The association among biomarkers of renal and heart function in patients with heart failure: the role of NGAL.
Biomark Med. 2018 Dec 04;:
Authors: Oikonomou E, Tsalamandris S, Karlis D, Siasos G, Chrysohoou C, Vogiatzi G, Dimitropoulos S, Charalambous G, Kouskouni E, Tousoulis D
Abstract
AIM: The NGAL is a biomarker of renal injury associated with the progression of heart failure (HF). We examine the association of NGAL with Galectin-3 in patients with chronic HF.
METHODS: We consecutively enrolled 115 subjects with stable ischemic HF of reduced ejection fraction. Serum levels of Galectin-3, b-type natriuretic peptide and NGAL were measured.
RESULTS: NGAL levels were positively correlated with Galectin-3 (rho = 0.26; p = 0.04) and b-type natriuretic peptide levels (rho = 0.30; p = 0.005) and inversely correlated with ejection fraction (rho = -0.31; p = 0.02) and creatinine clearance levels. The NGAL was independently associated with Galectin-3 levels.
CONCLUSION: A positive correlation between NGAL and Galectin-3 in HF patients was found, revealing a potential association between renal injury and myocardial fibrosis and remodeling in HF.
PMID: 30511581 [PubMed - as supplied by publisher]
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