IJMS, Vol. 21, Pages 3770: Transcriptional Activity and Stability of CD39+CD103+CD8+ T Cells in Human High-Grade Endometrial Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21113770 Authors: Hagma H. Workel Nienke van Rooij Annechien Plat Diana C.J. Spierings Rudolf S. N. Fehrmann Hans W. Nijman Marco de Bruyn Tumor-infiltrating CD8+ T cells (TIL) are of the utmost importance in anti-tumor immunity. CD103 defines tumor-resident memory...
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This manuscript reported the study of differentiating three different vegetable oils, including soybean oil, corn oil, and sunflower oil from olive oil by using UPC2‐QTOF MS and multivariate data analysis based on their differences in triacylglycerol compositions. After that, these three vegetable oils were adulterated to olive oil in 1%, 0.75%, and 0.5% (v/v), and the adulterated olive oil samples were differentiated from the pure olive oil using the similar analytical strategies but different data...
The excessive expression of SikRbcs2 can reduce the damage of low temperature to photosynthetic mechanism of tomato seedlings, maintain relatively stable photosynthesis, enhance the ability of ROS scavenging of tomato seedlings, maintain stable membrane structure, and improve cold tolerance of tomato. Abstract Red blood cell is a small subunit encoding 1, 5‐ribulose bisphosphate carboxylase/ oxygenase (Rubisco). It could control the catalytic activity of Rubisco and play an important role...
The effect of different microorganisms on calcium content. Abstract Nowadays, there is an increasing demand of healthier plant calcium supplements. Moringa oleifera leaves (MOL) are rich in calcium and thus are promising candidates for developing efficient calcium supplements. Here, using fermentation‐based approaches, we developed a Moringa oleifera leaf ferment (MOLF), which contents higher levels of calcium. The therapeutic potential of the MOLF was also examined both in vitro and in vivo....
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Publication date: Available online 26 May 2020Source: European Journal of Pharmaceutical SciencesAuthor(s): Krista Taipale-Kovalainen, Jarkko Ketolainen, Ossi Korhonen, Tuomas Ervasti
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Publication date: Available online 25 May 2020Source: Journal of Surgical EducationAuthor(s): Radhika Merh, Rebecca Selman
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Iodinated contrast media (CM) are utilized in approximately 40% of the 300 million computed tomography (CT) scans undertaken annually. This review focuses on the physicochemical properties and safety of iodinated CM, and the development of new x-ray CM, and it explores methods to optimize CT scanning parameters. It concludes that good x-ray CM should have high structural stability, hydrophilicity, and CT attenuation; low viscosity, osmolality, and protein binding; no metabolism and tissue accumulation;...
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Toxins, Vol. 12, Pages 349: Mining the Yucatan Coastal Microbiome for the Identification of Non-Ribosomal Peptides Synthetase (NRPS) Genes Toxins doi: 10.3390/toxins12060349 Authors: Mario Alberto Martínez-Núñez Zuemy Rodríguez-Escamilla Prokaryotes represent a source of both biotechnological and pharmaceutical molecules of importance, such as nonribosomal peptides (NRPs). NRPs are secondary metabolites which their synthesis is independent of ribosomes. Traditionally, obtaining...
Toxins, Vol. 12, Pages 348: Cylindrospermopsin-Microcystin-LR Combinations May Induce Genotoxic and Histopathological Damage in Rats Toxins doi: 10.3390/toxins12060348 Authors: Leticia Díez-Quijada Concepción Medrano-Padial María Llana-Ruiz-Cabello Giorgiana M. Cătunescu Rosario Moyano Maria A. Risalde Ana M. Cameán Ángeles Jos Cylindrospermopsin (CYN) and microcystins (MC) are cyanotoxins that can occur simultaneously in contaminated water and food....
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Suicidality in Childhood and Adolescence. Dtsch Arztebl Int. 2020 Apr 10;117(15):261-267 Authors: Becker M, Correll CU Abstract BACKGROUND: The suicide of minors in Germany is rare in absolute numbers: there were only 212 suicides among persons aged 10 to 20 in Germany in 2017. Nonetheless, in school surveys, 36.4-39.4% of those surveyed reported suicidal ideation, and 6.5-9% reported suicide attempts. Suicide among children and adolescents is thus a...
Sucrose Preference and Novelty-Induced Hypophagia Tests in Rats using an Automated Food Intake Monitoring System. J Vis Exp. 2020 May 08;(159): Authors: Schalla MA, Kühne SG, Friedrich T, Hanel V, Kobelt P, Goebel-Stengel M, Rose M, Stengel A Abstract The prevalence and incidence of depressive disorders are rising worldwide, affecting about 322 million individuals, underlining the need for behavioral studies in animal models. In this protocol, to study...
