Related Articles Phenotypic and molecular spectrum of pyridoxamine-5'-phosphate oxidase (PNPO) deficiency: a scoping review of 87 cases of PNPO deficiency. Clin Genet. 2020 Sep 04;: Authors: Alghamdi M, Bashiri FA, Abdelhakim M, Adly N, Jamjoom DZ, Sumaily KM, Alghanem B, Arold ST Abstract Pyridoxamine-5'-phosphate oxidase (PNPO) deficiency is an autosomal recessive PLP-vitamin-responsive epileptic encephalopathy. The emerging feature of PNPO...
Sun Sep 06, 2020 14:05
Related Articles Repetitive transcranial photobiomodulation but not long-term omega-3 intake reduces epileptiform discharges in rats with stroke-induced epilepsy. J Biophotonics. 2020 Sep 05;:e202000287 Authors: Vogel DDS, Ortiz-Villatoro NN, de Freitas L, Aimbire F, Scorza FA, Albertini R, Scorza CA Abstract Epilepsy is a yet under-recognized consequence after a stroke and nearly 30% of cases are pharmacoresistant. There is an unmet need for...
Sun Sep 06, 2020 14:05
Related Articles Initial treatment of seizures in children in an emergency department in rural Japan. Brain Dev. 2020 Sep 01;: Authors: Shiraki A, Yasui M, Kidokoro H, Kido S, Ando H, Takahashi Y, Natsume J Abstract OBJECTIVE: Although the initial treatment of childhood seizures is important, treatment within an appropriate time window is often difficult in resource-limited areas. This study examined childhood seizure treatment in a rural area...
Sun Sep 06, 2020 14:05
Related Articles When and How to Treat Status Epilepticus: The Tortoise or the Hare? J Clin Neurophysiol. 2020 Sep;37(5):393-398 Authors: Fong MWK, Hirsch LJ Abstract Status epilepticus (SE) is a collective term that is used to describe a variety of subtypes. Forgetting this point can be perilous, even resulting in exposing patients to unnecessary harms. This review revisits the foundations of many of our current treatment guidelines, providing...
Sun Sep 06, 2020 14:05
Related Articles Impact of ABCB1 Polymorphism on Levetiracetam Serum Concentrations in Epileptic Uygur Children in China. Ther Drug Monit. 2020 Sep 01;: Authors: Zhao T, Yu J, Wang TT, Feng J, Zhao WB, Sun L, Yu LH, Li HJ, Sun Y Abstract BACKGROUND: Interindividual variations in the efficacy of antiseizure medications make epilepsy treatment challenging. This is due to genetic factors such as gene polymorphisms in ATP-Binding Cassette sub-family...
Sun Sep 06, 2020 14:05
Related Articles Trans-auricular Vagus Nerve Stimulation in the Treatment of Recovered Patients Affected by Eating and Feeding Disorders and Their Comorbidities. Psychiatr Danub. 2020 Sep;32(Suppl 1):42-46 Authors: Melis Y, Apicella E, Macario M, Dozio E, Bentivoglio G, Mendolicchio L Abstract INTRODUCTION: Eating and feeding disorders (EFD's) represent the psychiatric pathology with the highest mortality rate and one of the major disorders...
Sun Sep 06, 2020 14:05
Related Articles Novel brain permeant mTORC1/2 inhibitors are as efficacious as rapamycin or everolimus in mouse models of acquired partial epilepsy and tuberous sclerosis complex. Neuropharmacology. 2020 Sep 02;:108297 Authors: Theilmann W, Gericke B, Schidlitzki A, Muneeb Anjum SM, Borsdorf S, Harries T, Roberds SL, Aguiar DJ, Brunner D, Leiser SC, Song D, Fabbro D, Hillmann P, Wymann MP, Löscher W Abstract Mechanistic target of rapamycin...
Sun Sep 06, 2020 14:05
Related Articles Responsive neurostimulation for refractory epilepsy in the pediatric population: A single-center experience. Epilepsy Behav. 2020 Sep 01;112:107389 Authors: Bercu MM, Friedman D, Silverberg A, Drees C, Geller EB, Dugan PC, Devinsky O, Doyle WH Abstract Drug-resistant focal epilepsy (DRFE) in children can impair cognition and behavior, and lead to premature death. Increased pediatric epilepsy surgery numbers reflect the improvements...
Sun Sep 06, 2020 14:05
Related Articles Radio surgical Corpus Callosotomy: A Review of Literature. World Neurosurg. 2020 Sep 03;: Authors: Tripathi M, Maskara P, Rangan VS, Mohindra S, De Salles AAF, Kumar N Abstract BACKGROUND: Microsurgical callosotomy is a procedure still under debate and to best a palliative treatment for drug-resistant epilepsy. Unlike microsurgery, radiosurgical callosotomy is an under practiced treatment option with no definite account on its...
Tue Sep 08, 2020 11:12
Related Articles Removal of epileptically compromised tissue in the frontal cortex restores oculomotor selection in the antisaccade task. J Neuropsychol. 2019 06;13(2):289-304 Authors: Van der Stigchel S, Leijten FSS, Vansteensel MJ, Dijkerman HC, Ramsey NF, Freudenburg ZV Abstract The frontal cortex is heavily involved in oculomotor selection. Here, we investigated the neural correlates of eye movement selection during an antisaccade task...
Tue Sep 08, 2020 17:14
Related Articles Standardization of an Arabic-Language Neuropsychological Battery for Epilepsy Surgical Evaluations. J Int Neuropsychol Soc. 2019 08;25(7):761-771 Authors: Al-Joudi HF, Mincari L, Baz S, Nester M, Al-Marzouki N, Abalkhail T, Aljehani N, Al-Ibrahim C, Brandt J Abstract OBJECTIVES: This study provides a standardized Arabic language neuropsychological test battery and tests its ability to distinguish patients with left and right...
Tue Sep 08, 2020 17:14
Related Articles Update on the treatment of vitamin B6 dependent epilepsies. Expert Rev Neurother. 2019 11;19(11):1135-1147 Authors: Mastrangelo M, Cesario S Abstract Introduction: Vitamin B6 dependent epilepsies are a group of treatable diseases (ALDH7A1 deficiency, PNPO deficiency, PLP binding protein deficiency, hyperprolinaemia type II and hypophosphatasia and glycosylphosphatidylinositol anchor synthesis defects) responding to pyridoxine...
Tue Sep 08, 2020 17:14
Related Articles Infant with status epilepticus secondary to systemic lidocaine toxicity from topical application. BMJ Case Rep. 2020 Jan 12;13(1): Authors: Walters E, Wurster Ovalle V, Yin S, Dribin T Abstract A previously healthy 11-month-old infant presented to the emergency department in status epilepticus. There was no clear trigger of her seizure activity which resolved with benzodiazepines and fosphenytoin. On further review, her parents...
Tue Sep 08, 2020 17:14
Related Articles A Syndrome of Apparent Renal Failure. Ann Emerg Med. 2020 08;76(2):191-193 Authors: Simler MAZ, Desouky E, Zakharious F, Mandal AKJ, Missouris CG Abstract Pseudo-azotemia is the syndrome of hypercreatininemia and hyperkaliemia without a change in glomerular filtration rate or structure of the kidney. A 57-year-old vulnerable woman with learning difficulties experienced an intraperitoneal bladder rupture in the absence of a...
Tue Sep 08, 2020 17:14
Related Articles Coordinated downregulation of KCC2 and GABAA receptor contributes to inhibitory dysfunction during seizure induction. Biochem Biophys Res Commun. 2020 Sep 03;: Authors: Wan L, Chen L, Yu J, Wang G, Wu Z, Qian B, Liu X, Wang Y Abstract The GABAA receptor (GABAAR) is the main inhibitory receptor in the adult mammalian brain. GABAAR function is dependent on its expression, distribution, and the chloride (Cl-) transmembrane gradient,...
Tue Sep 08, 2020 17:14
Related Articles Evolution of Surgical Management for Intractable Epileptic Spasms. Semin Pediatr Neurol. 2020 Oct;35:100581 Authors: Rashid S, Chugani HT Abstract The understanding and management of epileptic spasms has considerably evolved since the mid 19th century. The realization that epileptic spasms can be generated from a focal brain lesion played a pivotal role in the development of neurosurgical management for intractable forms of...
Tue Sep 08, 2020 17:14
Mitochondrial Dysfunction in Autism Spectrum Disorder: Unique Abnormalities and Targeted Treatments.
Related Articles Mitochondrial Dysfunction in Autism Spectrum Disorder: Unique Abnormalities and Targeted Treatments. Semin Pediatr Neurol. 2020 Oct;35:100829 Authors: Frye RE Abstract Several lines of evidence implicate mitochondria in the pathophysiology of autism spectrum disorder (ASD). In this review, we outline some of the evidence supporting this notion, as well as discuss novel abnormalities in mitochondrial function that appear to be...
Tue Sep 08, 2020 17:14
Related Articles Epilepsy in Angelman syndrome: A scoping review. Brain Dev. 2020 Sep 03;: Authors: Samanta D Abstract Angelman Syndrome (AS) is characterized by severe developmental delays including marked speech impairment, movement abnormalities(ataxia, tremor), and unique behaviors such as frequent laughter and is caused by dysfunctional maternal UBE3A gene (maternal 15q11-13 deletions, maternal specific UBE3A mutation, uniparental disomy,...
Tue Sep 08, 2020 17:14
Related Articles Glial Modulation of Electrical Rhythms in a Neuroglial Network Model of Epilepsy. IEEE Trans Biomed Eng. 2020 Sep 07;PP: Authors: Grigorovsky V, Breton V, Bardakjian BL Abstract OBJECTIVE: An important EEG-based biomarker for epilepsy is the phase-amplitude cross-frequency coupling (PAC) of electrical rhythms; however, the underlying pathways of these pathologic markers are not always clear. Since glial cells have been shown...
Tue Sep 08, 2020 17:14
Related Articles 'We've made the best of it. But we do not have a normal life': families' experiences of tuberous sclerosis complex and seizure management. J Intellect Disabil Res. 2019 08;63(8):947-956 Authors: McDonald A, Goodwin J, Roberts S, Fish L, Vaughan B, Cooper A, Cadwgan J Abstract BACKGROUND: Tuberous sclerosis complex (TSC) is a complex multisystem genetic disorder. Approximately 84% of people with TSC have epilepsy. However, there...
Wed Sep 09, 2020 14:23
Related Articles Trends in epilepsy diagnosis and surgery in western China during 2009-2017. J Neurol Sci. 2019 Aug 15;403:153-158 Authors: Qiu X, Lai W, Kinoshita M, Zhang L, Li H, Peng A, Li W, Chen L Abstract OBJECTIVE: Despite the strong evidence for the efficacy of surgery to treat temporal lobe epilepsy, the number of such surgeries has plateaued in western countries. This study examined trends in the number of epilepsy cases diagnosed,...
Wed Sep 09, 2020 14:23
Related Articles Massive Ossification with Hematopoietic Marrow on Both Surfaces of the Expanded Polytetrafluoroethylene Artificial Dura Mater. World Neurosurg. 2020 07;139:405-409 Authors: Maehara N, Morioka T, Shimogawa T, Suzuki SO, Mizoguchi M, Haga S Abstract BACKGROUND: Artificial dural substitute made from an expanded polytetrafluoroethylene (ePTFE) sheet has been widely used in surgical application. CASE DESCRIPTION: We describe...
Wed Sep 09, 2020 14:23
Related Articles [Gender differences in the pool of free amino acid neurotransmitters in Krushinsky-Molodkina rats]. Biomed Khim. 2020 Feb;66(2):124-129 Authors: Krivopalov SA, Yushkov BG, Bykova MY, Zabegalov KN Abstract The study of the role of neurotransmitter systems in the pathogenesis of epilepsy is one of the priorities of epileptology. New data on the functions of free neurotransmitter-like amino acid in the central nervous system are...
Wed Sep 09, 2020 14:23
Related Articles A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy. Proc Natl Acad Sci U S A. 2020 07 07;117(27):15977-15988 Authors: Venø MT, Reschke CR, Morris G, Connolly NMC, Su J, Yan Y, Engel T, Jimenez-Mateos EM, Harder LM, Pultz D, Haunsberger SJ, Pal A, Heller JP, Campbell A, Langa E, Brennan GP, Conboy K, Richardson A, Norwood BA, Costard LS, Neubert V, Del Gallo F, Salvetti...
Wed Sep 09, 2020 14:23
Related Articles International consensus recommendations on the diagnostic work-up for malformations of cortical development. Nat Rev Neurol. 2020 Sep 07;: Authors: Oegema R, Barakat TS, Wilke M, Stouffs K, Amrom D, Aronica E, Bahi-Buisson N, Conti V, Fry AE, Geis T, Andres DG, Parrini E, Pogledic I, Said E, Soler D, Valor LM, Zaki MS, Mirzaa G, Dobyns WB, Reiner O, Guerrini R, Pilz DT, Hehr U, Leventer RJ, Jansen AC, Mancini GMS, Di Donato N Abstract...
Wed Sep 09, 2020 14:23
Related Articles Cyproheptadine in the treatment of reversible cerebral vasoconstriction syndrome. Acta Neurol Belg. 2020 Sep 08;: Authors: Chima J, Mullaguri N, Fan T, George P, Newey CR PMID: 32895901 [PubMed - as supplied by publisher]
Wed Sep 09, 2020 14:23
Related Articles Epilepsy in systemic lupus erythematosus. Clin Exp Rheumatol. 2020 Sep 04; Authors: Grasso EA, Cacciatore M, Gentile C, Breda L, Giacomelli R, Verrotti A Abstract Systemic lupus erythematosus (SLE) is an autoimmune systemic disease characterised by a broad spectrum of clinical manifestations that may also affect the central nervous system. Among the neurological symptoms, seizures were included in the criteria for the classification...
Wed Sep 09, 2020 14:23
Related Articles Seizure clusters, rescue treatments, seizure action plans: Unmet needs and emerging formulations. Epilepsy Behav. 2020 Sep 05;112:107391 Authors: Gidal B, Klein P, Hirsch LJ Abstract PURPOSE OF REVIEW: The aim of the study was to provide an overview of the prevalence, risk factors, burden, and current and emerging pharmacologic treatments for seizure clusters in patients with epilepsy. RECENT FINDINGS: Close to half...
Wed Sep 09, 2020 14:23
Related Articles Analyzing 2,589 child neurology telehealth encounters necessitated by the COVID-19 pandemic. Neurology. 2020 09 01;95(9):e1257-e1266 Authors: Rametta SC, Fridinger SE, Gonzalez AK, Xian J, Galer PD, Kaufman M, Prelack MS, Sharif U, Fitzgerald MP, Melamed SE, Malcolm MP, Kessler SK, Stephenson DJ, Banwell BL, Abend NS, Helbig I Abstract OBJECTIVE: To assess the rapid implementation of child neurology telehealth outpatient care...
