Alpelisib and radiotherapy treatment enhances Alisertib-mediated cervical cancer tumor killing

xlomafota13 shared this article with you from Inoreader Alpelisib and radiotherapy treatment enhances Alisertib-mediated cervical cancer tumor killing Via American Journal of Cancer Research Am J Cancer Res. 2021 Jun 15;11(6):3240-3251. eCollection 2021. ABSTRACT Human papilloma virus (HPV) is the main causative agent in cervical cancers. High-risk HPV cancers, including cervical cancer, are driven by major HPV oncogene, E6 and E7, which promote uncontrolled cell growth and genomic instability. We have previously shown that the presence of HPV E7 sensitizes cells to inhibition of aurora kinases (AURKs), which regulates the control of cell entry into and through mitosis. Such treatment is highly effective at eliminating early tumors and reducing large, late tumors. In addition, the presence of HPV oncogenes also sensitizes cells to inhibition of phosphoinositide 3-kinases (PI3Ks), a family of enzymes involved in cellular functions such as cell growth and proliferation. Using MLN8237 (Alisertib), an oral, selective inhibitor of AURKs, we investigated whether Alisertib treatment can improve tumor response when combined with e ither radiotherapy (RT) treatment or with a PI3K inhibitor, BYL719 (Alpelisib). Indeed, both RT and Alpelisib significantly improved Alisertib-mediated tumor killing, and the promising achieved results warrant further development of these combinations, and potentially translating them to the clinics. PMID:34249458 | PMC:PMC8263691 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.