Molecular mechanisms and associated cell signalling pathways underlying the anticancer properties of phytochemical compounds from Aloe species (Review)

xlomafota13 shared this article with you from Inoreader Molecular mechanisms and associated cell signalling pathways underlying the anticancer properties of phytochemical compounds from <em>Aloe</em> species (Review) Via Experimental and therapeutic medicine Exp Ther Med. 2021 Aug;22(2):852. doi: 10.3892/etm.2021.10284. Epub 2021 Jun 8. ABSTRACT Naturally occurring components from various species of Aloe have been used as traditional folk medicine since the ancient times. Over the last few decades, the therapeutic effects of extracts and phytochemical compounds obtained from Aloe vera have been proven in preclinical and clinical studies. Recently, compounds from other Aloe species apart from Aloe vera have been investigated for the treatment of different diseases, with a particular focus on cancer. In the present review, the effects of phytochemical compounds obtained from different Aloe species are discussed, with a specific focus on the effects on cell signalling in cancer and normal cells, and their selectivity and efficacy. This information will be useful for the application of Aloe-derived compounds as therapeutic agents, either alone or in co mbination with other standard drugs for cancer treatment. PMID:34178125 | PMC:PMC8220653 | DOI:10.3892/etm.2021.10284 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.