Thymic epithelial neoplasms with sebaceous differentiation: a clinicopathological and Immunohistochemical study of 8 cases.
Hum Pathol. 2018 Dec 08;:
Authors: Kalhor N, Moran CA
Abstract
Eight cases of primary thymic epithelial neoplasms corresponding to seven thymomas and one thymic carcinoma with sebaceous differentiation are presented. The patients are five men and three women between the ages of 45 and 63years (average: 54years) who presented with non-specific symptomatology related to their mediastinal mass. All patients underwent complete surgical resection of the mediastinal mass. Grossly, all the tumors were described as round to oval measuring from 3.5 to 6.0cm in greatest diameter. In four cases, the tumors were described as with infiltrative borders. Histologically, one tumor corresponded to thymic carcinoma characterized by irregular islands of tumors cells showing cellular atypia and mitotic activity. Six of the seven thymomas showed mixed histologies corresponding to spindle cell, lymphocyte predominant, and mixed lymphocyte/epithelial types (WHO A, B1 and B2). One thymoma was mixed lymphocyte/epithelial (WHO B2). The areas of sebaceous differentiation characterized by clusters or strands of epithelial cells with ample clear cytoplasm were present within the lymphocytic component, while in the thymic carcinoma the areas of sebaceous differentiation were identified within the epithelial component of the tumor. Follow-up information was obtained in 5 patients showing that the patient with thymic carcinoma died 20months after initial diagnosis, while the patients with thymoma whether encapsulated or minimally invasive remained alive without recurrence 12 to 24months after initial diagnosis. The current cases represent an unusual feature that occasionally may be seen in thymomas and thymic carcinomas.
PMID: 30537491 [PubMed - as supplied by publisher]
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