurrence in CPAN. Patients and methods We report a retrospective study of patients with clinical and histopathologic...
Wiley: JDDG: Journal der Deutschen Dermatologischen Gesellschaft: Table of Contents
Sun Oct 04, 2020 21:00
Patient preferences for treatment of advanced melanoma: impact of comorbidities
Summary Background and objectives Choice of treatment for advanced melanoma is crucially influenced by comorbidities and patient preferences. Our study aimed to investigate the impact of comorbidities on preferences. Patients and methods 150 patients with melanoma stage IIC–IV completed a discrete choice experiment to determine preferences for outcome (overall response rate [ORR], 2‐year survival, progression‐free survival [PFS], time to response [TTR], kind of adverse events [AE], AE‐related...
Wiley: JDDG: Journal der Deutschen Dermatologischen Gesellschaft: Table of Contents
Sun Oct 04, 2020 21:00
Stigmatization caused by hair loss – a systematic literature review
Summary Hair loss is a symptom that can cause stigmatization and severe impairment of quality of life. The aim of this systematic review was to evaluate the literature on stigmatization of hair loss. Using predefined MeSH terms and keywords, a systematic search was performed in the databases MEDLINE (PubMed), EMBASE, PsycINFO and PsycNET. No time restriction was chosen (last update: May 07, 2019; PROSPERO registration number: CRD42019122966). A total of 98 studies were identified, of which eleven...
Wiley: JDDG: Journal der Deutschen Dermatologischen Gesellschaft: Table of Contents
Sun Oct 04, 2020 21:10
Genome and transcriptome biomarkers of response to immune checkpoint inhibitors in advanced solid tumours
Purpose: Immune checkpoint inhibitors (ICIs) have revolutionised the treatment of solid tumours with dramatic and durable responses seen across multiple tumour types. However, identifying patients who will respond to these drugs remains challenging, particularly in the context of advanced and previously treated cancers. Experimental Design: We characterised fresh tumour biopsies from a heterogeneous pan-cancer cohort of 98 patients with metastatic predominantly pre-treated disease through the Personalized...
Clinical Cancer Research Online First Articles
Mon Oct 05, 2020 16:29
Anatomical Variations and Relationships of the Infratemporal Fossa: Foundation of a Novel Endonasal Approach to the Foramen Ovale
J Neurol Surg B Skull BaseDOI: 10.1055/s-0040-1715815 Objective Access to the infratemporal fossa (ITF) is complicated by its complex neurovascular relationships. In addition, copious bleeding from the pterygoid plexus adds to surgical challenge. This study aims to detail the anatomical relationships among the internal maxillary artery (IMA), pterygoid plexus, V3, and pterygoid muscles in ITF. Furthermore, it introduces a novel approach that displaces the lateral pterygoid plate (LPP)...
Journal of Neurological Surgery Part B: Skull Base
Mon Oct 05, 2020 02:00
The Role of CD68 (+) Histiocytic Macrophages in Nasal Polyp Development
J Neurol Surg B Skull BaseDOI: 10.1055/s-0040-1715593 Objectives The aim of this study was to investigate the role of CD68 (+) histiocytic macrophages (H-M) in the nasal polyp pathogenesis. Materials and Methods The study group consisted of 24 adult patients with nasal polyposis. The control group consisted of 11 adult patients without nasal polyps. A total of 36 nasal polyp samples (10-nasal cavity, 10-maxillary sinus, and 16-ethmoid sinus) from the study group and 11 inferior...
Journal of Neurological Surgery Part B: Skull Base
Mon Oct 05, 2020 02:00
Vestibular Schwannoma Tumor Size and Growth Rate Predict Response with Gamma Knife Stereotactic Radiosurgery
J Neurol Surg B Skull BaseDOI: 10.1055/s-0040-1716677 Objective The aim of this study is to determine if pretreatment growth of sporadic vestibular schwannomas (VS) predicts postradiosurgery response. Methods This study was a retrospective chart review at a tertiary referral center of patients with VS that had at least two pretreatment magnetic resonance imaging (MRI) studies at least 6 months apart and underwent Gamma Knife radiosurgery with a minimum of 14 months postradiosurgery...
Journal of Neurological Surgery Part B: Skull Base
Mon Oct 05, 2020 02:00
Acute Sigmoid Sinus Compromise Following Skull Base Procedures: Is a “Laissez-Faire” Approach Best?