Thu Sep 10, 2020 14:31
Related Articles Did the COVID-19 pandemic silence the needs of people with epilepsy? Epileptic Disord. 2020 Aug 01;22(4):439-442 Authors: Granata T, Bisulli F, Arzimanoglou A, Rocamora R Abstract The COVID-19 pandemic shook European healthcare systems, with unavoidable gaps in the management of patients with chronic diseases. We describe the impact of the pandemic on epilepsy care in three tertiary epilepsy centres from Spain and Italy, the...
Thu Sep 10, 2020 14:31
P2 × 7 Receptor Inhibits Astroglial Autophagy via Regulating FAK- and PHLPP1/2-Mediated AKT-S473 Phosphorylation Following Kainic Acid-Induced Seizures. Int J Mol Sci. 2020 Sep 04;21(18): Authors: Lee DS, Kim JE Abstract Recently, we have reported that blockade/deletion of P2X7 receptor (P2X7R), an ATP-gated ion channel, exacerbates heat shock protein 25 (HSP25)-mediated astroglial autophagy (clasmatodendrosis) following kainic acid (KA) injection....
Thu Sep 10, 2020 14:31
Immunologic phenotype of a child with the MEHMO syndrome. Physiol Res. 2020 Sep 09; Authors: Trochanová I, Staníková D, Škopková M, Haštová K, Gašperíková D, Staník J, Čižnár P Abstract MEHMO syndrome is a rare X-linked syndrome characterized by Mental retardation, Epilepsy, Hypogenitalism, Microcephaly, and Obesity associated with the defect of protein synthesis caused by the EIF2S3 gene mutations. We hypothesized that the defect in protein...
Thu Sep 10, 2020 14:31
Profile of MIF in Developing Hippocampus: Association With Cell Proliferation and Neurite Outgrowth.
Profile of MIF in Developing Hippocampus: Association With Cell Proliferation and Neurite Outgrowth. Front Mol Neurosci. 2020;13:147 Authors: Chai X, Zhang W, Li L, Wu Y, Zhu X, Zhao S Abstract Proinflammatory cytokine macrophage migration inhibitory factor (MIF) is a multifunctional cytokine and has been found involved in many neurological diseases such as Alzheimer disease (AD), epilepsy, and multiple sclerosis. Previous studies have shown...
Thu Sep 10, 2020 14:31
Effects of levetiracetam and lacosamide on therapeutic efficacy and neural function in patients with epilepsy. Exp Ther Med. 2020 Oct;20(4):3687-3694 Authors: Liu A, Gu Q, Wang M Abstract The present study aimed to investigate the effects of levetiracetam tablets and lacosamide (LCM) on therapeutic efficacy and neural function in patients with epilepsy. We assigned 252 patients with refractory partial seizures admitted to our hospital to receive...
Thu Sep 10, 2020 14:31
Overcoming Presynaptic Effects of VAMP2 Mutations with 4-Aminopyridine Treatment. Hum Mutat. 2020 Sep 09;: Authors: Simmons RL, Li H, Alten B, Santos MS, Jiang R, Paul B, Lalani SJ, Cortesi A, Parks K, Khandelwal N, Smith-Packard B, Phoong MA, Chez M, Fisher H, Scheuerle AE, Shinawi M, Hussain SA, Kavalali ET, Sherr EH, Voglmaier SM Abstract Clinical and genetic features of five unrelated patients with de novo pathogenic variants in the synaptic...
Thu Sep 10, 2020 14:31
Related Articles Localization of Expressive Language Cortex in a 2-Year-Old Child Using High-Gamma Electrocorticography. J Child Neurol. 2019 11;34(13):837-841 Authors: Babajani-Feremi A, Fulton SP, Holder CM, Choudhri AF, Boop FA, Wheless JW Abstract Cortical stimulation mapping is the gold standard for presurgical language mapping; however, it cannot be reliably performed in very young patients. Language mapping using noninvasive modalities...
Sat Sep 12, 2020 08:43
Related Articles Continuous Dynamic Mapping to Identify the Corticospinal Tract in Motor Eloquent Brain Tumors: An Update. J Neurol Surg A Cent Eur Neurosurg. 2020 Mar;81(2):105-110 Authors: Seidel K, Schucht P, Beck J, Raabe A Abstract OBJECTIVE: We recently developed a new subcortical mapping technique based on the concept of stimulating the tissue at the site of and synchronously with resection. Our hypothesis was that instead of performing...
Sat Sep 12, 2020 08:43
Related Articles Quality improvement in neurology: Neurology Outcomes Quality Measurement Set. Neurology. 2020 06 02;94(22):982-990 Authors: Sico JJ, Sarwal A, Benish SM, Busis NA, Cohen BH, Das RR, Finsilver S, Halperin JJ, Kelly AG, Meunier L, Phipps MS, Thirumala PD, Villanueva R, von Gaudecker J, Bennett A, Shenoy AM PMID: 32398356 [PubMed - indexed for MEDLINE]
Sat Sep 12, 2020 08:43
Related Articles CASPR2 autoimmunity in children expanding to mild encephalopathy with hypertension. Neurology. 2020 06 02;94(22):e2290-e2301 Authors: Syrbe S, Stettner GM, Bally J, Borggraefe I, Bien CI, Ferfoglia RI, Huppke P, Kern J, Polster T, Probst-Müller E, Schmid S, Steinfeld R, Strozzi S, Weichselbaum A, Weitz M, Ziegler A, Wandinger KP, Leypoldt F, Bien CG Abstract OBJECTIVE: To delineate autoimmune disease in association with contactin-associated...
Sat Sep 12, 2020 08:43
Related Articles Acute Hemorrhage After Intracerebral Biopsy in COVID-19 Patients: Report of 3 Cases. World Neurosurg. 2020 09;141:157-161 Authors: Degeneffe A, Bruneau M, Spitaels J, Gilis N, De Witte O, Lubansu A Abstract BACKGROUND: When Belgium's coronavirus disease 2019 (COVID-19) outbreak began in March 2020, our neurosurgical department followed the protocol of most surgical departments in the world and postponed elective surgery. However,...
Sat Sep 12, 2020 08:43
Letter to the Editor Regarding "Neuroinflammation in Children With Infantile Spasms: A Prospective Study Before and After Treatment with Acthar Gel (Repository Corticotropin Injection)". J Child Neurol. 2020 Sep 09;:883073820956769 Authors: Jiong Y, Hui Y PMID: 32907445 [PubMed - as supplied by publisher]
Sat Sep 12, 2020 08:43
Levetiracetam Induced Behavioral Abnormalities in a Patient with Seizure Disorder: A Diagnostic Challenge. Case Rep Psychiatry. 2020;2020:8883802 Authors: Ogunsakin O, Tumenta T, Louis-Jean S, Mahbub A, Rabel P, Olupona T, Alam S Abstract Levetiracetam is a second-generation antiepileptic drug that is chemically unrelated to other antiepileptic drugs. Levetiracetam is a broad-spectrum antiseizure medication that is approved as an adjunctive...
Sat Sep 12, 2020 08:43
Coumaronochromone as antibacterial and carbonic anhydrase inhibitors from Aerva persica (Burm.f.) Merr.: experimental and first-principles approaches. Z Naturforsch C J Biosci. 2020 Sep 09;: Authors: Imran M, Irfan A, Assiri MA, Sumrra SH, Saleem M, Hussain R, Al-Sehemi AG Abstract The Aerva plants are exceptionally rich in phytochemicals and possess therapeutics potential. Phytochemical screening shows that Aerva persica (Burm.f.) Merr. contains...
Sat Sep 12, 2020 08:43
Cannabidiol inhibits multiple cardiac ion channels and shortens ventricular action potential duration in vitro. Eur J Pharmacol. 2020 Sep 07;:173542 Authors: Le Marois M, Ballet V, Sanson C, Maizières MA, Carriot T, Chantoiseau C, Partiseti M, Bohme GA Abstract Cannabidiol (CBD) is a non-psychoactive component of Cannabis which has recently received regulatory consideration for the treatment of intractable forms of epilepsy such as the Dravet...
Sat Sep 12, 2020 08:43
Cardiac arrhythmias and sudden unexpected death in epilepsy: results of long-time monitoring. Heart Rhythm. 2020 Sep 07;: Authors: Serdyuk S, Davtyan K, Burd S, Drapkina O, Boytsov S, Gusev E, Topchyan A Abstract BACKGROUND: Cardiac rhythm and conduction disorders are common in patients with epilepsy and are presumably one of the leading causes of sudden unexpected death. There are only a few published reports on ictal cardiac arrhythmias detected...
Sat Sep 12, 2020 08:43
Electrical status epilepticus during sleep in patients with congenital Zika virus syndrome: An unprecedented clinical finding. Seizure. 2020 Aug 21;81:250-253 Authors: Krueger MB, Magalhães SC, Pessoa A, Bueno C, Masruha MR, Sobreira-Neto MA Abstract BACKGROUND: Brazil experienced a disproportionately higher rate of microcephaly cases in November 2015 with evidence of a causal link with Zika virus (ZIKV) infections during pregnancy. Epilepsy...
Sat Sep 12, 2020 08:43
Increase in cognitive function is seen in many single-operated pediatric patients after epilepsy surgery. Seizure. 2020 Aug 28;81:254-262 Authors: de Knegt VE, Hoei-Hansen CE, Knudsen M, Jakobsen AV, Mûller E, Thomsen KM, Jespersen B, Uldall PV, Børresen ML Abstract PURPOSE: The recurrent seizures of pediatric drug-resistant epilepsy (DRE) are known to impair brain development and can lead to a loss in cognitive functioning. Surgery is increasingly...
Sat Sep 12, 2020 08:43
Effects of perampanel add-on therapy on immunoglobulin levels in pediatric patients with epilepsy. Epilepsy Res. 2020 Aug 21;167:106447 Authors: Ishikawa N, Tateishi Y, Tani H, Kobayashi Y, Okada S Abstract BACKGROUND: Perampanel (PER) has a unique pharmacological mechanism and marked efficacy in both focal and generalized epilepsy, but may cause adverse events similar to those of other antiepileptic drugs (AEDs). AEDs can affect multiple organ...
Sat Sep 12, 2020 08:43
Age-Dependent Reduction in Severity and Discrete Topographical Patterns in Rasmussen Encephalitis: A Link to Cortical Maturation? Pediatr Neurol. 2020 Aug 11;112:25-33 Authors: Benjamin RN, Thomas M, Muthusamy K, Yoganathan S, Mathew V, Chacko AG, Prabhu K, Chacko G Abstract BACKGROUND: Autopsy studies in Rasmussen encephalitis reveal areas of sparing within the affected hemisphere. Clinical progression and inflammation are milder with an older...
Sat Sep 12, 2020 08:43
28 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: epilepsy treatment These pubmed results were generated on 2020/09/12PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sat Sep 12, 2020 14:44
28 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: epilepsy treatment These pubmed results were generated on 2020/09/12PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sat Sep 12, 2020 23:49
Clinical characteristics of KCNQ2 encephalopathy. Brain Dev. 2020 Sep 08;: Authors: Kim HJ, Yang D, Kim SH, Won D, Kim HD, Lee JS, Choi JR, Lee ST, Kang HC Abstract PURPOSE: KCNQ2 mutations are associated with benign familial neonatal epilepsy (BFNE) or developmental and epileptic encephalopathy (DEE). In this study, we aimed to delineate the phenotype of KCNQ2 encephalopathy and evaluate the treatment response. METHODS: Thirteen patients...
Mon Sep 14, 2020 06:27
Brain-responsive corticothalamic stimulation in the centromedian nucleus for the treatment of regional neocortical epilepsy. Epilepsy Behav. 2020 Sep 09;112:107354 Authors: Burdette DE, Haykal MA, Jarosiewicz B, Fabris RR, Heredia G, Elisevich K, Patra SE Abstract OBJECTIVE: The aim of the study was to determine if corticothalamic responsive stimulation targeting the centromedian nucleus of the thalamus (CMT) is a potential treatment for neocortical...
Mon Sep 14, 2020 06:27
Clinical characteristics and outcomes in pregnant women with epilepsy. Epilepsy Behav. 2020 Sep 09;112:107433 Authors: Huang CY, Dai YM, Feng LM, Gao WL Abstract BACKGROUND: Epilepsy in pregnancy can lead to substantial maternal and neonatal morbidity and mortality. Early intervention in pregnant women with epilepsy (WWE), accurate assessment of the severity of their condition, and effective treatment are required to improve maternal and neonatal...
Mon Sep 14, 2020 06:27
Adipose-Derived Stem Cell transplantation improves learning and memory via releasing neurotrophins in rat model of temporal lobe epilepsy. Brain Res. 2020 Sep 10;:147121 Authors: Wang L, Zhao Y, Pan X, Zhang Y, Lin L, Wu Y, Huang Y, He H Abstract Epilepsy is a common neurological disease and its most common type is temporal lobe epilepsy (TLE). Novel therapeutics is needed as many TLE patients are resistant to treatments like anticonvulsants...
Tue Sep 15, 2020 04:08
Access to healthcare and prevalence of anxiety and depression in persons with epilepsy during the COVID-19 pandemic: A multicountry online survey. Epilepsy Behav. 2020 Sep 10;112:107350 Authors: Van Hees S, Siewe Fodjo JN, Wijtvliet V, Van den Bergh R, Faria de Moura Villela E, da Silva CF, Weckhuysen S, Colebunders R Abstract OBJECTIVE: The objective of this study was to assess access to healthcare and to estimate the prevalence of depression...
Tue Sep 15, 2020 04:08
Evaluation of pediatric patients in new-onset seizure clinic (NOSc). Epilepsy Behav. 2020 Sep 10;112:107428 Authors: Kim S, DeGrauw T, Berg AT, Hass KB, Koh S Abstract AIM: We evaluated the clinical and demographic features of children presenting with unprovoked seizures at a regional new-onset seizure clinic (NOSc). METHODS: We retrospectively reviewed charts of 492 consecutive patients evaluated in the NOSc at the Childrne's Healthcare...
Tue Sep 15, 2020 04:08
Cognitive, adaptive, and behavioral effects of adjunctive rufinamide in Lennox-Gastaut syndrome: A prospective observational clinical study. Epilepsy Behav. 2020 Sep 10;112:107445 Authors: Operto FF, Verrotti A, Marrelli A, Ciuffini R, Coppola G, Pastorino GMG, Striano P, Sole M, Zucca C, Manfredi V, Città S, Elia M Abstract INTRODUCTION: Lennox-Gastaut syndrome (LGS) is a severe pediatric epilepsy syndrome characterized by multiple drug-resistant...
