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Alternative Acts: Oncogenic Splicing of Steroidogenic Enzymes in Prostate Cancer.
Clin Cancer Res. 2018 Dec 10;:
Authors: Mostaghel EA
Abstract
Castration resistant prostate cancer is characterized by loss of the androgen inactivation enzyme HSD17B2, emphasizing the importance of intratumoral androgens in tumor progression. Inactive isoforms generated by alternative splicing destabilize the wild-type enzyme, adding steroidogenesis to other prostate cancer drivers that undergo oncogenic splicing, highlighting aberrant splicing as a therapeutic target.
PMID: 30530817 [PubMed - as supplied by publisher]
from PubMed via alexandrossfakianakis on Inoreader https://ift.tt/2QMpymQ
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