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Αλέξανδρος Γ. Σφακιανάκης

Thursday, October 28, 2021

Hemodynamic Alteration in the Liver in Acute Hepatitis: A Quantitative Evaluation Using Computed Tomographic Perfusion

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In Vivo. 2021 Nov-Dec;35(6):3537-3545. doi: 10.21873/invivo.12656.

ABSTRACT

BACKGROUND/AIM: We aimed to elucidate the hemodynamic alterations in the liver of patients with acute hepatitis (AH) using computed tomography perfusion imaging.

PATIENTS AND METHODS: For 14 patients with AH and nine patients with no disease (ND group), we compared the mean arterial blood flow (AF), portal blood flow (PF) and perfusion index (%) [PI=AF/(AF+PF) ×100] of the right and left liver lobes and investigated their relationship with clinical factors.

RESULTS: The mean PI of the right lobe in the AH group (30.5±10.0%) was significantly higher than that in the ND group (20.8±9.7%) (p=0.031). For all patients of the AH and ND groups, the PI of the right lobe was increased as the prothrombin time decreased (R=-0.56, p=0.006) and as the prothrombin time-international normalized ratio increased (R=0.48, p=0.02).

CONCLUSION: The PI of the r ight liver lobe may increase in AH and may be a predictive parameter for the severity of hepatic failure.

PMID:34697192 | DOI:10.21873/invivo.12656

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