Tue Sep 15, 2020 04:08
22 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: epilepsy treatment These pubmed results were generated on 2020/09/15PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Tue Sep 15, 2020 13:26
22 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: epilepsy treatment These pubmed results were generated on 2020/09/15PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Tue Sep 15, 2020 16:32
Related Articles [Audit on management of seizures in six Swedish hospitals]. Lakartidningen. 2020 04 22;117: Authors: Al-Jashami F, Berglund M, Bergström L, Bäärnhielm M, Eriksson H, Kumlien E, Melin S, Vall V, Zelano J Abstract Six Swedish hospitals (four university hospitals and two regional hospitals) participated in a pan-European quality assurance project regarding acute management of seizures. Three hundred consecutive emergency department...
Thu Sep 17, 2020 02:34
Related Articles Determinants of quality of life in adults living with epilepsy. Ann Afr Med. 2020 Jul-Sep;19(3):164-169 Authors: Ayanda KA, Sulyman D Abstract Background: Quality of life (QOL) is a vital outcome measure in people living with epilepsy. The aim of this study is to determine the sociodemographic and clinical factors that predict poor QOL in patients with epilepsy. Materials and Methods: This is a descriptive cross-sectional...
Thu Sep 17, 2020 02:34
Related Articles Effects of spore powder of ganoderma lucidum on CaSR and apoptosis-related proteins in hippocampus tissue of epilepsy following dementia: A protocol of systematic review. Medicine (Baltimore). 2020 Aug 14;99(33):e21711 Authors: Qin LH, Wang C, Jiang XX, Song Y, Feng Y, Qin LW, Zhang SP Abstract BACKGROUND: This study will investigate the effects of Spore Powder of Ganoderma Lucidum (SPGL) on CaSR and apoptosis-related proteins...
Thu Sep 17, 2020 02:34
Related Articles In vivo assessment of mechanisms underlying the neurovascular basis of postictal amnesia. Sci Rep. 2020 Sep 14;10(1):14992 Authors: Farrell JS, Colangeli R, Dudok B, Wolff MD, Nguyen SL, Jackson J, Dickson CT, Soltesz I, Teskey GC Abstract Long-lasting confusion and memory difficulties during the postictal state remain a major unmet problem in epilepsy that lacks pathophysiological explanation and treatment. We previously identified...
Thu Sep 17, 2020 02:34
Related Articles KA-104, a new multitargeted anticonvulsant with potent antinociceptive activity in preclinical models. Epilepsia. 2020 Sep 14;: Authors: Kamiński K, Mogilski S, Abram M, Rapacz A, Latacz G, Szulczyk B, Walczak M, Kuś K, Matyjaszczyk K, Kamiński RM Abstract OBJECTIVE: The main objective of the present work was to assess the utility of KA-104 as potential therapy for drug-resistant seizures and neuropathic pain, and to characterize...
Thu Sep 17, 2020 02:34
Related Articles [Resistant epileptic encephalopathy in a child with microcephalic capillary malformation syndrome]. Zh Nevrol Psikhiatr Im S S Korsakova. 2020;120(8):110-116 Authors: Shchugareva LM, Poteshkina OV, Shumeeva AG, Galaktionova SM Abstract Treatment resistant epileptic encephalopathy (EE) in childhood in a significant amount due to genetic damage or congenital abnormalities of the brain. The literature described a rare microcephalic-capillary...
Thu Sep 17, 2020 02:34
Related Articles Cysticercosis and suicide - an example from a forensic collection. Forensic Sci Med Pathol. 2020 Sep 15;: Authors: Nikolić S, Cvetković D, Živković V Abstract In this case from 1937, the deceased was a 52-year-old female who was suffering from systemic cysticercosis, with prominent neurological and psychiatric symptoms. Given the protracted clinical course and autopsy findings it appears likely that the disease led the woman...
Thu Sep 17, 2020 02:34
Related Articles The functional connectivity study on the brainstem-cortical/subcortical structures in responders following cervical vagus nerve stimulation. Int J Dev Neurosci. 2020 Sep 15;: Authors: Zhu J, Wang J, Xu C, Zhang X, Qiao L, Wang X, Zhang X, Yan X, Ni D, Yu T, Zhang G, Li Y Abstract BACKGROUND: Cervical vagus nerve stimulation (VNS) is an effective neuromodulation therapy for patients with drug-resistant epilepsy (DRE). The previous...
Thu Sep 17, 2020 02:34
Related Articles Etiology-related degree of sprouting of parvalbumin-immunoreactive axons in the human dentate gyrus in temporal lobe epilepsy. Neuroscience. 2020 Sep 12;: Authors: Ábrahám H, Molnár JE, Sóki N, Gyimesi C, Horváth Z, Janszky J, Dóczi T, Seress L Abstract In the present study, we examined parvalbumin-immunoreactive cells and axons in the dentate gyrus of surgically resected tissues of therapy-resistant temporal lobe epilepsy (TLE)...
Thu Sep 17, 2020 02:34
Related Articles A 2-point difference of NIHSS as a predictor of acute ischemic stroke outcome at 3 months after thrombolytic therapy. Clin Neurol Neurosurg. 2020 Sep 08;198:106206 Authors: Jantasri S, Tiamkao S, Sawanyawisuth K Abstract OBJECTIVE: A good functional response at 24 h from an intravenous recombinant tissue plasminogen activator (rtPA) treatment is associated with 3-month ischemic stroke outcome. The criterion for 24 -h neurological...
Thu Sep 17, 2020 02:34
Related Articles [Pyridoxine-dependent epilepsy due to deficiency in the PNPO gene]. Rev Neurol. 2019 10 01;69(7):303-304 Authors: Garcia-Ezquiaga J, Carrasco-Marina ML, Gutierrez-Cruz N, Iglesias-Escalera G, Castro-Reguera M, Perez-Gonzalez B PMID: 31559630 [PubMed - indexed for MEDLINE]
Thu Sep 17, 2020 14:58
Related Articles Evaluation of the ameliorative effects of oral administration of metformin on epileptogenesis in the temporal lobe epilepsy model in rats. Life Sci. 2020 Sep 15;257:118066 Authors: Vazifehkhah S, Ali MK, Babae JF, Hashemi P, Alireza MS, Nikbakht F Abstract AIMS: Understanding the underlying molecular mechanisms involved in epileptogenesis is necessary to target the best therapeutic interventions in epilepsy. Recently, it has...
Thu Sep 17, 2020 14:58
Related Articles Levetiracetam Reduced the Basal Excitability of the Dentate Gyrus without Restoring Impaired Synaptic Plasticity in Rats with Temporal Lobe Epilepsy. Brain Sci. 2020 Sep 11;10(9): Authors: González-H G, Contreras-García IJ, Sánchez-Huerta K, Queiroz CMT, Gallardo Gudiño LR, Mendoza-Torreblanca JG, Zamudio SR Abstract Temporal lobe epilepsy (TLE), the most common type of focal epilepsy, affects learning and memory; these effects...
Thu Sep 17, 2020 14:58
Related Articles The Child & Youth CompreHensIve Longitudinal Database for Deep Brain Stimulation (CHILD-DBS). Childs Nerv Syst. 2020 Sep 15;: Authors: Yan H, Siegel L, Breitbart S, Gorodetsky C, Gonorazky HD, Yau I, Go C, Donner E, Kalia SK, Fasano A, Weil AG, Fallah A, Ibrahim GM Abstract PURPOSE: Deep brain stimulation (DBS) is a common tool for the treatment of movement disorders in adults; however, it remains an emerging treatment modality...
Thu Sep 17, 2020 14:58
Related Articles Inclusion of medical fitness to drive in medical postgraduate training curricula. J R Coll Physicians Edinb. 2020 Sep;50(3):309-315 Authors: Azawi LA, O'Byrne A, Roche L, Ryan M Abstract BACKGROUND: Transport mobility and access to driving are important factors in social inclusion and wellbeing. Doctors have an important role to play in supporting safe mobility through applying the knowledge developed in the field of traffic...
Thu Sep 17, 2020 14:58
Related Articles The RNS System: brain-responsive neurostimulation for the treatment of epilepsy. Expert Rev Med Devices. 2020 Sep 16;:1-10 Authors: Jarosiewicz B, Morrell M Abstract INTRODUCTION: Epilepsy affects more than 1% of the US population, and over 30% of adults with epilepsy do not respond to antiseizure medications without life-impacting medication-related side effects. Resection of the seizure focus is not an option for many patients...
Thu Sep 17, 2020 14:58
Related Articles Application of Plasma Exchange in Steroid-Responsive Encephalopathy. Front Immunol. 2019;10:324 Authors: Jiang Y, Tian X, Gu Y, Li F, Wang X Abstract Plasma exchange has been widely used in autoimmune neurological diseases and is the standard treatment for myasthenia gravis crisis and Guillain-Barre syndrome. A growing body of research suggests that, in the clinical application of steroid-responsive encephalopathy, such as...
Fri Sep 18, 2020 15:46
Related Articles Evaluation of Cardiac Repolarization Indices in Epilepsy Patients Treated with Carbamazepine and Valproic Acid. Medicina (Kaunas). 2020 Jan 06;56(1): Authors: Asoğlu R, Özdemir M, Aladağ N, Asoğlu E Abstract BACKGROUND AND OBJECTIVES: Epilepsy patients have a higher risk of sudden unexplained death compared to the rest of the population. Cardiac repolarization abnormalities might be seen in epilepsy during interictal periods....
Fri Sep 18, 2020 15:46
Related Articles Incidence and case fatality rate of COVID-19 in patients with active epilepsy. Neurology. 2020 09 08;95(10):e1417-e1425 Authors: Cabezudo-García P, Ciano-Petersen NL, Mena-Vázquez N, Pons-Pons G, Castro-Sánchez MV, Serrano-Castro PJ Abstract OBJECTIVE: This article estimates the incidence and fatality of coronavirus disease 2019 (COVID-19) and identifies potential risk factors for fatality in patients with active epilepsy....
Fri Sep 18, 2020 15:46
Related Articles Neuroinflammation and progressive myoclonus epilepsies: from basic science to therapeutic opportunities. Expert Rev Mol Med. 2020 Sep 17;22:e4 Authors: Sanz P, Serratosa JM Abstract Progressive myoclonus epilepsies (PMEs) are a group of genetic neurological disorders characterised by the occurrence of epileptic seizures, myoclonus and progressive neurological deterioration including cerebellar involvement and dementia. The primary...
Fri Sep 18, 2020 15:46
Related Articles Changes in access to educational and healthcare services for individuals with intellectual and developmental disabilities during COVID-19 restrictions. J Intellect Disabil Res. 2020 Sep 17;: Authors: Jeste S, Hyde C, Distefano C, Halladay A, Ray S, Porath M, Wilson RB, Thurm A Abstract BACKGROUND: COVID-19 restrictions have significantly limited access to in-person educational and healthcare services for all, including individuals...
Fri Sep 18, 2020 15:46
Related Articles Sirolimus as a Potential Treatment for Sturge-Weber Syndrome. J Craniofac Surg. 2020 Sep 15;: Authors: Sun B, Han T, Wang Y, Gao Q, Cui J, Shen W Abstract BACKGROUND: Sturge-Weber syndrome (SWS) is a rare neurocutaneous syndrome characterized by port-wine stain, leptomeningeal angiomatosis, and glaucoma. Due to the involvement of the nervous system, patients are often accompanied with epilepsy. It reported that 75% of patients...
Fri Sep 18, 2020 15:46
Related Articles Gabapentin treatment in a patient with KCNQ2 developmental epileptic encephalopathy. Pharmacol Res. 2020 Sep 14;:105200 Authors: Soldovieri MV, Freri E, Ambrosino P, Rivolta I, Mosca I, Binda A, Murano C, Ragona F, Canafoglia L, Vannicola C, Solazzi R, Granata T, Castellotti B, Messina G, Gellera C, Labalme A, Lesca G, DiFrancesco JC, Taglialatela M Abstract DE NOVO: variants in KCNQ2 encoding for Kv7.2 voltage-dependent neuronal...
Fri Sep 18, 2020 15:46
Related Articles Efficacy of vagus nerve stimulation for drug-resistant epilepsy in children age six and younger. Epilepsy Behav. 2020 Sep 14;112:107373 Authors: Muthiah N, Zhang J, Remick M, Welch W, Sogawa Y, Jeong JH, Abel TJ Abstract OBJECTIVES: The objective of the study were to examine the safety and efficacy of vagus nerve stimulation (VNS) for reducing seizure frequency and antiepileptic drugs (AEDs) in children younger than six years...
Fri Sep 18, 2020 15:46
Related Articles Virtual Reality-Assisted Pain, Anxiety, and Anger Management in the Emergency Department. Telemed J E Health. 2019 12;25(12):1207-1215 Authors: Sikka N, Shu L, Ritchie B, Amdur RL, Pourmand A Abstract Study Objective: Pain management in emergency department (ED) patients is challenging. Although both pharmacological and nonpharmacological therapies exist, they are often suboptimal. Immersive virtual reality (VR) uses distraction...
Sun Sep 20, 2020 07:58
Related Articles Tacrolimus protects hippocampal neurons of rats with status epilepticus through suppressing oxidative stress and inhibiting mitochondrial pathway of apoptosis. Brain Res. 2019 07 15;1715:176-181 Authors: Wang A, Si Z, Xue P, Li X, Liu J Abstract OBJECTIVE: To investigate the mechanisms underlying the neuroprotective effect of tacrolimus (FK506) on the hippocampal neurons of rats with status epilepticus (SE). METHOD:...
Sun Sep 20, 2020 07:58
Related Articles Genomic and Personalized Medicine Perspective in Genetic Generalized Epilepsy. Arch Iran Med. 2019 09 01;22(9):516-526 Authors: Torabian P, Dehestani M, Morshedi Rad D, Peiravi S, Aghaie-Hakkak M, Ashraf H Abstract The genetic generalized epilepsies (GGEs) are a set of disorders presenting with generalized seizures, in addition to general spike-wave activity. The present study aims to investigate the clinical manifestations...
Sun Sep 20, 2020 07:58
Related Articles Clinical analysis of reversible splenial lesion syndrome in Chinese adults: A retrospective study of 11 cases. Medicine (Baltimore). 2020 Sep 04;99(36):e22052 Authors: Gao X, Feng Q, Arif S, Liaqat J, Li B, Jiang K Abstract Reversible splenial lesion syndrome (RESLES) is a clinico-radiological entity that defines a reversible lesion in the splenium of the corpus callosum (SCC) on magnetic resonance imaging (MRI). The clinical...
Sun Sep 20, 2020 07:58
Related Articles Youth Weigh In: Views on Advanced Neurotechnology for Drug-Resistant Epilepsy. J Child Neurol. 2020 Sep 17;:883073820957810 Authors: Udwadia FR, McDonald PJ, Connolly MB, Hrincu V, Illes J Abstract BACKGROUND: Epilepsy affects over 500,000 children in North America of whom 30% have drug-resistant epilepsy. Advancements with neurotechnologies show promising benefits, but the perceptions of these procedures by youth is unknown....