Related ArticlesEqually Interchangeable? How Sex and Gender Affect Transplantation. Transplantation. 2019 06;103(6):1094-1110 Authors: Melk A, Babitsch B, Borchert-Mörlins B, Claas F, Dipchand AI, Eifert S, Eiz-Vesper B, Epping J, Falk CS, Foster B, Geyer S, Gjertson D, Greer M, Haubitz M, Lau A, Maecker-Kolhoff B, Memaran N, Messner HA, Ostendorf K, Samuel U, Schmidt BMW, Tullius SG, West L, Wong G, Zimmermann T, Berenguer M Abstract Organ transplantation...
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Anticoagulation is ubiquitous in critical care. Considering the use of DVT prophylaxis, the majority of critically ill patients will receive some form of anticoagulation during their ICU stay. Anticoagulants are potentially high-risk medications, with relatively narrow therapeutic windows. Thus, it's important to understand the pharmacology of various agents to select and monitor anticoagulation optimally. The […] EMCrit Project by Josh Farkas.
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Publication date: Available online 25 May 2020Source: Archives of Physical Medicine and RehabilitationAuthor(s): Gonzalo Rivera-Lillo, Rodrigo Torres-Castro, Guilherme Fregonezi, Jordi Vilaró, Homero Puppo
Publication date: Available online 25 May 2020Source: Archives of Physical Medicine and RehabilitationAuthor(s): Vishwa S. Raj
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Publication date: Available online 25 May 2020Source: VaccineAuthor(s): Durenaz Jamal, Shehla Zaidi, Sara Husain, David W. Orr, Atif Riaz, Asif A. Farrukhi, Rabia Najmi
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History of the Pharmacological Society of Canada 1956-2008. Can J Physiol Pharmacol. 2020 May 25;:343-350 Authors: Sawynok J, Nakatsu K Abstract The Pharmacological Society of Canada (PSC) formed in 1956 and became a constituent society of the Canadian Federation of Biological Sciences (CFBS) in 1958. Over subsequent decades, it met annually with CFBS, matured as a society, and established an identity as the voice of pharmacology in Canada. During the...
The Adaptation of Older Adults' Transition to Nursing Homes in Mainland China: A Qualitative Study. J Transcult Nurs. 2020 May 23;:1043659620923387 Authors: Sun C, Zhou R, Cui Y, Ding Y, Li X, Li X, Zhang Y, Chen S, Xing Y Abstract Introduction: An increasing number of older adults have moved to nursing homes in China. This study was to explore the adaptation of older adults' transition to nursing homes in mainland China. Method: A qualitative study...
Alternatives to Acid Suppression Treatment for Laryngopharyngeal Reflux. Ann Otol Rhinol Laryngol. 2020 May 25;:3489420922870 Authors: Huestis MJ, Keefe KR, Kahn CI, Tracy LF, Levi JR Abstract OBJECTIVE: Laryngopharyngeal reflux (LPR) and associated symptoms can be refractory to treatment with acid suppressing medication. We investigated the role and evidence for complementary and alternative medicine (CAM) for LPR in this systematic review. ...
An epidemiological survey of laryngopharyngeal reflux disease at the otorhinolaryngology-head and neck surgery clinics in China. Eur Arch Otorhinolaryngol. 2020 May 25;: Authors: Xiao S, Li J, Zheng H, Yan Y, Li X, Zhang L, Lv Q, Zhang J, Zeng L, Gao X, Chen X, Yang H, Zhao C, Zhang J, Lu H, Luo X, Wang G, Yi H, Ye J, Lin Z, Tian L, Zhang J, Chen T, Yu A, Liu Z, Ren X, Yang X, Zhang S, Cui X, Li G, Wan G, Lin C, Chen H, Deng A, Tang X, Zhang Q, Tao Z, Shi L, Zhou J, Qin...
Swallowing difficulties caused by a voice prosthesis in a laryngectomee. Eur Ann Otorhinolaryngol Head Neck Dis. 2020 May 21;: Authors: Brook I, Cord L, Orestes M, Davidson B Abstract INTRODUCTION: The role of voice prosthesis (VP) in causing swallowing difficulties has not been thoroughly evaluated. A laryngectomee with dysphasia caused by a VP is presented. CASE REPORT: A 77-year-old laryngectomee presented with dysphagia. He had hypo pharyngeal...
