IJMS, Vol. 21, Pages 3750: In Vivo Transmigrated Human Neutrophils Are Highly Primed for Intracellular Radical Production Induced by Monosodium Urate Crystals International Journal of Molecular Sciences doi: 10.3390/ijms21113750 Authors: Lisa Davidsson Agnes Dahlstrand Rudin Felix Peter Sanchez Klose Alicia Buck Lena Björkman Karin Christenson Johan Bylund Gout is an inflammatory disease caused by monosodium urate (MSU) crystals. The role of neutrophils in...
IJMS, Vol. 21, Pages 3747: High Homology-Directed Repair Using Mitosis Phase and Nucleus Localizing Signal International Journal of Molecular Sciences doi: 10.3390/ijms21113747 Authors: Jeong Pil Han Yoo Jin Chang Dong Woo Song Beom Seok Choi Ok Jae Koo Seung Youn Yi Tae Sub Park Su Cheong Yeom In homology-directed repair, mediated knock-in single-stranded oligodeoxynucleotides (ssODNs) can be used as a homologous template and present high efficiency,...
IJMS, Vol. 21, Pages 3746: Differential Secretome Profiling of Human Osteoarthritic Synoviocytes Treated with Biotechnological Unsulfated and Marine Sulfated Chondroitins International Journal of Molecular Sciences doi: 10.3390/ijms21113746 Authors: Russo Vassallo Stellavato Valletta Cimini Pedone Schiraldi Chambery Symptomatic slow-acting drugs (SYSADOA) are increasingly used as effective therapies for osteoarthritis, representing an attractive...
IJMS, Vol. 21, Pages 3748: DI-5-Cuffs: Lumbar Intervertebral Disc Proteoglycan and Water Content Changes in Humans after Five Days of Dry Immersion to Simulate Microgravity International Journal of Molecular Sciences doi: 10.3390/ijms21113748 Authors: Treffel Loïc Navasiolava Nastassia Karen Mkhitaryan Jouan Emmanuelle Zuj Kathryn Gauquelin-Koch Guillemette Custaud Marc-Antoine Gharib Claude Most astronauts experience back pain after spaceflight, primarily...
IJMS, Vol. 21, Pages 3744: Hypercholesterolemia Interferes with Induction of miR-125b-1-3p in Preconditioned Hearts International Journal of Molecular Sciences doi: 10.3390/ijms21113744 Authors: Márton R. Szabó Renáta Gáspár Márton Pipicz Nóra Zsindely Petra Diószegi Márta Sárközy László Bodai Tamás Csont Ischemic preconditioning (IPre) reduces ischemia/reperfusion (I/R) injury in the heart. The non-coding microRNA miR-125b-1-3p has been demonstrated...
IJMS, Vol. 21, Pages 3743: Urinary 8-OHdG as a Biomarker for Oxidative Stress: A Systematic Literature Review and Meta-Analysis International Journal of Molecular Sciences doi: 10.3390/ijms21113743 Authors: Graille Wild Sauvain Hemmendinger Guseva Canu Hopf Oxidative stress reflects a disturbance in the balance between the production and accumulation of reactive oxygen species (ROS). ROS are scavenged by the antioxidant system, but when in excess concentration,...
IJMS, Vol. 21, Pages 3745: Bactericidal and Bioresorbable Calcium Phosphate Cements Fabricated by Silver-Containing Tricalcium Phosphate Microspheres International Journal of Molecular Sciences doi: 10.3390/ijms21113745 Authors: Michiyo Honda Yusuke Kawanobe Kohei Nagata Ken Ishii Morio Matsumoto Mamoru Aizawa Bacterial adhesion to the calcium phosphate surface is a serious problem in surgery. To prevent bacterial infection, the development of calcium-phosphate...
IJMS, Vol. 21, Pages 3741: From Graphite to Laccase Biofunctionalized Few-Layer Graphene: A “One Pot” Approach Using a Chimeric Enzyme International Journal of Molecular Sciences doi: 10.3390/ijms21113741 Authors: Sorrentino Stanzione Nedellec Piscitelli Giardina Le Goff A chimeric enzyme based on the genetic fusion of a laccase with a hydrophobin domain was employed to functionalize few-layer graphene, previously exfoliated from graphite in the presence...
IJMS, Vol. 21, Pages 3742: Effective Gold Nanoparticle-Antibody-Mediated Drug Delivery for Photodynamic Therapy of Lung Cancer Stem Cells International Journal of Molecular Sciences doi: 10.3390/ijms21113742 Authors: Crous Abrahamse Cancer stem cells (CSCs) are a leading contributor to lung cancer mortality rates. CSCs are responsible for tumor growth and recurrence through inhibition of drug-induced cell death, decreasing the effect of traditional cancer therapy and photodynamic...
