Epigenetic regulation and signaling pathways in Merkel cell development

xlomafota13 shared this article with you from Inoreader Epigenetic regulation and signaling pathways in Merkel cell development Via Experimental Dermatology Abstract Merkel cells are specialized epithelial cells connected to afferent nerve endings responsible for light-touch sensations, formed at specific locations in touch-sensitive regions of the mammalian skin. Although Merkel cells are descendants of the epidermal lineage, little is known about the mechanisms responsible for the development of these unique mechanosensory cells. Recent studies have highlighted that the Polycomb group (PcG) of proteins play a significant role in spatiotemporal regulation of Merkel cell formation. In addition, several of the major signaling pathways involved in skin development have been shown to regulate Merkel cell development as well. Here, we summarize the current understandings of the role of developmental regulators in Merkel cell formation, including the interplay between the epigenetic machinery and key signaling pathways, and the lineage-specific transcription factors involved in the regulation of Merkel cell development. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.