Neoadjuvant intraperitoneal chemotherapy for advanced stage gastric cancer (Review)

xlomafota13 shared this article with you from Inoreader Neoadjuvant intraperitoneal chemotherapy for advanced stage gastric cancer (Review) Via Experimental and therapeutic medicine Exp Ther Med. 2021 Nov;22(5):1314. doi: 10.3892/etm.2021.10749. Epub 2021 Sep 17. ABSTRACT Gastric cancer remains one of the most lethal malignancies especially when diagnosed in advanced stages of the disease; most often patients diagnosed later during the progression of their disease will present a certain degree of peritoneal contamination such as positive peritoneal cytology or peritoneal metastatic nodules. In such cases most often they then progress to peritoneal carcinomatosis and succumb to the disease within one year. In order to increase the lifespan in such cases multiple therapeutic strategies have been proposed such as radical surgery and intraperitoneal heated chemotherapy or direct intraperitoneal chemotherapy followed by radical surgery. To date, the benefits of intraperitoneal heated chemotherapy at the time of resection have been widely investigated; however the method is still associated with increased rates of perio perative complications. Therefore, attention was focused on investigating the benefits of such procedures as neoadjuvant therapies followed by radical surgery. The aim of the present review was to examine the most efficient therapeutic strategies in advanced-stage gastric cancer such as neoadjuvant laparoscopic heated intraperitoneal chemotherapy, perioperative heated intraperitoneal chemotherapy and neoadjuvant systemic and peritoneal chemotherapy. PMID:34630668 | PMC:PMC846 1609 | DOI:10.3892/etm.2021.10749 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.