Real-life data patterns of C-reactive protein and albumin level trajectories around bacteremia.

Real-life data patterns of C-reactive protein and albumin level trajectories around bacteremia.

Biomark Med. 2018 Nov 30;:

Authors: Gradel KO, Póvoa P, Vinholt PJ, Magnussen B, Pedersen C, Jensen TG, Kolmos HJ, Lassen AT

Abstract
AIM: To assess trajectory patterns of C-reactive protein (CRP) and plasma albumin (PA) levels around bacteremia.
PATIENTS & METHODS: Population-based study, 2418 community-acquired bacteremia patients, CRP and PA specimens from 30 days before through 30 days after bacteremia (day 0). A pattern was based on specimen occurring or not in days -30/-1, 0, 1/7 or 8/30. Mean daily CRP and PA levels on day -30/30 were computed for pattern subgroups.
RESULTS & CONCLUSION: Mean CRP rose on day -5 and reached its peak on day 1. Mean steady PA on day -30/0 declined abruptly on day 1, increasing slowly thereafter. Trajectories did not differ between subgroups. We conclude that longitudinal analysis results can be extrapolated to all community-acquired bacteremia patients.

PMID: 30499693 [PubMed - as supplied by publisher]

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