Abstract Background A bulk of investigations imply that women with rheumatoid arthritis (RA) deliver fewer children in comparison to healthy women. Purpose This review article attempts to clarify the involvement of infertility-related issues in both RA men and women. Moreover, the effect of RA disease on the fertility quality and quantity will be discussed....
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Abstract Living donor liver transplantation (LDLT) emerged to mitigate the deceased donor organ shortage. While this approach has excellent recipient outcomes – similar to the ones achieved with a full graft – it has a clear advantage over the latter given it provides faster access to transplantation and reduces waiting list mortality.1 However, it is well known that the success of this approach has a strict relation with donor and graft selection. In this regard, greater understanding of this technique...
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Objective To systematically review the efficacy and safety of exercise in patients with amyotrophic lateral sclerosis (ALS). Design Randomized controlled trials (RCTs) of exercises for ALS were searched in PubMed, EMBASE, Web of Science, Cochrane Library, China Biology Medicine database, China National Knowledge Internet, VIP database and Wanfang database. The primary outcomes were functional ability, pulmonary function and quality of life. The secondary outcomes were muscle strength,...
Objective Traumatic brain injury (TBI) represents a major public health concern, particularly in low- and middle-income countries like in Latin America. Family members are often caregivers for individuals with TBI, which can result in significant stress. Research is needed to examine depression and quality of the caregiving relationship in these dyads. This study examined relationship quality and depression longitudinally after TBI within the caregiving relationship. Design Dyads (N...
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The WHO declared a pandemic due to the serious health risk posed by Coronavirus disease (COVID-19). The number of infected cases is on the rise globally with escalating human, economic and societal costs. COVID-19 survivors may suffer a range of clinical, functional and psychological impairments, resulting in disabilities. Many are amenable to rehabilitation intervention. The current focus of COVID-19 management is on public health measures and acute management. As patients transfer to sub-acute...
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Publication date: Available online 26 May 2020Source: Atmospheric EnvironmentAuthor(s): Lewei Zeng, Juan Dang, Hai Guo, Xiaopu Lyu, Isobel J. Simpson, Simone Meinardi, Yu Wang, Luyao Zhang, Donald R. Blake
Publication date: Available online 26 May 2020Source: Atmospheric EnvironmentAuthor(s): M. Sowden, D. Blake
Publication date: Available online 26 May 2020Source: Atmospheric EnvironmentAuthor(s): Cristina Prados-Roman, Miguel Fernández, Laura Gómez-Martín, Emilio Cuevas, Manuel Gil-Ojeda, Nicolas Marusczak, Olga Puentedura, Jeroen E. Sonke, Alfonso Saiz-Lopez
Publication date: Available online 25 May 2020Source: Atmospheric EnvironmentAuthor(s): Xiaoling Nie, Huiting Mao, Panyan Li, Tao Li, Jie Zhou, Yan Wu, Minmin Yang, Jiebo Zhen, Xinli Wang, Yan Wang
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Publication date: Available online 25 May 2020Source: Progress in NeurobiologyAuthor(s): Christopher Lee, Stephanie M. Willerth, Haakon B. Nygaard
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Degraded hyaluronan is one of the key molecules that create cancer‐predisposing microenvironment and promote tumor development via Hippo‐YAP signaling as well as other important factors. Since inhibiting hyaluronidase‐mediated fragmentation of hyaluronan suppresses pro‐oncogenic activity of YAP, development of hyaluronidase inhibitors may provide novel therapeutic strategies for human malignant tumors. Abstract High‐molecular‐weight hyaluronan acts as a ligand of the tumor‐suppressive Hippo...
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Nutritional challenges in children and adolescents with Down syndrome. Lancet Child Adolesc Health. 2020 Jun;4(6):455-464 Authors: Nordstrøm M, Retterstøl K, Hope S, Kolset SO Abstract Several features and comorbidities in Down syndrome have nutritional implications and consequences. In infancy and early childhood, children with Down syndrome have a high risk of oral motor difficulties and pharyngeal dysphagia with aspiration, which both require systematic...
Perspectives of speech and language therapists in paediatric palliative care: an international exploratory study. Int J Lang Commun Disord. 2020 May 25;: Authors: Krikheli L, Erickson S, Carey LB, Carey-Sargeant CL, Mathisen BA Abstract BACKGROUND: The involvement of speech and language therapists (SLTs) within paediatric palliative care (PPC) settings has been recognized within the extant literature. However, there is little understanding of SLT's specific...