Hybrid simulation of pediatric gynecologic examination: a mix-methods study of learners' attitudes and factors affecting learning. BMC Med Educ. 2020 May 24;20(1):164 Authors: Torres A, Horodeńska M, Witkowski G, Torres K Abstract BACKGROUND: Children and adolescents with reproductive health issues may require immediate or emergency care, however in many countries availability of the pediatric and adolescent gynecology (PAG) service is low. That being...
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To evaluate the cost-effectiveness of screening children born at extremely low birth weight (ELBW) for hepatoblastoma using serial serum alpha-fetoprotein (AFP) measurements.
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The results of the present study showed that ruxolitinib plus SoC was well tolerated in the treatment of severe COVID-19. It significantly mitigated exuberant cytokine storm featured in severe COVID-19, with significant chest CT improvement.
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Publication date: Available online 26 May 2020Source: Clinical ImagingAuthor(s): Adrian Dawkins, Andres Ayoob, Shubham Gupta, Rashmi Nair
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No abstract available
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Introduction: Impulse control disorder (ICD) in Parkinson’s disease (PD) is a critical nonmotor symptom with personality or neuropsychiatric traits contributing to ICD. Objective: This study aimed to identify predictive traits for persistent or paradoxical aggravation of ICD after dopamine agonist substitution therapy for ICD in PD. Methods: We conducted a case-control study using a database of a multicenter intervention trial for ICD in PD. The poor-outcome group was defined by showing paradoxical...
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Purpose High-impact physical activity is associated with bone health, but higher volumes of lower intensity activity may also be important. The aims of this study were to: 1) investigate the relative importance of volume and intensity of physical activity accumulated during late adolescence for bone health at age 23; and 2) illustrate interpretation of the results. Methods This is a secondary analysis of data from the Iowa Bone Development Study, a longitudinal study of bone health...
Introduction Post-menopausal women have lower resting cardiac function than pre-menopausal women, but whether the menopause influences maximal cardiac output and hence exercise capacity is unclear. It is possible that pre- and post-menopausal women achieve similar improvements in maximal aerobic capacity (V[Combining Dot Above] O2max) and cardiac output with exercise training via different regional left ventricular muscle function (“LV mechanics”), as suggested by in vitro and animal studies....
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Abstract Studies of recognition memory often demonstrate a recency effect on behavioral performance, whereby response times (RTs) are faster for stimuli that were previously presented recently as opposed to more remotely in the past. One account of this relationship between performance and presentation lag posits that memories are accessed by serially searching backward in time, such that RT indicates the self‐terminating moment of such a process. Here, we investigated the conditions under which...
Abstract Electrogastrography (EGG) is the noninvasive electrophysiological technique used to record gastric electrical activity by means of cutaneous electrodes placed on the abdomen. EGG has been so far mostly used in clinical studies in gastroenterology, but it represents an attractive method to study brain‐viscera interactions in psychophysiology. Compared to the literature on electrocardiography for instance, where practical recommendations and normative data are abundant, the literature on...
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Publication date: June 2020Source: Journal of Electromyography and Kinesiology, Volume 52Author(s):
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Abstract Tumour‐associated macrophages (TAMs), which possess M2‐like characters and are derived from immature monocytes in the circulatory system, represent a predominant population of inflammatory cells in solid tumours. TAM infiltration in tumour microenvironment can be used as an important prognostic marker in many cancer types and is a potential target for cancer prevention or treatment. VEGI‐251 not only is involved in the inhibition of tumour angiogenesis, but also participates in the regulation...
Abstract Microtubule‐depolymerizing agents can selectively disrupt tumor vessels via inducing endothelial membrane blebbing. However, the mechanism regulating blebbing is largely unknown. IMB5046 is a newly discovered microtubule‐depolymerizing agent. Here, the functions of focal adhesion kinase (FAK) during IMB5046‐induced blebbing and the relevant mechanism are studied. We found that IMB5046 induced membrane blebbing and reassembly of focal adhesions in human vascular endothelial cells. Both FAK...
Abstract Sepsis is the most common cause of death in intensive care units. This study investigated the circular RNA (circRNA) and mRNA expression profiles and functional networks of the aortic tissue in sepsis. We established a lipopolysaccharide (LPS)‐induced rat sepsis model. High‐throughput sequencing was performed on the aorta tissue to identify differentially expressed (DE) circRNAs and mRNAs, which were validated by real‐time quantitative polymerase chain reaction (RT‐qPCR). Bioinformatic...
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