Response to Perspectives on the Classical Enzyme Carbonic Anhydrase and the Search for Inhibitors

payt.helady61 shared this article with you from Inoreader Response to Perspectives on the Classical Enzyme Carbonic Anhydrase and the Search for Inhibitors Via Biophysical Journal In a recent paper by Jonsson and Liljas (1), some inhibition data from the supporting information of several papers from the Supuran group were considered where carbonic anhydrase (CA, EC 4.2.1.1) inhibitors (CAIs) were reported (2–10). The concentrations of the enzyme and substrate concentrations used in some experiments were questioned, and the authors assumed that the measurements were performed incorrectly (1). For example, Jonsson and Liljas state that "inhibition curves [from the supporting information in a few of our papers] do not show normal inhibition." This and other statements from this paper (1) are fully inconsistent and are based on conceptual errors, which will be detailed here. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.