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Tuesday, March 16, 2021

Diagnosis of isolated congenital anosmia using simultaneous functional magnetic resonance imaging and olfactory event‐related potentials: Our experience in six patients

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Abstract

‐ Primary anosmia is usually associated with Kallmann syndrome, which is characterized by hormonal abnormalities such as hypogonadotropic hypogonadism.

‐ On very rare occasions, a primary anosmia presents as olfactory bulb agenesis without this associated syndrome.

‐ In previous studies of such cases, diagnosis is usually based on the absence of an olfactory bulb on structural MRI, rather than on objective functional measures.

‐ Simultaneous functional MRI and olfactory event‐related potential recordings can provide highly objective evidence of olfactory function.

‐ We examined both structural and functional MRI and olfactory event‐related potential data to diagnose primary anosmia with isolated olfactory bulb agenesis, gaining objective evidence of olfactory function.

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