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Natural killer/T-cell lymphoma and secondary haemophagocytic lymphohistiocytosis in pregnancy.
BMJ Case Rep. 2018 09 15;2018:
Authors: Neistadt B, Carrubba A, Zaretsky MV
Abstract
Haemophagocytic lymphohistiocytosis (HLH) is a rare and potentially fatal disorder. It is challenging to diagnose due to its rarity and variation in clinical presentation, laboratory abnormalities and underlying aetiologies. A reproductive-aged woman, gravida 2 para 1001 at 27 weeks gestation presented with fever, hypotension and subacute upper respiratory infection. She delivered a male infant by caesarean section secondary to fetal distress. Subsequently, she was diagnosed with T-cell lymphoma and secondary HLH. Despite management with supportive care and multiple chemotherapeutic agents, she ultimately died of multiorgan failure. Patients with HLH secondary to malignancy have a particularly poor prognosis. This case highlights the importance of considering secondary HLH in the differential diagnosis of a patient with fever, pancytopenia and systemic symptoms of unclear aetiology in pregnancy.
PMID: 30219776 [PubMed - indexed for MEDLINE]
from PubMed via alexandrossfakianakis on Inoreader https://ift.tt/2ME250R
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