Sun Sep 20, 2020 07:58
Related Articles Changes in caregiver depression, anxiety, and satisfaction with family relationships in families of children who did and did not undergo resective epilepsy surgery. Epilepsia. 2020 Sep 17;: Authors: Phillips NL, Widjaja E, Smith ML Abstract OBJECTIVE: To evaluate longitudinal changes in caregiver depression, anxiety, and family relationships following resective surgery for pediatric drug-resistant epilepsy (DRE). METHODS:...
Sun Sep 20, 2020 07:58
Related Articles Long-term efficacy and safety of eslicarbazepine acetate monotherapy for adults with newly diagnosed focal epilepsy: An open-label extension study. Epilepsia. 2020 Sep 17;: Authors: Trinka E, Rocamora R, Chaves J, Moreira J, Ikedo F, Soares-da-Silva P, BIA-2093-311/EXT Investigators Study Group Abstract OBJECTIVE: To assess the efficacy, safety, and tolerability of eslicarbazepine acetate (ESL) monotherapy during long-term treatment....
Sun Sep 20, 2020 07:58
Related Articles Seizure-onset regions demonstrate high inward directed connectivity during resting-state: An SEEG study in focal epilepsy. Epilepsia. 2020 Sep 18;: Authors: Narasimhan S, Kundassery KB, Gupta K, Johnson GW, Wills KE, Goodale SE, Haas K, Rolston JD, Naftel RP, Morgan VL, Dawant BM, González HFJ, Englot DJ Abstract OBJECTIVE: In patients with medically refractory focal epilepsy, stereotactic-electroencephalography (SEEG) can aid...
Sun Sep 20, 2020 07:58
Related Articles Odor identification predicts postoperative seizure control following magnetic resonance-guided laser interstitial thermal therapy. Epilepsia. 2020 Sep 17;: Authors: Kang JY, Yenokyan G, Hwang BY, Chen M, Penn R, Mampre D, Sperling MR, Kamath V Abstract OBJECTIVE: Olfactory dysfunction has been well documented in individuals with temporal lobe epilepsy, but its use in presurgical planning has yet to be examined. We assessed the...
Sun Sep 20, 2020 07:58
Related Articles Effects of zonisamide monotherapy on bone health in drug-naive epileptic patients. Epilepsia. 2020 Sep 18;: Authors: Koo DL, Nam H Abstract OBJECTIVE: Alteration of bone strength is an adverse effect of antiepileptic drug treatment. We investigated the effects of zonisamide (ZNS) monotherapy on bone mineral density (BMD) and biomarkers of bone metabolism after 13 months of treatment in drug-naive epileptic patients. ...
Sun Sep 20, 2020 07:58
Related Articles MicroRNAs and target genes in epileptogenesis. Epilepsia. 2020 Sep 18;: Authors: Feng Y, Yang H, Yue Y, Tian F Abstract Epilepsy is a chronic brain dysfunction. Current antiepileptic medicines cannot prevent epileptogenesis. Increasing data have shown that microRNAs (miRNAs) are selectively altered within the epileptic hippocampi of experimental models and human tissues, and these alterations affect the genes that control epileptogenesis....
Sun Sep 20, 2020 07:58
Related Articles Safety and tolerability associated with chronic intermittent use of diazepam buccal film in adult, adolescent, and pediatric patients with epilepsy. Epilepsia. 2020 Sep 17;: Authors: Seinfeld S, Gelfand MA, Heller AH, Buan C, Slatko G Abstract OBJECTIVE: Diazepam buccal film (DBF) is in development for treatment of patients experiencing bouts of increased seizure activity. We assessed safety, tolerability, and usability of self-...
Sun Sep 20, 2020 07:58
Related Articles miR‑15a inhibits cell apoptosis and inflammation in a temporal lobe epilepsy model by downregulating GFAP. Mol Med Rep. 2020 Jul 30;: Authors: Fan Y, Wang W, Li W, Li X Abstract Temporal lobe epilepsy (TLE) is a type of epilepsy, which is associated with high morbidity and recurrence rates, and is also difficult to treat. Therefore, it is important to identify novel treatments for TLE. In recent years, with the development of...
Sun Sep 20, 2020 07:58
Related Articles Efficacy and safety of Fenfluramine hydrochloride for the treatment of seizures in Dravet syndrome: A real-world study. Epilepsia. 2020 Sep 18;: Authors: Specchio N, Pietrafusa N, Doccini V, Trivisano M, Darra F, Ragona F, Cossu A, Spolverato S, Battaglia D, Quintiliani M, Luigia Gambardella M, Rosati A, Mei D, Granata T, Dalla Bernardina B, Vigevano F, Guerrini R Abstract OBJECTIVE: Dravet syndrome (DS) is a drug-resistant,...
Sun Sep 20, 2020 07:58
Related Articles Verbal memory dysfunction is associated with alterations in brain transcriptome in dominant temporal lobe epilepsy. Epilepsia. 2020 Sep 18;: Authors: Busch RM, Yehia L, Bazeley P, Seyfi M, Blümcke I, Hermann BP, Najm IM, Eng C Abstract OBJECTIVE: Memory dysfunction is prevalent in many neurological disorders and can have a significant negative impact on quality of life. The genetic contributions to memory impairment in epilepsy,...
Sun Sep 20, 2020 07:58
Related Articles Discovery of Vixotrigine: A Novel Use-Dependent Sodium Channel Blocker for the Treatment of Trigeminal Neuralgia. ACS Med Chem Lett. 2020 Sep 10;11(9):1678-1687 Authors: Witty DR, Alvaro G, Derjean D, Giblin GMP, Gunn K, Large C, Macpherson DT, Morisset V, Owen D, Palmer J, Rugiero F, Tate S, Hinckley CA, Naik H Abstract Drugs that block voltage-gated sodium channels (NaVs) have utility in treating conditions including pain,...
Sun Sep 20, 2020 07:58
Related Articles Evaluation of the interrater and intermethod agreement of the German multiparametric ultrasound criteria for the grading of internal carotid artery stenosis. Neuroradiology. 2020 Sep 18;: Authors: Richter C, Weinreich A, Mucha S, Saur D, Pelz JO Abstract PURPOSE: The interdisciplinary German guidelines for the diagnosis and treatment of internal carotid artery stenosis (ICAS) recommend a multiparametric approach for the sonographic...
Sun Sep 20, 2020 07:58
Related Articles Prevalence and predictors of post-stroke epilepsy among Ghanaian stroke survivors. J Neurol Sci. 2020 Sep 12;418:117138 Authors: Sarfo FS, Akassi J, Obese V, Adamu S, Agbenorku M, Ovbiagele B Abstract BACKGROUND: Post-stroke epilepsy (PSE) is associated with poorer quality of life, higher mortality, and greater health expenditures. We are unaware of any published reports on the frequency of and factors associated with PSE in...
Sun Sep 20, 2020 07:58
Related Articles Quality of life in patients with epilepsy or psychogenic nonepileptic seizures and the contribution of psychiatric comorbidities. Epilepsy Behav. 2020 Sep 15;112:107447 Authors: Avalos JC, Silva BA, Tevés Echazu MF, Rosso B, Besocke AG, Del Carmen Garcia M Abstract Epilepsy is a common neurological disorder, and psychogenic nonepileptic seizures (PNES) is an important differential diagnosis. Psychiatric comorbidities are prevalent...
Sun Sep 20, 2020 07:58
Related Articles Impact of Early Initiation of Eslicarbazepine Acetate on Economic Outcomes Among Patients with Focal Seizure: Results from Retrospective Database Analyses. Neurol Ther. 2020 Sep 19;: Authors: Mehta D, Davis M, Epstein AJ, Wensel B, Grinnell T, Williams GR Abstract INTRODUCTION: This study assessed the association between early initiation of eslicarbazepine acetate (ESL) as first-line therapy (1L cohort) or as first adjunctive...
Sun Sep 20, 2020 14:10
Related Articles Spectral power of interictal EEG in the diagnosis and prognosis of idiopathic generalized epilepsies. Epilepsy Behav. 2020 Sep 16;112:107427 Authors: Pegg EJ, Taylor JR, Mohanraj R Abstract INTRODUCTION: Idiopathic generalized epilepsies (IGE) are characterized by generalized interictal epileptiform discharges (IEDs) on a normal background electroencephalography (EEG). However, the yield of IEDs can be low. Approximately 20%...
Sun Sep 20, 2020 17:11
Related Articles Prevalence and incidence of vertebral fractures: a 7-year follow-up study in institutionalized adults with refractory epilepsy and intellectual disability. Epilepsy Res. 2020 Sep 10;167:106461 Authors: Berkvens J, Majoie M, Mergler S, Beerhorst K, Verschuure P, Tan I, den Bergh JV Abstract OBJECTIVE: The main objective of this cohort study is to determine the prevalence and incidence of morphometric vertebral fractures (VFs)...
Sun Sep 20, 2020 17:11
Related Articles Familial mesial temporal lobe epilepsy in Mexico: Inheritance pattern and clinical features. Epilepsy Res. 2020 Sep 01;167:106450 Authors: Guzmán-Jiménez DE, Campos JB, Venegas-Vega CA, Sánchez MA, Velasco AL Abstract PURPOSE: The objectives of this study were to determine the inheritance pattern by which familial mesial temporal lobe epilepsy (FMTLE) is segregated in Mexican families, and to identify if there was an association...
Sun Sep 20, 2020 17:11
Evolving targets for anti-epileptic drug discovery. Eur J Pharmacol. 2020 Sep 17;:173582 Authors: Raut D, Bhatt LK Abstract Epilepsy is a neurological disorder that affects almost 70 million people worldwide of all socioeconomic groups. The currently available medications aim to restore the balance between excitatory and inhibitory neurotransmitters by acting on ion channels, receptors, transporters, and enzymes, thus providing symptomatic...
Mon Sep 21, 2020 14:22
Physical exercise and 5-hydroxytryptophan, a precursor for serotonin synthesis, reduce penicillin-induced epileptiform activity. Epilepsy Behav. 2020 Sep 17;112:107403 Authors: Kayacan Y, Ghojebeigloo BE, Çerit G, Kocacan SE, Ayyıldız M Abstract AIM: Previous studies have shown that 5- hydroxytryptophan (5-HTP) and exercise play an important role in the synthesis of serotonin independently. The effects of the treadmill exercise and 5- hydroxytryptophan...
Mon Sep 21, 2020 14:22
Related Articles The role of melatonin and its analogues in epilepsy. Rev Neurosci. 2020 Sep 21;: Authors: Khan S, Khurana M, Vyas P, Vohora D Abstract Extensive research has gone into proposing a promising link between melatonin administration and attenuation of epileptic activity, the majority of which suggest its propensity as an antiseizure with antioxidant and neuroprotective properties. In the past few years, a number of studies highlighting...
Mon Sep 21, 2020 14:22
Related Articles Subthalamic nucleus deep brain stimulation modulates two distinct neurocircuits. Ann Neurol. 2020 Sep 20;: Authors: Shen L, Jiang C, Hubbard CS, Ren J, He C, Wang D, Dahmani L, Guo Y, Liu Y, Xu S, Meng F, Zhang J, Liu H, Li L Abstract OBJECTIVE: Current understanding of the neuromodulatory effects of deep brain stimulation (DBS) on large-scale brain networks remains elusive, largely due to the lack of techniques that can reveal...
Mon Sep 21, 2020 14:22
Treating insomnia in Swiss primary care practices: A survey study based on case vignettes. J Sleep Res. 2020 Sep 20;:e13169 Authors: Linder S, Duss SB, Dvořák C, Merlo C, Essig S, Tal K, Del Giovane C, Syrogiannouli L, Heinzer R, Nissen C, Bassetti CLA, Auer R, Maire M Abstract Guidelines recommend cognitive behavioural therapy for insomnia (CBT-I) as first-line treatment for chronic insomnia, but it is not clear how many primary care physicians...
Mon Sep 21, 2020 14:22
25 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: epilepsy treatment These pubmed results were generated on 2020/09/22PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Tue Sep 22, 2020 14:34
25 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: epilepsy treatment These pubmed results were generated on 2020/09/22PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Tue Sep 22, 2020 17:35
Related Articles Excavating precursors from the traditional Chinese herb Polygala tenuifolia and Gastrodia elata: Synthesis, anticonvulsant activity evaluation of 3,4,5-trimethoxycinnamic acid (TMCA) ester derivatives. Bioorg Chem. 2019 07;88:102832 Authors: Zhao Z, Bai Y, Xie J, Chen X, He X, Sun Y, Bai Y, Zhang Y, Wu S, Zheng X Abstract Epilepsy is a group of neurological disorders characterized by recurrent seizures that disturbs about 60...
Wed Sep 23, 2020 14:44
Related Articles [Scalp-recorded cortical spreading depolarizations (CSDs) of EEG with time constant of 2 seconds in a patient with acute traumatic brain injury]. Rinsho Shinkeigaku. 2020 Jul 31;60(7):473-478 Authors: Tsukamoto T, Kajikawa S, Hitomi T, Funaki T, Urushitani M, Takahashi R, Ikeda A Abstract An 82-year-old female suffered from head trauma, and developed acute consciousness disturbance 6 days after the event. Head CT showed the...
Wed Sep 23, 2020 14:44
Related Articles A pediatric patient with autism spectrum disorder and epilepsy using cannabinoid extracts as complementary therapy: a case report. J Med Case Rep. 2020 Sep 22;14(1):162 Authors: Ponton JA, Smyth K, Soumbasis E, Llanos SA, Lewis M, Meerholz WA, Tanguay RL Abstract BACKGROUND: The pharmacological treatment for autism spectrum disorders is often poorly tolerated and has traditionally targeted associated conditions, with limited...
Wed Sep 23, 2020 14:44
Related Articles Neurostimulation stabilizes spiking neural networks by disrupting seizure-like oscillatory transitions. Sci Rep. 2020 Sep 21;10(1):15408 Authors: Rich S, Hutt A, Skinner FK, Valiante TA, Lefebvre J Abstract An improved understanding of the mechanisms underlying neuromodulatory approaches to mitigate seizure onset is needed to identify clinical targets for the treatment of epilepsy. Using a Wilson-Cowan-motivated network of inhibitory...
Wed Sep 23, 2020 14:44
Related Articles The burden of decisional uncertainty in the treatment of status epilepticus. Epilepsia. 2020 Sep 22;: Authors: Sánchez Fernández I, GaÃnza-Lein M, Barcia Aguilar C, Amengual-Gual M, Loddenkemper T Abstract OBJECTIVE: Treatments for convulsive status epilepticus (SE) have a wide range of effectiveness. The estimated effectiveness of non-intravenous benzodiazepines (non-IV BZDs) ranges from approximately 70% to 90% and the...
