Regulatory effect of insulin on the structure, function and metabolism of Na+/K+-ATPase (Review)

xlomafota13 shared this article with you from Inoreader Regulatory effect of insulin on the structure, function and metabolism of Na<sup>+</sup>/K<sup>+</sup>-ATPase (Review) Via Experimental and therapeutic medicine Exp Ther Med. 2021 Nov;22(5):1243. doi: 10.3892/etm.2021.10678. Epub 2021 Sep 1. ABSTRACT Na+/K+-ATPase is an ancient enzyme, the role of which is to maintain Na+ and K+ gradients across cell membranes, thus preserving intracellular ion homeostasis. The regulation of Na+/K+-ATPase is affected by several regulatory factors through a number of pathways, with hormones serving important short-term and long-term regulatory functions. Na+/K+-ATPase can also be degraded through activation of the ubiquitin proteasome and autophagy-lysosomal pathways, thereby affecting its abundance and enzymatic activity. As regards the regulatory effect of insulin, it has been found to upregulate the relative abundance of Na+/K+-ATPase and restore the transport efficiency in multiple in vitro and in vivo experiments. Therefore, elucidati ng the role of insulin in the regulation Na+/K+-ATPase may help uncover new drug targets for the treatment of related diseases. The aim of the present study was to review the structure and function of Na+/K+-ATPase and to discuss the possible mechanisms through which it may be regulated by insulin, in order to investigate the possibility of designing new therapies for related diseases. PMID:34539839 | PMC:PMC8438676 | DOI:10.3892/etm.2021.10678 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.