Role of High‐Risk HPV Detected by PCR in Malignant Sinonasal Inverted Papilloma: A Meta‐Analysis

xlomafota13 shared this article with you from Inoreader Role of High‐Risk HPV Detected by PCR in Malignant Sinonasal Inverted Papilloma: A Meta‐Analysis Via The Laryngoscope Introduction Prior studies suggest that there may be a link between human papillomavirus (HPV) infection and malignant sinonasal inverted papilloma (SNIP). This systematic review and meta-analysis was performed to further evaluate this potential association. Study design Systematic review with meta-analysis. Methods The Medline and Embase databases were used to identify case–control studies reporting the risk of malignant SNIP in patients with high-risk HPV subtypes identified by polymerase chain reaction (PCR). Meta-analysis was performed to determine pooled odds ratios (ORs) and 95% confidence intervals (CI). Results Twenty-one studies were identified, including a total of 841 subjects with SNIP. Seventeen studies were included in the final analysis, as four studies did not have any HPV-positive tumors in either group. A total of 56 malignant SNIP and 551 benign SNIP were ultimately identified. The pooled log-OR was 1.80 (95% CI: 1.03–2.57) for all high-risk HPV subtypes. Stratification by high-risk HPV subtype showed a log-OR of 1.67 (95% CI: 0.88–2.46) for HPV-16 and log-OR of 2.68 (95% CI: 1.30–4.05) for HPV-18. Conclusion Infection with high-risk HPV subtypes may be associated with an increased risk of malignant SNIP. HPV-18 showed the greatest overall average effect size of the common high-risk subtypes. Level of Evidence n/a Laryngoscope, 2021 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.