Wed Sep 23, 2020 14:44
Related Articles Standard procedures for the diagnostic pathway of sleep-related epilepsies and comorbid sleep disorders: an EAN, ESRS and ILAE-Europe consensus review. Eur J Neurol. 2020 Sep 21;: Authors: Nobili L, de Weerd A, Rubboli G, Beniczky S, Derry C, Eriksson S, Halasz P, Högl B, Santamaria J, Khatami R, Ryvlin P, Rémi J, Tinuper P, Bassetti C, Manni R, Koutroumanidis M, Vignatelli L Abstract BACKGROUND AND PURPOSE: Some epilepsy...
Wed Sep 23, 2020 14:44
Related Articles Standard procedures for the diagnostic pathway of sleep-related epilepsies and comorbid sleep disorders: A European Academy of Neurology, European Sleep Research Society and International League against Epilepsy-Europe consensus review. J Sleep Res. 2020 Sep 21;:e13184 Authors: Nobili L, de Weerd A, Rubboli G, Beniczky S, Derry C, Eriksson S, Halasz P, Högl B, Santamaria J, Khatami R, Ryvlin P, Rémi J, Tinuper P, Bassetti C, Manni R, Koutroumanidis...
Wed Sep 23, 2020 14:44
Related Articles Doctor Gachet, in the kitchen, with the foxglove. Cardiol Young. 2020 Sep 22;:1-10 Authors: Mainwaring RD, Mainwaring S Abstract Vincent van Gogh (1853-1890) is one of the most famous artists in the world. During his 10-year career as an artist, he created more than 850 paintings. These works of art are now displayed in museums around the globe. It is therefore even more surprising that van Gogh sold just one painting during...
Wed Sep 23, 2020 14:44
Related Articles Pharmacology and legal status of cannabidiol. Ann Ist Super Sanita. 2020 Jul-Sep;56(3):285-291 Authors: Brunetti P, Lo Faro AF, Pirani F, Berretta P, Pacifici R, Pichini S, Busardò FP Abstract Cannabidiol (CBD) is the second most abundant cannabinoid present in Cannabis sativa L. It is not associated with psychotropic activity and is capable to mitigate the psychotomimetic effects produced by tetrahydrocannabinol (THC). The...
Wed Sep 23, 2020 14:44
Related Articles Structural basis of AMPA receptor inhibition by 4-BCCA. Br J Pharmacol. 2020 Sep 22;: Authors: Yelshanskaya MV, Singh AK, Narangoda C, Williams RSB, Kurnikova MG, Sobolevsky AI Abstract BACKGROUND AND PURPOSE: AMPA receptors, which shape excitatory postsynaptic currents and are directly involved in overactivation of synaptic function during seizures, represent a well-accepted target for antiepileptic drugs (AEDs). Trans-4-butylcyclohexane...
Wed Sep 23, 2020 14:44
Related Articles Autism BrainNet. Arch Pathol Lab Med. 2020 Sep 22;: Authors: Anderson MP, Quinton R, Kelly K, Falzon A, Halladay A, Schumann CM, Hof PR, Tamminga CA, Hare CK, Amaral DG Abstract CONTEXT.—: Autism spectrum disorder is a neurodevelopmental condition that affects over 1% of the population worldwide. Developing effective preventions and treatments for autism will depend on understanding the neuropathology of the disorder. While...
Wed Sep 23, 2020 14:44
Related Articles Study on the mechanism of high-frequency stimulation inhibiting low-Mg2+-induced epileptiform discharges in juvenile rat hippocampal slices. Brain Res Bull. 2020 Sep 19;: Authors: Zheng Y, Zhang K, Dong L, Tian C Abstract Study on the mechanism of high-frequency stimulation inhibiting low-Mg2+-induced epileptiform discharges in juvenile rat hippocampal slices High-frequency stimulation (HFS) has been demonstrated to be an effective...
Wed Sep 23, 2020 14:44
Related Articles Incremental burden of mental health conditions in adult patients with focal seizures. Epilepsy Behav. 2020 Sep 19;112:107426 Authors: Petrilla AA, Sutton BS, Leinwand BI, Parente A, Ferrari L, Wade CT Abstract INTRODUCTION: Clinical research has consistently established mental health conditions (MHCs) as frequent comorbidities of epilepsy. However, the extent of economic burden of comorbid MHC in patients with focal seizures...
Wed Sep 23, 2020 14:44
Related Articles Predictors of one-year language and seizure outcomes in children with epileptic encephalopathy with continuous spike-and-wave during sleep (CSWS). Seizure. 2020 Aug 28;81:315-324 Authors: Saraf UU, Asranna A, Menon RN, Mohan P M, Vp V, Radhakrishnan A, Cherian A, V Thomas S Abstract PURPOSE: Epileptic encephalopathy with continuous spike-and-wave during sleep (CSWS), with its associated impact on language, is an important cause...
Wed Sep 23, 2020 14:44
Related Articles StatPearls Book. 2020 01 Authors: Abstract Epilepsy surgery is indicated in 30% to 40% of patients with refractory seizure disorders despite being on one year of therapy with an adequate dosage of two antiepileptic therapy.[1] Though the anterior temporal lobectomy has been the prototype epilepsy surgery, there has been a paradigm shift in the surgical principle of ensuring maximum disconnection of the epileptic neural pathways, in sharp contrast...
Thu Sep 24, 2020 14:54
Related Articles StatPearls Book. 2020 01 Authors: Abstract Vagus nerve is the longest mixed cranial nerve associated structurally with the post olivary sulcus of the medulla oblongata. The literal translation of the vagus is 'wanderer,' which aptly represents its widespread interfacing of cortex, brainstem, hypothalamus, and the body. Its afferent and efferent pathways comprise about 80% and 20%, respectively. With a premise that venous hyperemia caused seizures,...
Thu Sep 24, 2020 14:54
Related Articles Analysis of Differential Expression of Synaptic Vesicle Protein 2A in the Adult Rat Brain. Neuroscience. 2019 11 01;419:108-120 Authors: Mendoza-Torreblanca JG, García-Cruz ME, Sánchez-Cruz I, Gomez-Gonzalez B, Juárez-Méndez S, Gómez-Lira G Abstract Synaptic vesicle protein 2A (SV2A), which plays an important role in the pathophysiology of epilepsy, is a unique vesicular protein recognized as a pharmacological target of anticonvulsant...
Thu Sep 24, 2020 14:54
Related Articles Adenosine Receptor Ligands: Coumarin-Chalcone Hybrids as Modulating Agents on the Activity of hARs. Molecules. 2020 Sep 19;25(18): Authors: Vazquez-Rodriguez S, Vilar S, Kachler S, Klotz KN, Uriarte E, Borges F, Matos MJ Abstract Adenosine receptors (ARs) play an important role in neurological and psychiatric disorders such as Alzheimer's disease, Parkinson's disease, epilepsy and schizophrenia. The different subtypes of ARs...
Thu Sep 24, 2020 14:54
Related Articles Barriers to biomedical care for people with epilepsy in Uganda: A cross-sectional study. Epilepsy Behav. 2020 Sep 19;:107349 Authors: Kaddumukasa MN, Kaddumukasa M, Kajumba M, Smith PJ, Bobholz S, Kakooza-Mwesige A, Sinha DD, Almojuela A, Chakraborty P, Nakasujja N, Nakku J, Gualtieri A, Onuoha E, Kolls BJ, Muhumuza C, Smith CE, Sanchez N, Fuller AT, Haglund MM, Koltai DC Abstract OBJECTIVE: Epilepsy, a neurological disorder...
Thu Sep 24, 2020 14:54
Related Articles Therapeutic effects of rosemary (Rosmarinus officinalis L.) and its active constituents on nervous system disorders. Iran J Basic Med Sci. 2020 Sep;23(9):1100-1112 Authors: Ghasemzadeh Rahbardar M, Hosseinzadeh H Abstract Rosemary (Rosmarinus officinalis L.) is an evergreen bushy shrub which grows along the Mediterranean Sea, and sub-Himalayan areas. In folk medicine, it has been used as an antispasmodic, mild analgesic, to...
Thu Sep 24, 2020 14:54
The prevalence of comorbidities in patients with multiple sclerosis: population-based registry data.
Related Articles The prevalence of comorbidities in patients with multiple sclerosis: population-based registry data. Neurol Sci. 2020 Sep 22;: Authors: Maric GD, Pekmezovic TD, Mesaros ST, Tamas OS, Ivanovic JB, Martinovic VN, Andabaka MM, Jovanovic AL, Veselinovic ND, Kisic-Tepavcevic DB, Drulovic JS Abstract BACKGROUND: Comorbidities occur frequently in persons with multiple sclerosis (MS). The aim of the present study was to determine the...
Thu Sep 24, 2020 14:54
Related Articles Epilepsy syndromes, etiologies, and the use of next-generation sequencing in epilepsy presenting in the first 2 years of life: A population-based study. Epilepsia. 2020 Sep 23;: Authors: Stödberg T, Tomson T, Barbaro M, Stranneheim H, Anderlid BM, Carlsson S, Åmark P, Wedell A Abstract OBJECTIVE: Population-based data on epilepsy syndromes and etiologies in early onset epilepsy are scarce. The use of next-generation sequencing...
Thu Sep 24, 2020 14:54
Related Articles Protocol for a single patient therapy plan: A randomised, double-blind, placebo-controlled N-of-1 trial to assess the efficacy of cannabidiol in patients with intractable epilepsy. J Paediatr Child Health. 2020 Sep 23;: Authors: Ong KS, Carlin JB, Fahey M, Freeman JL, Scheffer IE, Gillam L, Anderson M, Huque MH, Legge D, Dirnbauer N, Lilley B, Slota-Kan S, Cranswick N Abstract AIM: This paper describes the use of the single...
Thu Sep 24, 2020 14:54
Related Articles Altered amplitude of low-frequency fluctuations and regional homogeneity in drug-resistant epilepsy patients with vagal nerve stimulators under different current intensity. CNS Neurosci Ther. 2020 Sep 23;: Authors: Zhu J, Xu C, Zhang X, Qiao L, Wang X, Zhang X, Yan X, Ni D, Yu T, Zhang G, Li Y Abstract BACKGROUND: The mechanisms of vagal nerve stimulation (VNS) for the treatment of drug-resistant epilepsy (DRE) remain unclear....
Thu Sep 24, 2020 14:54
Related Articles Potential role of brivaracetam in paediatric epilepsy. Acta Neurol Scand. 2020 Sep 23;: Authors: Verrotti A, Grasso EA, Cacciatore M, Mastricardi S, Striano P Abstract Brivaracetam (BRV) is a new antiseizure medication (ASM) that is currently approved for adjunctive treatment in patients with focal onset seizures. Similarly to Levetiracetam (LEV), BRV works by binding SV2A vesicles with a high affinity and a linear pharmacokinetic...
Thu Sep 24, 2020 14:54
Related Articles Vagus Nerve Stimulation at the Interface of Brain-Gut Interactions. Cold Spring Harb Perspect Med. 2019 08 01;9(8): Authors: Bonaz B, Sinniger V, Pellissier S Abstract The vagus nerve, a key component of the cross-communication between the gut and the brain, is a major element of homeostasis sensing the "milieu intérieur" and boosting the nervous and endocrine responses to maintain the gastrointestinal health status. This nerve...
Fri Sep 25, 2020 15:06
Related Articles Progesterone modulates post-traumatic epileptogenesis through regulation of BDNF-TrkB signaling and cell survival-related pathways in the rat hippocampus. Neurosci Lett. 2019 09 14;709:134384 Authors: Ghadiri T, Vakilzadeh G, Hajali V, Khodagholi F Abstract Female sex hormone, progesterone, in addition to seizure modifying activity is also known as a potential protective agent against various brain injury conditions. Considering...
Fri Sep 25, 2020 15:06
Related Articles Endogenous protection against the 6-OHDA model of Parkinson's disease in the Amazonian rodent Proechimys. Neurosci Lett. 2019 09 14;709:134381 Authors: Guimarães Marques MJ, Real CC, Victorino DB, Britto LR, Cavalheiro EA, Scorza FA, Ferraz HB, Scorza CA Abstract BACKGROUND: Proechimys, an epilepsy-resistant rodent from Amazon Rainforest, is a promising alternative animal model for studying neurodegenerative disorders. ...
Fri Sep 25, 2020 15:06
Related Articles [Clinical and neuropsychological studies of patients before and after insular glioma resection]. Zh Vopr Neirokhir Im N N Burdenko. 2020;84(1):43-54 Authors: Buklina SB, Bykanov AE, Pitskhelauri DI Abstract AIM: The study was aimed to investigate the insula function based on analysis and comparison of epileptic seizures (irritation symptoms) and cognitive impairment (memory loss) in patients with insular gliomas. MATERIAL...
Fri Sep 25, 2020 15:06
Related Articles Pharmacological treatment and SUDEP risk: A nationwide population-based case-control study. Neurology. 2020 Sep 23;: Authors: Sveinsson O, Andersson T, Mattsson P, Carlsson S, Tomson T Abstract OBJECTIVE: We conducted a nationwide case-control study in Sweden to test the hypothesis that antiepileptic drugs (AEDs), mono- polytherapy, adherence, antidepressants, neuroleptics, beta-blockers, and statins are associated with sudden...
Fri Sep 25, 2020 15:06
Related Articles Variant-specific changes in persistent or resurgent sodium current in SCN8A-related epilepsy patient-derived neurons. Brain. 2020 Sep 24;: Authors: Tidball AM, Lopez-Santiago LF, Yuan Y, Glenn TW, Margolis JL, Clayton Walker J, Kilbane EG, Miller CA, Martina Bebin E, Scott Perry M, Isom LL, Parent JM Abstract Missense variants in the SCN8A voltage-gated sodium channel gene are linked to early-infantile epileptic encephalopathy...
Fri Sep 25, 2020 15:06
Related Articles Cannabidiol in conjunction with clobazam: analysis of four randomized-controlled trials. Acta Neurol Scand. 2020 Sep 24;: Authors: Gunning B, Mazurkiewicz-Beldzinska M, Chin RFM, Bhathal H, Nortvedt C, Dunayevich E, Checketts D Abstract OBJECTIVES: To assess the efficacy and safety profile of add-on cannabidiol (CBD) in patients with Lennox-Gastaut syndrome (LGS) and Dravet syndrome (DS) on clobazam and in the overall population...