IJMS, Vol. 21, Pages 3739: The Potential of CD16 on Plasma-Derived Exosomes as a Liquid Biomarker in Head and Neck Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21113739 Authors: Hofmann Ludwig Schuler Hoffmann Brunner Theodoraki Head and neck squamous cell carcinomas (HNSCC) are highly immune suppressive and aggressive malignancies. As part of the tumor microenvironment, exosomes contribute to this immune suppression. The Fc receptor...
IJMS, Vol. 21, Pages 3740: Progesterone Attenuates Stress-Induced NLRP3 Inflammasome Activation and Enhances Autophagy following Ischemic Brain Injury International Journal of Molecular Sciences doi: 10.3390/ijms21113740 Authors: Espinosa-Garcia Atif Yousuf Sayeed Neigh Stein NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome inhibition and autophagy induction attenuate inflammation and improve outcome in rodent models of cerebral ischemia....
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Modern Pathology, Published online: 26 May 2020; doi:10.1038/s41379-020-0576-2Molecular patterns in salivary duct carcinoma identify prognostic subgroups
Modern Pathology, Published online: 26 May 2020; doi:10.1038/s41379-020-0574-4Clinicopathologic and molecular characterization of NTRK-rearranged thyroid carcinoma (NRTC)
Modern Pathology, Published online: 26 May 2020; doi:10.1038/s41379-020-0577-1Tiny but mighty: use of next generation sequencing on discarded cytocentrifuged bile duct brushing specimens to increase sensitivity of cytological diagnosis
Modern Pathology, Published online: 26 May 2020; doi:10.1038/s41379-020-0572-6Intraductal pancreatic cancer is less responsive than cancer in the stroma to neoadjuvant chemotherapy
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PurposeThe purpose of this study is to identify the extent of diagnostic error lawsuits related to point-of-care ultrasound (POCUS) in internal medicine, paediatrics, family medicine and critical care, of which little is known.MethodsWe conducted a retrospective review of the Westlaw legal database for indexed state and federal lawsuits involving the diagnostic use of POCUS in internal medicine, paediatrics, family medicine and critical care. Retrieved cases were reviewed independently by three physicians...
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Abstract The Wnt/β-catenin pathway participates in many important physiological events such as cell proliferation and differentiation in the male reproductive system. We found that Kinesin-2 motor KIF3A is highly expressed during spermatogenesis in Eriocheir sinensis; it may potentially promote the intracellular transport of cargoes in this process. However, only a few studies have focused on the relationship between KIF3A and the Wnt/β-catenin pathway in the male reproductive...
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Nature Reviews Immunology, Published online: 26 May 2020; doi:10.1038/s41577-020-0346-xIn this Comment, Michaela Gack and colleagues discuss how the dysregulation of type I interferon responses may contribute to COVID-19 pathology.
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Nature Reviews Neurology, Published online: 26 May 2020; doi:10.1038/s41582-020-0372-0Author Correction: Zoonotic and vector-borne parasites and epilepsy in low-income and middle-income countries
Nature Reviews Neurology, Published online: 26 May 2020; doi:10.1038/s41582-020-0359-xAntibodies to glutamic acid decarboxylase (GAD) are associated with several neurological syndromes but their importance and role are controversial. In this Review, Graus et al. propose criteria for assessing the association between GAD antibodies and neurological syndromes and discuss the pathogenicity of GAD antibodies.
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Publication date: Available online 25 May 2020Source: Biological PsychologyAuthor(s): Olivier Desmedt, Olivier Corneille, Olivier Luminet, Jennifer Murphy, Geoffrey Bird, Pierre Maurage
Publication date: Available online 25 May 2020Source: Biological PsychologyAuthor(s): Mona M. Voges, Claire-Marie Giabbiconi, Benjamin Schöne, Thomas Gruber, Andrea S. Hartmann, Silja Vocks
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Publication date: Available online 25 May 2020Source: ImmunityAuthor(s): Chetna Soni, Oriana A. Perez, William N. Voss, Joseph N. Pucella, Lee Serpas, Justin Mehl, Krystal L. Ching, Jule Goike, George Georgiou, Gregory C. Ippolito, Vanja Sisirak, Boris Reizis
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Despite the considerable progress made so far, the effectiveness and mass application of odour-baited outdoor mosquito control devices in pipelines is limited by several factors. These include the design and size of the devices, optimal placement of attractive blends, and nature of materials into which the blends are impregnated. The primary aim of this study was to manipulate these factors to improve the attractiveness of our recently developed passive outdoor host seeking device (POHD) to outdoor...
