Calcium signaling: breast cancer’s approach to manipulation of cellular circuitry

xlomafota.13 shared this article with you from Inoreader Calcium signaling: breast cancer's approach to manipulation of cellular circuitry Via Latest Results for Biophysical Reviews Abstract Calcium is a versatile element that participates in cell signaling for a wide range of cell processes such as death, cell cycle, division, migration, invasion, metabolism, differentiation, autophagy, transcription, and others. Specificity of calcium in each of these processes is achieved through modulation of intracellular calcium concentrations by changing the characteristics (amplitude/frequency modulation) or location (spatial modulation) of the signal. Breast cancer utilizes calcium signaling as an advantage for survival and progression. This review integrates evidence showing that increases in expression of calcium channels, GPCRs, pumps, effectors, and enzymes, as well as resulting intracellular calcium signals, lead to high calcium and/or an elevated calcium- mobilizing capacity necessary for malignant functions such as migratory, invasive, proliferative, tumorigenic, or metastatic capacities. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.