Fri Sep 25, 2020 15:06
Related Articles A Novel Mouse Model for Pyridoxine-Dependent Epilepsy Due to Antiquitin Deficiency. Hum Mol Genet. 2020 Sep 24;: Authors: Al-Shekaili HH, Petkau TL, Pena I, Lengyell TC, Verhoeven-Duif NM, Ciapaite J, Bosma M, van Faassen M, Kema IP, Horvath G, Ross C, Simpson EM, Friedman JM, Karnebeek C, Leavitt BR Abstract Pyridoxine-dependent epilepsy (PDE) is a rare autosomal recessive disease caused by mutations in the ALDH7A1 gene leading...
Fri Sep 25, 2020 15:06
Related Articles The Effect of Epilepsy and Antiepileptic Drugs on Cortical Motor Excitability in Patients With Temporal Lobe Epilepsy. Clin Neuropharmacol. 2020 Sep 21;: Authors: Hamed SA, Tohamy AM, Mohamed KO, El Mageed Abd El Zaher MA Abstract OBJECTIVES: Transcranial magnetic stimulation (TMS) has been used to assess cortical disinhibition/excitation with epilepsy and determine the degree of patients' response to antiepileptic drugs (AEDs)....
Fri Sep 25, 2020 15:06
Related Articles High lead impedances requiring revision during vagal nerve stimulator generator replacement. Acta Neurochir (Wien). 2020 Sep 24;: Authors: Entezami P, German JW, Adamo MA Abstract OBJECTIVE: Vagal nerve stimulation (VNS) therapy is among the growing options in the treatment of intractable epilepsy. The phenomenon of surprise lead impedance issues found at the time of surgery resulting in unplanned lead revision is a challenge...
Fri Sep 25, 2020 15:06
Related Articles Electroencephalographic findings in antileucine-rich glioma-inactivated 1 (LGI1) autoimmune encephalitis: A systematic review. Epilepsy Behav. 2020 Sep 21;112:107462 Authors: Roberto KT, Espiritu AI, Fernandez MLL, Gutierrez JC Abstract BACKGROUND: Antileucine-rich glioma-inactivated 1 (LGI1) autoimmune encephalitis is a distinct syndrome of early onset faciobrachial dystonic seizures (FBDS) and other focal seizures followed...
Fri Sep 25, 2020 15:06
Related Articles Psychiatric Comorbidities and Psychiatric Medication Use Are Highly Prevalent in Patients With Eosinophilic Esophagitis and Associate With Clinical Presentation. Am J Gastroenterol. 2020 06;115(6):853-858 Authors: Reed CC, Corder SR, Kim E, Sanders E, Tappata M, Eluri S, Dellon ES Abstract OBJECTIVES: The prevalence of psychiatric disease in patients with eosinophilic esophagitis (EoE) is not fully characterized. We aimed to...
Sat Sep 26, 2020 15:14
Related Articles A Framework to Assess the Information Dynamics of Source EEG Activity and Its Application to Epileptic Brain Networks. Brain Sci. 2020 Sep 22;10(9): Authors: Kotiuchyi I, Pernice R, Popov A, Faes L, Kharytonov V Abstract This study introduces a framework for the information-theoretic analysis of brain functional connectivity performed at the level of electroencephalogram (EEG) sources. The framework combines the use of common...
Sat Sep 26, 2020 15:14
Related Articles Is it really a seizure? The challenge of paroxysmal non-epileptic events in young infants. Clin Exp Pediatr. 2020 Sep 18;: Authors: Jung SY, Kang JW Abstract Paroxysmal non-epileptic events (PNE) comprise of a variety of non-epileptic behaviors and are divided into various types. A more accurate diagnosis is possible by examining the video clip provided by the caregiver. In infants, physiologic PNE accounts for the majority...
Sat Sep 26, 2020 15:14
Related Articles Implanted vagus nerve stimulation in 126 patients: surgical technique and complications. Rozhl Chir. 2020;99(7):304-310 Authors: Bláha M, Tichý M Abstract INTRODUCTION: Vagus nerve stimulation is a palliative treatment for patients with refractory epilepsy to reduce the frequency and intensity of seizures. A bipolar helical electrode is placed around the left vagus nerve at the cervical level and is connected to the pulse generator...
Sat Sep 26, 2020 15:14
Related Articles An immunotherapy effect analysis in Rasmussen encephalitis. BMC Neurol. 2020 Sep 24;20(1):359 Authors: Liba Z, Vaskova M, Zamecnik J, Kayserova J, Nohejlova H, Ebel M, Sanda J, Ramos-Rivera GA, Brozova K, Liby P, Tichy M, Krsek P Abstract BACKGROUND: Immune-mediated mechanisms substantially contribute to the Rasmussen encephalitis (RE) pathology, but for unknown reasons, immunotherapy is generally ineffective in patients who...
Sat Sep 26, 2020 15:14
Related Articles Neurophysiological and Genetic Findings in Patients With Juvenile Myoclonic Epilepsy. Front Integr Neurosci. 2020;14:45 Authors: Stefani S, Kousiappa I, Nicolaou N, Papathanasiou ES, Oulas A, Fanis P, Neocleous V, Phylactou LA, Spyrou GM, Papacostas SS Abstract Objective: Transcranial magnetic stimulation (TMS), a non-invasive procedure, stimulates the cortex evaluating the central motor pathways. The response is called motor...
Sat Sep 26, 2020 15:14
Related Articles Effect of Brivaracetam on Efficacy and Tolerability in Patients With Brain Tumor-Related Epilepsy: A Retrospective Multicenter Study. Front Neurol. 2020;11:813 Authors: Maschio M, Maialetti A, Mocellini C, Domina E, Pauletto G, Costa C, Mascia A, Romoli M, Giannarelli D Abstract Background: Epilepsy is a common symptom of brain tumors and is often pharmacoresistent. Among new antiseizure medications (ASMs) Brivaracetam (BRV)...
Sat Sep 26, 2020 15:14
Related Articles The Concept of an Epilepsy Brain Bank. Front Neurol. 2020;11:833 Authors: Hernandez-Ronquillo L, Miranzadeh Mahabadi H, Moien-Afshari F, Wu A, Auer R, Zherebitskiy V, Borowsky R, Mickleborough M, Huntsman R, Vrbancic M, Cayabyab FS, Taghibiglou C, Carter A, Tellez-Zenteno JF Abstract Epilepsy comprises more than 40 clinical syndromes affecting millions of patients and families worldwide. To decode the molecular and pathological...
Sat Sep 26, 2020 15:14
Related Articles Preoperative evaluation of dynamic contrast-enhanced MRI-guided lesion identification using morphometric and textural analysis for patients with epilepsy. Exp Ther Med. 2020 Nov;20(5):98 Authors: Feizhou D, Jing G, Peng W, Jialing W, Rui J Abstract Diagnosing epilepsy at the early stages is pivotal in the prevention and subsequent treatment of major epileptic events. MRI has been previously demonstrated to be beneficial in optimizing...
Sat Sep 26, 2020 15:14
Related Articles Transient coating of γ-Fe2O3 nanoparticles with glutamate for its delivery to and removal from brain nerve terminals. Beilstein J Nanotechnol. 2020;11:1381-1393 Authors: Paliienko K, Pastukhov A, Babič M, Horák D, Vasylchenko O, Borisova T Abstract Glutamate is the main excitatory neurotransmitter in the central nervous system and excessive extracellular glutamate concentration is a characteristic feature of stroke, brain trauma,...
Sat Sep 26, 2020 15:14
Related Articles Mortality implications and factors associated with nonengagement in a public epilepsy care initiative in a transient population. Epilepsy Behav. 2020 Sep 22;112:107438 Authors: Chawla A, Singh G, Sharma S, Bansal R, Bansal N, Chowdhury A, Paul BS, Sharma S, Sander JW Abstract BACKGROUND: Community-based, public care programs are a requisite to close the epilepsy treatment gap in disadvantaged communities in low- and middle-income...
Sat Sep 26, 2020 15:14
Related Articles Intra-Operative Detection of a Left-Sided Non-Recurrent Laryngeal Nerve during Vagus Nerve Stimulator Implantation. Medicina (Kaunas). 2020 Sep 23;56(10): Authors: Labuschagne JJ, Hammer N Abstract Left sided non-recurrent laryngeal nerves (NRLN) are very rarely observed during surgery in the head and neck region. Arising directly from the cervical aspect of the vagus nerve, the NRLN lies in a vulnerable position distant from...
Mon Sep 28, 2020 12:47
Related Articles Epilepsy. Handb Clin Neurol. 2020;174:137-158 Authors: Bastos F, Cross JH Abstract Epilepsy is considered a disease characterized by an underlying predisposition to seizures as well as neurobiologic, cognitive, psychologic, and social consequences. It is the most frequent chronic neurologic condition of childhood, affecting 0.5%-1% of children worldwide. It comprises a variety of disorders with many different etiologies, consequently...
Mon Sep 28, 2020 12:47
Related Articles The efficacy of assisted reproductive treatment in women with epilepsy. Reprod Biomed Online. 2020 Aug 01;: Authors: Larsen MD, Jølving LR, Fedder J, Nørgård BM Abstract RESEARCH QUESTION: The question of interest for this study was to examine the chance of a live birth following assisted reproductive technology (ART) treatment in women with epilepsy compared with women without epilepsy. In sub-analyses, the chance of biochemical...
Mon Sep 28, 2020 12:47
Related Articles Risk-benefit assessment of treatment of epileptic women of childbearing age with valproic acid. Seizure. 2020 Sep 16;82:27-30 Authors: Quílez A, Baraldés-Rovira M, Gallego Y, Sanahuja J, Mauri-Capdevila G, Purroy F Abstract AIM: Valproic acid (VPA) is a widely used anti-epileptic drug (AED) of demonstrated efficacy. However, its teratogenic effects have resulted in many regulatory agencies recommending that it should not be...
Mon Sep 28, 2020 12:47
Related Articles Prevalence of photoparoxysmal response in patients with epilepsy: Effect of the underlying syndrome and treatment status. Seizure. 2020 Sep 18;82:39-43 Authors: Rathore C, Prakash S, Makwana P Abstract OBJECTIVE: To prospectively study the prevalence of photoparoxysmal response (PPR) and its determinants in epilepsy patients. METHODS: Consecutive patients, older than 2 years, undergoing EEG from January 2016 to December...
Mon Sep 28, 2020 12:47
Related Articles Medically compromised patients in orthodontic practice: Review of evidence and recommendations. Int Orthod. 2019 12;17(4):776-788 Authors: Alqahtani H Abstract INTRODUCTION: Due to advances in the field of medicine, early diagnosis and high-quality medical management has become available for medically compromised patients. This increases their life expectancy and improves their quality of life. Therefore, orthodontic treatment...
Tue Sep 29, 2020 16:32
Related Articles Protocol on transcranial alternating current stimulation for the treatment of major depressive disorder: a randomized controlled trial. Chin Med J (Engl). 2020 Jan 05;133(1):61-67 Authors: Wang HX, Wang K, Zhang WR, Zhao WF, Yang XT, Wang L, Peng M, Sun ZC, Xue Q, Jia Y, Li N, Dong K, Zhang Q, Zhan SQ, Min BQ, Fan CQ, Zhou AH, Song HQ, Yin L, Si TM, Huang J, Lu J, Leng HX, Ding WJ, Liu Y, Yan TY, Wang YP Abstract BACKGROUND:...
Tue Sep 29, 2020 16:32
Related Articles Surgical complications of decompressive craniectomy in patients with head injury. Rozhl Chir. 2020;99(7):316-322 Authors: Mork J, Mraček J, Štěpánek D, Runt V, Přibáň V Abstract INTRODUCTION: Decompressive craniectomy is an important method for managing refractory intracranial hypertension. Although decompressive craniectomy is a relatively simple procedure, various complications may arise. The aim of our paper was to determine...
Tue Sep 29, 2020 16:32
Related Articles Physical exercise and seizure activity. Biochim Biophys Acta Mol Basis Dis. 2020 Sep 24;:165979 Authors: Arida RM Abstract Neuroprotective and antiepileptogenic therapies have been extensively investigated for epilepsy prevention and treatment. This review gives an overview of the promising contribution of the ketogenic diet, a complementary treatment, on the intestinal microbiota to reduce seizure susceptibility. Next, the...
Tue Sep 29, 2020 16:32
Related Articles Towards an Outpatient Model of Care for Motor Functional Neurological Disorders: A Neuropsychiatric Perspective. Neuropsychiatr Dis Treat. 2020;16:2119-2134 Authors: Saxena A, Godena E, Maggio J, Perez DL Abstract Functional neurological disorder (FND), a condition at the intersection of neurology and psychiatry, is a common and disabling outpatient referral to neurology and neuropsychiatry clinics. In this perspective article,...
Tue Sep 29, 2020 16:32
Related Articles Magnitude, Symptom Presentation and Correlates of Psychological Distress Among People with Epilepsy in Southern Ethiopia: A Cross-Sectional Study. Neuropsychiatr Dis Treat. 2020;16:2143-2151 Authors: Mekuriaw B, Mantefardo B, Molla A, Berhanu G, Mehare T, Belayneh Z Abstract Background: Psychological distress is a common co-morbid condition among people with epilepsy. Untreated comorbid psychosocial problems are associated with...
Tue Sep 29, 2020 16:32
Related Articles P2X7 Receptor-Dependent microRNA Expression Profile in the Brain Following Status Epilepticus in Mice. Front Mol Neurosci. 2020;13:127 Authors: Conte G, Nguyen NT, Alves M, de Diego-Garcia L, Kenny A, Nicke A, Henshall DC, Jimenez-Mateos EM, Engel T Abstract The ionotropic ATP-gated P2X7 receptor is an important contributor to inflammatory signaling cascades via the release of Interleukin-1β, as well as having roles in cell...
Tue Sep 29, 2020 16:32
Related Articles Cognitive outcomes following laser interstitial therapy for mesiotemporal epilepsies. Neurol Clin Pract. 2020 Aug;10(4):314-323 Authors: Bermudez CI, Jermakowicz WJ, Kolcun JPG, Sur S, Cajigas I, Millan C, Ribot R, Serrano EA, Velez-Ruiz N, Lowe MR, Tornes L, Palomeque M, Kanner AM, Jagid JR, Rey GJ Abstract Objective: To provide a review of cognitive outcomes across a full neuropsychological profile in patients who underwent...
Tue Sep 29, 2020 16:32
Related Articles Seizures and Epilepsy in Times of Corona Virus Disease 2019 Pandemic. J Epilepsy Res. 2020 Jun;10(1):3-7 Authors: Parihar J, Tripathi M, Dhamija RK Abstract The end of the year 2019 was marked by novel coronavirus (severe acute respiratory syndrome coronavirus-2, SARS-CoV-2) outbreak in China that rapidly spread to the rest of the world. While the involvement of the lower respiratory system causing pneumonia is identified as...
