Randomized controlled trial on a PRP-like cosmetic, biomimetic peptides based, for the treatment of Alopecia Areata.

Randomized controlled trial on a PRP-like cosmetic, biomimetic peptides based, for the treatment of Alopecia Areata.

J Dermatolog Treat. 2018 Dec 04;:1-26

Authors: Fabio R, Barbara M, Daniela P, Elisabetta S

Abstract
Background Alopecia areata (AA) is a non-scarring auto-immune hair disorder. Recent researches explained the role of growth factors (GFs) in hair follicle cycling. The main reservoir of GFs are alpha-granules of platelets and novel procedures have been implemented aimed at collecting platelet-rich plasma (PRP). PRP has been safely implemented in many medical application and has also been successfully used as alternative cell-based therapies for the treatment of hair growth disorder, among which also AA. Objectives By mean of a randomized double-blinded, placebo and active-controlled, parallel group study we have studied the efficacy of a cosmetic product (named TR-M-PRP plus) comprising biomimetic peptides specific for hair growth mimicking PRP composition for the treatment of AA. Subjects were treated for three months end evaluated, at the end of the study and after one month of follow-up, as regards hair growth using SALT score. Results PRP-like topic produced a statistically significant (p < 0.001) clinical improvement in SALT score after 3 month of therapy, compared to baseline. Hair growth resulted further improved after 1 month of follow-up. Conclusions This clinical investigation suggest that the biotechnological designed PRP-like cosmetic could represent a valid and safer alternative to autologous PRP for the treatment of AA.

PMID: 30513014 [PubMed - as supplied by publisher]

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