Blog Archive

Αλέξανδρος Γ. Σφακιανάκης

Wednesday, December 12, 2018

Cortical abnormalities in episodic migraine: A multi-center 3T MRI study.

Related Articles

Cortical abnormalities in episodic migraine: A multi-center 3T MRI study.

Cephalalgia. 2018 Dec 10;:333102418795163

Authors: Magon S, May A, Stankewitz A, Goadsby PJ, Schankin C, Ashina M, Amin FM, Seifert CL, Mallar Chakravarty M, Müller J, Sprenger T

Abstract
BACKGROUND: Several previous studies have investigated cortical abnormalities, specifically cortical thickness, in patients with migraine, with variable results. The relatively small sample sizes of most previous studies may partially explain these inconsistencies.
OBJECTIVE: To investigate differences of cortical thickness between control subjects and migraineurs in a large cohort.
METHODS: Three Tesla MRI data of 131 patients (38 with and 93 without aura) and 115 control subjects were analysed. A vertex-wise linear model was applied controlling for age, gender and MRI scanner to investigate differences between groups and determine the impact of clinical factors on cortical thickness measures.
RESULTS: Migraineurs showed areas of thinned cortex compared with controls bilaterally in the central sulcus, in the left middle-frontal gyrus, in left visual cortices and the right occipito-temporal gyrus. Frequency of migraine attacks and the duration of the disorder had a significant impact on cortical thickness in the sensorimotor cortex and middle-frontal gyrus. Patients without aura showed thinner cortex than controls bilaterally in the central sulcus and in the middle frontal gyrus, in the left primary visual cortices, in the left supramarginal gyrus and in the right cuneus. Patients with aura showed clusters of thinner cortex bilaterally in the subparietal sulcus (between the precuneus and posterior cingulate cortex), in the left intraparietal sulcus and in the right anterior cingulate.
CONCLUSION: These results indicate cortical abnormalities in specific brain regions in migraineurs. Some of the observed abnormalities may reflect a genetic susceptibility towards developing migraine attacks, while others are probably a consequence of repeated head pain attacks.

PMID: 30525946 [PubMed - as supplied by publisher]



from PubMed via alexandrossfakianakis on Inoreader https://ift.tt/2Gb4FO1

No comments:

Post a Comment