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Atypical Hepatic Mesenchymal Hamartoma: Histologic Appearance, Immunophenotype, and Molecular Findings.
Pediatr Dev Pathol. 2018 Nov 29;:1093526618806750
Authors: El Demellawy D, Lee JY, McDonell L, Dyment DA, Knisely AS, McGowan-Jordan J, Ngan B, Finegold M, Kapur RP, Nasr A
Abstract
Hepatic mesenchymal hamartoma is a rare benign neoplasm principally encountered in young children. Its origin is unknown. We report an unusual hepatic mesenchymal hamartoma in a 7-month-old girl, including histopathologic findings, immunophenotype, and karyotype. Chromosomal microarray analysis of tumoral tissue and circulating lymphocytes found 4 copies of a segment at 1q44 and fluorescence in situ hybridization indicated tandem triplication, ascribed to expansion of a paternal tandem duplication. This genetic abnormality may have played a role in pathogenesis.
PMID: 30497332 [PubMed - as supplied by publisher]
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