Protein modification characteristics of the malaria parasite Plasmodium falciparum and the infected erythrocytes [Research]

alwin shared this article with you from Inoreader Protein modification characteristics of the malaria parasite Plasmodium falciparum and the infected erythrocytes [Research] Via MCP Papers in Press Malaria elimination is still pending on the development of novel tools that rely on a deep understanding of parasite biology. Proteins of all living cells undergo a myriad number of posttranslational modifications (PTMs) that are critical to multifarious life processes. An extensive proteome-wide dissection revealed a fine PTM map of most proteins in both Plasmodium falciparum, the causative agent of severe malaria, and the infected red blood cells. More than two-thirds of proteins of the parasite and its host cell underwent extensiv e and dynamic modification throughout the erythrocytic developmental stage. PTMs critically modulate the virulence factors involved in the host-parasite interaction and pathogenesis. Furthermore, P. falciparum stabilized the supporting proteins of erythrocyte origin by selective de-modification. Collectively, our multiple omic analyses, apart from having furthered a deep understanding of the systems biology of P. falciparum and malaria pathogenesis, provide a valuable resource for mining new antimalarial targets. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.