Age at onset of metabolic syndrome among women with and without polycystic ovary syndrome-like status.
J Clin Endocrinol Metab. 2018 Dec 03;:
Authors: Peng Q, Karvonen-Gutierrez CA, Randolph JF, Nan B, McConnell D, Harlow SD
Abstract
Context: Women with polycystic ovary syndrome (PCOS) have a higher prevalence of metabolic syndrome (MetS), but whether they develop MetS earlier than women without PCOS is unknown. Understanding the impact of PCOS on the timing of MetS onset is important for screening and clinical care in this population.
Design: Women with PCOS-like status ("PCOSp") were identified from participants of the Michigan Bone Health and Metabolism Study based upon history of irregular menstrual cycles, high free-androgen index and high levels of anti-müllerian hormone. MetS was defined according to the Adult Treatment Panel III criteria. Age at MetS onset was compared between women with and without PCOSp using an accelerated failure time model adjusted for baseline education, lifestyle factors and midlife body weight.
Results: Among the 496 women in the analysis, 11.7% (n=58) were determined to have PCOSp. Over a mean follow-up of 11 years, 20 women with PCOSp and 136 women without PCOSp developed MetS. After adjusting for smoking, education and physical activity, women with PCOSp developed MetS at an age 14.4% (95% confidence interval (CI) -22.7, -5.2) younger than women without PCOSp. The magnitude of the association was attenuated to 5.4% in models additionally adjusted for BMI (95% CI -12.4, 2.1). Since a typical study participant without PCOSp developed MetS at 51.5, 5.4% translates to almost three years earlier onset of MetS for a comparable woman with PCOSp.
Conclusions: Women with PCOSp develop MetS at a younger age. Earlier screening for MetS in women with PCOS may be warranted.
PMID: 30517661 [PubMed - as supplied by publisher]
from PubMed via alexandrossfakianakis on Inoreader https://ift.tt/2Qg1kll
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