Future Applications of 3D Bioprinting: A promising technology for treating recessive dystrophic epidermolysis bullosa

xlomafota13 shared this article with you from Inoreader Future Applications of 3D Bioprinting: A promising technology for treating recessive dystrophic epidermolysis bullosa Via Experimental Dermatology Abstract Three-dimensional (3D) bioprinting is a rapidly developing technology that has potential to initiate a paradigm shift in the treatment of skin wounds arising from burns, ulcers, and genodermatoses. Recessive dystrophic epidermolysis bullosa (RDEB), a severe form of epidermolysis bullosa, is a rare genodermatosis that results in mechanically induced blistering of epithelial tissues that leads to chronic wounds. Currently, there is no cure for RDEB, and effective treatment is limited to protection from trauma and extensive bandaging. The care of chronic wounds and burns significantly burdens the healthcare system, further illustrating the dire need for more beneficial wound care.1 Although in its infancy, 3D bioprinting offers therapeutic potential for wound healing and could be a breakthrough technology for the treatment of rare, incurable genodermatoses like RDEB. This viewpoint essay outlines the promise of 3D bioprinting applications for treating RDEB, including skin regeneration, a delivery system for gene-edited cells and small molecules, and disease modeling. While the future of 3D bioprinting is encouraging, there are many technical challenges to overcome―including optimizing bioink and cell source―before this approach can be widely implemented in clinical practice. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.