Tumor-treating fields as a proton beam-sensitizer for glioblastoma therapy

xlomafota13 shared this article with you from Inoreader Tumor-treating fields as a proton beam-sensitizer for glioblastoma therapy Via American Journal of Cancer Research Am J Cancer Res. 2021 Sep 15;11(9):4582-4594. eCollection 2021. ABSTRACT Few advances in GBM treatment have been made since the initiation of the Stupp trials in 2005. Experimental studies on immunotherapy drugs, molecular inhibitors, radiation dosage escalation and vascular growth factor blockers have all failed to provide satisfactory outcomes. TTFields therapy, on the other hand, have emerged as a viable substitute to therapies like radiation in GBM patients having a highly immunosuppressive tumor microenvironment. To enhance the biofunctional impacts, we explored the combination events with TTFields and proton treatment in this study. We conducted a cell viability test, a cell death detection evaluation, a ROS analysis, a three-dimensional (3D) culture system, and a migration assay. The combination of proton radiation and TTFields therapy laid a substantial anticancer impact on the F98 and U373 as compared to the consequences of ei ther of these therapies used separately. The combination proton beam therapy used by TTFields was very successful in curbing GBM from migrating. GBM cell metastasis is restricted by TTFields combined proton by downregulating the MAPK, NF-κB, and PI3K/AKT indicating pathways, caused by reduced EMT marker expression. These findings furnish biological proof for the molecular grounds of TTFields in combination with proton used for GBM therapy. PMID:34659907 | PMC:PMC8493382< /p> View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.