Recently, there has been a worldwide concern regarding soil contamination by heavy metals and organic compounds, especially in the developing countries including Lebanon that has suffered from solid waste mismanagement for decades. Deir Kanoun Ras El Ain is a village in southern Lebanon that possesses one of the country’s worst dumps, and its leachates influx into a running canal that irrigates surrounding agricultural lands. The aim of this study was to determine the levels of some toxic heavy metals...
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Publication date: August 2020Source: International Immunopharmacology, Volume 85Author(s): João Rafael Valentim-Silva, Sharon Rose Aragão Macedo, Neuza Biguinati de Barros, Amália dos Santos Ferreira, João Hermínio Martins da Silva, Larissa Deadame de Figueiredo Nicolete, Roberto Nicolete
Publication date: August 2020Source: International Immunopharmacology, Volume 85Author(s): Sreerohini Sagi, Balakrishna Konduru, Manmohan Parida
Publication date: August 2020Source: International Immunopharmacology, Volume 85Author(s): Wenlei Zhang, Wei Chai, Zifeng Zhu, Xingliang Li
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Publication date: September 2020Source: Photodiagnosis and Photodynamic Therapy, Volume 31Author(s): Marcelo Saito Nogueira
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Publication date: Available online 25 May 2020Source: Free Radical Biology and MedicineAuthor(s): Anna Jørs, Morten A.V. Lund, Thomas Jespersen, Torben Hansen, Henrik E. Poulsen, Jens-Christian Holm
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The most common adverse drug reaction from statins are statin-associated muscle symptoms (SAMS), characterized by myopathy (weakness), myalgia (muscle pain), and commonly elevation in serum creatine kinase. All statins are substrates of the organic anion transporter 1B1 (OATP1B1; gene: SLCO1B1), albeit to different degrees. A genetic polymorphism in SLCO1B1, c.521T>C (rs4149056), markedly decreases OATP1B1 function. The literature is currently unclear as to whether SLCO1B1 c.521T>C is significantly...
Objective Carriage of human leukocyte antigen (HLA)-B*57:01 allele increases the risk of abacavir hypersensitivity reaction. Therefore, since 2008 HIV treatment guidelines recommend HLA-B*57:01 screening before abacavir administration, greatly reducing hypersensitivity reaction rate. However, clinically suspected abacavir-related hypersensitivity reactions are described in allele non-carriers. Major aim of this study was to evaluate the relationship between HLA-B*57:01 pattern and abacavir-related...
Reduced function alleles in the TPMT and NUDT15 genes are risk factors for thiopurine toxicity. This study evaluated the influence of Native ancestry on the distribution of TPMT (rs1142345, rs1800460 and rs1800462) and NUDT15 (rs116855232) polymorphisms and compound metabolic phenotypes in 128 healthy males from the Brazilian Amazon. The average proportion of Native and European ancestry differed greatly and significantly between self-declared Amerindians and non-Amerindians, although extensive admixture...
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Batch extraction of antioxidants from black chokeberry pomace using supercritical carbon dioxide with an ethanol modifier was used to examine the variables plant load, pressure, temperature, and weight‐% ethanol. Multivariate analyses were performed to determine relationships of extraction conditions upon total phenolic content. Chokeberry extracts displayed antiproliferative effects on the SKBr3 breast cancer cell line, and HPLC‐MS spectra at 254 nm suggest major components of anthocyanins cyanidin...
In general, the results of the study confirm the technology of using CMC and nano‐sour tea extract to enhance quality and shelf life of nugget. Therefore, the combination of CMC and nano‐sour tea extracts can provide the demand of consumers for chemical‐free meat products and healthy and safe food. Abstract In this study, the antioxidant properties of sour tea extract (Hibiscus sabdariffa L.) were investigated in both free and nanoencapsulated forms to increase the quality and shelf life of chicken...
Optimized process for oyster meat Maillard reaction products with the best sensory. Increased antioxidative activity of oyster meat Maillard reaction products. Increased antioxidative (phenolic and acids) compounds after Maillard reaction. Abstract A two‐step process of enzymatic hydrolyzation followed by Maillard reaction was used to produce oyster meat hydrolysate Maillard reaction products (MRPs). The flavor of oyster meat hydrolysate MRPs was significantly improved through an optimized orthogonal...
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