Tue Sep 29, 2020 16:32
Related Articles Artificial Intelligence and Computational Approaches for Epilepsy. J Epilepsy Res. 2020 Jun;10(1):8-17 Authors: An S, Kang C, Lee HW Abstract Studies on treatment of epilepsy have been actively conducted in multiple avenues, but there are limitations in improving its efficacy due to between-subject variability in which treatment outcomes vary from patient to patient. Accordingly, there is a growing interest in precision medicine...
Tue Sep 29, 2020 16:32
Related Articles Epilepsy in Children with Tuberous Sclerosis Complex: A Prospective Observational Study in Bangladesh. J Epilepsy Res. 2020 Jun;10(1):18-23 Authors: Rahman MM, Fatema K Abstract Background and Purpose: Epilepsy is an important neurologic feature of patients with tuberous sclerosis complex (TSC). Most common seizure types are focal seizure and epileptic spasm. Seizure control often requires multiple antiepileptic drugs. This...
Tue Sep 29, 2020 16:32
Related Articles Epilepsy Research in Mali: A Pilot Pharmacokinetics Study on First-Line Antiepileptic Drug Treatment. J Epilepsy Res. 2020 Jun;10(1):31-39 Authors: Sangare M, Doumbia F, Sidibe O, Oumar AA, Bah S, Kouyate M, Diakite SS, Traore K, Karembe A, Haidara MS, Coulibaly SP, Coulibaly S, Togora A, Dolo H, Traore D, Doumbia S, Diakite M, Maiga Y, Diawara A, Kuate C, Kim HG, Awandare GA Abstract Background and Purpose: The indication and...
Tue Sep 29, 2020 16:32
Related Articles Mortality of all causes and sudden unexplained death in epilepsy (SUDEP) in a cohort of 235 persons living with epilepsy in Rwanda using WHO Verbal Autopsy Questionnaire. Epilepsy Behav Rep. 2020;14:100383 Authors: Sebera F, Uwacu BH, Nsanzabaganwa W, Umwiringirwa J, Dedeken P, Teuwen DE, Boon PAJM Abstract Introduction: Mortality in persons living with epilepsy (PwE) is 1.6-9.3-fold higher than in the general population. Mortality...
Tue Sep 29, 2020 16:32
Related Articles [Advances in sleep-related hypermotor epilepsy]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2020 Aug 25;49(4):425-430 Authors: Xu J, Jin B, Zhang L, Wang S Abstract Sleep-related hypermotor epilepsy (SHE), formerly known as nocturnal frontal epilepsy, is characterized by asymmetrical tonic or complex hypermotor seizures during sleep, with transient, frequent and clustering attack. The accurate incidence is not known but somehow low,...
Tue Sep 29, 2020 16:32
Related Articles Acute-on-chronic subdural hematoma: a new entity for prophylactic anti-epileptic treatment? Eur J Trauma Emerg Surg. 2020 Sep 28;: Authors: Won SY, Dubinski D, Freiman T, Seifert V, Gessler F, Strzelczyk A, Konczalla J Abstract PURPOSE: Acute-on-chronic subdural hematoma (acSDH) describes acute bleeding into a chronic subdural hematoma (SDH), after surgery or second trauma. Because seizures are a well-known complication of SDH,...
Tue Sep 29, 2020 16:32
Predictive ability of published population pharmacokinetic models of valproic acid in Thai manic patients. J Clin Pharm Ther. 2020 Sep 28;: Authors: Methaneethorn J, Leelakanok N Abstract WHAT IS KNOWN AND OBJECTIVE: Population pharmacokinetic (PopPK) models of valproic acid (VPA) have been developed to aid individualized drug dosing, but most of these have been based on the treatment of epileptic patients and recent evidence shows that VPA...
Tue Sep 29, 2020 16:32
Ketogenic diet and Neuroinflammation. Epilepsy Res. 2020 Sep 06;167:106454 Authors: Koh S, Dupuis N, Auvin S Abstract The high-fat, low-carbohydrate ketogenic diet (KD) is an established treatment for drug-resistant epilepsy with a proven efficacy. The KD is being explored for Febrile Infection-Related Epilepsy Syndrome (FIRES) and epileptic encephalopathies. There is growing evidence that KD works by targeting dysregulated adaptive and innate...
Tue Sep 29, 2020 16:32
Evaluation of patients with late-onset and medically refractory temporal lobe epilepsy with mesial temporal sclerosis. Clin Neurol Neurosurg. 2020 Sep 25;198:106209 Authors: Ayas S, Kurtish SY, Tanrıverdi T, Yeni SN Abstract OBJECTIVES: Our study aims to compare demographics, clinical features and postsurgical outcomes between early and late-onset patients with medically refractory temporal lobe epilepsy (TLE) related to mesial temporal sclerosis...
Tue Sep 29, 2020 16:32
Related Articles EEG lateralization and seizure outcome following peri-insular hemispherotomy for pediatric hemispheric epilepsy. Childs Nerv Syst. 2019 07;35(7):1189-1195 Authors: Abraham AP, Thomas MM, Mathew V, Muthusamy K, Yoganathan S, Jonathan GE, Prabhu K, Daniel RT, Chacko AG Abstract OBJECTIVE: To determine whether preoperative non-lateralizing scalp electroencephalography (EEG) influences seizure outcome following peri-insular hemispherotomy...
Wed Sep 30, 2020 14:08
Related Articles A child with a stroke, drug-refractory epilepsy and congenital heart disease: can a hemispherectomy be safely performed between staged cardiac procedures? Childs Nerv Syst. 2019 07;35(7):1245-1249 Authors: Jain P, Haller C, Pulcine E, Ochi A, Dipchand A, Weiss SK, Chin V, Ibrahim GM Abstract BACKGROUND: The safety of hemispherectomy between staged cardiac procedures is unknown and not previously reported. METHOD: Retrospective...
Wed Sep 30, 2020 14:08
Related Articles A systematic review of the association between coping strategies and quality of life among caregivers of children with chronic illness and/or disability. BMC Pediatr. 2019 07 01;19(1):215 Authors: Fairfax A, Brehaut J, Colman I, Sikora L, Kazakova A, Chakraborty P, Potter BK, Canadian Inherited Metabolic Diseases Research Network Abstract BACKGROUND: Parents of children with chronic illness have reported decreased psychological...
Wed Sep 30, 2020 14:08
Related Articles Reachability Analysis of Neural Masses and Seizure Control Based on Combination Convolutional Neural Network. Int J Neural Syst. 2020 Jan;30(1):1950023 Authors: Ma Z Abstract Epileptic seizures arise from synchronous firing of multiple spatially separated neural masses; therefore, many synchrony measures are used for seizure detection and characterization. However, synchrony measures reflect only the overall interaction strength...
Wed Sep 30, 2020 14:08
Related Articles The effects of antihistamine on the duration of the febrile seizure: A single center study with a systematic review and meta-analysis. Brain Dev. 2020 Feb;42(2):103-112 Authors: Sugitate R, Okubo Y, Nariai H, Matsui A Abstract BACKGROUND: Several studies have investigated the potential effects of antihistamines on febrile seizure. However, these findings are inconsistent across the studies. METHOD: A retrospective...
Wed Sep 30, 2020 14:08
Related Articles Mental and somatic comorbidity of depression: a comprehensive cross-sectional analysis of 202 diagnosis groups using German nationwide ambulatory claims data. BMC Psychiatry. 2020 03 30;20(1):142 Authors: Steffen A, Nübel J, Jacobi F, Bätzing J, Holstiege J Abstract BACKGROUND: Depression is frequently accompanied by other mental disorders and various somatic diseases; however, previous comorbidity studies often relied on...
Wed Sep 30, 2020 14:08
Families' Perception of Classic Ketogenic Diet Management in Acute Medical Conditions: A Web-Based Survey. Nutrients. 2020 Sep 24;12(10): Authors: Pasca L, Varesio C, Ferraris C, Guglielmetti M, Trentani C, Tagliabue A, Veggiotti P, De Giorgis V Abstract Objective: To describe families' experiences in managing epileptic patients undergoing ketogenic dietary therapies (KDTs) in acute medical settings. Methods: We conducted a short online survey...
Wed Sep 30, 2020 14:08
Perception of service users and their caregivers on primary care-based mental health services: a qualitative study in Nepal. BMC Fam Pract. 2020 Sep 28;21(1):202 Authors: Luitel NP, Jordans MJD, Subba P, Komproe IH Abstract BACKGROUND: Integration of mental health services into primary health care systems has been advocated as a strategy to minimize the tremendous mental health treatment gap, particularly in low- and middle-income countries....
Wed Sep 30, 2020 14:08
Severe pallid breath-holding spells treated with low-dose theophylline. Brain Dev. 2020 Sep 25;: Authors: Sato A, Oda Y, Asakai H Abstract BACKGROUND: The medical treatment for severe pallid breath-holding spells accompanied with severe bradycardia or transient cardiac arrest is controversial. Although various medications have been reported to be effective, patients treated with pacemaker insertion are not always evaluated for pharmacological...
Wed Sep 30, 2020 14:08
An electric-field-responsive paramagnetic contrast agent enhances the visualization of epileptic foci in mouse models of drug-resistant epilepsy. Nat Biomed Eng. 2020 Sep 28;: Authors: Wang C, Sun W, Zhang J, Zhang J, Guo Q, Zhou X, Fan D, Liu H, Qi M, Gao X, Xu H, Gao Z, Tian M, Zhang H, Wang J, Wei Z, Long NJ, Mao Y, Li C Abstract For patients with drug-resistant focal epilepsy, excision of the epileptogenic zone is the most effective treatment...
Wed Sep 30, 2020 14:08
PHARMACOLOGICAL TREATMENT OF FOCAL EPILEPSY IN ADULTS: AN EVIDENCE BASED APPROACH. Expert Opin Pharmacother. 2020 Sep 29;: Authors: Mula M Abstract INTRODUCTION: Focal seizures represent the most common seizure type and focal epilepsies the most common epilepsy type. Anti-seizure medications (ASMs) still represent the main form of treatment for epilepsy. AREAS COVERED: The aim of this review article is to provide an overview of available...
Wed Sep 30, 2020 14:08
[Cenobamate-a new perspective for epilepsy treatment]. Nervenarzt. 2020 Sep 29;: Authors: Steinhoff BJ Abstract In spite of the introduction of numerous new antiseizure drugs (ASD) over the last decades, the percentage of drug-resistant epilepsies has remained almost stable. To achieve seizure freedom in such patients with any modified ASD regimen is an exception. Cenobamate (CNB) is a new ASD that showed unusually high efficacy in the pivotal...
Wed Sep 30, 2020 14:08
Neuroprotective role of chrysin-loaded poly(lactic-co-glycolic acid) nanoparticle against kindling-induced epilepsy through Nrf2/ARE/HO-1 pathway. J Biochem Mol Toxicol. 2020 Sep 29;:e22634 Authors: Zhang Y, Zhao J, Afzal O, Kazmi I, Al-Abbasi FA, Altamimi ASA, Yang Z Abstract Chrysin is the major bioactive compound of blue passionflower, an important medicinal plant used in traditional herbal formulations since ancient times. In the present...
Wed Sep 30, 2020 14:08
White matter and neurite morphology differ in psychogenic nonepileptic seizures. Ann Clin Transl Neurol. 2020 Sep 29;: Authors: Goodman AM, Allendorfer JB, Blum AS, Bolding MS, Correia S, Ver Hoef LW, Gaston TE, Grayson LE, Kraguljac NV, Lahti AC, Martin AN, Monroe WS, Philip NS, Tocco K, Vogel V, LaFrance WC, Szaflarski JP Abstract OBJECTIVE: To further evaluate the relationship between the clinical profiles and limbic and motor brain regions...
Wed Sep 30, 2020 14:08
Related Articles Right-ventricular outflow tract obstruction by adrenocorticotrophic hormone therapy for infantile spasms after Norwood operation. Pediatr Int. 2020 Jan;62(1):96-97 Authors: Kusuda M, Hazeki D, Maruyama S, Ueno K, Kawano Y PMID: 31957208 [PubMed - indexed for MEDLINE]
Thu Oct 01, 2020 20:59
Related Articles Statistical models for longitudinal zero-inflated count data: application to seizure attacks. Afr Health Sci. 2019 Sep;19(3):2555-2564 Authors: Mekonnen FH, Lakew WD, Tesfaye ZD, Swain PK Abstract Background: Chronic non-communicable diseases:- such as epilepsy, are increasingly recognized as public health problems in developing and African countries. This study aimed at finding determinants of the number of epileptic seizure...
Thu Oct 01, 2020 20:59
Related Articles Implementing standardized provider documentation in a tertiary epilepsy clinic. Neurology. 2020 07 14;95(2):e213-e223 Authors: Jones FJS, Smith JR, Ayub N, Herman ST, Buchhalter JR, Fureman BE, Cash SS, Hoch DB, Moura LMVR Abstract OBJECTIVE: To incorporate standardized documentation into an epilepsy clinic and to use these standardized data to compare patients' perception of epilepsy diagnosis to provider documentation. ...
Thu Oct 01, 2020 20:59
Related Articles Hepatocellular type II fibrinogen inclusions in a patient with severe COVID-19 and hepatitis. J Hepatol. 2020 Oct;73(4):967-970 Authors: Fraga M, Moradpour D, Artru F, Romailler E, Tschopp J, Schneider A, Chtioui H, Neerman-Arbez M, Casini A, Alberio L, Sempoux C PMID: 32585161 [PubMed - indexed for MEDLINE]
Thu Oct 01, 2020 20:59
Neurological Development, Epilepsy, and the Pharmacotherapy Approach in Children with Congenital Zika Syndrome: Results from a Two-Year Follow-up Study. Viruses. 2020 Sep 25;12(10): Authors: Quilião ME, Venancio FA, Mareto LK, Metzker SA, Nascimento AID, Vitorelli-Venancio DC, Santos-Pinto CDB, de Oliveira EF Abstract Clinical outcomes related to congenital Zika syndrome (CZS) include microcephaly accompanied by specific brain injuries. Among...
Thu Oct 01, 2020 20:59
Resolution of EEG findings and clinical improvement in a patient with encephalopathy and ESES with a combination of immunomodulating agents other than corticosteroids: A case report. Epilepsy Behav Rep. 2020;14:100379 Authors: Jyonouchi H, Geng L Abstract Encephalopathy with electrical status epilepticus in sleep (ESES) syndrome is characterized by a near-continuous spike-and-wave discharges during sleep with marked developmental regression,...
Thu Oct 01, 2020 20:59
Cortical and thalamic electrode implant followed by temporary continuous subthreshold stimulation yields long-term seizure freedom: A case report. Epilepsy Behav Rep. 2020;14:100390 Authors: Alcala-Zermeno JL, Gregg NM, Van Gompel JJ, Stead M, Worrell GA, Lundstrom BN Abstract Neuromodulation strategies that target the epileptogenic network are options for treating focal drug-resistant epilepsy. These brain stimulation approaches include responsive...
