TDP‐43 as structure‐based biomarker in amyotrophic lateral sclerosis

payt.helady61 shared this article with you from Inoreader TDP‐43 as structure‐based biomarker in amyotrophic lateral sclerosis Via Annals of Clinical and Translational Neurology Abstract Pathologic alterations of Transactivation response DNA‐binding protein 43 kilo Dalton (TDP‐43) are a major hallmark of amyotrophic lateral sclerosis (ALS). In this pilot study, we analyzed the secondary structure distribution of TDP‐43 in cerebrospinal fluid of ALS patients (n = 36) compared to Parkinson´s disease patients (PD; n = 30) and further controls (Ctrl; n = 24) using the immuno‐infrared sensor technology. ALS patients could be discriminated from PD and Ctrl with a sensitivity/specificity of 89 %/77 % and 89 %/83 %, respectively. Our findings demonstrate that TDP‐43 misfolding measured by the immuno‐infrared sensor technology has the potential to serve as a biomarker candidate for ALS. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.