Notch dysregulation and HS: let's talk about Numb.

Notch dysregulation and HS: let's talk about Numb.

Br J Dermatol. 2018 Dec 04;:

Authors: Marasca C, Scala E, Di Caprio R, Raimondo A, Cacciapuoti S, Balato A, Fabbrocini G

Abstract
We read with great interest the article by J. W. Frew regarding Notch Dysregulation as an Epiphenomenon in Inflammatory Skin Diseases.1 The paper pointed out some controversies among Notch activity and keratinocyte proliferation as well as maturation in Hidradenitis Suppurativa (HS), Psoriasis, Atopic Dermatitis and Lichen Planus. Because of a recognized involvement of Notch in HS, but at the same time still not clear, we also explored other components of the same signalling. This article is protected by copyright. All rights reserved.

PMID: 30515753 [PubMed - as supplied by publisher]

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