Thu Oct 01, 2020 20:59
Successful treatment of cannabinoid administration against refractory epilepsy in Batten disease: a case report. Neurol Sci. 2020 Sep 30;: Authors: Georgiou F, Maghsoudlou P, Loukaidis P, Markoullaki D, Giorgi C, Christodoulou I, Matsentidou C PMID: 32995993 [PubMed - as supplied by publisher]
Thu Oct 01, 2020 20:59
Related Articles Intranasal midazolam as first-line inhospital treatment for status epilepticus: a pharmaco-EEG cohort study. Ann Clin Transl Neurol. 2019 12;6(12):2413-2425 Authors: Kay L, Merkel N, von Blomberg A, Willems LM, Bauer S, Reif PS, Schubert-Bast S, Rosenow F, Strzelczyk A Abstract OBJECTIVE: We sought to evaluate the efficacy and tolerability of intranasal midazolam (in-MDZ) as first-line inhospital therapy in patients with status...
Fri Oct 02, 2020 15:30
Related Articles Application of Cannabinoids in Neurosciences: Considerations and Implications. Crit Care Nurs Q. 2020 Apr/Jun;43(2):216-231 Authors: Owusu KA, Saliba L, Ammar AA, Ammar MA, Mucksavage J Abstract Medicinal cannabinoid use continues to evolve across the United States, although legitimate federal recognition for medicinal purpose is lacking. Variability exists across states within the United States with respect to legislation,...
Fri Oct 02, 2020 15:30
Inherited Disorders of Lysine Metabolism: A Review. J Nutr. 2020 Oct 01;150(Supplement_1):2556S-2560S Authors: Bouchereau J, Schiff M Abstract Lysine is an essential amino acid, and inherited diseases of its metabolism therefore represent defects of lysine catabolism. Although some of these enzyme defects are not well described yet, glutaric aciduria type I (GA1) and antiquitin (2-aminoadipic-6-semialdehyde dehydrogenase) deficiency represent...
Fri Oct 02, 2020 15:30
Osthole inhibits proliferation of kainic acid‑activated BV‑2 cells by modulating the Notch signaling pathway. Mol Med Rep. 2020 Nov;22(5):3759-3766 Authors: Li YZ, Sun Z, Xu HR, Zhang QG, Zeng CQ Abstract Epilepsy is a syndrome involving chronic recurrent transient brain dysfunction. Activation and proliferation of microglia serve important roles in epilepsy pathogenesis and may be targets for treatment. Although osthole, an active constituent...
Fri Oct 02, 2020 15:30
Response to lacosamide monotherapy in a patient with medically refractory Jeavons syndrome: a case report and review of the literature. Epileptic Disord. 2020 Sep 30;: Authors: Zawar I, Franic L, Knight EP Abstract Jeavons syndrome is a childhood genetic generalized epilepsy characterized by eyelid myoclonia with or without absences, eyelid closure-induced epileptiform discharges and/or seizures and photoparoxysmal response. This syndrome accounts...
Fri Oct 02, 2020 15:30
The phenotype and treatment of SCN2A-related developmental and epileptic encephalopathy. Epileptic Disord. 2020 Sep 30;: Authors: Kim HJ, Yang D, Kim SH, Kim B, Kim HD, Lee JS, Choi JR, Lee ST, Kang HC Abstract AIMS: We aimed to delineate the phenotypic spectrum of SCN2A-related developmental and epileptic encephalopathy (DEE) and determine the effectiveness of various treatment modalities, including sodium channel blockers and the ketogenic...
Fri Oct 02, 2020 15:30
CircHivep2 contributes to microglia activation and inflammation via miR-181a-5p/SOCS2 signalling in mice with kainic acid-induced epileptic seizures. J Cell Mol Med. 2020 Oct 01;: Authors: Xiaoying G, Guo M, Jie L, Yanmei Z, Ying C, Shengjie S, Haiyan G, Feixiang S, Sihua Q, Jiahang S Abstract Epilepsy is a chronic brain disease characterized by recurrent seizures. Circular RNA (circRNA) is a novel family of endogenous non-coding RNAs that...
Fri Oct 02, 2020 15:30
Epilepsy surgery for pediatric patients with mild malformation of cortical development. Seizure. 2020 Sep 23;82:50-55 Authors: Kwon HE, Kim SH, Kang HC, Lee JS, Kim HD Abstract PURPOSE: The observation of mild malformation of cortical development (mMCD) has yet to have a major clinical impact due to the lack of clinical and research data. We characterized the clinical features, surgical outcomes, and postoperative seizure control patterns in...
Fri Oct 02, 2020 15:30
Risk factors, comorbidities, quality of life, and complications after surgery in idiopathic normal pressure hydrocephalus: review of the INPH-CRasH study. Neurosurg Focus. 2020 Oct;49(4):E8 Authors: Israelsson H, Larsson J, Eklund A, Malm J Abstract OBJECTIVE: Idiopathic normal pressure hydrocephalus (INPH) is a dementia treatable by insertion of a shunt that drains CSF. The cause of the disease is unknown, but a vascular pathway has been suggested....
Fri Oct 02, 2020 15:30
Related Articles Successful Management of Ketogenic Parenteral Nutrition: A Pediatric Case Study. JPEN J Parenter Enteral Nutr. 2019 08;43(6):815-818 Authors: Lowe H, Segal S, Mouzaki M, Langos V, Dlamini N PMID: 30570167 [PubMed - indexed for MEDLINE]
Sat Oct 03, 2020 13:06
Mens Sana in Corpore Sano: Does the Glycemic Index Have a Role to Play? Nutrients. 2020 Sep 29;12(10): Authors: Carneiro L, Leloup C Abstract Although diet interventions are mostly related to metabolic disorders, nowadays they are used in a wide variety of pathologies. From diabetes and obesity to cardiovascular diseases, to cancer or neurological disorders and stroke, nutritional recommendations are applied to almost all diseases. Among such...
Sat Oct 03, 2020 13:06
Genetic Etiologies of Neonatal Seizures. Neoreviews. 2020 Oct;21(10):e663-e672 Authors: Kaur S, Pappas K Abstract Neonates presenting with seizures are frequently assessed and managed by neonatologists in the NICU. Although hypoxic-ischemic encephalopathy and infection are common underlying causes of neonatal seizures, many patients with neonatal epilepsy will have an identifiable genetic etiology. Often these cases will be evaluated in collaboration...
Sat Oct 03, 2020 13:06
Seizures elevate gliovascular unit Ca2+ and cause sustained vasoconstriction. JCI Insight. 2020 Oct 02;5(19): Authors: Tran CHT, George AG, Teskey GC, Gordon GR Abstract Seizures can result in a severe hypoperfusion/hypoxic attack that causes postictal memory and behavioral impairments. However, neither postictal changes to microvasculature nor Ca2+ changes in key cell types controlling blood perfusion have been visualized in vivo, leaving...
Sat Oct 03, 2020 13:06
Altered Static and Dynamic Spontaneous Neural Activity in Drug-Naïve and Drug-Receiving Benign Childhood Epilepsy With Centrotemporal Spikes. Front Hum Neurosci. 2020;14:361 Authors: Jiang S, Luo C, Huang Y, Li Z, Chen Y, Li X, Pei H, Wang P, Wang X, Yao D Abstract The present study aims to investigate intrinsic abnormalities of brain and the effect of antiepileptic treatment on brain activity in Benign childhood epilepsy with centrotemporal...
Sat Oct 03, 2020 13:06
Primary carnitine deficiency in two sisters with intractable epilepsy and reversible metabolic cardiomyopathy: Two case reports. Exp Ther Med. 2020 Nov;20(5):118 Authors: Yang XF, Liu GS, Yi B Abstract Primary carnitine deficiency (PCD) is a disorder of the carnitine cycle that results in defective fatty acid oxidation. When carnitine cannot be transported into the cells, fatty acid oxidation is impaired, resulting a variety of symptoms, such...
Sat Oct 03, 2020 13:06
Coffin-Siris syndrome and epilepsy. Neurol Sci. 2020 Oct 02;: Authors: Curcio MR, Ferranti S, Lotti F, Grosso S Abstract Coffin-Siris syndrome is a rare genetic disorder defined by the presence of particular facial traits, congenital malformations, intellectual disability, and speech impairment. Epilepsy in Coffin-Siris syndrome has only occasionally been reported, and its features are poorly defined. We provide a detailed description of the...
Sat Oct 03, 2020 13:06
Carbamazepine Versus levetiracetam in epilepsy due to neurocysticercosis. Acta Neurol Scand. 2020 Oct 02;: Authors: Santhosh AP, Goyal MK, Modi M, Kharbanda PS, Ahuja CK, Tandyala N, Prabhat N, Singh R, Mehta S, Mahesh KV Abstract BACKGROUND: The choice of antiepileptic drug (AED) in newly diagnosed neurocysticercosis (NCC) patients with epilepsy continues to be arbitrary. We compared efficacy and side effect profile of Levetiracetam (LEV)...
Sat Oct 03, 2020 13:06
Valeriana officinalis extract and 7-Nitroindozole ameliorated seizure behaviours, and 7-Nitroindozole reduced blood pressure and ECG parameters in pentylenetetrazole-kindled rats. Pol J Vet Sci. 2020 Sep;23(3):349-357 Authors: Kapucu A, Ustunova S, Akgun-Dar K Abstract Nitric oxide (NO) is known to be a neuromodulator with dual proconvulsive and anticonvul- sive action. Valeriana officinalis (VAL) was previously believed to be antiepileptic,...
Sat Oct 03, 2020 13:06
Brain structural and neuroendocrine basis of sex differences in epilepsy. Handb Clin Neurol. 2020;175:223-233 Authors: Reddy DS Abstract This chapter reviews the current information about sex differences in epilepsy and potential mechanisms underlying sex differences in seizure susceptibility and epilepsy. The susceptibility to and occurrence of seizures are generally higher in men than women. There is gender-specific epilepsies such as catamenial...
Sun Oct 04, 2020 13:45
D-serine mitigates cell loss associated with temporal lobe epilepsy. Nat Commun. 2020 Oct 02;11(1):4966 Authors: Beesley S, Sullenberger T, Crotty K, Ailani R, D'Orio C, Evans K, Ogunkunle EO, Roper MG, Kumar SS Abstract Temporal lobe epilepsy (TLE) is the most common type of drug-resistant epilepsy in adults, with an unknown etiology. A hallmark of TLE is the characteristic loss of layer 3 neurons in the medial entorhinal area (MEA) that underlies...
Sun Oct 04, 2020 13:45
Repetitive transcranial magnetic stimulation in drug-resistant idiopathic epilepsy of dogs: A noninvasive neurostimulation technique. J Vet Intern Med. 2020 Oct 03;: Authors: Charalambous M, Van Ham L, Broeckx BJG, Roggeman T, Carrette S, Vonck K, Kervel RR, Cornelis I, Bhatti SFM Abstract BACKGROUND: Although repetitive transcranial magnetic stimulation (rTMS) has been assessed in epileptic humans, clinical trials in epileptic dogs can provide...
Sun Oct 04, 2020 13:45
Patterns of anticonvulsant use and adverse drug events in older adults. Pharmacoepidemiol Drug Saf. 2020 Oct 02;: Authors: Moura LMVR, Smith JR, Yan Z, Blacker D, Schwamm LH, Newhouse JP, Hernandez-Diaz S, Hsu J Abstract PURPOSE: To examine indications for, duration of use, and rate of adverse drug events (ADE) attributable to anticonvulsant initiation, as adjudicated by expert review of electronic health records (EHR) of older adults. ...
Sun Oct 04, 2020 13:45
Lister hooded rats as a novel animal model of attention-deficit/hyperactivity disorder. Neurochem Int. 2020 Sep 30;:104857 Authors: Jogamoto T, Utsunomiya R, Sato A, Kihara N, Choudhury ME, Miyanishi K, Kubo M, Nagai M, Nomoto M, Yano H, Shimizu YI, Fukuda M, Ishii E, Eguchi M, Tanaka J Abstract Appropriate animal models are necessary to determine the molecular and cellular mechanisms underlying attention-deficit/hyperactivity disorder (ADHD)....
Sun Oct 04, 2020 13:45
How does the COVID-19 cause seizure and epilepsy in patients? The potential mechanisms. Mult Scler Relat Disord. 2020 Sep 28;46:102535 Authors: Nikbakht F, Mohammadkhanizadeh A, Mohammadi E Abstract The new coronavirus has spread throughout the world in a very short time and now has become a pandemic. Most infected people have symptoms such as dry cough, dyspnea, tiredness, and fever. However, the Covid-19 infection disrupts various organs,...
Sun Oct 04, 2020 13:45
Digoxin enhances the effect of antiepileptic drugs with different mechanism of action in the pentylenetetrazole-induced seizures in mice. Epilepsy Res. 2020 Sep 11;167:106465 Authors: Tsyvunin V, Shtrygol' S, Shtrygol' D Abstract The worldwide prevalence of epilepsy with high percentage of multidrug-resistant patients make it urgent to find new approaches to treating, including the use of combinations of classic anticonvulsants with drugs that...
Sun Oct 04, 2020 13:45
NREM sleep arousal-related disorders reflect cognitive impairment in Parkinson's disease. Sleep Med. 2020 Sep 05;75:491-496 Authors: Terzaghi M, Minafra B, Zangaglia R, Picascia M, Pozzi N, Cremascoli R, Arnaldi D, Versino M, Sinforiani E, Rustioni V, Pacchetti C, Manni R Abstract BACKGROUND: Sleep disorders and cognitive impairment are frequently reported in Parkinson's disease (PD) as non-motor disabling symptoms. While it is known that REM...
Mon Oct 05, 2020 13:50
Inflammatory and immune mechanisms underlying epileptogenesis and epilepsy: From pathogenesis to treatment target. Seizure. 2020 Sep 26;82:65-79 Authors: Mukhtar I Abstract Epilepsy is a brain disease associated with epileptic seizures as well as with neurobehavioral outcomes of this condition. In the last century, inflammation emerged as a crucial factor in epilepsy etiology. Various brain insults through activation of neuronal and non-neuronal...
Mon Oct 05, 2020 13:50
Thalamohippocampal atrophy in focal epilepsy of unknown cause at the time of diagnosis. Eur J Neurol. 2020 Oct 04;: Authors: Leek NJ, Kreilkamp BAK, Neason M, de Bezenac C, Ziso B, Elkommos S, Das K, Marson AG, Keller SS Abstract BACKGROUND: Patients with chronic focal epilepsy may have atrophy of brain structures important for the generation and maintenance of seizures. However, little research has been conducted in patients with newly diagnosed...
Mon Oct 05, 2020 13:50
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