Regulation of Beclin 1-Mediated Autophagy by Oncogenic Tyrosine Kinases.

payth.elady61 shared this article with you from Inoreader Regulation of Beclin 1-Mediated Autophagy by Oncogenic Tyrosine Kinases. Via pubmed: autophagy Regulation of Beclin 1-Mediated Autophagy by Oncogenic Tyrosine Kinases. Int J Mol Sci. 2020 Dec 03;21(23): Authors: Vega-Rubín-de-Celis S, Kinch L, Peña-Llopis S Abstract Beclin 1 is a major regulator of autophagy, and it is a core component of the class III PI3K complexes. Beclin 1 is a highly conserved protein and its function is regulated in a number of ways, including post-translational modifications. Several studies indicate that receptor and non-receptor tyrosine kinases regulate autophagy activity in cancer, and some suggest the importance of Beclin 1 tyrosine phosphorylation in this process. Here we summarize the current knowledge of the mechanism whereby some oncogenic tyrosine kinases regulate autophagy through Beclin 1. PMID: 33287140 [PubMed - in process] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.