Increased circulating interleukin-8 levels in systemic lupus erythematosus patients: a meta-analysis.
Biomark Med. 2018 Dec 04;:1291-1302
Authors: Mao YM, Zhao CN, Liu LN, Wu Q, Dan YL, Wang DG, Pan HF
Abstract
AIM: We performed this meta-analysis in order to evaluate circulating interleukin-8 (IL-8) levels in systemic lupus erythematosus (SLE) patients more accurately and explore its related influencing factors.
METHODS: The related literature was systematically searched in PubMed, Embase and The Cochrane Library database (up to 28 March 2018). All data analysis was performed by Stata 12.0 software.
RESULTS: The results showed SLE patients had a higher circulating IL-8 levels than normal controls (pooled standardized mean difference = 0.963; 95% CI: 0.416-1.511). Subgroup analyses indicated SLE patients with age <40 years, Asia group and disease duration <10 years had higher IL-8 levels.
CONCLUSION: Compared with normal controls, circulating IL-8 levels in SLE patients are elevated and affected by age, region and disease duration.
PMID: 30511585 [PubMed - as supplied by publisher]
from PubMed via alexandrossfakianakis on Inoreader https://ift.tt/2PgtgjL
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