The Roles of Insulin-Like Growth Factor Binding Protein Family in Development and Diseases

xlomafota.13 shared this article with you from Inoreader The Roles of Insulin-Like Growth Factor Binding Protein Family in Development and Diseases Via Latest Results for Advances in T... Abstract The insulin-like growth factor (IGF) system comprises ligands of IGF-I/II, IGF receptors (IGFR), IGF binding proteins (IGFBPs), and IGFBP hydrolases. The IGF system plays multiple roles during various disease development as IGFs are widely involved in cell proliferation and differentiation through regulating DNA transcription. Meanwhile, IGFBPs, which are mainly synthesized in the liver, can bind to IGFs and perform two different functions: either inhibition of IGFs by forming inactive compounds with IGF or enhancement of the function of IGFs by strengthening the IGF–IGFR interaction. Interestingly, IGFBPs may have wider functions through IGF-independent mechanisms. Studies have shown that IGFBPs play important roles in cardiovascular disease, tumor progression, fetal growth, and neuro-nutrition. In this review, we emphasize that different IGFBP family members have common or unique functions in numerous diseases; moreover, IGFBPs may serve as biomarkers for dis ease diagnosis and prediction. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.