Related ArticlesPeroral endoscopic myotomy (POEM) opens the door of third-space endoscopy. Endoscopy. 2019 11;51(11):1010-1012 Authors: Inoue H, Maydeo A PMID: 31661708 [PubMed - indexed for MEDLINE]
Related ArticlesRegarding epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux. Eur Respir J. 2019 10;54(4): Authors: Perotin JM, Djukanovic R, Davies DE PMID: 31601724 [PubMed - indexed for MEDLINE]
Related ArticlesSurvey of nocturnal reflux in patients with gastroesophageal reflux disease in China. J Dig Dis. 2019 Nov;20(11):589-595 Authors: Zhang L, Hou XH, Zou XP, Li RZ, Wang CD, Sun J, Wang CH, Xu CF, Chen CX, Deng MM, Zuo XL, Zou DW Abstract To evaluate current diagnosis and treatment of patients with nocturnal gastroesophageal reflux (nGER). METHODS: This multicenter observational study was conducted in 44 hospitals in China from...
Related ArticlesFunctional lumen imaging probe in gastrointestinal motility diseases. J Dig Dis. 2019 Nov;20(11):572-577 Authors: Chen HM, Li BW, Li LY, Xia L, Chen XB, Shah R, Abdelfatah MM, Jain A, Cassani L, Massaad J, Keilin S, Cai Q Abstract Dysfunction of gastrointestinal (GI) sphincters, including the lower esophageal sphincter (LES) at the esophagogastric junction (EGJ) and the pyloric sphincter, plays a vital role in GI motility disorders,...
Related ArticlesBoyce's sign in a large Zenker's diverticulum. Lancet Gastroenterol Hepatol. 2019 09;4(9):742 Authors: Sharma SC, Sakthivel P, Singh S, Kumar D PMID: 31387737 [PubMed - indexed for MEDLINE]
Related ArticlesEndoscopic fundoplication in a pediatric patient: a new concept. Endoscopy. 2019 11;51(11):E343-E344 Authors: Tyberg A, Jha K, Gaidhane M, Kahaleh M PMID: 31174221 [PubMed - indexed for MEDLINE]
Related ArticlesMalnutrition associated with nutrition impact symptoms and localization of the disease: Results of a multicentric research on oncological nutrition. Clin Nutr. 2019 06;38(3):1274-1279 Authors: de Pinho NB, Martucci RB, Rodrigues VD, D'Almeida CA, Thuler LCS, Saunders C, Jager-Wittenaar H, Peres WAF Abstract BACKGROUND & AIMS: Malnutrition in cancer is an independent factor associated with negative clinical outcomes. The aim was to...
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Abstract Data on clinical characteristics of adults with Down syndrome (DS) are limited and the clinical phenotype of these persons is poorly described. This study aimed to describe the occurrence of chronic diseases and pattern of medication use in a population of adults with DS. Participants were 421 community dwelling adults with DS, aged 18 years or older. Individuals were assessed through a standardized clinical protocol. Multimorbidity was defined as the occurrence of two or more chronic conditions...
Abstract Holt–Oram syndrome (HOS) is a rare, autosomal dominant disorder caused by heterozygous pathogenic variants in cardiac T‐box transcription factor, TBX5. Classically, it is associated with upper limb malformations and variable cardiac abnormalities. Limb manifestations are considered to be invariably present, ranging in severity from limitation in movement, to triphalangeal thumbs, absent thumbs, shortened forearms, or phocomelia. Cardiac involvement is characterized by congenital heart...
Abstract The mitochondrial aconitase gene (ACO2 ) encodes an enzyme that catalyzes the conversion of citrate to isocitrate in the tricarboxylic acid cycle. Biallelic variants in ACO2 are purported to cause two distinct disorders: infantile cerebellar‐retinal degeneration (ICRD) which is characterized by CNS abnormalities, neurodevelopmental phenotypes, optic atrophy and retinal degeneration; and optic atrophy 9 (OPA9), characterized by isolated ophthalmologic phenotypes including optic atrophy...
Abstract Genetic therapies have shown recent promise in alleviating some of the cognitive issues associated with some genetic disorders; however, these therapies may come with significant health and socio‐ethical concerns, particularly when they involve child participants. Little is known about what parents of children with genetic disorders think about genetic therapies, or about their knowledge of how genetic‐based therapy might treat their child's symptoms. Forty‐two parents of children with...
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Publication date: Available online 25 May 2020Source: Revista Española de Medicina Nuclear e Imagen MolecularAuthor(s): N. Sánchez, I. Valduvieco, M.J. Ribal, F. Campos, F. Casas, C. Nicolau, R. Salvador, B. Mellado, S. Jorcano, D. Fuster, P. Paredes
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Abstract As a multifunctional lactic acid bacterium, Lactobacillus plantarum has been proved to survive in the human gastrointestinal tract, and it can also colonize this tract. In this study, the effects of L. plantarum ATCC 14917 metabolic profile caused by initial acid–base (pH 5.5 and 8.5) stress were investigated using 1H nuclear magnetic resonance spectroscopy and multivariate data analysis. The results showed that the metabolome mainly consisted of 14 metabolites, including the components...
