Effects of weight loss on dynamic hyperinflation in women obese asthmatics.

Effects of weight loss on dynamic hyperinflation in women obese asthmatics.

J Appl Physiol (1985). 2018 Dec 06;:

Authors: Silva AG, Freitas PD, Ferreira PG, Stelmach R, Pinto RMC, Salge JM, Martins MA, Carvalho CRF

Abstract
Obese adults with asthma are more likely to develop dynamic hyperinflation (DH) and expiratory flow limitation (EFL) than non-obese asthmatics, and weight-loss seems to improve the breathing mechanics during exercise. However, studies evaluating the effect of weight-loss on DH in obese adults with asthma have not been performed.
OBJECTIVE: To evaluate the effect of a weight-loss program on DH in obese adults with asthma.
METHODS: Forty-two asthma patients were enrolled in a weight-loss program (diet, psychological support and exercise) and were subsequently divided into two groups according to the percentage of weight-loss: the ≥5%group (n=19) and the <5%group (n=23). Before and after the intervention, DH and EFL (constant load exercise), health-related quality of life (HRQoL), asthma control, quadriceps muscle strength and endurance, body composition and lung function were assessed.
RESULTS: Both groups exhibited a decrease of ≥10% in inspiratory capacity (DH) before intervention, and only the ≥5%group showed clinical improvement in DH compared to <5%group post-intervention (-9.1±14.5% vs. -12.5±13.5%, respectively). In addition, the ≥5%group displayed a significant delay in the onset of both DH and EFL and a clinically significant improvement in HRQoL and asthma control. Furthermore, a correlation was observed between reduced waist circumference and increased inspiratory capacity (r=-0.45, p=0.05) in the ≥5%group.
CONCLUSION: A weight-loss ≥5% of the body weight improves DH, which is associated with waist circumference in obese adults with asthma. In addition, the group with greater weight-loss showed a delayed onset of DH and EFL during exercise and improved asthma clinical control and HRQoL.

PMID: 30521428 [PubMed - as supplied by publisher]

from PubMed via alexandrossfakianakis on Inoreader https://ift.tt/2L1BaNm