J Neurol Surg B Skull BaseDOI: 10.1055/s-0040-1715811 Objective Venous sinus compromise (VSC) of the sigmoid sinus can manifest as either venous sinus thrombosis, stenosis, or a combination of the two. It may occur following retro and presigmoid craniotomy, even in the absence of overt intraoperative sinus injury. Currently, the optimal management of VSC in the perioperative period is not well established. We report our incidence and management of VSC following skull base surgery around...
Journal of Neurological Surgery Part B: Skull Base
Mon Oct 05, 2020 02:00
Regional Recurrences and Hyams Grade in Esthesioneuroblastoma
J Neurol Surg B Skull BaseDOI: 10.1055/s-0040-1715809 Objective The aim of this study is to determine if Hyams grade may help predict which patients with esthesioneuroblastoma (ENB) tumors are likely to develop regional recurrences, and to determine the impact of tumor extent on regional failure in ENB patients without evidence of nodal disease at presentation. Design The study was designed as a retrospective review for ENB patients. Settings The study was prepared...
Journal of Neurological Surgery Part B: Skull Base
Mon Oct 05, 2020 02:00
Temporal Bone Adenoma: A Comprehensive Analysis of Clinical Aspects and Surgical Outcome on a Very Rare Entity
J Neurol Surg B Skull BaseDOI: 10.1055/s-0040-1715812 Objective The aim of this study is to present our experience in dealing with middle ear adenomas (MEAs), very rare tumors of the middle ear. Methods The medical notes of individuals with MEAs treated in tertiary referral; academic settings were retrospectively reviewed. We recorded the presenting symptoms, imaging findings, and pathology results. We additionally examined our surgical outcomes, follow-up period, recurrence,...
Journal of Neurological Surgery Part B: Skull Base
Mon Oct 05, 2020 02:00
Predicting Anticoagulation Need for Otogenic Intracranial Sinus Thrombosis: A Machine Learning Approach
J Neurol Surg B Skull BaseDOI: 10.1055/s-0040-1713105 Objective The role of anticoagulation (AC) in the management of otogenic cerebral venous sinus thrombosis (OCVST) remains controversial. Our study aims to better define when AC is used in OCVST. Methods MEDLINE, EMBASE, and The Cochrane Library were searched from inception to February 14, 2019 for English and English-translated articles. References cited in publications meeting search criteria were searched. Titles and...
Journal of Neurological Surgery Part B: Skull Base
Mon Oct 05, 2020 02:00
Ovoid Foramen Magnum Shape is Associated with Increased Complications and Decreased Extent of Resection for Anterolateral Foramen Magnum Meningiomas
J Neurol Surg B Skull BaseDOI: 10.1055/s-0040-1715559 Background Antero-laterally located meningiomas of the foramen magnum (FM) pose significant surgical resection challenges. The effect of FM shape on surgical resection of FM meningiomas has not been previously studied. The present study investigates how FM shape effects the extent of tumor resection and complication rates in antero-lateral FM meningiomas. Materials and Methods This retrospective study included 16 consecutive...
Journal of Neurological Surgery Part B: Skull Base
Mon Oct 05, 2020 02:00
A first-in-human phase 1 and pharmacological study of TAS-119, a novel selective Aurora A kinase inhibitor in patients with advanced solid tumours
Cancer
03:00
Searching for causal relationships of glioma: a phenome-wide Mendelian randomisation study
Cancer
03:00
Deep sequencing detects human papillomavirus (HPV) in cervical cancers negative for HPV by PCR
Cancer
03:00
Deep sequencing detects human papillomavirus (HPV) in cervical cancers negative for HPV by PCR
British Journal of Cancer, Published online: 06 October 2020; doi:10.1038/s41416-020-01111-0Deep sequencing detects human papillomavirus (HPV) in cervical cancers negative for HPV by PCR
Cancer
03:00
A first-in-human phase 1 and pharmacological study of TAS-119, a novel selective Aurora A kinase inhibitor in patients with advanced solid tumours
British Journal of Cancer, Published online: 06 October 2020; doi:10.1038/s41416-020-01100-3A first-in-human phase 1 and pharmacological study of TAS-119, a novel selective Aurora A kinase inhibitor in patients with advanced solid tumours
Cancer
03:00

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