Abstract The P‐type ATPase CrpA is an important Cu2+/Cd2+ pump in the Aspergilli, significantly contributing to the heavy metal stress tolerance of these ascomycetous fungi. As expected, the deletion of crpA resulted in Cu2+/Cd2+‐sensitive phenotypes in Aspergillus nidulans on stress agar plates inoculated with conidia. Nevertheless, paradoxical growth stimulations were observed with the ΔcrpA strain in both standard Cu2+ stress agar plate experiments and cellophane colony harvest (CCH) cultures,...
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Publication date: August 2020Source: Journal of Human Evolution, Volume 145Author(s): René Bobe, David R. Braun, Anna K. Behrensmeyer, John W.K. Harris
Publication date: July 2020Source: Journal of Human Evolution, Volume 144Author(s): Rachna B. Reddy, John C. Mitani
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Publication date: Available online 25 May 2020Source: Trends in Cognitive SciencesAuthor(s): Maxime Derex, Alex Mesoudi
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Growth hormone deficiency (GHD) in children has significant impacts on growth and metabolism. Two-agent GH stimulation tests are commonly used to diagnose GHD, and these tests are generally considered safe. We report the case of a 5-year 5-month-old boy with a history of anaplastic ependymoma who underwent GH stimulation testing for growth deceleration using clonidine and arginine. He developed bilateral calf myalgia and gross hematuria within 24 hours of the tests. Myalgia and hematuria resolved...
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Breast metastasis from thyroid papillary carcinoma is an exceptional situation. Here, we present the diagnostic approach and the management of a 19-year-old woman with single breast metastasis from thyroid carcinoma. There was no extra thyroidal extension, neoplastic emboli, or lymph node invasion. The metastasis was revealed by whole-body radioactive 131I scan, explored by a fine-needle aspiration, and confirmed by elevated thyroglobulin in situ. Received for publication December 9, 2019; revision...
A 52-year-old woman with no medical history was admitted on March 18, 2020, presenting since 3 days asthenia, abdominal pain, and dry cough but no fever. Adenomegalies, splenomegaly, leukocytosis, and elevated LDH suggested mature lymphoproliferation. Considering the current health context, an RT-PCR testing for COVID-19 (coronavirus disease 2019) was performed and found to be positive. Early chest CT showed no sign of pulmonary infection but multiple adenomegalies. An 18F-FDG PET/CT performed 5...
We present the first intraoperative detection of a hyperplastic parathyroid gland with a positron emitter 18F-fluorocholine and handheld probe, with the estimation of the absorbed dose to the surgeon and surgical staff. Intraoperative positron emitter detection enabled the resection of a small parathyroid gland, resulting in normal postoperative values of PTH and serum calcium in a 69-year-old woman. Calculated whole-body dose to the surgical staff and surgeons’ fingers is well below the annual limits...
A 75-year-old man with a history of prostate cancer (T1N0M0, Gleason score 4 + 3) was referred to radionuclide bone scan and 68Ga-PSMA PET/CT to detect recurrence. Multiple abnormal foci were observed in the axial and appendicular skeleton, which were suggestive of metastatic superscan from prostate cancer. However, histopathological examinations (from bone biopsy) did not support the metastases from prostate cancer. 68Ga-FAPI PET/CT was then performed to detect the occult tumor, which showed intense...
Purpose Insulinomas are predominantly benign neuroendocrine tumors originating from beta cells within the islets of Langerhans of the endocrine pancreas. Because surgical resection represents the only curative therapy option, exact tumor localization and discrimination of insulinomas from focal or diffuse manifestations of congenital hyperinsulinism are crucial for optimal treatment strategies. We investigated the diagnostic value of glucagon-like peptide 1 receptor PET/CT using 68Ga-DOTA-exendin...
18F-NaF PET/CT in hyperparathyroidism and osteitis fibrosa cystica is rarely reported. We report the case of a 16-year-old boy who underwent NaF PET/CT for the evaluation of bilateral bone destruction, which was incidentally noted on an abdominal x-ray. The PET/CT images identified multiple bony abnormalities in the skull, pelvis, and limbs. In addition, a hypodense nodule was found posterior to the inferior pole of the right lobe of thyroid gland. Subsequent 99mTc-sestamibi imaging showed abnormal...
Liposarcoma is a common soft tissue sarcoma in retroperitoneum, but adrenal liposarcoma is rare. We here described a 61-year-old man with left-upper-quadrant pain, hypertension, and weight loss. Abdominal CT showed a large, heterogeneously enhanced mass on the left adrenal area, which compressed the surrounding pancreas, spleen, and left kidney. Subsequent FDG PET/CT demonstrated heterogeneous uptake by the lesion. Postoperative pathological findings confirmed the diagnosis of adrenal liposarcoma....
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