Exploiting the Microhomology-Mediated End-Joining Pathway in Cancer Therapy

alwin shared this article with you from Inoreader Exploiting the Microhomology-Mediated End-Joining Pathway in Cancer Therapy Via Cancer Research current issue Repair of DNA double-strand breaks (DSB) is performed by two major pathways, homology-dependent repair and classical nonhomologous end-joining. Recent studies have identified a third pathway, microhomology-mediated end-joining (MMEJ). MMEJ has similarities to homology-dependent repair, in that repair is initiated with end resection, leading to single-stranded 3′ ends, which require microhomology upstream and downstream of the DSB. Importantly, the MMEJ pathway is commonly upregulated in cancers, especiall y in homologous recombination-deficient cancers, which display a distinctive mutational signature. Here, we review the molecular process of MMEJ as well as new targets and approaches exploiting the MMEJ pathway in cancer therapy. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.